ライフサイエンスコーパス: w(as|ere) discovered

1 an archetype-like noncoding cont rol region was discovered.

2 cyclization based on the C10 stereochemistry was discovered.

3 e sequence, a second homolog of PPO (JrPPO2) was discovered.

4 iabilities found for earlier compound series was discovered.

5 binding inhibitor of ADAM10 with Ki = 883 nM was discovered.

6 ide rich hot springs and soda lakes where it was discovered.

7 zation of Achmatowicz rearrangement products was discovered.

8 novel piperidinylisoxazole system LY2562175 was discovered.

9 (alpha4)(3)(beta2)(2) receptor subpopulation was discovered.

10 scientists for more than a century since it was discovered.

11 drogen-bonding network between Man3 and CV-N was discovered.

12 notriazolopyrimidinone-based PDE1 inhibitors was discovered.

13 to target rapid evolution to specific genes was discovered.

14 related to the early detection of mycotoxins was discovered.

15 of aldehydes requiring neither metals nor O2 was discovered.

16 in lengths of ethylene-bridged BODIPY motifs was discovered.

17 tion an overexpression of phosphatidic acids was discovered.

18 volved in adipocyte triglyceride homeostasis was discovered.

19 n has remained a mystery since these enzymes were discovered.

20 , and selective noncovalent AChE1 inhibitors were discovered.

21 interaction hubs and functional interactions were discovered.

22 dified before six new Pb-containing gelators were discovered.

23 ctivity and very low systemic clearance (CL) were discovered.

24 o an industrial wastewater, and 36 new PFASs were discovered.

25 phosphate and tryptophan metabolic pathways were discovered.

26 ibbean Hispanic families where the mutations were discovered.

27 ater transport, growth, and defense response were discovered.

28 ocarbon production pathways in cyanobacteria were discovered.

29 ghly potent and selective inhibitors of nNOS were discovered.

30 stinct chemical scaffolds that bind to Mcl-1 were discovered.

31 for OM prediction, and several interactions were discovered.

32 ly reduced the amount of cytoplasmic HBV DNA were discovered.

33 Genotype specific 45S rDNA sequences were discovered.

34 mples and illegal proportions of ingredients were discovered.

35 Three categories of association were discovered: (1) OI arising for the first time durin

36 The stem terminus element (STE), which was discovered 13 y ago in human telomerase RNA, is requ

37 ecognition of CD1-lipid complexes by T cells was discovered 20 years ago and has since been an emergi

38 n the hippocampal samples of the argon group was discovered 24 hours after subarachnoid hemorrhage.

39 e AKT, also known as protein kinase B (PKB), was discovered 25 years ago and has been the focus of te

40 NF-kappaB was discovered 30 years ago as a rapidly inducible trans

41 Although IgE was discovered 50 years ago, the ultimate evidence for i

42 As a result, two new palladium macrocycles were discovered: a structural analogue of the existing {

43 astic modulus over a wide temperature range, was discovered almost 100 years ago by Guillaume.

44 bdomyoblasts (desmin- and myogenin-positive) was discovered along with rare clusters of persistent ne

45 DCl and DBr using a controlled amount of D2O was discovered along with the critical role of hydrolysi

46 Another 466 putative effectors were discovered among the genes that have no sequence si

47 , where a significant alternative VI pathway was discovered and altered so that it could be manipulat

48 67, the fifth class of immunoglobulins, IgE, was discovered and found to be able to carry reagin acti

49 d the expression of upstream pathway enzymes was discovered and identified as a key obstacle for func

50 an abundant protein component of human tears was discovered and named lacritin (Lacrt).

51 g the late stage of stationary growth phase, was discovered and purified from the culture medium of B

52 In total, nine ISDs were discovered and a core determinant defined using a s

53 ew phenylalanine ammonia lyase (PAL) enzymes were discovered and characterised with respect to their

54 tact histidine, lysine, or cysteine residues were discovered and characterized from high-molecular we

55 ously unrecognized inhibitors of Wee kinases were discovered and characterized.

56 ecently, GABAergic neurons caudal to the VTA were discovered and named the tail of VTA (tVTA).

