ライフサイエンスコーパス: washout

1 anterol 100/25 mug or placebo (7-day minimum washout).

2 2 weeks and placebo for 12 additional weeks (washout).

3 oration of the normal walking pattern during washout.

4 maintained for 4 weeks, followed by a 1-week washout.

5 channel that would otherwise cause bacterial washout.

6 e IOP was obtained on 2 different days after washout.

7 rin (control)/d for 8 wk separated by a 4-wk washout.

8 ligand but are recruited to IBs after ligand washout.

9 All subjects underwent a 1-month washout.

10 ls could be drug resensitized following drug washout.

11 , 1.9 at 1 min after injection) with a rapid washout.

12 rse epigenetic drug tolerance following drug washout.

13 lesions that showed enhancement followed by washout.

14 homogeneity, the pattern of vascularity, and washout.

15 blind, randomized design separated by a 4-wk washout.

16 n kinetics showed rapid high uptake and fast washout.

17 more rapidly while also experiencing faster washout.

18 RyR2 channels, and this was reversed by drug washout.

19 3 times/d) diets for 5 d followed by a 10-d washout.

20 AT107 can persist for over 30 min after drug washout.

21 usion, hypoxia-dependent cardiac uptake, and washout.

22 ligand concentration and reversed upon drug washout.

23 transmission were fully reversible upon drug washout.

24 RyR2 activity that was not reversed by drug washout.

25 nd a reduction of vesicle release even after washout.

26 t of the incentive was not sustained after a washout.

27 .5 at 1 min after injection) and rapid brain washout.

28 ate and magnitude of the contrast uptake and washout.

29 arterial hypervascularity and portal venous washout.

30 residual receptor activation continued after washout.

31 eversible GABA-AT resynthesis following drug washout.

32 and 20.9 +/- 3.0 mm Hg, respectively, after washout.

33 he need for hydrodynamic shear and selective washout.

34 oderate initial brain uptake and rapid brain washout.

35 to a randomized crossover design with a 4-wk washout.

36 After washout 10 to 14 days, patients switched regimens.

37 ergetic diets of 4 wk each separated by 4-wk washouts: 2 diets rich in SFAs (12.4-12.6% of calories)

38 patients vs 15 of 42 patients, P < .001) and washout (33 of 44 patients vs five of 42 patients, P < .

39 s 39.79 +/- 70.85; P = .001), and AUC during washout (-49.36 +/- 47.42 vs 42.65 +/- 97.09; P = .001).

40 +/- 67.72 vs 89.44 +/- 145.32; P = .001) and washout (-5.64 +/- 130.71 vs 166.83 +/- 204.44; P = .002

41 ability of ATP to evoke channel activity on washout after desensitization was not dependent on the d

42 extension enrolled 65 of the patients after washout; after 12 weeks, we did an interim analysis.

43 gated nanoparticles highly resist convective washout and enable photothermal stimulation with lower d

44 t reactor failures (characterized by biomass washout and failure of ammonia removal) that were preced

45 leading to minimized tailing of the aerosol washout and helping to separate the signals even at repe

46 One patient in the washout and re-initiation group (300 mg daclizumab HYP)

47 tinuous treatment group (8%), and ten in the washout and re-initiation group (6%) had any serious adv

48 d (1:1) to continue their present dose with (washout and re-initiation group) or without (continuous

49 e continuous treatment group, and 174 in the washout and re-initiation group.

50 initiation group, and two (2%) of 129 in the washout and re-initiation group.

51 ment with daclizumab HYP or during treatment washout and re-initiation.

52 s followed by SLT, 3-month delay followed by washout and SLT, or 6-month delay followed by washout an

53 ashout and SLT, or 6-month delay followed by washout and SLT.

54 relationship between the percentage of high washout and SUVmax and a negative relationship between t

55 mouth followed by 2 weeks of a no treatment washout and then 12 weeks of placebo; subjects in group

56 placebo followed by 2 weeks of no treatment washout and then 12 weeks of valACV 500 mg twice daily.

