ライフサイエンスコーパス: wakefulness

1 and recoupling during REM sleep (similar to wakefulness).

2 eep-wake cycles with highest activity during wakefulness.

3 stabilized after sleep but diminished after wakefulness.

4 emporal reactivated patterns in SWS or quiet wakefulness.

5 e and acetylcholine are highly active during wakefulness.

6 oral functions, such as control of sleep and wakefulness.

7 onset of muscle weakness or paralysis during wakefulness.

8 dividual neurons and the cortical LFP during wakefulness.

9 hcrt) are necessary for normal regulation of wakefulness.

10 e performance of a voluntary movement during wakefulness.

11 normal waking day, but also during overnight wakefulness.

12 e EEG and metabolic consequences of extended wakefulness.

13 , but not to the thalamus, mediate PB-driven wakefulness.

14 aracterized by hypersomnolence during normal wakefulness.

15 mice with an exceptional amount of sustained wakefulness.

16 onsolidation, indicating that GABAT promotes wakefulness.

17 the use of sedation strategies that promoted wakefulness.

18 e epochs of visual-like processing as during wakefulness.

19 these neurons as important for cognition and wakefulness.

20 activation of each cell type rapidly induced wakefulness.

21 neurotransmitter systems promoted nighttime wakefulness.

22 uction or loss, and REM sleep instruction in wakefulness.

23 onal activity during subsequent SWS, but not wakefulness.

24 internal clock and by the duration of prior wakefulness.

25 p switch" hypothesized to regulate sleep and wakefulness.

26 rocesses that are perturbed during prolonged wakefulness.

27 zyme histidine decarboxylase (HDC), enhances wakefulness.

28 g of synapses that have been built up during wakefulness.

29 first 2 postnatal weeks, despite behavioral wakefulness.

30 s that either were or were not enhanced over wakefulness.

31 er cigarette-smoking behavior during ensuing wakefulness.

32 ycle toward the orexinergic system promoting wakefulness.

33 me sleep followed by afternoon and nighttime wakefulness.

34 by increasing arousal levels and maintaining wakefulness.

35 a 24-h wake/sleep cycle, followed by 24 h of wakefulness.

36 e for orexin signaling in the maintenance of wakefulness.

37 d active awake animals, but not during quiet wakefulness.

38 ex of awake mice during locomotion and quiet wakefulness.

39 ptoms such as irritability or fatigue during wakefulness.

40 ne recording followed by six hours of forced wakefulness.

41 rapid eye movement sleep muscle atonia into wakefulness.

42 gy costs associated with prolonged nocturnal wakefulness.

43 re increasingly disarranged during sustained wakefulness.

44 ratio of neural responses during subsequent wakefulness.

45 d loss of consciousness, and the recovery of wakefulness.

46 ously learned material both during sleep and wakefulness.

47 ors, which activity is impaired by prolonged wakefulness.

48 that are crucial for the efficacy of AAOM in wakefulness.

49 rement for the maintenance of arousal during wakefulness.

50 le to study somnambulism behaviorally during wakefulness.

51 strength of the peaks with EEG-defined sleep/wakefulness.

52 with impaired behavioral performance during wakefulness.

53 onnected to mental ability both in sleep and wakefulness.

54 hown to depend on EEG-defined stage of sleep/wakefulness.

55 y young and older volunteers under extendend wakefulness.

56 urons and their specific role in maintaining wakefulness.

57 REM sleep, nor of theta power during resting wakefulness.

58 rousal and promote the maintenance of normal wakefulness.

59 ctivity changes during transitions to active wakefulness.

60 d was observed, even after 4 days of induced wakefulness.

61 nic REM sleep, the latter resembling relaxed wakefulness.

62 ans, this occurs during sleep but not during wakefulness.

63 delta power spectrum and slightly decreased wakefulness.

64 he decisive role of the LTD and PPT in sleep-wakefulness.

65 ice increases local acetylcholine levels and wakefulness.

66 ffects on spiking activity across periods of wakefulness.

67 ral cortex, rather than to induce behavioral wakefulness.

