ライフサイエンスコーパス: vulnerable plaque

1 of necrosis, or thin-cap fibrous atheromas (vulnerable plaques).

2 e and may hold promise for identification of vulnerable plaque.

3 the treatment of coronary atherosclerosis or vulnerable plaque.

4 s a method for high-resolution assessment of vulnerable plaque.

5 of vascular remodeling in the prediction of vulnerable plaque.

6 ctivation in the development of noncalcified vulnerable plaque.

7 as a potential noninvasive method to detect vulnerable plaque.

8 atheroma, the most common form of high-risk, vulnerable plaque.

9 plaque imaging may enhance identification of vulnerable plaque.

10 ormation of other features characteristic of vulnerable plaque.

11 nd rapid progression should be considered as vulnerable plaques.

12 ioscopy may be valuable for the detection of vulnerable plaques.

13 onary syndromes often result from rupture of vulnerable plaques.

14 hy is a promising tool for the evaluation of vulnerable plaques.

15 CAD-induced deaths are due to the rupture of vulnerable plaques.

16 g techniques increase diagnostic accuracy of vulnerable plaques.

17 tric mapping of plaques and clearly identify vulnerable plaques.

18 e presence of a lipid core, and therefore of vulnerable plaques.

19 est, especially for the early recognition of vulnerable plaques.

20 IgG can activate macrophages and destabilize vulnerable plaques.

21 ger receptors on macrophages, a biomarker of vulnerable plaques.

22 ne that explicitly evaluate the treatment of vulnerable plaques.

23 es, increased inflammation, and more complex vulnerable plaques.

24 ammatory cells should noninvasively identify vulnerable plaques.

25 therosclerosis, acute coronary syndromes and vulnerable plaques.

26 components that might be useful in targeting vulnerable plaques.

27 rosclerotic plaques and potentially identify vulnerable plaques.

28 between FC accumulation and inflammation in vulnerable plaques.

29 target for drug therapy aimed at stabilizing vulnerable plaques.

30 inical as well as pathological evaluation of vulnerable plaques.

31 (1) Rupture-prone plaques are not the only vulnerable plaques.

32 Is this a vulnerable plaque?

33 dden cardiac death, cardiac arrhythmias, and vulnerable plaque?

34 o two groups: 41 resulting from rupture of a vulnerable plaque (a thin fibrous cap overlying a lipid-

35 strate that macrophages, a characteristic of vulnerable plaques, also assist in expansive remodeling,

36 sus document, we cover the new definition of vulnerable plaque and its relationship with vulnerable p

37 ng metalloproteinase that is associated with vulnerable plaque and may be a predictor of cardiovascul

38 LMPs favor the neovascularization within the vulnerable plaque and, in the ruptured plaque, they take

39 larly be a valuable imaging tool to identify vulnerable plaques and associated intraplaque inflammati

40 ance imaging techniques may be able to image vulnerable plaques and characterize plaques in terms of

41 If vulnerable plaques and patients can be successfully iden

42 er consideration as methods to stabilize the vulnerable plaques and patients that might be detected,

43 tic resonance for the noninvasive imaging of vulnerable plaques and the characterization of plaques i

44 carry contrast agents for early detection of vulnerable plaques and the initiation of preventative th

45 g the ability of such techniques to diagnose vulnerable plaques and to assess the effects of both pha

46 s on the attempted localization of so-called vulnerable plaques and vulnerable, or high-risk patients

47 eaturing occlusive coronary atherosclerosis, vulnerable plaque, and premature death and that these ef

48 ion, endothelial dysfunction, development of vulnerable plaque, and ventricular remodeling following

49 real-time the risk posed by plaques, detect vulnerable plaques, and optimize treatment decisions.

50 Identification and stabilization of vulnerable plaques are important new directions in the t

51 ility, contributing to the concept that more vulnerable plaques are more likely to have a greater deg

52 (2) Vulnerable plaques are not the only culprit factors for

53 Diagnostic techniques to identify vulnerable plaques are rapidly evolving.

54 "Vulnerable" plaques are atherosclerotic plaques that hav

55 acute atherothrombotic vascular occlusion ("vulnerable plaques") are abundant inflammatory mediators

56 cus has been placed on the identification of vulnerable plaques as a means of improving the predictio

57 ries, one of the features that characterizes vulnerable plaques at risk of rupture, can be imaged usi

58 The ability of IVUS to detect vulnerable plaques before rupture is currently being eva

59 Local treatment of vulnerable plaques by percutaneous coronary intervention

60 tively, metalloproteinases could destabilize vulnerable plaques by promoting matrix destruction, angi

61 hanism by which lipid lowering may stabilize vulnerable plaques by reduced expression and activity of

62 odegradable HDL-NP platform for detection of vulnerable plaques by targeting the collapse of mitochon

63 ard to depiction of the criteria that define vulnerable plaques by using existing MR techniques.

