ライフサイエンスコーパス: voltage-gated potassium channel

1 onitor localized electric field changes in a voltage-gated potassium channel.

2 ion of a slowly activating, noninactivating, voltage-gated potassium channel.

3 ere used to analyze mechanisms of block in a voltage-gated potassium channel.

4 The KvLQT1 gene encodes a voltage-gated potassium channel.

5 to Slo1, the large conductance, calcium- and voltage-gated potassium channel.

6 model for the transmembrane topology of the voltage-gated potassium channel.

7 odes a protein with structural features of a voltage-gated potassium channel.

8 n human ether-a-go-go-related gene (HERG), a voltage-gated potassium channel.

9 se mutation in KCNB1 that encodes the KV 2.1 voltage-gated potassium channel.

10 nsitivity in closely related Kv1.4 and Kv1.5 voltage gated potassium channels.

11 t peptide that binds selectively to Kv2-type voltage gated potassium channels.

12 cerebellum, only partly in association with voltage-gated potassium channels.

13 ggest that FMRP might also directly regulate voltage-gated potassium channels.

14 limbic encephalitis previously attributed to voltage-gated potassium channels.

15 disorders with or without antibodies against voltage-gated potassium channels.

16 other major classes of chloride channels and voltage-gated potassium channels.

17 e in skeletal muscle to create subthreshold, voltage-gated potassium channels.

18 similarity and belong to the superfamily of voltage-gated potassium channels.

19 s are the most conserved among the family of voltage-gated potassium channels.

20 utative binding sites for other blockers and voltage-gated potassium channels.

21 are important constituents of the underlying voltage-gated potassium channels.

22 channels, slowly activating, noninactivating voltage-gated potassium channels.

23 at are critical to the proper functioning of voltage-gated potassium channels.

24 ody cells based on the oxygen sensitivity of voltage-gated potassium channels.

25 e with structural characteristics similar to voltage-gated potassium channels.

26 ose metabolism or the activities of KATP and voltage-gated potassium channels.

27 nctional role of KCNE cleavage in regulating voltage-gated potassium channels.

28 ) is an important regulator of Kv7.x (KCNQx) voltage-gated potassium channels.

29 l as Kir2.1, Kir2.2, Kir2.3, Kir3.1/3.2, and voltage-gated potassium channel 2.1.

30 K(V)10.1 is a voltage-gated potassium channel aberrantly expressed in

31 -activated potassium (BK) channels and Kv3.3 voltage-gated potassium channels accompanies the inabili

32 membrane domain of the IsK protein with slow voltage-gated potassium channel activity, has been incor

33 idine (4-AP), a nonselective blocker of K(v) voltage-gated potassium channels, alleviates attacks of

34 ne et al. provide evidence of a role for the voltage-gated potassium channel alpha subunit Kv3.4 and

35 Mice lacking the voltage-gated potassium channel alpha subunit, K(V)1.1,

36 Kv4 family voltage-gated potassium channel alpha subunits and Kv ch

37 KCNV2 codes for the modulatory voltage-gated potassium channel alpha-subunit, Kv8.2, wh

38 l and BK-KCa mRNAs (encoding the Shal-family voltage-gated potassium channel and large-conductance ca

39 ic encephalitis and antibodies attributed to voltage-gated potassium channels and 148 control individ

40 by members of the closely related family of voltage-gated potassium channels and also differs consid

41 main responsible for the ordered assembly of voltage-gated potassium channels and interactions with o

42 C-type inactivation is present in many voltage-gated potassium channels and is probably related

43 rom multiple gene families including one for voltage-gated potassium channels and one for inwardly re

44 A-Kv1.3 subunits, which is conserved in many voltage-gated potassium channels and prevents strong non

45 el, these adaptations include low-threshold, voltage-gated potassium channels and unusually rapid-act

46 In the presynaptic terminal, voltage-gated potassium channels and voltage-gated calci

47 Voltage-gated potassium channel antibodies (VGKC-Ab) hav

48 EAG-like (ELK) voltage-gated potassium channels are abundantly expresse

49 Voltage-gated potassium channels are comprised of four s

50 Many voltage-gated potassium channels are controlled through

51 rophysiological evidence indicates that KCNQ voltage-gated potassium channels are critical regulators

