ライフサイエンスコーパス: wasting

1 ncreased glucagon, without preventing muscle wasting.

2 e DOX-induced cardiac atrophy and whole-body wasting.

3 ed by elevated urinary calcium and phosphate wasting.

4 the fiber area by 20%, protecting them from wasting.

5 ation and cleavage of ENaC, despite the salt wasting.

6 ) cotransporter (NCC) manifest profound salt wasting.

7 e, likely as a consequence of chronic muscle wasting.

8 ect of selected miRNAs on age-related muscle wasting.

9 ng suggest novel approaches to combat muscle wasting.

10 in signaling, as a secreted factor mediating wasting.

11 d elevated levels in urine, indicating renal wasting.

12 TFEB/MuRF1 pathway to induce skeletal muscle wasting.

13 ss skeletal muscle growth and promote muscle wasting.

14 ytes were resistant to Ang II-induced muscle wasting.

15 severe wasting and <115-125 mm for moderate wasting.

16 ino acid catabolism without affecting muscle wasting.

17 r tenotomy did not prevent subsequent muscle wasting.

18 ion of HDAC6 in mice protects against muscle wasting.

19 nt, but not benign, tumors induce peripheral wasting.

20 s different modes of non-degenerative muscle wasting.

21 ed from ATP synthesis, resulting in nutrient wasting.

22 -based therapies for non-degenerative muscle wasting.

23 , which is required for prevention of muscle wasting.

24 epletion, and rescue from severe precipitous wasting.

25 me variables were stunting, underweight, and wasting.

26 basal lamina, leading to progressive muscle wasting.

27 ties for the treatment of progressive muscle wasting.

28 ative skeletal muscle resistant to catabolic wasting.

29 ight reduce the rate of bone loss and muscle wasting.

30 for underweight, and 0.984 (0.981-0.986) for wasting.

31 inhibitor, benzamil, reversed excessive K(+) wasting.

32 for underweight, and 0.983 (0.979-0.986) for wasting.

33 for underweight, and 0.991 (0.978-1.004) for wasting.

34 ng, 485,152 for underweight, and 459,538 for wasting.

35 at disrupt this activity cause severe muscle wasting.

36 cell-based therapy to combat skeletal muscle wasting.

37 sary and sufficient for tumor-induced muscle wasting.

38 xhibited severe hypokalemia and urinary K(+) wasting.

39 salt wasting, low BP, and profound potassium wasting.

40 abnormal substrate utilization and lean mass wasting.

41 mation and massive muscle and adipose tissue wasting.

42 mo and at 1 y-for reducing the risk of child wasting.

43 eting TLR4 alone effectively abrogate muscle wasting.

44 for the development of therapies for muscle wasting.

45 ren younger than 5 years with anthropometric wasting.

46 nsible for tumor's capacity to induce muscle wasting.

47 dy weight loss and muscle and adipose tissue wasting.

48 therapeutic target of cancer-induced muscle wasting.

49 bednets (20%), vaccines (17%), reductions in wasting (11%) and stunting (9%), facility birth care (7%

50 ein intake is associated with protein-energy wasting, a risk factor that affects outcome.

51 tion might be captured by the measurement of wasting alone, but this is unknown.

52 Muscle wasting, also known as cachexia, is associated with many

53 derweight analysis, 384,163 children for the wasting analysis, and 187,744 children for the low-birth

54 ence (MUAC) with a cutoff <115 mm for severe wasting and <115-125 mm for moderate wasting.

55 an 2.5% and the highest were 42% (34-50) for wasting and 54% (49-59) for underweight.

56 ng and edematous malnutrition, but the terms wasting and acute malnutrition are often used interchang

57 sis of adipose tissues is involved in energy wasting and also point to a link between the atrophy of

58 Presentations vary from neonatal salt wasting and atypical genitalia, to adult presentation of

59 n leads to myopathy, characterized by muscle wasting and cardiac hypertrophy.

60 nourishment inevitably led to massive muscle wasting and death in double-knockout animals.

