ライフサイエンスコーパス: vulnerability

1 d environmental confounding (eg, preexisting vulnerabilities).

2 ly applicable indicators of microtidal marsh vulnerability.

3 trackers model essential aspects of relapse vulnerability.

4 o determine if there are distinct periods of vulnerability.

5 ealth outcomes and may be an early marker of vulnerability.

6 s focused on identifying critical windows of vulnerability.

7 effects of political pressures on livestock vulnerability.

8 ase clustering and interaction as well as to vulnerability.

9 -stress" model, in which genes confer excess vulnerability.

10 e forebrain cholinergic system mediates such vulnerability.

11 within the NAC as a mediator of MA addiction vulnerability.

12 eracts with the environment to shape disease vulnerability.

13 pert opinion, as were markers of hemodynamic vulnerability.

14 not always equate to accurate predictions of vulnerability.

15 istic and sensitive indicators of salt marsh vulnerability.

16 tuitary-adrenal axis hyperactivity in stress vulnerability.

17 esistant AR expression in CRPC induces redox vulnerability.

18 ct of seasonal changes in gamma on hydraulic vulnerability.

19 a-enriched environment contributes to the EC vulnerability.

20 regulation of the LC could determine stress vulnerability.

21 and a shifting generation mix to alter this vulnerability.

22 avorable for men and those with psychosocial vulnerability.

23 , which may contribute to their differential vulnerability.

24 mon genetic variants associated with disease vulnerability.

25 mediating impulsivity relevant to drug abuse vulnerability.

26 ut mechanisms of axon guidance and selective vulnerability.

27 mine the glutamate underpinnings of MA abuse vulnerability.

28 isk factors, which differentially shape PTSD vulnerability.

29 mechanism for biological predisposition and vulnerability.

30 major type of glial cell, leads to neuronal vulnerability.

31 roving our understanding of anxiety disorder vulnerability.

32 potential is an important indicator of delta vulnerability.

33 model as a valid model of alcohol addiction vulnerability.

34 r-specific and genotype-specific therapeutic vulnerabilities.

35 ary drug screening reveals mutation-specific vulnerabilities.

36 partly be viewed as a symptom of preexisting vulnerabilities.

37 orks in cancer cells that may create special vulnerabilities.

38 PI3K/mTOR inhibitors and uncover cell death vulnerabilities.

39 ntifying and adaptively targeting associated vulnerabilities.

40 tumor heterogeneity to discover therapeutic vulnerabilities.

41 are acknowledged to be 2 features of plaque vulnerability, although their temporal expression and th

42 gly little exploration into the differential vulnerability among neuron types and the circuits they u

43 ight be a useful indicator of climate change vulnerability among tropical species.

44 These effects also are relevant in vulnerability analyses, where the use of standard soluti

45 ndings presented demonstrate transcriptional vulnerabilities and elucidate previously unknown mechani

46 representation inferiorly may enhance fiber vulnerability and correlate with severe, prolonged defic

47 graphic range) to predict, respectively, the vulnerability and exposure of all data-sufficient terres

48 rders, including mechanisms of male-specific vulnerability and female-specific resilience impacting i

49 an extra risk for individuals with combined vulnerability and high number of reported personal life

50 model predicts specific patterns of neuronal vulnerability and network involvement on the basis of th

51 luding the contributions of aging, selective vulnerability and non-cell-autonomous factors such as al

52 The vulnerability and plasticity of hippocampal GABAergic in

53 ntments might thus provide a risk marker for vulnerability and poor health outcomes.

54 inforcer over aggression, heightened relapse vulnerability and progressive ratio responding, and resi

55 produce an aggregate index of climate change vulnerability and uncertainty based on the level of agre

56 alternans (a marker of electrophysiological vulnerability), and genetic testing.

57 icular Cav1.3, appears to contribute to this vulnerability, and the LTCC inhibitor isradipine is curr

58 The three dimensions of climate change vulnerability are as follows: (i) exposure to climate ch

59 Efforts to explain dopamine neuron vulnerability are hindered by the lack of dopaminergic c

60 se to changing fire regimes to reduce future vulnerability, are needed.