52 Kv3.1 and Kv3.2 voltage-gated potassium channels are expressed on parval

53 Voltage-gated potassium channels are formed by the tetra

54 The gating properties of voltage-gated potassium channels are largely determined

55 Voltage-gated potassium channels are six-transmembrane (

56 The voltage-gated potassium channels are the prototypical me

57 Voltage-gated potassium channels are the site of action

58 Voltage-gated potassium channels are thought to be the t

59 Oligomers of homomeric voltage-gated potassium channels associate early in biog

60 he presence of antibodies directed against 2 voltage-gated potassium channel-associated proteins: LGI

61 al amino acid was incorporated in the Shaker voltage-gated potassium channel at key regions that were

62 This gene, a voltage-gated potassium channel, based on homology, is a

63 Consistent with this idea, administration of voltage-gated potassium channel blockers restores conduc

64 rane segments, making it more similar to the voltage-gated potassium channels, but the ion selectivit

65 the pore much like the "hanging gondola" of voltage-gated potassium channels, but the permeation pat

66 Activation of voltage-gated potassium channels by a chemical opener is

67 The open gate of the Kv1.2 voltage-gated potassium channel can just hold a hydrated

68 ction mutations in hERG (encoding the Kv11.1 voltage-gated potassium channel) cause long-QT syndrome

69 In the heart, KCNQ1 voltage-gated potassium channels coassemble with KCNE1 b

70 litis (LE) associated with antibodies to the voltage-gated potassium channel complex (VGKC) is a pote

71 n 7 patients (6.3%): 3 (2.7%) had TPO-Ab and voltage-gated potassium channel complex (VGKCc) Ab, 2 (1

72 ic encephalitis that is associated with anti-voltage-gated potassium channel complex (VGKCC) antibodi

73 Voltage-gated potassium channel complex antibodies, part

74 Voltage-gated potassium channel complex antibody (VGKCc-

75 ts with memory disorders, such as those with voltage-gated potassium channel complex antibody limbic

76 On both paradigms, voltage-gated potassium channel complex antibody patient

77 Voltage-gated potassium channel complex antibody-associa

78 requently associated with antibodies against voltage-gated potassium channel complex proteins.We pres

79 1, CASPR2 and Contactin-2, components of the voltage-gated potassium channel complex, have been detec

80 propose models of DPPX interaction with the voltage-gated potassium channel complex.

81 a inactivated 1 (LGI1) is a component of the voltage-gated potassium channel complex.

82 All 10 cases were positive for voltage-gated potassium channel-complex antibodies (346-

83 Voltage-gated potassium channel-complex antibodies persi

84 se antibodies (>1000 U/ml), and one had high voltage-gated potassium channel-complex antibody (2442 p

85 Antibodies to components of voltage-gated potassium channel complexes (VGKCs), NMDA

86 nduce neurological autoimmunity and identify voltage-gated potassium channel complexes as a major imm

87 sferring the NOMPC ARs to mechanoinsensitive voltage-gated potassium channels confers mechanosensitiv

88 Voltage-gated potassium channels constitute the largest

89 Voltage-gated potassium channels control cardiac repolar

90 nds of the four S6 transmembrane segments of voltage-gated potassium channels converge in a bundle cr

91 bitor that causes G1-S arrest; (d) KvLQT1, a voltage-gated potassium channel; (e) TSSC3, a gene that

92 nsitivity to external tetraethylammonium for voltage-gated potassium channels endows SK channels with

93 ense mutation in KCNA5 that encodes Kv1.5, a voltage-gated potassium channel expressed in human atria

94 Kv1.3 is the predominant voltage-gated potassium channel expressed in T lymphocyt

95 Kv1.3 is a voltage-gated potassium channel expressed on myelin-reac

96 KV10.1 is a voltage-gated potassium channel expressed selectively in

97 Kv1.2 and Kv1.5 are two subtypes of voltage-gated potassium channels expressed in heart that

98 recipitate (125)I-alpha-dendrotoxin-labelled voltage-gated potassium channels extracted from mammalia