61 in rodents causes sustained skeletal muscle wasting and decreases muscle regenerative potential thro

62 imilar phenotype to Bartter syndrome of salt wasting and dehydration due to reduced Na-K-2Cl-cotransp

63 LE: Critical illness is hallmarked by muscle wasting and disturbances in glucose, lipid, and amino ac

64 with diabetes, deafness, progressive muscle wasting and ectopic calcifications specifically occurrin

65 It includes both wasting and edematous malnutrition, but the terms wastin

66 ase phenotypes such as cancer-related muscle wasting and fibrosis.

67 WEAK) is a potent inducer of skeletal muscle wasting and fibrosis.

68 When wasting and global acute malnutrition prevalence estimat

69 ely, low circulating aldosterone causes salt wasting and hypotension.

70 the implication of HDAC6 in skeletal muscle wasting and identify HDAC6 as a new downstream target of

71 y fed contribute to bone and skeletal muscle wasting and impose risk of adrenocortical atrophy.

72 fr1393 knockout mice exhibit urinary glucose wasting and improved glucose tolerance, despite euglycem

73 ing Mtm1 mutations remarkably rescued muscle wasting and lethality, and this effect was muscle specif

74 ons in KCNJ1 underlying renal salt and water wasting and lower blood pressure has sparked interest in

75 nd arl15b knockdown resulted in renal Mg(2+) wasting and metabolic disturbances.

76 ults, is characterized by progressive muscle wasting and multi-systemic complications.

77 development of therapeutics to combat muscle wasting and neuromuscular disorders.

78 Both wasting and obesity are associated with inflammation, bu

79 and lower motor neuron degeneration, muscle wasting and paralysis.

80 ed; the other two had transient massive salt-wasting and polyuria reminiscent of antenatal Bartter's

81 nderstanding of conditions of adipose tissue wasting and review microenvironmental determinants of ad

82 ibed here, have slowly progressive weakness, wasting and sensory loss, with an axonal neuropathy typi

83 ition prevalence estimates as well as severe wasting and severe acute malnutrition prevalence estimat

84 sented in early infancy with renal phosphate wasting and symptomatic hypercalcemia, mutations in CYP2

85 which is characterised by progressive muscle wasting and the discovery of reliable blood-based biomar

86 ed in the quadriceps of patients with muscle wasting and to determine the molecular pathways by which

87 Increased urinary Mg(2+) wasting and Trpm6 mRNA levels were observed in the urine

88 -26) and 76% (69-83); the lowest figures for wasting and underweight were both less than 2.5% and the

89 LMN) syndromes typically present with muscle wasting and weakness and may arise from pathology affect

90 signaling pathway in CMV-mediated diaphragm wasting and weakness in rats.

91 of diseases characterized by chronic muscle wasting and weakness.

92 le diseases characterized by skeletal muscle wasting and weakness.

93 on of McArdle disease with severe paraspinal wasting and weakness.

94 hypoaminoacidemia, without affecting muscle wasting and without a sustained impact on blood glucose.

95 roup of genetic diseases that lead to muscle wasting and, in most cases, premature death.

96 olic and anabolic signals, leading to tissue wasting and, ultimately, to cachexia.

97 ated in the pathogenesis of cachexia (muscle wasting) and the hallmark symptom, exercise intolerance.

98 eus; (3) denervation is likely to drive this wasting, and (4) the neuromuscular synapse is a primary

99 atures of ataxia, paralysis, skeletal muscle wasting, and degeneration.

100 nases would lead to polyuria and severe salt-wasting, and generated SPAK/OSR1 double knockout mice to

101 nce of airfall, surface dust transport, mass wasting, and insolation weathering for cometary surface

102 ith motor neuron degeneration, severe muscle wasting, and premature death by 6 mo of age.

103 n mice, miR-542 overexpression caused muscle wasting, and reduced mitochondrial function, 12S rRNA ex

104 ector of IL-6, are also elevated with muscle wasting, and STAT3 has been implicated in the regulation

105 uma, with a focus on hypermetabolism, muscle wasting, and stress-induced diabetes.

106 factors contribute to cancer-induced muscle wasting, and therefore therapy requires combinational st

107 We estimated the prevalences of stunting, wasting, and underweight among children and of underweig

108 At 19 mo of age, prevalences of stunting, wasting, and underweight were 19.8%, 6.0%, and 10.8%, re

109 were used to compare incidences of stunting, wasting, and underweight.

