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1                                                MaxLCBI(4mm) was defined as the maximum LCBI within any 4-mm-long segment.
2                          The cumulative failure of the AADI was defined as intraocular pressure (IOP) >18 mm Hg or not re
3                                        Metabolic adaptation was defined as a significantly different (lower or higher) me
4                                       Conduction delay (CD) was defined as interelectrode conduction time of 7 to 11 ms a
5                                                         CHD was defined as >=1 inpatient code or >=2 outpatient CHD diagn
6 rall (three stakeholder groups combined) results, consensus was defined as outcomes scoring greater than 90% "critical" a
7                                             Failure to cure was defined as: 1) no surgical resection due to intraoperativ
8                                                 DAT deficit was defined as less than 65% of putamen striatal binding rati
9                                       The date of diagnosis was defined as the index date.
10                                                    Efficacy was defined as complete response (CR) rate on end-of-treatmen
11                                           Treatment failure was defined as (1) any further surgical procedure related to
12                                             Vaccine failure was defined as TBE despite adherence to the recommended vacci
13                                     A true-positive finding was defined as the presence of a pathology-confirmed cancer w
14                                       Metabolic flexibility was defined as the change in 24-h RQ from EBL during fasting
15                                                     Frailty was defined as having >=3 of the following 5 criteria from th
16                                         Refractory glaucoma was defined as IOP >21 mmHg on maximum tolerated glaucoma med
17                                                Hypertension was defined as prescription of blood pressure-lowering drugs
18                                        Cognitive impairment was defined as the lowest tertile in the main analysis and as
19                           Clinically relevant CMV infection was defined as either plasma CMV DNAemia >= 1000 IU/mL with/w
20 NPV) and positive predictive value (PPV) occurred when iPET was defined as positive if the Deauville score was 4-5 (89% a
21                           A chronic or resolved PAMM lesion was defined as inner nuclear layer thinning with outer plexif
22                                        Incident visual loss was defined as the development of or worsening of visual loss
23                                                  Lymphedema was defined as a >= 10% relative increase in arm volume arisi
24                                               Relapse of ME was defined as increase in macular thickness to >=240 mum in
25                                                          MM was defined as at least 3 coexistent morbidities of high bloo
26                                              Noninferiority was defined as the lower limit of the 95% CI for the differen
27                                           Recipient obesity was defined as body mass index (BMI) >35 adjusted for ascites
28                                          Airway obstruction was defined as forced expiratory volume in 1-second (FEV1)/fo
29                                             Adverse outcome was defined as intensive care unit (ICU) admission or death.
30                               Favourable functional outcome was defined as a modified Rankin Scale score of 0-2 or a Glas
31                                                Poor outcome was defined as invasive ventilation and/or death.
32                                        Unfavourable outcome was defined as death or significant grey matter injury on MRI
33           Short-term variability during a particular period was defined as the variability in IOP measurements obtained d
34                                                        POAF was defined as occurrence of postcardiac surgery atrial fibri
35                              For this study, lead poisoning was defined as a blood lead level (BLL) greater than or equal
36                                                     The PPV was defined as the proportion of patients who had true-positi
37                                                 Proteinuria was defined as Delta urine protein >=300 mg/24 h at 1 year af
38                                            Tumor recurrence was defined as biopsy-proven vital tumor at the initial tumor
39                                                     Relapse was defined as new or reappearing symptoms or worsening disea
40                                    Maintenance of remission was defined as absence of clinical and histologic relapse and
41                                              Failure of SLT was defined as any further glaucoma procedure post-SLT or any
42                                                          SR was defined as modified thrombolysis in cerebral ischemia 2b
43                                                     Success was defined as improvement in 3 Early Treatment Diabetic Reti
44                                          Anatomical success was defined as the maintenance of retinal reattachment withou
45                                           Treatment success was defined as rCDI prevention through 8 weeks after treatmen
46                                                          TC was defined as same-nodule histologic malignancy.
47                         Hypercoagulable thromboelastography was defined as two or more hypercoagulable parameters.
48                          Symptomatic venous thromboembolism was defined as deep vein thrombosis, pulmonary embolism, or b
49                          Worsening traction after treatment was defined as the occurrence within 6 months of worsening or
50  viral load in the year preceding elicitation, and viraemia was defined as a viral load of 200 copies per mL or more.