61 We compare the outputs of 12 climate change vulnerability assessment methodologies, using both real

62 Our results show that the different vulnerability assessment methods are not consistent with

63 , we perform a continent-wide climate change vulnerability assessment whereby we compare the baseline

64 Validation of the different vulnerability assessments suggests that methods incorpor

65 for the evaluation of ecosystem functioning vulnerabilities associated with increased climatic anoma

66 t within the biotechnology community creates vulnerabilities at the interface between cyberspace and

67 g this prediction and understanding organism vulnerability at a global scale, over evolutionary times

68 conceptualize myocardial disease and patient vulnerability based on the extent of disease involving i

69 reelin (RELN) is a critical mediator of this vulnerability because (1) periadolescent HFD (pHFD) sele

70 olar disorder and confirm the shared genetic vulnerability between these two disorders.

71 nt p53 gain of function and their associated vulnerabilities can vary according to mutation type.

72 eling suggested that outside-xylem hydraulic vulnerability can protect the xylem from tensions that w

73 gests that ferroptosis represents an ancient vulnerability caused by the incorporation of polyunsatur

74 cocaine addicts experience enhanced relapse vulnerability compared with males, an effect tied to ele

75 ation analysis to identify an 'interpersonal vulnerability' dimension.

76 These findings reveal a metabolic vulnerability downstream of mTORC1 triggered by anabolic

77 tion of opportunities to aggress and relapse vulnerability during abstinence.

78 sms initiating glaucoma and driving neuronal vulnerability during normal aging are unknown.

79 An additional goal was to examine neuronal vulnerability early during the degenerative process to g

80 features in watershed assessments of climate vulnerability, especially in topographically complex reg

81 species showed that outside-xylem hydraulic vulnerability explained 75% to 100% of Kleaf decline acr

82 ponents of climate-related risk for species: vulnerability, exposure and hazard.

83 complex subunit, SNF5; however, whether this vulnerability extends to other SWI/SNF subunit mutations

84 st that exaggerated amygdala reactivity is a vulnerability factor for posttraumatic stress disorder (

85 Vulnerability factors include a pessimistic attributiona

86 es that focus on mechanisms, resiliency, and vulnerability factors would further strengthen the evide

87 previously found to beneficially impact PTSD vulnerability factors, including neural fear responsiven

88 stment, organizing these into resilience and vulnerability factors.

89 ression predicts anxiety and trauma disorder vulnerability, FGF2 may be a clinically useful biomarker

90 ND DATA: PHS is a transient period of health vulnerability following inpatient hospitalization for ac

91 Established memories undergo a period of vulnerability following retrieval, a process termed 'rec

92 hlighting p62 and redox homeostasis as nodal vulnerabilities for therapeutic targeting in these tumor

93 nomics Consortium as a direct measure of the vulnerability for depression in a sample of 5221 individ

94 on of arousal, and provide new insights into vulnerability for stress-related psychopathology.

95 loperoxidase deficiency profoundly decreased vulnerability for ventricular tachycardia on programmed

96 e being faced with assessing risk of disease vulnerability from incidentally identified genetic varia

97 umes, it is possible that selective neuronal vulnerability has a role in these volumetric losses.

98 , maintain indispensable functions, and mask vulnerabilities have shaped the sequences of the >220M p

99 ssion risk are dependent on the diathesis or vulnerability, implying multiplicative interactive effec

100 get KRAS mutant cancers focus on identifying vulnerabilities in downstream signaling pathways or in s

101 d includes agents that target cancer-related vulnerabilities in receptor tyrosine kinases and intrace

102 AS, which themselves may lead to therapeutic vulnerabilities in tumors.

103 try structure and function and lapse/relapse vulnerability in 2 independent studies of adult smokers.

104 he most important considerations for species vulnerability in a straightforward framework, and can be

105 p and circadian rhythms changes on addiction vulnerability in adolescence and suggest areas that warr

106 ies by Wec et al. and Zhao et al. identified vulnerability in an internal fusion loop of an ebolaviru

107 systems that exploit and defend against this vulnerability in different contexts.