57 century has passed since interferons (IFNs) were discovered and shown to inhibit virus infection in

58 , we discuss how these CRISPR-Cas inhibitors were discovered and their modes of action were elucidate

59 A paraspinal mass was discovered, and tumor and bone marrow biopsies discl

60 Over 10 million high-quality SNPs were discovered, and 35.34% of these have not been previ

61 el anionic, zwitterionic, and cationic PFASs were discovered, and an additional 17 previously reporte

62 Four candidate CPPs were discovered, and further study on one peptide (PepB2

63 In the 1980s, excess infrared emission was discovered around main-sequence stars; subsequent di

64 A decade after LUBAC was discovered as a cellular activity of unknown functio

65 A bicyclic olefin was discovered as a cocatalyst in a Cp*Rh(III)-catalyzed

66 n this study, the cytoskeletal adaptor OBSL1 was discovered as a previously unrecognized interaction

67 eta-epoxyketone proteasome inhibitor TMC-86A was discovered as a previously unreported metabolite of

68 In our first series compound 2 was discovered as a promising hit showing strong activit

69 the cuprate high-temperature superconductors was discovered as a suppression of the Knight shift and

70 Hydrogen sulfide (H2S) was discovered as a third gasotransmitter in biological

71 Finally, 5-lipoxygenase was discovered as an additional molecular target of ajud

72 The indole-3-glyoxamide 6 was discovered as an inhibitor of HIV-1 infectivity usin

73 noid Receptor Interacting Protein 1 (Cnrip1) was discovered as an interactor with the intracellular r

74 Shortly after HIV-1 was discovered as the cause of AIDS, the search for epit

75 ic anterior motion (SAM) of the mitral valve was discovered as the cause of LV outflow tract obstruct

76 Apelin-36 was discovered as the endogenous ligand for the previous

77 2017, Swope Supernova Survey 2017a (SSS17a) was discovered as the optical counterpart of the binary

78 More than 60 years ago, cristae were discovered as characteristic elements of mitochondr

79 Organic oligomers were discovered as dominant components in SOA over a dec

80 Neutrophil extracellular traps (NETs) were discovered as extracellular strands of decondensed

81 a" or "FAM150A" and "FAM150B," respectively) were discovered as physiological ligands of Alk and Ltk.

82 The ARPP-16/19 proteins were discovered as substrates for PKA, but the function

83 The new dinosaur was discovered at Aysen, a fossil locality in the Upper

84 d bottom-up proteomics, hundreds of proteins were discovered at each locus in each condition.

85 dditionally, a new through-space interaction was discovered between O and Sn in the fragmentation as

86 A noteworthy linear relationship was discovered between the known pKa's of strong acids a

87 Positive associations were discovered between airborne 10:2 FTOH and serum PFO

88 ion of end wall resistance with plant height was discovered, but found to be independent of end wall

89 cycloaromatizations of enediynes and enynes was discovered by combining a twisted alkene excited sta

90 antisense-to-latency transcript (ALT) lncRNA was discovered by genome-tiling microarray.

91 This class of antibiotics was discovered by in silico docking and scoring against

92 between the bulbous urethra and the scrotum was discovered by MDCT.

93 Recently, a novel bacteriophage, crAssphage, was discovered by metagenomic data mining and reported t

94 erent process parameters on the oil recovery was discovered by using statistical optimization, beside

95 -1 encodes a distant paralog of HIM-5, which was discovered by whole-genome sequencing and confirmed

96 Several interesting metabolites were discovered by accurate mass and comparing MS2 spect

97 on clinical features of autoimmune disorders were discovered by chance during World War II.

98 f LIMK, a series of aminothiazole inhibitors were discovered by high throughput screening.

99 t, efficient -1 PRF stimulatory RNA elements were discovered by in vitro selection; then, ligand-resp

100 with functional roles in melanoma metastasis were discovered by next-generation sequencing and valida

101 s with dual activity on these receptors that were discovered by rational design.