110 nd with purified enzymes differed among salt-wasting- and nonclassical-associated variants, but these

111 Several mouse models of skeletal muscle wasting are associated with lipin1 mutation or altered e

112 utilization but results in increased carbon wasting as overflow metabolism.

113 pathway in muscle suppresses the deleterious wasting associated with cancer.

114 phenotype, which could contribute to muscle wasting associated with metabolic disorders.

115 racterized by lower limb muscle weakness and wasting, associated with reduced numbers of lumbar motor

116 immunoglobulin G uptake, and reduced muscle wasting at 3 and 6 months after treatment.

117 t of two ubiquitin ligases induced in muscle wasting, atrogin-1 and MuRF1, suggesting a possible clin

118 Skeletal muscle wasting attributed to inactivity has significant adverse

119 proposed as therapeutics for treating muscle wasting but concerns regarding possible off-target effec

120 and lipid metabolism, did not affect muscle wasting, but drastically suppressed markers of hepatic a

121 ger cash transfer had the greatest effect on wasting, but only at 6 mo.

122 ptor 4 (TLR4) mediates cancer-induced muscle wasting by directly activating muscle catabolism as well

123 both kinases causes severe polyuria and salt-wasting by generating SPAK/OSR1 double knockout (DKO) mi

124 A total of 143 patients with salt-wasting CAH were identified; none were missed.

125 Sensitivity of the screening for salt-wasting CAH.

126 her demonstrate that primary renal phosphate wasting caused by defective NaPi-IIa function induces in

127 d to prevent neuronal dysfunction and muscle wasting caused by protein misfolding in HD.

128 expression profiling of mouse muscles under wasting conditions such as fasting, denervation, diabete

129 n which to study extremely aggressive muscle-wasting conditions.

130 associated with both age-related and muscle-wasting conditions.

131 c approach to improve regeneration in muscle wasting conditions.

132 ce also had inflammatory symptoms, including wasting, dermatitis, colitis, hypereosinophilia, and hig

133 on skeletal muscle and thereby induce muscle wasting described as cachexia.

134 Childhood wasting did not differ between groups (OR 0.92, 95% CI 0

135 g born to muntjac dams infected with chronic wasting disease (CWD) (1).

136 ed conversion (RT-QuIC) and compared chronic wasting disease (CWD) and classical bovine spongiform en

137 is a reservoir for prions that cause chronic wasting disease (CWD) and influences the risk of transmi

138 Chronic wasting disease (CWD) in cervids and bovine spongiform e

139 t factors on phenotypic diversity of chronic wasting disease (CWD) in different host species that exp

140 Chronic wasting disease (CWD) is a fatal prion disease of North

141 Chronic wasting disease (CWD) is a naturally occurring, fatal ne

142 Chronic wasting disease (CWD) is a rapidly spreading prion disor

143 to precede neuroinvasion.IMPORTANCE Chronic wasting disease (CWD) is a universally fatal transmissib

144 Chronic wasting disease (CWD) is an emergent, rapidly spreading

145 Chronic wasting disease (CWD) is an emerging and uniformly fatal

146 which facilitate the transmission of chronic wasting disease (CWD) of cervids and allow prion strain

147 rodegenerative diseases that include chronic wasting disease (CWD) of cervids.

148 In nature, cervids are infected with chronic wasting disease (CWD) prions by oral and nasal mucosal e

149 ative errors to test deer saliva for chronic wasting disease (CWD) prions.

150 Traditional diagnostic detection of chronic wasting disease (CWD) relies on immunodetection of misfo

151 , a species naturally susceptible to chronic wasting disease (CWD), a burgeoning, contagious epidemic

152 lations that have been infected with chronic wasting disease (CWD), a contagious, fatal prion disease

153 omotes propagation of prions causing chronic wasting disease (CWD), a fatal, transmissible, neurodege

154 Chronic wasting disease (CWD), a transmissible spongiform enceph

155 Chronic wasting disease (CWD), a transmissible spongiform enceph

156 Chronic wasting disease (CWD), a transmissible spongiform enceph

157 e, we removed the lipid content from chronic wasting disease (CWD)-infected white-tailed deer brain h

158 rapie in sheep or prions that caused chronic wasting disease (CWD; hereafter "CWD prions") in deer, u

159 an extensive outbreak of sea-star (asteroid) wasting disease (SSWD).