108 mechanisms that contribute to increased PTSD vulnerability in females.

109 ngs suggest a dual mechanism of white matter vulnerability in Huntington's disease, in which abnormal

110 Our findings provide evidence for selective vulnerability in mice resulting in highly regulated leve

111 l specialization and, potentially, selective vulnerability in neurological disorders.

112 rain dopaminergic (DAergic) neuron-selective vulnerability in PD is essential for the development of

113 site for C1 represents a new pharmacological vulnerability in the capsid assembly stage of the HIV-1

114 Increased vulnerability in the higher order veins would also be co

115 e begun to elucidate mechanisms of selective vulnerability in the nervous system.

116 ence of behavioural type-dependent predation vulnerability in the wild, i.e. that there is a predatio

117 otypes, we measured population diversity and vulnerability in these two species by: (i) describing ge

118 untered in AMKL, and elucidate a therapeutic vulnerability in this poor-prognosis leukemia.

119 complex (PRC2) and EZH2 represents one such vulnerability in tumors with mutations in the SWI/SNF co

120 eased power-communication coupling decreases vulnerability, in contrast to the percolation model.

121 These were combined into metrics of vulnerability, including an overall index and spatially

122 We developed a Community Health-Vulnerability Index (CHVI) based on factors known to inc

123 We introduce a Dam Environmental Vulnerability Index to quantify the current and potentia

124 re-type risk category, number of hemodynamic vulnerability indicators, renal insufficiency, single-ve

125 ternally at utilities to incorporate drought vulnerability into long-term strategic planning, potenti

126 which loss of estradiol contributes to this vulnerability is lacking.

127 these studies suggest that sex-specific PTSD vulnerability is partly regulated by sex differences in

128 played by extreme climatic events on forest vulnerability is still little understood.

129 d effects of climate change and suggest that vulnerability may depend on phylogeny or associated anat

130 bodies targeting different sites of envelope vulnerability may display differential activity against

131 based on species distribution, endemism, and vulnerability may underrepresent biologically unique spe

132 target conserved antigenic regions of viral vulnerability might facilitate better immune control aft

133 Vulnerability modulated the expression of prediction err

134 These findings also shed light on inherent vulnerabilities of brain networks in diseases.

135 CE STATEMENT: The basis for the differential vulnerabilities of CA1 versus CA3 pyramidal neurons is u

136 es phenotypes, signaling network states, and vulnerabilities of transgenic intestinal organoids as a

137 hnique is carried out by measuring the xylem vulnerability of 13 conifers and two short-vesseled angi

138 We assessed the vulnerability of 20 tree species in western North Americ

139 m our characterization of the resilience and vulnerability of a broad range of ecosystems and agricul

140 These results demonstrate the vulnerability of a nontarget organism to a biopesticide

141 uncover replication stress as an underlying vulnerability of all VHL mutated renal cancers that coul

142 amper efforts to understand and mitigate the vulnerability of anadromous fish habitat to climate-indu

143 The vulnerability of anaerobically protected carbon to futur

144 By calling attention to this heightened vulnerability of black Americans, our findings underscor

145 CSCs over the corresponding non-CSCs and the vulnerability of breast CSCs to mitochondrial damage to

146 Variations in the vulnerability of butterflies at the site level were also

147 STAG1 represents a vulnerability of cancer cells carrying mutations in the

148 Somatic gene mutations can alter the vulnerability of cancer cells to T-cell-based immunother

149 ker, genetic load might be a new, unexplored vulnerability of cancer.

150 ost 5-10 m, which may account for the higher vulnerability of coastal Louisiana wetlands compared to

151 To assess the vulnerability of conifer forests to increased fire activ

152 l cell types cannot account for the specific vulnerability of corticospinal motor neurons in ALS.