99 Unlike voltage-gated potassium channels, families of small- and

100 ocitrate cycling regulates expression of the voltage-gated potassium channel family member Kv2.2 in i

101 Voltage-gated potassium channels form potassium-selectiv

102 Kv7.x (KCNQ) voltage-gated potassium channels form the cardiac and au

103 Voltage-gated potassium channels formed by KCNQ2 and KCN

104 Voltage-gated potassium channels formed with the cardiac

105 The Kv2.1 voltage-gated potassium channel forms stable clusters on

106 .1 or KvLQT1) encodes the alpha-subunit of a voltage-gated potassium channel found in tissues includi

107 n which the four voltage sensor domains of a voltage-gated potassium channel from Aeropyrum pernix (K

108 al membrane proteins whose role in governing voltage-gated potassium channel gating is emerging.

109 Point mutations in the voltage-gated potassium channel gene KCNA1 on chromosome

110 siological properties of a variety of cloned voltage-gated potassium channel genes have been characte

111 the successful positional cloning of two new voltage-gated potassium channel genes.

112 recently determined structure of a mammalian voltage-gated potassium channel has important implicatio

113 Kv1.2 and related voltage-gated potassium channels have a highly conserved

114 Voltage-gated potassium channels have also been localize

115 The Kcnh1 gene encodes a voltage-gated potassium channel highly expressed in neur

116 icantly alter the expression and function of voltage-gated potassium channels; however, their role in

117 LGI1-IgG-positive specimens had higher voltage-gated potassium channel-IgG immunoprecipitation

118 proteins, we present the detailed view of a voltage-gated potassium channel in its inactivated state

119 The voltage-gated potassium channel in T lymphocytes, Kv1.3,

120 tion of hDlg in coupling tyrosine kinase and voltage-gated potassium channel in T lymphocytes.

121 e the only sites of expression for the Kv2.2 voltage-gated potassium channel in the auditory brainste

122 voltage-sensing arginine residues of certain voltage-gated potassium channels in activated conformati

123 e a physiological perspective on the role of voltage-gated potassium channels in an identified neuron

124 We investigated voltage-gated potassium channels in human peripheral mye

125 ctly visualize the recruitment of individual voltage-gated potassium channels into forming CCPs in li

126 a syntaxin-dependent incorporation of Kv2.1 voltage-gated potassium channels into the plasma membran

127 The Kv2.1 voltage-gated potassium channel is abundantly present in

128 The Kv2.1 voltage-gated potassium channel is conditionally localiz

129 The Kv2.1 voltage-gated potassium channel is unique in its ability

130 ver, antibody testing using cells expressing voltage-gated potassium channels is negative; hence, we

131 variation in the V50 value between different voltage-gated potassium channels is not well defined.

132 The Kv4 subfamily of voltage-gated potassium channels is responsible for the

133 The ether a go-go family of voltage-gated potassium channels is structurally distinc

134 Kv1.1, a Shaker-like voltage-gated potassium channel, is strongly expressed i

135 a novel immunosuppressant that inhibits the voltage-gated potassium channel K(v)1.3.

136 ether natural products and primarily targets voltage-gated potassium channels (K(v) channels) in exci

137 on in a glucose-dependent manner by blocking voltage-gated potassium channels (K(v)) and calcium-acti

138 ingly showed similar potency to gambierol on voltage-gated potassium channels (K(v)) inhibition.

139 (CASPR2) is encoded by CNTNAP2 and clusters voltage-gated potassium channels (K(v)1.1) at the nodes

140 high-resolution open-state structure of the voltage-gated potassium channel, K(v)1.2.