57 r 12 weeks, followed by 12 weeks of placebo (washout) and 12 additional weeks of placebo (placebo per

58 PET scans indicated good brain entry, rapid washout, and a favorable metabolism pattern.

59 monstrated a favorable biodistribution, slow washout, and excellent performance with respect to the q

60 lication and receptor deactivation after ATP washout, and makes the receptor pore permeable to NMDG+,

61 reversed within tens of seconds after oxo-M washout, and not relieved by a strong depolarization, su

62 n, including the effects of drug taper, drug washout, and placebo administration on mood state.

63 inhalation for 2 weeks, followed by a 2 week washout, and then crossed over to the other arm.

64 opanib 800 mg per day for 10 weeks, a 2-week washout, and then sunitinib 50 mg per day (4 weeks on, 2

65 ce interval {CI}: 0.65, 0.69]), moderate for washout appearance (0.48 [95%CI: 0.46, 0.50]), moderate

66 Two of three major features for HCC (washout appearance and pseudocapsule) have only moderate

67 erenhancement, 0.85 (95% CI: 0.81, 0.88) for washout appearance, and 0.84 (95% CI: 0.80, 0.87) for ca

68 jor HCC features (arterial hyperenhancement, washout appearance, pseudocapsule) were recorded for eac

69 > 0.1 for change), indicating absence of a 'washout' artifact seen in larger mammals.

70 nce Index (LCI), measured by multiple breath washout, as a means to track disease progression in pres

71 We recently utilized the cyclosporine (CsA) washout assay, in which TRIM-CypA-mediated restriction o

72 ity were assessed using a cyclosporine (CsA) washout assay.

73 arallel drug addition and cyclosporine (CsA) washout assays to detect the kinetics of drug susceptibi

74 In nocodazole washout assays, FAs in arrestin-deficient cells were unr

75 r to placebo (1:1), and then, after a 2 week washout, assigned patients to receive the other treatmen

76 tery-to-artery thromboembolism with impaired washout at border zones was a common mechanism in stroke

77 ng features, which included the retention or washout at HBP and degree of transporter expression.

78 FEV1 improvement (absolute change from post-washout baseline at week 12: placebo-to-ivacaftor, 5.0 p

79 h dietary conditions lasted 4 wk with a 2-wk washout before crossing over into the alternate conditio

80 irst drug for 28 days followed by 28 days of washout before taking the second drug for 28 days.

81 were willing to undergo a 1-week medication washout before the study start, and could not have had i

82 ithout flavanones for 6 mo each, with a 2-mo washout between beverages.

83 iagnosed by WSI and TM with a minimum 30-day washout between methodologies.

84 ns together, or placebo/placebo, with 21-day washouts between the conditions.

85 diet sequence, feeding period, baseline and washout biomarker concentrations, age, acculturation, an

86 Medullary hyperosmolarity is protected from washout by countercurrent exchange and efficient removal

87 and Cp as reported in literature, simulated washout curves appear to be similar to the experimentall

88 aluation of experimentally determined tracer washout curves.

89 Pretreatment with menthol followed by its washout did not affect agonist-induced desensitization,

90 ow that using a single IOP measurement after washout does not adequately approximate the mean of mult

91 Upon centrinone washout, each cancer cell line returned to an intrinsic

92 edback was removed during either learning or washout, errors reappeared with performance immediately

93 Washout experiments and inhibition of IFN-gamma-induced

94 we used microfluidics-assisted fast tubulin washout experiments to induce microtubule depolymerizati

95 E], peak signal enhancement ratio [SER], and washout fraction) and normal tissue features (background

96 ble kinetic properties, with relatively fast washout from the brain.

97 amine chase increased (11)C-hydroxyephedrine washout from the heart (2.43% +/- 0.15%/min, P < 0.001),

98 muscle is predicted by also considering the washout from the muscle of the interstitially loaded NO

99 n the striatum expressing hP2X7R, with rapid washout from the noninjected control striatum and other

100 penetration, low tumor specificity and rapid washout from tumors.