153 s disease; however, the mechanism(s) for the vulnerability of DA neurons is(are) not fully understood

154 h aSM Cav1.2.SIGNIFICANCE STATEMENT The high vulnerability of dopamine (DA) neurons in the substantia

155 e imbalance may contribute to the particular vulnerability of dopaminergic and noradrenergic neurons

156 There is increasing recognition of the vulnerability of electric power systems to drought and t

157 Despite the vulnerability of EpSCs to inflammatory pressures, neithe

158 esulting indices were overlaid to assess the vulnerability of European freshwater ecosystems at the c

159 h drought is especially important, given the vulnerability of forests around the world to the warming

160 de insights into the molecular mechanism and vulnerability of HIV-1 entry.

161 ase (AD) model that reveals species-specific vulnerability of human neurons to AD pathology.

162 mprinted genes in human placentation and the vulnerability of imprinted genes to loss of imprinting c

163 environmental change that is increasing the vulnerability of infrastructure.

164 e of vertebrate extinctions by revealing the vulnerability of large and small taxa, and identifying s

165 Our genetic studies highlight the heightened vulnerability of liver cells to subtle changes in nononc

166 mitochondrial complex 1 activity, increased vulnerability of mitochondria to mitochondrial stressors

167 pes, how mitochondrial impairment causes the vulnerability of neuronal subtypes remains unknown.

168 ncers (SE) as a key mechanism underlying the vulnerability of NPC cells to THZ1 treatment.

169 ydration arose first and foremost due to the vulnerability of outside-xylem tissues.

170 The vulnerability of plant water transport tissues to a loss

171 Clear analysis of the vulnerability of polycentric governance to both diminish

172 hyperflexible phenotype, which might reflect vulnerability of prodromal patients to substance abuse.

173 se challenges may include concerns about the vulnerability of prospective disaster research participa

174 Vulnerability of pulmonary arterial endothelial cells (P

175 eurons, which could explain the differential vulnerability of SN dopamine and DMV neurons in PD and c

176 leaves, can be adapted to measure the xylem vulnerability of stems.

177 vides the first mechanistic insight into the vulnerability of the adolescent mPFC towards nutritional

178 ronounced in Arctic regions and increase the vulnerability of the Arctic coastal zone.

179 Despite the consistently low vulnerability of the British swine industry to large CSF

180 Given the vulnerability of the CNS we reasoned that brain aromatiz

181 sors could therefore explain the exceptional vulnerability of these cells to Zika infection.

182 n be explained, in part, by the differential vulnerability of these regions to mechanisms mediating a

183 ickness provides an avenue for assessing the vulnerability of tree communities to fire and demands in

184 ocal PV installation sites, would reduce the vulnerability of urban populations and infrastructure to

185 and quantified experimentally the hydraulic vulnerability of xylem and outside-xylem pathways and mo

186 nt water status as a proxy for physiological vulnerability or (ii) external water and carbon fluxes a

187 re large individual differences, with marked vulnerability or resilience among individuals.

188 eater variability in some demographic rates (vulnerability pathway).

189 te suitability indicated both resistance and vulnerability pathways of population responses to climat

190 d in the brain and provide insights into the vulnerability profile of MDD.

191 To identify vulnerabilities relevant to specific cancer subtypes, we

192 logical processes underlying this heightened vulnerability remain poorly understood.

193 nisms driving the sex specificity of disease vulnerability remain unclear.

194 m whereby LRRK2 mutants contribute to nigral vulnerability remains unclear.

195 Together, these data identify a critical vulnerability resulting from the reliance of HCV on mult

196 If the vulnerability segmentation hypothesis holds within leave

197 utics aim to exploit tumor-specific, genetic vulnerabilities specifically affecting neoplastic cells

198 nd combination therapy that targets multiple vulnerabilities (STAT3 and BCL6) downstream of common on

199 vironmental conditions and take into account vulnerability status such as age.

200 novel framework for assessing climate change vulnerability tailored to freshwater ecosystems.

201 olecular adaptations responsible for relapse vulnerability take place in astrocyte systems that regul

202 iron chelators, and thus creates a metabolic vulnerability that can be exploited therapeutically.