141 rpene natural product, potently inhibits the voltage-gated potassium channel, K(v)1.3, and [(3)H]dihy

142 ted cyclohexyl (DSC) derivatives inhibit the voltage-gated potassium channel, K(v)1.3, and have immun

143 The voltage-gated potassium channel, K(v)1.3, is a novel tar

144 m Stichodactyla helianthus venom, blocks the voltage-gated potassium channels, K(v)1.1 and K(v)1.3, w

145 ation in the third extracellular loop of the voltage-gated potassium channel KCND3 that cosegregated

146 The voltage-gated potassium channel Kcnh4a, which is express

147 gle-span membrane protein that modulates the voltage-gated potassium channel KCNQ1 (K V7.1) by slowin

148 Mutations in the human voltage-gated potassium channel KCNQ1 are associated wit

149 Here we report the expression of the voltage-gated potassium channel KCNQ1 in mammalian taste

150 The voltage-gated potassium channel Kcnq2 is responsible for

151 leted region identified one encoding a novel voltage-gated potassium channel, KCNQ2, which belongs to

152 Mutations in KCNQ2 and KCNQ3, encoding the voltage-gated potassium channels KV 7.2 and KV 7.3, are

153 Each subunit of a voltage-gated potassium channel (Kv) contains six putati

154 olecular dynamics simulations, we show how a voltage-gated potassium channel (KV) switches between ac

155 CKO) mice, cardiac myocyte excitability and voltage-gated potassium channel (Kv), as well as inwardl

156 Urotoxin is a potent blocker of human voltage-gated potassium channel (Kv)1.2 channels, with a

157 hought to be due, in part, to suppression of voltage-gated potassium channels (Kv ) in pulmonary arte

158 hought to be due, in part, to suppression of voltage-gated potassium channels (Kv ) in pulmonary arte

159 FMRP has been confirmed to bind voltage-gated potassium channels (Kv 3.1 and Kv 4.2) mRN

160 Voltage-gated potassium channels (Kv channels) are invol

161 ed a framework for understanding the related voltage-gated potassium channels (Kv channels) that are

162 omic-scale models on the gating mechanism of voltage-gated potassium channels (Kv) are based on linea

163 Voltage-gated potassium channels (Kv) are targets for dr

164 Voltage-gated potassium channels (Kv), which play a role

165 late the function of KCNQ1 and certain other voltage-gated potassium channels (KV).

166 s a sequence homologous to the VS domains of voltage-gated potassium channels (Kv).

167 Shaker genes encode voltage-gated potassium channels (Kv).

168 Kv7.5 alpha-subunits belong to the family of voltage-gated potassium channels (Kv).

169 Subunits of the voltage-gated potassium channel Kv1.1 containing mutatio

170 sine RNA editing in transcripts encoding the voltage-gated potassium channel Kv1.1 converts an isoleu

171 se-dependent translational regulation of the voltage-gated potassium channel Kv1.1 messenger RNA (mRN

172 EA1 is caused by mutations in the voltage-gated potassium channel Kv1.1, and affected indi

173 The voltage-gated potassium channel Kv1.2 undergoes tyrosine

174 The voltage-gated potassium channel Kv1.3 has been recently

175 Our previous work demonstrated a role of the voltage-gated potassium channel Kv1.3 in effector T cell

176 lusions were used to investigate whether the voltage-gated potassium channel Kv1.3 was a substrate fo

177 is, demonstrate that MMP23-PD suppresses the voltage-gated potassium channel KV1.3, but not the close

178 4A] is a potent and selective blocker of the voltage-gated potassium channel Kv1.3, which is a highly

179 reas effector memory T (T(EM)) cells use the voltage-gated potassium channel Kv1.3.

180 for conditions treatable by blockade of the voltage-gated potassium channel Kv1.3.