101 EGCG (600 mg/d) and placebo over 12 wk (4-wk washout in between).

102 e balance between tumor uptake and metabolic washout in healthy tissue causes the TNR to increase wit

103 material uptake and of 2.38 for the lack of washout in menopausal patients as compared with nonmenop

104 unfavorable radiotracer properties like fast washout in rodent studies, [(18)F]3 is the first (18)F-l

105 Rapid washout in the cerebellum resulted in SUVs of 0.2 at 120

106 This effect persisted after a complete drug washout in the interrupted group.

107 for Golgi ribbon formation after nocodazole washout; in vitro, Mena and microfilaments enhanced GRAS

108 4-wk treatment period was separated by 4-wk washout intervals.

109 vals following SLT when compared to the post-washout IOP (P < 0.0001).

110 Key eligibility included washout IOP of 23 mmHg or more at time 0, IOP of 20 mmHg

111 The post-washout IOP was 16.2 +/- 2.2 mmHg.

112 cloud scavenging (as opposed to below-cloud "washout") is the main contributor to rain WSON.

113 ting yielded significantly faster uptake and washout kinetics than suboptimal heating in all organs f

114 ting yielded significantly faster uptake and washout kinetics than suboptimal heating in all organs f

115 High standardized uptake values and slow washout kinetics were seen in bacterial abscesses.

116 Slow washout kinetics were seen in the salivary glands, heart

117 Moreover, Casodex washout led to the reversal of telomere dysfunction, ind

118 Pre-pump obstruction was treated by washout maneuver in 9 cases (success rate, 100%), thromb

119 hine amine congener (XAC) or VUF 5455 during washout markedly accelerated the reduction in the number

120 scillometry (IOS), multiple breath inert gas washout (MBW), body plethysmography, single-breath deter

121 g, exhaled nitric oxide, and multiple breath washout measures.

122 clearance index (LCI) using multiple-breath washout might be an alternative to and more sensitive me

123 e imaging scan that was preceded by a 30-day washout (modified intent-to-treat population).

124 onths) while receiving the study drug plus 1 washout month.

125 nd by using free-breathing dynamic (19)F gas washout MR imaging after inhalation of the gas mixture w

126 lung ventilation by using dynamic (19)F gas washout MR imaging in free breathing is feasible at 1.5

127 from benign tumors, with a typical prolonged washout observed in Leydig cell tumors (12 of 21 patient

128 Eligible participants underwent washout of all IOP-lowering drops, and the diurnal IOP w

129 am, 12 pm, and 4 pm after patients underwent washout of all IOP-lowering eyedrops.

130 After a washout of all pre-study ocular hypotensive medications,

131 Participants with TRD (n = 24) underwent a washout of antidepressant medication followed by a serie

132 WT Kir6.2 channels re-open after rapid washout of ATP with a time constant of approximately 60

133 Channels remained latched open even after washout of ATP.

134 Washout of auxin and restoration of endogenous Plk4 leve

135 Washout of CaCCinh-A01 rescued ANO1 protein levels and r

136 Washout of Ceapins resensitized ATF6alpha to ER stress.

137 nfall in the study area, indicating that the washout of contaminants from snowpack by rainfall was an

138 (+) resulted in time- and cofactor-dependent washout of deuterium from 3b, as a result of EryKR3(0)-c

139 ase, resulted in first-order, time-dependent washout of deuterium from 6a.

140 pectively, did not result in any significant washout of deuterium.

141 on, whereas MRP3 was the key determinant for washout of gadoxetic acid at HBP (P < .001).

142 This effect was reversed following washout of HS38 and correlated with a reduction in the r

143 Washout of hypotensive medications was repeated at 12 an

144 h established POAG were randomized to prompt washout of IOP-lowering medications followed by SLT, 3-m

145 These processes are reversible, and washout of IPAG before cell death results in a return of

146 d triglyceride levels below 4.5 mmol/L after washout of lipid-lowering treatments.

147 ng applications and eliminating the need for washout of mislocalized sensor.

148 f those without FA treatment, suggesting the washout of NOB.