160 e challenged domestic swine with the chronic wasting disease agent by inoculation directly into the b

161 dystrophy (DMD) is a lethal, X-linked muscle-wasting disease caused by lack of the cytoskeletal prote

162 ular dystrophy (DMD) is a devastating muscle wasting disease caused by mutations in dystrophin.

163 trophy (DMD) is an incurable X-linked muscle-wasting disease caused by mutations in the dystrophin ge

164 phy (DMD) is a severe and progressive muscle-wasting disease caused by mutations in the dystrophin ge

165 rophy (BMD) is a progressive X-linked muscle wasting disease for which there is no treatment.

166 ographic spread in the prevalence of chronic wasting disease in white-tailed deer (Odocoileus virgini

167 Chronic wasting disease is a fatal, neurological disease caused

168 lar dystrophy is a rare, progressive, muscle-wasting disease leading to severe disability and prematu

169 seases with high prevalence, notably Chronic Wasting Disease of deer and elk and atypical/Nor98 scrap

170 istics upon passage to cats but that chronic wasting disease prions adapt to the cat and are distingu

171 Additionally, we showed that chronic wasting disease prions are effective at seeding the conv

172 trains of mouse prions and with deer chronic wasting disease prions.

173 ransporter NBCe1, results in the bicarbonate-wasting disease proximal renal tubular acidosis (pRTA).

174 Muscular dystrophy is a progressive muscle wasting disease that is thought to be initiated by unreg

175 type 1A (MDC1A) is a severe and fatal muscle-wasting disease with no cure.

176 PORTANCE The facile dissemination of chronic wasting disease within captive and free-range cervid pop

177 educes C-reactive protein levels, alleviates wasting disease, and extends host survival during experi

178 ie, BSE, mouse-adapted scrapie, deer chronic wasting disease, and hamster-adapted scrapie prions.

179 Triple(lo)CD4(+) T cells induced colitis and wasting disease.

180 e muscular dystrophy (DMD), a genetic muscle-wasting disease.

181 reutzfeldt-Jakob disease, and cervid chronic wasting disease.

182 uces IRIS pathology, even after the onset of wasting disease.

183 egenerative response and ameliorating muscle-wasting diseases.

184 Cachexia is a wasting disorder of adipose and skeletal muscle tissues

185 o the pathogenesis of an inherited magnesium-wasting disorder of the kidney (isolated renal hypomagne

186 is a severe and progressive striated muscle wasting disorder that leads to premature death from resp

187 ntial, providing a new therapeutic target in wasting disorders such as CHF and CKD.

188 further cohorts with these and other muscle-wasting disorders would suggest that MRI biomarkers migh

189 ne in the prevention and treatment of muscle-wasting disorders, particularly given the lack of drugs

190 it is a prime therapeutic target for muscle wasting disorders.

191 elevated in the serum of progressive muscle wasting DM1 patients compared to disease-stable DM1 pati

192 In addition to skeletal muscle wasting, DMD patients develop cardiomyopathy, which sign

193 aring TLR4(-/-) mice were spared from muscle wasting due to a blockade in muscle catabolic pathways.

194 ein response pathways causes skeletal muscle wasting during cancer cachexia.

195 id, and amino acid homeostasis and in muscle wasting during critical illness.

196 ens with their mate experience reduced fetal wasting, establishing a role for vertical transmission o

197 ation of recent and present-day martian mass wasting features, as much less water may be required to

198 H was highly effective in detecting the salt-wasting form and thereby reducing mortality.

199 lasia (CAH) owing to low sensitivity in salt-wasting forms and a high rate of recall (ie, a positive

200 ital admission, followed by malnutrition and wasting, haematological disorders, and, in the African r

201 rome across vertebrate species that includes wasting, hepatosteatosis, and thymus atrophy.

202 ied mice, we have shown that renal phosphate wasting hypophosphatemic states arising from high levels

203 ith chemotherapy and appetite stimulation in wasting illnesses.

204 ice restored their longevity, reduced muscle wasting, improved function and greatly increased the poo

205 on, which are highlighted by renal phosphate wasting in AC6(-/-) mice.