181 Complexes of HsTX1 with the voltage-gated potassium channels Kv1.3 and Kv1.1 were cr

182 Point mutations in the human voltage-gated potassium channel (Kv1.1) gene on chromoso

183 Also recombinant voltage-gated potassium channels (Kv1.1, Kv1.4) were ame

184 e the second transmembrane segment, S2, of a voltage-gated potassium channel, Kv1.3, as a model to pr

185 demonstrated that elevated expression of the voltage-gated potassium channel, Kv1.3, is a functional

186 Voltage-gated potassium channels, Kv1.1, Kv1.2 and Kv1.6

187 Voltage-gated potassium channel Kv10.2 (KCNH5) is expres

188 The Kv2 voltage-gated potassium channels, Kv2.1 and Kv2.2, are i

189 We found that FMRP binds mRNA encoding the voltage-gated potassium channel Kv3.1b in brainstem syna

190 The fast-activating/deactivating voltage-gated potassium channel Kv3.3 (Kcnc3) is express

191 s for the fast-activating/fast-deactivating, voltage-gated potassium channels Kv3.1 and Kv3.3, which

192 l aminopeptidase X (DPPX) interacts with the voltage-gated potassium channel Kv4 and that co-expressi

193 We identified heterozygous mutations in the voltage-gated potassium channel Kv4.3-encoding gene KCND

194 ith the N-terminal domain of three Shal-type voltage-gated potassium channels (Kv4.1, Kv4.2, and Kv4.

195 ical properties and cellular localization of voltage-gated potassium channel Kv7.4.

196 nom toxin which binds to the archaebacterial voltage-gated potassium channel KvAP.

197 We find that the curvature-coupled voltage-gated potassium channel (KvAP) undergoes a signi

198 The mechanism by which mutations in voltage-gated potassium channels lead to EA is still unk

199 Mutations in KCNQ2 and KCNQ3 voltage-gated potassium channels lead to neonatal epilep

200 macromolecular complexes containing neuronal voltage-gated potassium channels ligated with a high aff

201 s indicate that the distribution of a set of voltage-gated potassium channels may relate specifically

202 Voltage-gated potassium channel modulatory membrane prot

203 role of the 3' non-coding region of a mouse voltage-gated potassium channel mRNA (mKv1.4 mRNA) in po

204 The mammalian Kv1.4 voltage-gated potassium channel mRNA contains an unusual

205 e selectivity-determining pore region of the voltage-gated potassium channel of human heart through w

206 The subthreshold, voltage-gated potassium channel of skeletal muscle is sh

207 Voltage-gated potassium channels of the KCNQ (Kv7) subfa

208 Many voltage-gated potassium channels open in response to mem

209 es to cell-surface membrane proteins such as voltage-gated potassium channels or N-methyl-D-aspartate

210 Voltage-gated potassium channels play an important role

211 this was attributable to interdependence of voltage-gated potassium channel properties.

212 OR inhibitor, rapamycin, increased the Kv1.1 voltage-gated potassium channel protein in hippocampal n

213 unctional expression of a new Shaker-related voltage-gated potassium channel, rabKv1.3, that is expre

214 action surfaces of delta-dendrotoxin and its voltage-gated potassium channel receptor.

215 limbic encephalitis previously attributed to voltage-gated potassium channels recognise LGI1, a neuro

216 Voltage-gated potassium channels responsible for the del

217 Blockage of low-threshold voltage-gated potassium channels selectively eliminated

218 Kv voltage-gated potassium channels share a cytoplasmic ass

219 ephalitis associated with antibodies against voltage-gated potassium channels should be changed to li

220 The voltage-gated potassium channel subfamily A member 3 (Kv

221 Drug block of voltage-gated potassium channel subtype 11.1 human ether

222 both nicotinic acetylcholine receptors and a voltage-gated potassium channel subtype.

223 Coimmunoprecipitations of caveolin-3 and the voltage-gated potassium channel subunit (Kv11.1) were pe

224 A typical voltage-gated potassium channel subunit has six transmem

225 Nerve injury-induced downregulation of voltage-gated potassium channel subunit Kcna2 in the dor

226 The voltage-gated potassium channel subunit Kv3.1 confers fa

227 Voltage-gated potassium channel subunit Kv3.3 is promine

228 severity and identified Kcnv2, encoding the voltage-gated potassium channel subunit Kv8.2, as a cand

229 the ultrastructural localization of a novel voltage-gated potassium channel subunit, Kv3.2, in the p