149 US contrast agents is valuable as the rapid washout of nonhepatocyte malignancies is highly contribu

150 After a 1- to 3-week washout of phosphate binders, we randomly assigned 162 e

151 crease during reperfusion is consistent with washout of potassium and continued activation of the ATP

152 in gene silencing that can be reversed upon washout of the chemical dimerizer.

153 idual proliferation rate persists long after washout of the drug and until cells recover.

154 eases only with increasing cell number after washout of the drug.

155 enefit of BPN14770 persisted two weeks after washout of the drug.

156 atory response was not affected by extensive washout of the drug.

157 nist-mediated effect was reversible, because washout of the ligand resulted in the regeneration of ma

158 served, which was followed by a further slow washout of the residual therapeutic effect.

159 The system described here achieved washouts of 1.5, 3.2, and 4.9 ms for NIST 612 glass, at

160 ng/ml concentrations of human Tg from needle washouts of fine-needle aspiration biopsies of thyroid n

161 the label-free detection of Tg in the needle washouts of fine-needle aspiration biopsies, at concentr

162 e tumor had classic arterial enhancement and washout on venous and delayed-phase computed tomography

163 At baseline following washout, open-angle glaucoma patients (n = 75) were admi

164 t baseline session occurred after medication washout or immediately after enrollment for treatment-na

165 an adult; These effects were reversible upon washout or the addition of GLI or HMR1098.

166 anotransducer channels, recover upon blocker washout or tip link regeneration and can be replicated b

167 which demonstrated soluble contrast material washout over time.

168 The multiple-breath inert gas washout parameter acinar ventilation heterogeneity (Saci

169 with median and interquartile range of (19)F washout parameters.

170 After a 3-month placebo washout, participants were then crossed over to the alte

171 In phase B, after a 2-week washout, patients were randomized to ezetimibe or evoloc

172 After a washout period >/= 4 wk, subjects received an intravenou

173 Following a minimum 7-day washout period (until the symptoms induced by the previo

174 ab treatment, duration and management of the washout period (WP), and relapse or adverse events durin

175 itching to the other TNF inhibitor without a washout period after insufficient primary response to th

176 witching to a second TNF inhibitor without a washout period after primary failure to a first TNF inhi

177 ons were noted to persist following a 3-week washout period and corresponding restoration of circadia

178 ntly activated Notch followed by a prolonged washout period and observed that, in addition to decreas

179 the first intervention, followed by a 3 day washout period and then 5 days with the other interventi

180 or placebo for 4 weeks followed by a 2-week washout period and then crossover to the alternate treat

181 therapy for 4 weeks, followed by a 2-4 week washout period and then the other intervention for 4 wee

182 eek oral lead-in phase, followed by a 1 week washout period and, after safety assessment, three intra

183 The mean washout period before the initiation of fingolimod was 2

184 twice weekly, each for 4 weeks with a 1 week washout period between crossover.

185 administered in a random order with a 28-day washout period between infusions.

186 orally in a crossover fashion after a 2-week washout period between treatments.

187 ed for a 10-week period followed by a 2-week washout period during which patients were bathed with no

188 00 mg BID for 14 days, or vice-versa, with a washout period in between.

189 steroid for 1 to 2 weeks with a 1- to 2-week washout period in between.

190 randomized Latin square design study with a washout period of >/=14 d was conducted.

191 After the washout period of >/=28 d, the same participants consume

192 s who each completed 5 visits with a minimum washout period of 1 wk between testing days.

193 After a washout period of 1 wk, the protocol was repeated with a

194 ional treatment for 26 weeks, separated by a washout period of 17 weeks.

195 p) or without (continuous treatment group) a washout period of 20 weeks.

196 y protein/d) diets for 1 week, followed by a washout period of at least 2 weeks.

197 or a typical Australian diet, followed by a washout period of at least 21 days, before crossing over

198 r 3 hours daily for 5 months, with a 1-month washout period of no patching before the 6-month primary

199 Medication conditions were separated by a washout period that was 7 days.

200 the effect, followed by a randomised 4-week washout period to assess withdrawal effects.