64 lprit lesions in patients with ACS have more vulnerable plaque characteristics compared with those wi

65 The identification of vulnerable plaque characteristics with MR imaging aids i

66 y occlusions will lead to future advances in vulnerable plaque detection technology and potentially l

67 Present "vulnerable plaque" detection technology focuses on ident

68 tent diameters suggests that embolization of vulnerable plaque elements may play a pathogenic role.

69 need to identify the factors responsible for vulnerable plaque formation.

70 al to atherosclerotic lesion development and vulnerable plaque formation.

71 duced in the model of shear stress-modulated vulnerable plaque formation.

72 ssessed in a model of shear stress-modulated vulnerable plaque formation.

73 o diagnose the disease early and distinguish vulnerable plaques from harmless ones.

74 The recognition of the role of the vulnerable plaque has opened new avenues of opportunity

75 The ability to image a vulnerable plaque in susceptible patients would theoreti

76 Advances in the understanding of the role of vulnerable plaque in the causation of coronary events, c

77 ecular profiling of a number of proteases in vulnerable plaque in vivo.

78 e clinically useful in imaging the unstable, vulnerable plaques in coronary arteries.

79 olic activity and characteristic features of vulnerable plaques in patients.

80 echnology may be well suited for identifying vulnerable plaques in patients.

81 The mean (SD) number of vulnerable plaques in the coronary arteries of men in th

82 mpowered the clinician to identify suspected vulnerable plaques in vivo and paved the way for the eva

83 ging catheters (to localize and characterize vulnerable plaque) in combination with future genomic an

84 Characteristic histomorphologic features of vulnerable plaques include a high lipid content, increas

85 Proposed definition criteria of vulnerable plaque included active inflammation, a thin c

86 Unfortunately, the search for the so-called vulnerable plaque is hampered by the lack of both natura

87 Because vulnerable plaque is not an established medical diagnosi

88 Rupture of high-risk, vulnerable plaques is responsible for coronary thrombosi

89 The "vulnerable" plaque is smaller in size, richer in lipids,

90 that until the natural history of presumed "vulnerable plaques" is known one can never truly identif

91 leading to myocardial infarction (so-called "vulnerable plaques") is an important area of cardiovascu

92 follow-up, although these large atheromatous vulnerable plaques may angiographically seem mild.

93 Such unstable, vulnerable plaques may be associated with outward remode

94 plaques that cause severe luminal stenosis, vulnerable plaques may cause relatively minor stenosis,

95 can never truly identify what constitutes a "vulnerable plaque." Much work needs to be done in this a

96 elastase and macrophages colocalized in such vulnerable plaques (n=7).

97 ology- and imaging-based definitions of the "vulnerable plaque," necessitating an improved approach f

98 terol to HDL cholesterol and the presence of vulnerable plaques (P<0.001).

99 methods can be used in the future to detect vulnerable plaques, potentially to determine patients' p

100 nosis and might find applications to prevent vulnerable plaque progression.

101 Vulnerable plaques prone to rupture were defined as thos

102 lammatory reaction, the result of which is a vulnerable plaque, prone to rupture and thrombosis.

103 across branch ostia, disruption of adjacent vulnerable plaques, radiation therapy, and extensive pla

104 Passivation of vulnerable plaque represents a therapeutic concept that

105 eatures characteristic of the rupture-prone, vulnerable plaques responsible for acute coronary syndro

106 The most accepted features of vulnerable plaques, such as a large lipid core, increase

107 Vulnerable plaques that had not ruptured were counted in

108 Early identification and treatment of the vulnerable plaque, that is, a coronary artery lesion wit

109 wall could digest and weaken fibrous caps of vulnerable plaques, thus provoking thrombosis.

110 possibility of local or regional therapy of "vulnerable plaques" to prevent future events.

111 inical, as well as pathologic, evaluation of vulnerable plaques was recently put forward in which fiv

112 cope of recent literature on the concept of "vulnerable plaque" was reviewed by examining 463 abstrac

113 to develop an imaging agent for detection of vulnerable plaques, we evaluated the feasibility of a li

114 In cases of coronary death, vulnerable plaques were associated with elevated cholest

115 five major and five minor criteria to define vulnerable plaques were proposed.

116 ther proteases, may serve as a biomarker for vulnerable plaques when probed with beacons.

117 with or without and thin-cap fibroatheroma (vulnerable plaque), whereas in erosions and total occlus

118 lesterol - predispose patients to rupture of vulnerable plaques, whereas cigarette smoking predispose

119 As such, it is these vulnerable plaques which are more prone to rapid plaque

120 dvance particularly in the identification of vulnerable plaques, which are associated with specific p

121 The diagnosis of vulnerable plaques, which have the propensity to develop

122 defines histomorphologic characteristics of vulnerable plaques, which may help develop imaging strat

123 o determine whether identifying and treating vulnerable plaques will lead to improved clinical outcom

124 he rate of plaque progression might identify vulnerable plaques with an increased potential for adver

125 ic antibodies allow for in vivo detection of vulnerable plaques with magnetic resonance imaging (MRI)

126 artery plaque but, given to older women with vulnerable plaque, would have a null or even harmful eff