68 ociated with visual-like activity, as during wakefulness?

69 with an incomplete structure; compared with wakefulness, a specific peak reflecting prediction error

70 and month 3 by polysomnography end points of wakefulness after persistent sleep onset and latency to

71 o placebo on subjective total sleep time and wakefulness after persistent sleep onset at night 1/week

72 latencies, non-REM and REM sleep stages, and wakefulness after sleep onset); and Mini-Mental State Ex

73 otential (Vm) depolarization associated with wakefulness/alertness in cortical networks, called the "

74 Wakefulness, along with fast cortical rhythms and associ

75 Prolonged wakefulness alters cortical excitability, which is essen

76 ross the circadian cycle, during 42 hours of wakefulness and after recovery sleep, in 33 healthy part

77 ess, whereas TAAR1 partial agonism increases wakefulness and also reduces NREM and also REM sleep.

78 system are elevated in schizophrenia during wakefulness and are also induced in the N-methyl-D-aspar

79 halamic area and plays a fundamental role in wakefulness and arousal.

80 , and it has a crucial function in promoting wakefulness and arousal.

81 in place when transitioning between resting wakefulness and attention selection.

82 ng been thought to be involved in behavioral wakefulness and cortical activation.

83 visual cortical neurons, even during active wakefulness and decision making.SIGNIFICANCE STATEMENT A

84 ctroencephalography (EEG) theta power during wakefulness and delta power during sleep, were greater i

85 Cortical state changes also occur at full wakefulness and during rapid cognitive acts, such as per

86 c and magnetoencephalographic signals during wakefulness and during sleep in normal subjects listenin

87 ceed by recurrent reactivations, both during wakefulness and during sleep, culminating in the distrib

88 These findings indicate morning wakefulness and eating during the biological night is a

89 OX-A is crucial for the control of wakefulness and energy homeostasis and promotes, in OX-1

90 mice were unable to maintain long periods of wakefulness and had an increased propensity for rapid ey

91 n of BF GABAergic neurons produced sustained wakefulness and high-frequency cortical rhythms, whereas

92 tamine (HA) system, implicated in supporting wakefulness and higher brain function, but has been diff

93 orexin neuron-dependent regulation of sleep/wakefulness and highlight a pharmacogenetic approach for

94 ergic projections to cortex directly control wakefulness and illustrates the utility of "opto-dialysi

95 oral wakefulness, whereas inhibition reduced wakefulness and increased non-REM (NREM) sleep.

96 s continue to live under extended periods of wakefulness and ingestion events, daily eating pattern o

97 itical for maintaining normal daily cycle of wakefulness and involving astrocyte-neuron metabolic int

98 hat occur to a different extent during quiet wakefulness and light general anesthesia.

99 ence in ineffective triggering index between wakefulness and light sedation was negligible (from 5.9%

100 ed up to 21.8% (p < 0.0001, compared to both wakefulness and light sedation).

101 THIP (1) increased 1-4 Hz power in wakefulness and nonrapid-eye movement (NREM) sleep; (2)

102 vioral task remained segregated during quiet wakefulness and NREM sleep.

103 of an association between theta waves during wakefulness and performance errors and may contribute ex

104 Conversely, chemogenetic inhibition opposed wakefulness and promoted NREM sleep, even in the face of

105 ) GABAergic neurons, were more active during wakefulness and rapid eye movement (REM) sleep (wake/REM

106 r anesthesia, matching those observed during wakefulness and reconciling earlier studies conducted un

107 REV-ERB agonists induce wakefulness and reduce REM and slow-wave sleep.

108 ne is sufficient to suppress SWS and promote wakefulness and REM sleep.

109 l of the neocortical fast rhythms typical of wakefulness and REM sleep.

110 ng been considered a key site for regulating wakefulness and REM sleep.

111 The ERP recordings were made during wakefulness and repeated in stage II sleep.

112 oles for this neurotransmitter in regulating wakefulness and sleep are incompletely understood.