102 They were discovered by serendipitous observations on weed gr

103 ule inhibitor of C3larvin enzymatic activity was discovered called M3 (Ki = 11 +/- 2 mum), and to our

104 Further, multipotent compounds were discovered, characterized, and for example, assigne

105 that mediates the conformational transition was discovered computationally and validated experimenta

106 encies (the first domain in which Zipf's law was discovered), data with variable sequence length, and

107 Despite the fact that these viruses were discovered decades ago, our knowledge of the mechan

108 ies of nine polyfluorinated carboxylic acids was discovered, each differing by CF2CH2.

109 ion used for controlling optomotor responses was discovered early.

110 An ultraconserved element was discovered (evolutionary conserved region 47) that f

111 Two promoter variants, EP01rec and EP14rec, were discovered exhibiting enhanced protein expression.

112 rol, piceatannol, astringin and isorhapontin were discovered, explaining 22-59% of phenotypic variati

113 2:3 and the glycerophospholipid lysoPCaC24:0 was discovered for sepsis diagnosis with a sensitivity o

114 Higher expression in NGS was discovered for uracil-rich miRNAs (p = 7 x 10(-37)),

115 Significant associations were discovered for all phenotypes and are indicative th

116 3 blood samples drawn at similar time points were discovered for patients, who had undergone at least

117 Tocopherols were discovered for their role in animal reproduction, b

118 A 1,3-oxazole KRM-II-81 (9) was discovered from a series of six bioisosteres with si

119 bable primitive member of the gorilla clade, was discovered from the formation.

120 gents as bait, >150 putative protein targets were discovered from a eukaryotic cell lysate (Saccharom

121 These compounds were discovered from a TNBC phenotypic screen and posses

122 ormation, four additional putative CCR genes were discovered from sorghum genomic data.

123 ic acid A (1) and iodocallophycols A-D (2-5) were discovered from the Fijian red alga Callophycus sp.

124 Several previously un-annotated promoters were discovered, further investigations confirm their pr

125 ntage of patients with high level of anxiety was discovered (>/=7 sten), as compared to their peers w

126 the reconstituted basement membrane Matrigel was discovered, I had the intuition that Matrigel coatin

127 It was discovered in 1874 by Heinrich Caro, Director of the

128 Although insulin was discovered in 1921, the drug is unattainable to many

129 and controversial history since its activity was discovered in 1939, has long been thought to be mono

130 Zika virus (ZIKV) was discovered in 1947 and was thought to lead to relati

131 Although Lands' cycle was discovered in 1958, its function and cellular regula

132 een fully resolved, despite the fact that it was discovered in 1961--a fact that severely limits our

133 MARV was discovered in 1967, and yet little is known about ho

134 This remarkable behavior was discovered in 1984 when Tim Mitchison and Marc Kirsc

135 This human gammaherpesvirus was discovered in 1994 by Drs.

136 Telavancin (TD-6424) was discovered in 2000 and became the first marketed sem

137 o known as interleukin-28 [IL-28] and IL-29) was discovered in 2003, its antiviral function was expec

138 Asteroid 2015 BZ509 was discovered in 2015, but with too much uncertainty in

139 *13 TRDN-encoded triadin frameshift mutation was discovered in a 10-year-old female patient with LQTS

140 domain missense mutation, LAMB2-S80R, which was discovered in a patient with Pierson syndrome and un

141 with a recurrent nonsense mutation in ENPP1 was discovered in a pediatric PXE case.

142 e biosynthesis of the antibiotic valanimycin was discovered in a Streptomyces strain.

143 n 800 million years after the Big Bang) that was discovered in a wide-field survey.

144 Mitochondrial movement was discovered in an experiment designed to select for c

145 Recently, a quality control pathway was discovered in Bacillus subtilis which monitors the a

146 The Lethal giant larvae (Lgl) protein was discovered in Drosophila as a tumor suppressor in bo

147 Zika virus was discovered in East Africa in 1947 by the Rockefeller

148 ertion sequence (IS) excision enhancer (IEE) was discovered in EHEC O157:H7 that promoted the excisio

149 Schmallenberg virus (SBV) was discovered in Germany in late 2011 and then spread r

150 Polar tweed was discovered in mechanically stressed LaAlO3.

151 In 30 years since editing was discovered in mitochondria of trypanosomes, several

152 United States) and the Netherlands belonged, was discovered in Riyadh.

153 used to a heme peroxidase/dioxygenase domain was discovered in Saprolegnia declina.