201 nsitized state that requires an agonist-free washout period to recover.

202 y placebo for 8 weeks, followed by a 2-week "washout period" and then 8 weeks of the alternative trea

203 3-wk run-in periods and separated by a 5-wk washout period, 20 healthy subjects (7 men and 13 women)

204 oric period of 2 weeks, followed by a 6-week washout period, and then again during a hypercaloric 2-w

205 After a 5-day washout period, five patients received 5 mg apixaban twi

206 Following a 2-week washout period, participants crossed over to the alterna

207 After a 1-week washout period, patients crossed over to treatment B (pl

208 After a 2-week washout period, subjects received the alternate treatmen

209 Following a 90-day washout period, they were treated for 90 days with the o

210 r US diet for 24 d each, separated by a 28-d washout period.

211 ) twice daily for 6 months after a screening washout period.

212 ven sequentially for 50 d followed by a 50-d washout period.

213 ssed over to another treatment after an 8-wk washout period.

214 daily) in random order separated by a 2 week washout period.

215 treatment period was separated by a 3-4 week washout period.

216 intervention phases were separated by a 14-d washout period.

217 ir regular medication, followed by a 12-week washout period.

218 ebo or PF-04958242 for 5 days separated by a washout period.

219 from rice and seafood following a three-day washout period.

220 intervention periods separated by an 8-week washout period.

221 as followed by a 6-week single-blind placebo washout period.

222 ne if changes were sustained during a 4-week washout period.

223 he 2 assessments were separated by a 6-month washout period.

224 ly consumed for 2 wk and separated by a 4-wk washout period.

225 that were separated by a 14-d habitual diet washout period.

226 switched to the other TNF inhibitor with no washout period.

227 ries from total fat) for 28 d with a >/=2-wk washout period.Consumption of the cashew diet resulted i

228 golimod treatment may happen even with short washout periods (4 weeks) and may perpetuate despite ste

229 rage, 9.2, 22.5, 46.3 and 91 mg . d(-1) with washout periods of 2 wk between each intake.

230 -DASH diet) for 3 wk each, separated by 2-wk washout periods.

231 ree 10-week treatment periods and two 6-week washout periods.

232 -wk duration were provided separated by 2-wk washout periods.

233 periods was randomized with at least 2-week washout periods.

234 ll 5 doses with each dose separated by >2-wk washout periods.

235 This phenotype was fully reversed during the washout phase and readily reproducible across institutio

236 pression were all reversed by the end of the washout phase, indicating that the metabolic alterations

237 Of the children, 356 (89%) entered into the washout phase.

238 Mean global washout rate at 125 min was 15% +/- 14% (range, 0%-34%),

239 yocardial activity/blood pool integral), and washout rate were calculated.

240 l the cardiac autonomic measures (except the washout rate) was associated with reduced CFR.

241 ate, 0.42% +/- 0.57%/min) and (18)F-LMI1195 (washout rate, 0.058% +/- 0.28%/min).

242 control rabbits for (11)C-hydroxyephedrine (washout rate, 0.42% +/- 0.57%/min) and (18)F-LMI1195 (wa

243 ed signal intensity, T2 value, wash-in rate, washout rate, time to peak (TTP), mean apparent diffusio

244 d as the late heart-to-mediastinum ratio and washout rate.

245 assessed with heart-to-mediastinal ratio and washout rates was preserved in all patients at baseline

246 could result in a wide physiologic range of washout rates.

247 h calculation of enhancement ratio (ER), and washout ratio (WR).

248 ed intravenously for 15 minutes, followed by washout (rebaseline) and infusion of acyl ghrelin at the

249 s, including cardiac extraction fraction and washout, requires the study of isolated perfused hearts

250 were tested; all showed similar activity and washout resistance.

251 tistically with gadoxetic acid retention and washout, respectively, in the HBP.

252 esponses to KCl and carbachol treatments and washouts, respectively.