113 , sigma, beta) of rhythmic brain activity in wakefulness and sleep in a DAT1 genotype-dependent manne

114 al sharp wave-ripple (SPW-R) events of quiet wakefulness and sleep is believed to play a crucial role

115 Genioglossus activity during wakefulness and sleep, genioglossus muscle responsivenes

116 Episodes occurred during wakefulness and sleep, lasted seconds, and were accompan

117 the neocortex and hippocampus of rats during wakefulness and sleep.

118 point to a novel target to improve disturbed wakefulness and sleep.

119 ny of fMRI activity in healthy humans during wakefulness and slow-wave sleep.

120 parameter for all brain nodes to best match wakefulness and slow-wave sleep.

121 AAR1 partial agonist RO5263397 also promoted wakefulness and suppressed nonrapid eye movement sleep.

122 ation, in contrast, initiated and maintained wakefulness and suppressed sleep and sleep-related nesti

123 linked to the global physiological state of wakefulness and that cortical resting activity organizes

124 ajor contribution of BF GABAergic neurons to wakefulness and the fast cortical rhythms associated wit

125 responsible for silencing MCH neurons during wakefulness and thus may be directly involved in the reg

126 neurally adjusted ventilatory assist during wakefulness and with two doses of propofol, administered

127 similarly reset following REMs in sleep and wakefulness, and after controlled visual stimulation.

128 inked with traumatic brain injury, prolonged wakefulness, and aging.

129 The Alzheimer, Wakefulness, and Amyloid Kinetics (AWAKE) study at the R

130 vels, metabolism, gene expression, sleep and wakefulness, and appetite.

131 Dopamine (DA) promotes wakefulness, and DA transporter inhibitors such as dextr

132 al lobe (MTL) and neocortex during sleep and wakefulness, and during visual stimulation with fixation

133 hmic activity in states of anesthesia, quiet wakefulness, and sleep, but not when the organism is eng

134 h prevents improvements from developing over wakefulness, and so when this signal is abolished improv

135 standard clinical measures of awareness and wakefulness, and specific patterns of local brain pathol

136 supermemorization during sleep as opposed to wakefulness, and the developmental role of rapid eye mov

137 Their prevalence in sleep and quiet wakefulness, and the memory deficits that result from th

138 neurons is necessary for the maintenance of wakefulness, and their silencing not only impairs arousa

139 However, MCH cell dynamics during wakefulness are unknown, leaving it unclear if they diff

140 sive (RR) VTA neurons coordinated with quiet wakefulness-associated hippocampal SPW-R events that rep

141 Even though wakefulness at night leads to profound performance deter

142 ich protein kinase A (PKA) stabilizes active wakefulness, at least in part through two of its downstr

143 information during cognitive states such as wakefulness, attention, learning, and memory.

144 es during rapid-eye movement (REM) sleep and wakefulness-behavioral states that do not naturally expr

145 However, besides prior wakefulness, brain function and cognition are also affec

146 vels of brain activity are commensurate with wakefulness, but conscious awareness is radically transf

147 mation from the cortex to hippocampus during wakefulness, but in the reverse direction during slow-wa

148 to specifically mediate feeding and promote wakefulness, but it is now clear that they participate i

149 has important roles in controlling sleep and wakefulness, but the underlying neural circuit remains p

150 sistently dysregulated patterns of sleep and wakefulness by blunting serotonergic signaling in the la

151 reotypical electroencephalography pattern of wakefulness by simply imposing a change in the extracell

152 two dominant mutations that affect sleep and wakefulness by using an electroencephalogram/electromyog

153 homeostatic recovery sleep, indicating that wakefulness can be dissociated from accrual of sleep nee

154 Surprisingly, the enhanced wakefulness caused by cholinergic stimulation was abolis

155 he DR, while the consolidation of fragmented wakefulness correlated with the number of noradrenergic

156 strate that hippocampal astrocytes sense the wakefulness-dependent activity of septal cholinergic fib

157 ured subjects in various states of conscious wakefulness, disconnected consciousness, and unconscious

158 : 63.6 (1.3) y)] underwent 40-h of sustained wakefulness during 3 balanced crossover segments, once u

159 Patient tolerance, wakefulness during sedation, and cooperation were simila

160 n causes excessive sleepiness and fragmented wakefulness during the nocturnal active phase.