203 se findings reveal a mitochondrial metabolic vulnerability that might be exploited to kill chemothera

204 hich corticospinal neurons exhibit selective vulnerability, that changes in excitability are not rest

205 chological stressors superimposed on genetic vulnerability, the neurobiological basis of EDs remains

206 iance in depression explained by the genetic vulnerability, the stressors and their interactions, we

207 uts males at risk by moving them closer to a vulnerability threshold that could more easily be breach

208 ng to evaluate plant responses and elucidate vulnerabilities to climate change.

209 killing and the identification of apoptotic vulnerabilities to overcome drug resistance in ovarian a

210 ng environments might result in the specific vulnerabilities to PSM and PSB.

211 g produces a distinct gene signature and new vulnerabilities to the proapoptotic drug, ABT-263.

212 smokers with psychiatric disorders and other vulnerabilities to tobacco addiction respond to cigarett

213 e with near infrared (NIR) light on synaptic vulnerability to Abeta oligomers.

214 ough this mechanism may contribute to female vulnerability to AD.

215 Insomnia symptoms are associated with vulnerability to age-related morbidity and mortality.

216 These anatomical features may confer vulnerability to anhedonia and thus, may inform early id

217 The results suggest that the cellular vulnerability to anti-PE antibodies may be mediated by t

218 higher in preCGG brain, indicating a greater vulnerability to apoptotic activation.

219 The authors found that trait-related vulnerability to bipolar disorder was associated with re

220 ic network, which therefore may increase the vulnerability to both early-onset bipolar disorder and s

221 d disease, identifying periods of heightened vulnerability to chemical exposures, and determining the

222 a framework and application for tree species vulnerability to climate change in the eastern United St

223 ogical system is a key step in assessing its vulnerability to climate change.

224 creased uncertainty in estimates of species' vulnerability to climate change.

225 th implications for adaptation and ecosystem vulnerability to climate change.

226 Growth models can be used to assess forest vulnerability to climate warming.

227 the case of inner hair cells of the cochlea, vulnerability to damage from noise trauma.

228 sess whether this dietary supplement reduces vulnerability to depressed mood at postpartum day 5, the

229 ctions of elevated MAO-A activity eliminates vulnerability to depressed mood during the peak of PPB.

230 hypothesis is that genetic factors influence vulnerability to depression following stress.

231 her changes in DCC levels in the PFC lead to vulnerability to depression-like behaviors.

232 roglial HMGB1-RAGE expression that increases vulnerability to depressive-like behaviors long after ch

233 ve a mild neurological phenotype and display vulnerability to developing dystonic movements after sys

234 hat gene groups differ with respect to their vulnerability to different mutagenic processes, and help

235 unknown about their role in vision and their vulnerability to disease leading to blindness.

236 ces on their collective behaviours and their vulnerability to disease outbreaks.

237 We analyzed their vulnerability to drought-induced embolism using solution

238 m(-1) Solutions with low gamma caused higher vulnerability to drought-induced xylem embolism.

239 Cocaine use during adolescence increases vulnerability to drug dependence and decreases the likel

240 patterns of a mobile species influence their vulnerability to ECEs?

241 Vulnerability to environmental contaminants such as pest

242 s, a novel type of metabolic resistance, and vulnerability to excessive fear memory formation and rev

243 Their demonstrated vulnerability to exploitation has recently turned them i

244 We identify vulnerability to ferroptic cell death induced by inhibit

245 NRF2-associated antioxidant system and high vulnerability to free oxygen species in the tumor microe

246 ecies distribution data allowed us to assess vulnerability to future climate and fire conditions: tro

247 in novelty-seeking adolescents may increase vulnerability to future problematic drug use.

248 distinct pace of angiogenesis and selective vulnerability to hemorrhage during development.

249 s and silicon, and thus could suffer greater vulnerability to herbivores.

250 nder women across the world face significant vulnerability to HIV.

251 " status of this ecosystem and its perceived vulnerability to human impacts.

252 une system and, with time, lead to increased vulnerability to infectious diseases.

253 OR activity in hepatocytes decreases hepatic vulnerability to injury through a mechanism dependent on

254 e alternative hypothesis of shared addiction vulnerability to legal and illegal drugs.