230 we consider the regulation of two proteins (voltage-gated potassium channel subunits Kv1.1 and Kv3.1

231 Voltage-gated potassium channels such as Shaker help to

232 Some vanillotoxins also inhibit voltage-gated potassium channels, supporting potential s

233 ), studied here, is caused by mutations in a voltage-gated potassium channel that contributes to the

234 KCNQ1 is a voltage-gated potassium channel that is modulated by the

235 ein called ether a go-go, EAG1 or KV10.1), a voltage-gated potassium channel that is predominantly ex

236 Kv11.1 (hERG) is a voltage-gated potassium channel that shows very slow ion

237 ng subunits coassemble to form a heteromeric voltage-gated potassium channel that underlies the neuro

238 KvLQT1 is a Shaker-like voltage-gated potassium channel that when complexed with

239 heterologous cells, KCNQ2 expression yields voltage-gated potassium channels that activate slowly (t

240 Voltage-gated potassium channels that are composed of Kv

241 Mammalian Shaker voltage-gated potassium channels that contain the Kv1.4

242 Kv9.3 subunits are present in voltage-gated potassium channels that contribute to the

243 We focused on two dendritic voltage-gated potassium channels that exhibit distinct l

244 M-channels are voltage-gated potassium channels that regulate cell exci

245 stal structure of Kv1.2, a six-transmembrane voltage-gated potassium channel, the linker between a cy

246 hypoxia-induced downregulation of selective voltage-gated potassium channels, the latter a hallmark

247 tein that binds at the N terminus of the Kv4 voltage-gated potassium channel through interactions at

248 instances patients often have antibodies to voltage-gated potassium channels; thymoma and small-cell

249 that KCNE1 and KCNE2, auxiliary subunits of voltage-gated potassium channels, undergo sequential cle

250 go-related gene (hERG; or KCNH2) encodes the voltage-gated potassium channel underlying IKr, a repola

251 Serum voltage-gated potassium channel (VGKC) antibodies were d

252 e of the neuropil antibodies corresponded to voltage-gated potassium channel (VGKC) antibodies; the o

253 ndertaken to describe the clinical spectrum, voltage-gated potassium channel (VGKC) complex antibody

254 agnetic resonance imaging has linked chronic voltage-gated potassium channel (VGKC) complex antibody-

255 ies against the extracellular domains of the voltage-gated potassium channel (VGKC) complex proteins,

256 ped redefine antigenic components within the voltage-gated potassium channel (VGKC) complex.

257 Antibodies against the voltage-gated potassium channel (VGKC) were first recogn

258 ceptor (NMDAR), the glycine receptor (GlyR), voltage-gated potassium channel (VGKC)-complex and the a

259 Voltage-gated potassium channel (VGKC)-complex antibodie

260 Voltage-gated potassium channel (VGKC)-complex antibodie

261 otein-like 2 in 11 patients, uncharacterised voltage-gated potassium channel (VGKC)-complex antigens

262 y and safety of rituximab in 5 patients with voltage-gated potassium channel (VGKC)-complex/leucine-r

263 neoplastic antibodies, in whom antibodies to voltage-gated potassium channels (VGKC) were detected re

264 MVP, a Methanococcus jannaschii voltage-gated potassium channel, was cloned and shown to

265 odes for the pore-forming alpha-subunit of a voltage-gated potassium channel, was identified as a gas

266 a member of the Shaker-related subfamily of voltage-gated potassium channels, was shown to mediate i

267 port dendritic localization of mRNA of Kv4.2 voltage-gated potassium channel, which regulates synapti

268 chinery, and yet contains a dense cluster of voltage-gated potassium channels whose functional contri

269 The BK channel is a Ca(2)+- and voltage-gated potassium channel with many important phys

270 Kv1.3 is a voltage-gated potassium channel with roles in human T ce

271 HERG (Kv11.1, KCNH2) is a voltage-gated potassium channel with unique gating chara

272 Kv1.4 channels are Shaker-related voltage-gated potassium channels with two distinct inact