161 For instance, compared to wakefulness, during non-rapid eye movement (NREM) sleep

162 arousal and that their inhibition suppresses wakefulness, even in the face of ethologically relevant

163 Human ventilatory activity persists, during wakefulness, even when hypocapnia makes it unnecessary.

164 The durations of epochs of active wakefulness exhibited non-Poisson statistics.

165 Volunteers participated in two prolonged wakefulness experiments (24 h), each including 12 h of p

166 Stable membrane depolarization during wakefulness finally emerges 1-2 d before eye opening and

167 ypothalamus, which promote the transition to wakefulness from non-rapid eye movement (NREM) and rapid

168 We propose that during wakefulness GCs may shape MT odor responses through broa

169 Thus, during wakefulness, GCs exhibited stronger odor responses with

170 Rapid variations in cortical state during wakefulness have a strong influence on neural and behavi

171 e episodes and pathological fragmentation of wakefulness (i.e., sleepiness), respectively.

172 increases transitions between NREM sleep and wakefulness, implicating cholinergic projections to cort

173 r neural activity in the RN during sleep and wakefulness in 1-week-old unanesthetized rats.

174 d eye movement sleep, and slightly increased wakefulness in both light and dark phases, whereas inhib

175 leep, which was consistent with decreases in wakefulness in C57BL/6Slac mice compared with their own

176 ation) before and after periods of sleep and wakefulness in humans (female and male participants).

177 amine-associated receptor 1 (TAAR1) promote wakefulness in mice and rats, we evaluated whether TAAR1

178 increased acetylcholine levels and increased wakefulness in mice.

179 0, Nc) were recordable during both sleep and wakefulness in patients and controls.

180 a optogenetics, we replicated the effects of wakefulness in terms of timing but not of amplitude.

181 nduced a delayed increase in the duration of wakefulness in the subsequent inactive period.

182 ring the wake/sleep cycle and during 24 h of wakefulness in untargeted and targeted analysis.

183 illate in mouse hippocampus as a function of wakefulness, in vitro and in vivo.

184 ribe the main modulatory drives of sleep and wakefulness, including homeostatic, circadian, and motiv

185 Further, wakefulness increased (median Richmond Agitation Sedatio

186 Moreover, caffeine and modafinil affected wakefulness-induced changes in functional bands (delta,

187 By contrast, during wakefulness, inhibition was much stronger than excitatio

188 This global wakefulness instability was mimicked with viral delivery

189 Sleep deprivation, or prolonged wakefulness, interferes with a physiological morning dec

190 Maintaining wakefulness is associated with a progressive increase in

191 Brain activity during wakefulness is characterized by rapid fluctuations in ne

192 Conversely, wakefulness is characterized by the sequential explorati

193 Here we demonstrate that the level of wakefulness is critical for this arousal resetting of th

194 However, this increase is abolished when wakefulness is dominated by running wheel activity.

195 Wakefulness is driven by the widespread release of neuro

196 and cognition, but their role in regulating wakefulness is less clear.

197 systems and circuits that regulate sleep and wakefulness is often disrupted as part of the pathophysi

198 However, during lethargus, when active wakefulness is strongly suppressed, the native role of P

199 type-specific silencing of HA neurons during wakefulness is sufficient to not only impair arousal but

200 Prolonged wakefulness is thought to gradually increase 'sleep need

201 that is evoked by visual stimulation during wakefulness is unknown.

202 ly control the generation and maintenance of wakefulness is unknown.

203 in non-REM (NREM) sleep and anesthesia than wakefulness, it is unknown how neuronal communication is

204 xcitation far better than inhibition; during wakefulness, it predicted them equally well, and visual

205 ing specific cortical areas during prolonged wakefulness lead to a region-specific homeostatic increa

206 Prolonged wakefulness leads to an increased pressure for sleep, bu

207 ow complexity during xenon anesthesia, and a wakefulness-like, complex spatiotemporal activation patt

208 fluctuations in population synchrony during wakefulness modulate the accuracy of sensory encoding an

209 maintaining their rhythmicity during 24 h of wakefulness, most with reduced amplitude (n = 66).