253 e-related increase in myopia during phase 2 (washout), resulting in atropine 0.01% being most effecti

254 = .002) and significantly reduced late-phase washout slope (P = .002) when compared with healthy cont

255 e first-pass peak (P = .011), and late-phase washout slope (P = .032), estimated by using the median

256 ty, wash-in slope of 10%-90% and 5%-45%, and washout slope of 100%-10% and 50%-10% were significantly

257 Following washout, subjects exhibited a strong and persistent afte

258 d only small changes in IOP after medication washout, suggesting either that they were not using the

259 s fast and uniform before whole-cell pipette washout, suggesting little voltage attenuation along the

260 erated structures after copper treatment and washout, suggesting that forward trafficking out of this

261 Subsequently, activated WASHout T cells experience reduced glucose uptake and me

262 died in vivo by use of the radioactive xenon washout technique after a hydrocortisone infusion (2 mg/

263 istribution derived from the multiple-breath washout technique.

264 CI determined by age-adapted multiple breath washout techniques and MRI studies were performed in 97

265 the slope of phase III of the single-breath washout test (S) of He (S(He)) and sulfur hexafluoride (

266 e and SSF6, respectively) from single-breath washout tests were measured to identify sites of airway

267 Multiple breath washout tests were performed at baseline, 1, 3, 6, and 1

268 537 mumol were flavanones, and after a 2-wk washout, the procedure was repeated, and a placebo drink

269 Upon inhibitor washout, the receptor is readily rephosphorylated.

270 eks; this treatment was followed by a 2-week washout, then the other study treatment was administered

271 llular TRE, we observed that, upon inhibitor washout, there was a rapid and dramatic regeneration of

272 Both uptake and washout time constants were faster (P < 0.01) in animals

273 curves were analyzed to calculate uptake and washout time constants.

274 sex, disability status, time on natalizumab, washout time, follow-up time, and study center).

275 ied by using volume defect percentage (VDP), washout time, number of breaths, and fractional ventilat

276 olongation of the posterior tibial vein SvO2 washout time.

277 of breaths (r = -0.82; P < .0001) and median washout times (r = -0.77; P < .0001) with percentage pre

278 le undoubtedly a valuable research tool, the washout times and sensitivity of current technology have

279 0 mg/dl and a 1.5-mg/dl increase from before washout) to one of six tenapanor regimens (3 or 30 mg on

280 ablation crater profiles [ACP]) and aerosol washout/transfer/ICPMS measurement (via single pulse res

281 or 2.0 mm Hg from the increase in IOP after washout using only 1 of the postwashout measurements.

282 n of eyes in which the increase in IOP after washout, using the mean of the 3 measurements, differed

283 The mean increase in IOP after washout, using the mean of the 3 measurements, was 5.3 (

284 The mean (SD) IOP before washout was 18.5 (4.0) mm Hg.

285 ion, was slightly voltage-dependent, and its washout was accelerated by bovine serum albumin.

286 Control experiments confirmed that this washout was due to KR(0)-catalyzed isotope exchange of t

287 (123)I-MIBG cardiac washout was lower during carvedilol than metoprolol trea

288 Phenylephrine washout was not different from healthy volunteers in the

289 0.15%/min, P < 0.001), whereas (18)F-LMI1195 washout was not influenced (0.059% +/- 0.11%/min, not st

290 Washout was only observed for phenylephrine (T(1/2) 49+/

291 very of the conformational change on agonist washout was state-dependent, with a faster time constant

292 ek periods of treatment, separated by 2-week washout was used.

293 Previously, we identified Drosophila washout (wash) as a new member of the WAS family with es

294 phosphate concentrations at baseline (after washout) were 7.32-7.92 mg/dl for tenapanor groups and 7

295 During washout when patients used conventional therapy, 7 patie

296 The treatments were separated by a 3-wk washout with AA-MFs.

297 y plethysmography, multiple-breath inert gas washout (with the tracer gas sulfur hexafluoride), and h

298 n of the recovery of fluorescence on agonist washout, with channel activation to a second agonist app

299 vealing rapid myocardial redistribution, and washout within 30 minutes (n=6).

300 dies should carefully consider the length of washout within crossover designs.