154 BD monomer, the natural product anthramycin, was discovered in the 1960s, and the best known PBD dime

155 e fossil 'Lucy' (Australopithecus afarensis) was discovered in the Afar region of Ethiopia in 1974 an

156 form of diamond, also known as lonsdaleite, was discovered in the Canyon Diablo meteorite where its

157 Abundant molecular oxygen was discovered in the coma of comet 67P/Churyumov-Gerasi

158 or cell cycle-regulated E3 ubiquitin ligase, was discovered in the control of axon growth and pattern

159 y involving methylerithritol phosphate (MEP) was discovered in the early 1990s.

160 umi chickens, and a duplication of defensin7 was discovered in the Fayoumi breed.

161 new icosahedral mineral formed naturally and was discovered in the Khatyrka meteorite, a recently des

162 quasicrystal, with composition Al71Ni24Fe5, was discovered in the Khatyrka meteorite, a recently des

163 he Nozaki-Hiyama-Takai-Kishi (NHTK) reaction was discovered in the late 1970s and, since then, its ma

164 The effect was discovered in the late thirties with a basic observa

165 Superconductivity was discovered in the layered compound RbBi11/3Te6, feat

166 It was discovered in the mid-1990s and has been intensively

167 n that same year a second human polyomavirus was discovered in the urine of a kidney transplant patie

168 Queuosine (Q) was discovered in the wobble position of a transfer RNA

169 y, a unique charge-resonance (CR) phenomenon was discovered in this intermediate, and a biological, l

170 A higher rate of pump-specific malfunctions was discovered in those implanted with an HM II versus a

171 WNT signaling was discovered in tumor models and has been recognized a

172 Zika virus was discovered in Uganda in 1947 and is transmitted by A

173 t 7) encoding a novel protein designated VP7 was discovered in WFBV.

174 From these studies, a novel binding motif was discovered in which only 1 equiv of peptide binds to

175 operty of Rhodotorula mucilaginosa (NCYC 65) was discovered in which sugar substrate is cleaved but t

176 rmline findings related to patient phenotype were discovered in 15 (10%) of 150 cases: 13 pathogenic

177 t met 1 or more and >/=3 of the new criteria were discovered in 87% and 54% of patients, respectively

178 Although these phases were discovered in a solid-state setting, recent innovat

179 In contrast, 234 miRNAs were discovered in all 10 replicated array measurements

180 No differences were discovered in any of the other outcomes such as sur

181 n well-supported candidate regulators of RCN were discovered in CCLONES, including genes associated a

182 Up until now, most longevity pathways were discovered in invertebrates because of their short

183 f common and strain-specific genetic changes were discovered in MIL-adapted parasites, including dele

184 to histidine-histidine (His-His) cross-links were discovered in monoclonal antibody HMW species.

185 the twentieth century, two nuclear receptors were discovered in our laboratory and, very surprisingly

186 ers, novel elicitor-responsive cis-sequences were discovered in promoters of pathogen-upregulated gen

187 rcokinin (OK) are related neuropeptides that were discovered in protostomian invertebrates (mollusks,

188 year, three candidates for bacterial actins were discovered in silico.

189 While nitroimidazoles were discovered in the 1950s, there has been renewed int

190 s horses (PHs, Equus ferus ssp. przewalskii) were discovered in the Asian steppes in the 1870s and re

191 Thereby, also, more compact molecules were discovered in the gas phase with thus far unknown s

192 Boratriazaroles were discovered in the late 1960s, and since then, a var

193 romycin, and aminoglycoside resistance genes were discovered in these fecal samples.

194 tic anomalies of genome-wide DNA methylation were discovered in these SCNT DSD dogs.

195 ion of toxic elements in the solid residuals were discovered in this study.