206 We have developed a model for organ wasting in adult Drosophila, whereby overproliferation i

207 We determined the cutoffs for MUAC to detect wasting in Bangladeshi children aged 6-60 mo.A secondary

208 In clinical settings, wasting in childhood has primarily been assessed with th

209 There are no approved therapies for muscle wasting in children infected with human immunodeficiency

210 of which are recommended to identify severe wasting in children, often identify different children.

211 gnatures of processes associated with muscle wasting in CKD, including proteolysis, myogenesis and mu

212 brogates tumor-induced muscle catabolism and wasting in cultured myotubes and in mice.

213 arkers for monitoring the progress of muscle wasting in DM1 patients.

214 re associated with the progression of muscle wasting in DM1 patients.

215 approaches to alleviate muscle weakness and wasting in DMD patients should not only target the myoge

216 egeneration are major contributors to muscle wasting in Duchenne muscular dystrophy (DMD).

217 sults demonstrate that PTHrP mediates energy wasting in fat tissues and contributes to the broader as

218 eresting opportunity to prevent increases in wasting in humanitarian aid settings.

219 70 and Hsp90 as key cachexins causing muscle wasting in mice.Cachexia affects many cancer patients ca

220 receptors (Ifnar1 or Ifngr1) does not rescue wasting in Pdgfrb(+/D849V) mice, indicating that interfe

221 or absence of TP53INP2 did not affect muscle wasting in response to denervation, a condition in which

222 ession of Tp53inp2 exhibited enhanced muscle wasting in streptozotocin-induced diabetes that was depe

223 t since the CA12(E143K) mutation causes salt wasting in sweat and dehydration in humans.

224 uses autoimmune disease that leads to severe wasting in syngeneic recipients.

225 the incidences of underweight, stunting, or wasting in Tanzanian infants.

226 n model for pathological fibrosis and muscle wasting in the muscular dystrophies is likely generaliza

227 the pathogenesis of cachexia-induced muscle wasting in tumor-bearing mice.

228 n of PGC-1alpha inhibited progressive muscle wasting in TWEAK-Tg mice.

229 maternal BMI and stunting, underweight, and wasting in U5s over time.

230 ch for therapeutic targets to prevent muscle wasting, in particular sarcopenia and cachexia.

231 s, which is characterized by renal phosphate wasting, inappropriately low circulating levels of the a

232 c hepatitis such as fever, neutrophilia, and wasting, interfering with the IL-1 pathway might be an a

233 In all affected individuals, weakness and wasting is lower-limb predominant, and typically involve

234 Skeletal muscle wasting is prevalent in many chronic diseases, necessita

235 The pathogenic mechanism triggering muscle wasting is unknown.

236 er-induced cachexia, characterized by muscle wasting, is a lethal metabolic syndrome with undefined e

237 Cachexia, characterized by muscle wasting, is a major contributor to cancer-related mortal

238 Cachexia, or muscle wasting, is a serious health threat to victims of radiol

239 ients that results from tumor-induced energy wasting, is a serious problem that interferes with respo

240 V and food insecurity, but in the absence of wasting, it is not known if RUSF confers benefit above l

241 -for-age), underweight (low weight-for-age), wasting (low weight-for-height), and low birth weight in

242 ney-specific MR-knockout mice exhibited salt wasting, low BP, and hyperkalemia.

243 of Kir4.1 in these mice led to moderate salt wasting, low BP, and profound potassium wasting.

244 Cirrhosis is characterized by muscle wasting, malnutrition, and functional decline that confe

245 tabolism, such as insulin resistance, muscle wasting, mitochondrial dysfunction and hyperlactatemia.

246 ch correlated with the progression of muscle wasting observed in DM1 patients.

247 ntation of tumors into adults induces robust wasting of adipose, muscle, and gonadal tissues that are

248 us nonhypochloremic patients exhibited renal wasting of chloride (P=0.04) and of chloride relative to

249 ntially at synapses on slow fibers, precedes wasting of mutant soleus; (3) denervation is likely to d

250 ns and inflammation can lead to cachexia and wasting of skeletal muscle and fat tissue by as yet poor

251 ystrophies are characterized by weakness and wasting of skeletal muscle tissues.

252 ortholog, in intestinal stem cells leads to wasting of the ovary, fat body, and muscle.