210 ight of total sleep deprivation (24 hours of wakefulness) (n = 13).

211 sed short sleep duration resulted in morning wakefulness occurring during the biological night (i.e.,

212 tion that the human ventilatory drive during wakefulness often results from a corticosubcortical coop

213 r space to recover the state consistent with wakefulness on a physiologically relevant timescale.

214 the effect of voluntary wheel running during wakefulness on neuronal activity in the motor and somato

215 We studied the effect of sleep and wakefulness on pattern separation (i.e., orthogonalizati

216 sure days (p = 0.002) with no differences in wakefulness or agitation.

217 y and are typically active during periods of wakefulness or arousal.

218 e (up) and silent (down) states during quiet wakefulness or NREM sleep regulate fundamental cortical

219 Excitation of ch-BF neurons during wakefulness or REM sleep sustained the cortical activati

220 They were retested after 8 h of wakefulness or sleep, respectively.

221 during sharp-wave ripples observed in quiet wakefulness or slow wave sleep.

222 tio of light-induced transitions from SWS to wakefulness or to REM sleep did not significantly differ

223 LH neurons releases neuropeptides promoting wakefulness (orexin/hypocretin; OH), or sleep (melanin-c

224 decreased CREB activity destabilized active wakefulness outside of, but not during, lethargus.

225 of the PB was highly effective in extending wakefulness over 4 days, although subsequent PB activati

226 t not following aversive conditioning during wakefulness (p < 0.05).

227 tonic (median, 96% [86-120] vs. 75% [50-92] wakefulness; P = 0.01) but not phasic genioglossus activ

228 verse events, measures of sedative exposure (wakefulness, pain, and agitation), and occurrence of iat

229 utcomes suggest a complex relationship among wakefulness, pain, and agitation.

230 During wakefulness, PG and SA cell responses increased in magni

231 We term this effect Prolonged Morning Wakefulness (PMW).

232 of interictal spikes during the last hour of wakefulness preceding sleep.

233 sting Up/Down states (slow-wave sleep, quiet wakefulness), probably as a result of a higher firing pr

234 nd that acute silencing of HA neurons during wakefulness promotes slow-wave sleep, but not rapid eye

235 uated whether CBT-I, in combination with the wakefulness-promoting agent armodafinil (A), results in

236 figuration of functional connectivity during wakefulness, propofol-induced sedation and loss of consc

237 t also remains significantly elevated during wakefulness recovery.

238 cordings, we established that the effects of wakefulness reflect changes in neurovascular coupling, n

239 e of calcium transients was increased during wakefulness relative to an extremely low rate during ane

240 During sleep and wakefulness, REM onsets are associated with distinct int

241 However, unlike either deep sleep or wakefulness, REM was characterized by a more widespread,

242 te to consolidating memories acquired during wakefulness remain unclear.

243 dulation of arousal states such as sleep and wakefulness remain unclear.

244 However, during wakefulness, responses were four times larger and twice

245 During wakefulness, responses were more spatially selective and

246 rstitial space volume expands (compared with wakefulness), resulting in faster waste removal.

247 How wakefulness shapes neural activity is a topic of intense

248 rom a metabolic standpoint, induced extended wakefulness significantly reduced body weight and leptin

249 strated well-organized EEG background during wakefulness, spindling activity during sleep, and relati

250 e patients: 72 vegetative state/unresponsive wakefulness state (VS/UWS), 36 minimally-conscious state

251 ased Galphas signaling stabilized the active wakefulness state before, during and after lethargus.

252 ut not by other transmitters associated with wakefulness such as orexin, histamine or neurotensin.

253 y conscious state (MCS) and the unresponsive wakefulness syndrome (UWS) is a persistent clinical chal

254 Patients with the unresponsive wakefulness syndrome (UWS; formerly vegetative state) or

255 27 patients in vegetative state/unresponsive wakefulness syndrome (VS/UWS; n = 70) and minimally cons

256 nscious state, vegetative state/unresponsive wakefulness syndrome and coma.