196 II-I) which had not been previously detected were discovered in two enhanced biological phosphorus re

197 nts with gallbladder cancer, 207 cases (46%) were discovered incidentally and underwent reoperation a

198 These lesions were discovered incidentally at multiphase contrast mate

199 scale matter specific to inorganic materials were discovered, including three-dimentional lithography

200 conformational changes of the viral protein was discovered, indicating GP10 may not be a static chan

201 favorable biochemical profile of the enzyme was discovered, making NicA2 a prospective therapeutic c

202 A total of 27 lipid A structures were discovered, many of which were isomeric, showcasing

203 Although this pattern was discovered more than sixty years ago, it remains an

204 Although the growth factor progranulin was discovered more than two decades ago, the functional

205 finger transcription factors Gfi1 and Gfi1b were discovered more than 20 years ago and are recognize

206 consistent with such a cold accretion flow, was discovered near the quasi-stellar object QSO UM287 a

207 Two new protein densities were discovered near the decoding center and the peptidy

208 s, belonging to isotypes IgM, IgG3, and IgA, were discovered nearly half a century ago.

209 The realignment was discovered on the heteropolymeric sequence T5C5 and

210 al examples in which secondary binding sites were discovered on proteins using fragment screening app

211 Oz catalysts with only Lewis acid-base pairs were discovered, on which nearly a theoretical selectivi

212 These cells were discovered only in 2005, but after 10 years of inve

213 Although retromer was discovered over 15 years ago, the mechanisms for car

214 act that many members of this alkaloid class were discovered over 50 years ago, synthetic chemistry h

215 Ras-oncogenes were discovered over three decades ago, but there are st

216 Five novel mutations of DNMT1 were discovered; p.C353F, p.T481P, p.P491L, p.Y524D and

217 Long before the cause was discovered, peptic ulcers were known to occur prefer

218 Accordingly, it was discovered recently that an R290H missense mutation

219 ed on endothelial cells in colon tumors that was discovered recently to be upregulated in TNBC.

220 arrivals are king crabs (Lithodidae), which were discovered recently on the adjacent continental slo

221 Giant viruses of amoebae were discovered serendipitously in 2003; they are visibl

222 Striosomes were discovered several decades ago as neurochemically i

223 lthough many of these chemical modifications were discovered several decades ago, their functions wer

224 arrangements (e.g., macA-macB and tetA-tetR) were discovered shared by chicken, pig and human feces.

225 Neutralization escape variants were discovered shortly thereafter, and, after almost th

226 n,Mn)2As2 (BZA), with high Curie temperature was discovered, showing an independent spin and charge-d

227 Soon after these radiation belts were discovered six decades ago, it was recognized that

228 nd fullerene-like nanoparticles (NPs) of WS2 were discovered some 25 years ago and are produced now o

229 Specifically, it was discovered that 4 nm Au nanoparticles deposited on z

230 successive rounds of design and synthesis it was discovered that cis-fluoro substitution on 4-hydroxy

231 a special group of anaerobic microorganisms was discovered that could conserve energy by reducing or

232 It was discovered that delta-oxocarboxylic acids can serve

233 Recently, it was discovered that exposure to mainstream antibiotics a

234 It was discovered that forced convective flow of electrolyt

235 Recently, it was discovered that Gram-positive pathogens use a unique

236 It was discovered that if the reactions were performed unde

237 It was discovered that in order to maximize the response, t

238 me positioning maps for the human genome, it was discovered that in our genome, unlike in that of yea

239 An unusual diastereodivergent NCAL process was discovered that leads to two different products; a t

240 Recently, it was discovered that physical magnification of specimens

241 to azetidine nitrones from N-alkenylnitrones was discovered that provides facile access to these unsa

242 It was discovered that rats with chronically indwelling int

243 adjuvant (IFA) as a co-delivery vehicle, it was discovered that the controlled release of autoantige

244 Over two decades ago, it was discovered that the human T-cell repertoire contains

245 pensions of 3 mum absorbing microspheres, it was discovered that the perceived heterogeneity is not o

246 It was discovered that the sulfur in sodium chromium sulfid

247 It was discovered that this seaweed was high in dietary fib

248 e than 30 years ago, two unexpected findings were discovered that challenged conventional thinking in

249 initial library, several high-titer mutants were discovered that resulted in up to a 63-fold improve

250 ssociated with glycyl radical enzymes (GREs) were discovered; these are widespread and comprise at le

251 tional and structural study of CBM_E1, which was discovered through a metagenomics approach and is th

252 ected link between aneuploidy and aging that was discovered through attempts to investigate the CIN-c