255 fferent cell types have different degrees of vulnerability to loss of Atoh1 function and that hypomor

256 ense mutations in ATOH1 could increase human vulnerability to loss of hair cells because of aging or

257 heightened reward sensitivity and increased vulnerability to mental health disorders that characteri

258 e is a notable exception, exhibiting extreme vulnerability to monkeypox virus, cowpox virus, and vacc

259 suggesting such carriers may have increased vulnerability to myelin damage following injury or disea

260 c properties appear to be good predictors of vulnerability to neurodegeneration.SIGNIFICANCE STATEMEN

261 icate that Gba1 deficiency enhances neuronal vulnerability to neurodegenerative processes triggered b

262 during tumorigenesis; however, the cellular vulnerability to nononcogenic RTK fluctuations has not b

263 s of 4R-TAU isoforms, demonstrated increased vulnerability to oxidative stress and elevated protein u

264 usly demonstrated to exhibit greater relapse vulnerability to Pavlovian drug cues paired with drug de

265 determined if there are periods of enhanced vulnerability to phthalates.

266 nase/Akt (PI3K/Akt) activation and increased vulnerability to PI3K/Akt/mTOR inhibitors.

267 that egg cannibalism reduces L. decemlineata vulnerability to predation by improving larval nutrition

268 ing cells contributes to their extraordinary vulnerability to proinflammatory cytokine toxicity and m

269 to midgestation infections have an increased vulnerability to psychiatric disorder later in life, and

270 rtant implications for research on pretrauma vulnerability to PTSD.

271 nd highly active mitochondria with increased vulnerability to reactive oxygen species (ROS).

272 substantial individual variability, and high vulnerability to risk factors and developmental disorder

273 embly are thought to play a critical role in vulnerability to schizophrenia (SZ), but the pathogenic

274 e often monogenic disorders characterized by vulnerability to specific infectious pathogens.

275 larly, in 24 healthy adults, neurobehavioral vulnerability to SR exposures, separated by 78-3,058 day

276 rapid increase in population size and limit vulnerability to stochastic events, 'slow' strategies an

277 not in mothers may be attributable to a high vulnerability to stress during intrauterine development

278 of Dcc in mouse PFC pyramidal neurons causes vulnerability to stress-induced social avoidance and anh

279 ings suggest a role for the immune system in vulnerability to stress-related psychiatric illness.

280 va model to investigate genetic influence on vulnerability to sugar overconsumption.

281 Understanding individual differences in vulnerability to THC SA may lead to novel treatment stra

282 pocampus, suggesting a brain region-specific vulnerability to the G2019S mutation.

283 of melanoma and supports the hypothesis that vulnerability to the harmful effects of indoor tanning i

284 effects, sensitivity to which may influence vulnerability to tobacco dependence, yet mechanisms of n

285 In 23 healthy adults, neurobehavioral vulnerability to TSD exposures, separated by 27-2,091 da

286 assessed the effects of the mutations on the vulnerability to unidirectional conduction patterns and

287 Ptolemaic vulnerability to volcanic eruptions offers a caution for

288 provides accessible tools to evaluate forest vulnerability to warmer conditions.

289 ty margin, providing strong support for leaf vulnerability to water deficit as an index of damage und

290 locus would create cancer-specific metabolic vulnerability upon targeting of its paralogous isoform M

291 ried with leopard sex and age, prey size and vulnerability, vegetation, elevation, climate, and the i

292 ypes, these pathways elucidate mechanisms of vulnerability versus resilience in carriers of disease-a

293 To identify periods of vulnerability, we used two statistical methods to estima

294 and 6 independent indicators of hemodynamic vulnerability were identified.

295 ng of neural circuits, as well as windows of vulnerability when abnormal experience could cause lasti

296 characterized by a motor unit (MU)-dependent vulnerability where MNs with fast-fatigable (FF) charact

297 occurs in infants with underlying biological vulnerability who experience an exogenous stressor, such

298 Understanding individual differences in PTSD vulnerability will allow the development of improved pre

299 vely, this reveals a mitochondrial metabolic vulnerability with potential therapeutic applications ag

300 This vulnerability would have been missed by simplistic trait