257 te compared to vegetative state/unresponsive wakefulness syndrome encompassed bilateral auditory and

258 sed to be vigilant but unaware (Unresponsive Wakefulness Syndrome) and 17 patients revealing signs of

259 ous state, one vegetative state/unresponsive wakefulness syndrome, one emerged from minimally conscio

260 ious state, 19 vegetative state/unresponsive wakefulness syndrome, six coma; 15 females; mean age 49

261 8 patients (11 vegetative state/unresponsive wakefulness syndrome, VS/UWS, and 7 minimally conscious

262 ious state and vegetative state/unresponsive wakefulness syndrome.

263 ious state and vegetative state/unresponsive wakefulness syndrome.

264 us state, five vegetative state/unresponsive wakefulness syndrome; New York: five minimally conscious

265 e algorithmically identify a theta-dominated wakefulness (TDW) substate underlying motivated behavior

266 rate fluctuations) was globally stronger in wakefulness than in NREM sleep (with distinct traits for

267 d rats required more stimulation to maintain wakefulness than VEH- or ALM-treated rats.

268 During quiet wakefulness, the brain produces spontaneous firing event

269 In wakefulness, the ventilatory response to normoxic hyperc

270 active during REM sleep (REMmax), and during wakefulness they were preferentially active during eatin

271 ability to reversibly switch the brain from wakefulness to a state of unconsciousness, knowing how a

272 ones of CA1 pyramidal cells during sleep and wakefulness to coordinate segregated glutamatergic input

273 Some surgeons use substances that promote wakefulness to counteract these effects.

274 that this property gradually decreases from wakefulness to deep nonrapid eye movement sleep and that

275 this novel and noninvasive model of induced wakefulness to explore the EEG and metabolic consequence

276 The transition from wakefulness to general anesthesia is widely attributed t

277 enioglossus muscle activity that occurs from wakefulness to non-REM sleep and reduces airway collapsi

278 rmal reduction of genioglossus activity from wakefulness to non-REM sleep that occurred on the placeb

279 state of arousal leading to transition from wakefulness to sleep and it is further considered to be

280 k and suggest that a transitional state from wakefulness to unconsciousness is not a continuous proce

281 ween damped to sustained oscillations during wakefulness, to a stable focus during slow-wave sleep.

282 timulation in 22 participants during 29 h of wakefulness under constant conditions.

283 sleep/wake cycle prior to 24 h of continual wakefulness under highly controlled environmental condit

284 less, the clinical measures of awareness and wakefulness upon which differential diagnosis rely were

285 ow ACh shapes differing mental states during wakefulness vs. sleep.

286 ABAergic neurons are maximally active during wakefulness (wake-max).

287 Baseline wakefulness was modestly increased in OE compared with W

288 The increase that was observed after 52 h of wakefulness was restored to control levels during a 14-h

289 We found that these periods of "quiet wakefulness" were characterized by state fluctuations on

290 increased homeostatic response to prolonged wakefulness when compared with wild-type animals.

291 t form of chemoreceptor interaction in quiet wakefulness when the chemosensory control system is inta

292 prolonged cortical activation and behavioral wakefulness, whereas inhibition reduced wakefulness and

293 of SuM(Nos1/Vglut2) neurons potently drives wakefulness, whereas inhibition reduces REM sleep theta

294 etic activation of PBel(CGRP) neurons caused wakefulness, whereas optogenetic inhibition of PBel(CGRP

295 some motor skill memories are enhanced over wakefulness, whereas others are instead enhanced over sl

296 TAAR1 overexpression modestly increases wakefulness, whereas TAAR1 partial agonism increases wak

297 were rescued when sounds were applied during wakefulness, whereas the entire set of low-value associa

298 h consisted of an afternoon nap and extended wakefulness, whereas total daily energy expenditure decr

299 bling loss of the daily pattern of sleep and wakefulness, which may be reflective of a compromise to

300 We hypothesized that prolonged wakefulness would increase mGluR5 availability in human