253 Another "bug" was discovered through proteomic analysis, associated wi

254 This pathway was discovered through the creation and analysis of Hmmr

255 This therapy is based on principles that were discovered through basic research more than a decad

256 Key structural features interacting with KHK were discovered through fragment-based screening and sub

257 Early leads were discovered through X-ray crystallographic analysis,

258 2,3-O-Me2)Rhaalpha-O-(p-C6H4)-OCH2CH2NH2 PLL was discovered to be a homotetramer with an intersubunit

259 The stimulator of IFN genes pathway was discovered to be a potent inducer of sIL-15 complexe

260 Sarcosine was discovered to be an excellent ligand for cobalt-cata

261 The presence of O2 was discovered to be important for catalyst activation w

262 e interplay between superconductivity (MoTe2 was discovered to be superconducting recently) and their

263 ically engaged TOP1, TOP1 bound at promoters was discovered to become fully active only after pause-r

264 the alpha-box transcription factor MAT1-1-1 was discovered to control sexual development in P. chrys

265 ications, a novel pyrophosphate ester linker was discovered to enable the targeted delivery of glucoc

266 To add to the uniqueness, our patient was discovered to harbour bilateral testicular adrenal r

267 Interestingly, A. thaliana was discovered to have a recognition system for the effe

268 Levetiracetam was discovered to have antiseizure activity in animal mo

269 atient died on study day 31, and one patient was discovered to have multiple embolic infarcts of the

270 However, the golden SNP was discovered to not affect PSY protein levels and caro

271 rbazole derived with fluorophore compound 12 was discovered to target STAT3 phosphorylation.

272 que fixed ligand kinetic method combinations were discovered to achieve chiral discrimination for thi

273 Nevertheless, cholesterol esters were discovered to be abundant in human OS.

274 26A mutations (p.K93E, p.M112V, and p.K297X) were discovered to be associated with atypical parkinson

275 chloroplast 16:1/18:1 fatty acyl desaturase, were discovered to be suppressors.

276 Three compounds, 3c, 3j, and 3h, were discovered to display IC50 less than 10 muM against

277 Iron-based catalysts were discovered to effect the stereoselective polymeriza

278 In addition, ZFHX3 and ABCA1 were discovered to have protein-coding variants associat

279 Recently, gold nanoparticles (AuNPs) were discovered to inhibit cancer cell migration and pre

280 n this work, crystalline cellulose particles were discovered to lift off heated surfaces by high spee

281 RE1, another plastid PPR-DYW editing factor, were discovered to require their DYW motifs for efficien

282 A novel neuroprotective small molecule was discovered using a target-agnostic in vivo screen in

283 h in vivo efficacy against Candida albicans, was discovered using LCMS-based metabolomics to investig

284 other parts of the turmeric rhizomes and it was discovered using modern atmospheric ionisation sourc

285 V) and the Tibetan frog hepadnavirus (TFHBV) were discovered using in silico analyses of the whole-ge

286 h allosteric inhibitors and novel activators were discovered using this site.

287 ely called the hypocretins or orexins, which were discovered using two different approaches.

288 rus (EPEV), named after the village where it was discovered, was isolated from sand flies (Psathyromy

289 sive progenitors, until two isolated objects were discovered where massive galaxies performing the st

290 ach, a remarkably rich molecular ion pattern was discovered, which proved the presence of a large num

291 addition, two alternative binding interfaces were discovered, which are essential to explain the expe

292 ciated with flavonoid metabolic biosynthesis were discovered, which enhance catechin production, terp

293 Three genes were discovered whose expression was altered within the

294 An unexpected acidanion heterodimer was discovered with weaker picric acid, which helped rev

295 688 and mitochondrial ribosomal protein L43 were discovered with higher frequencies in patients with

296 Several aptamers were discovered with nanomolar dissociation constants.

297 Gravitational waves were discovered with the detection of binary black-hole

298 liminating these, 13 new mutational pathways were discovered with the newly arising WS types having f

299 f three bilayer thick PbSe-SnSe alloy layers was discovered within [(Pbx Sn1-x Se)1+delta ]n (TiSe2 )

300 st frequently used synthetic reactions, none were discovered within the past 20 years and only two in