253 ommunity referral for admission, more severe wasting on admission, younger age, and a long commute fo

254 agnesaemia, hypocalciuria and displayed salt wasting on switching to a low-Na diet.

255 signaling pathway is downregulated in muscle wasting or atrophying diseases, with a decrease of myost

256 50 21A2 variants associated with either salt-wasting or nonclassical forms of CAH were expressed, pur

257 t elevated PDGFRbeta signaling causes tissue wasting or overgrowth reminiscent of human genetic syndr

258 ght-for-age z score or on rates of stunting, wasting, or underweight.

259 cord die progressively, resulting in muscle wasting, paralysis, and death.

260 hospital admission included malnutrition and wasting, parasitic infections, and haematological disord

261 diseases characterized by connective tissue wasting (Penttinen syndrome) or overgrowth (Kosaki overg

262 vation of TWEAK-Fn14 signaling causes muscle wasting, PGC-1alpha preserves muscle mass in several con

263 mpared with Sgcg mice, which normally show a wasting phenotype similar to human muscular dystrophy pa

264 These organ-wasting phenotypes are associated with a reduction in sy

265 nsights into the mechanisms underlying organ-wasting phenotypes in Drosophila and how overproliferati

266 mpL2, specifically in the tumor, ameliorates wasting phenotypes.

267 ing that metal ligation inhibits this energy wasting reaction is of direct relevance to solar energy

268 (DSS) colitis, characterized by significant wasting, rectal bleeding, colonic pathology, and enhance

269 Organ wasting, related to changes in nutrition and metabolic a

270 cachexins that mediate cancer-induced muscle wasting remain elusive.

271 hat some recipients may not use the product, wasting resources (overinclusion).

272 chologically, and can harm health systems by wasting resources and deflecting investments in both pub

273 interest is of critical importance to avoid wasting resources.

274 myostatin increased mass or prevented muscle wasting, respectively, highlighting the potential therap

275 in distant tissues, thus driving a systemic wasting response.

276 a disorder characterized by renal phosphate wasting resulting in hypophosphatemia, correspondingly e

277 ermatitis, multiple allergies, and metabolic wasting (SAM) syndrome is a recently recognized syndrome

278 ve overgrowth, a distinct phenotype from the wasting seen in Stat1(+/-)Pdgfrb(+/D849V) mice.

279 The pronounced cachexia (unexplained wasting) seen in Huntington's disease (HD) patients sugg

280 The terms acute malnutrition and wasting should not be used interchangeably.

281 ndicated by muscle pain, muscle weakness and wasting, significant fat replacement of muscles on imagi

282 tion but decreased ATP production (an energy-wasting state); and (4) overproduction of glutamate that

283 hysiology of FGF23-dependent renal phosphate wasting states and implicate pharmacologic CYP24 inhibit

284 ally manifested by postweaning multisystemic wasting syndrome (PMWS), respiratory and enteric disease

285 a, IL-6, and CCL2 mRNAs), and attenuated the wasting syndrome and severity of colitis ( approximately

286 sporadic cases of postweaning multisystemic wasting syndrome in Canada in the early 1990s, an epidem

287 Cachexia is a life-threatening wasting syndrome lacking effective treatment, which aris

288 Cachexia is a muscle-wasting syndrome that contributes significantly to morbi

289 epatic damage, steatohepatitis, and a lethal wasting syndrome; however, the mechanisms are still unkn

290 IL-6 are implicated in cancer-induced muscle wasting, there is limited understanding of muscle gp130'

291 ted protein (PTHrP) has an important role in wasting, through driving the expression of genes involve

292 succinate mitigates infection-induced lipid wasting to extend survival of V. cholerae-infected flies

293 ice by a strain of Escherichia coli prevents wasting triggered by infections or physical damage to th

294 RT1 decreased p65K310 acetylation and muscle wasting upon starvation.

295 The prevalence of stunting, thinness, and wasting was 49.2%, 27.8%, and 59.7% of all children.

296 e overlap between edematous malnutrition and wasting was assessed, and the impact of including/exclud

297 In low-income countries, childhood wasting was the leading cause of DALYs in Afghanistan, S

298 Skeletal muscle wasting with accompanying cachexia is a life threatening

299 f-function mutations of NCC cause renal salt wasting with arterial hypotension (Gitelman syndrome).

300 k of severe (WHZ <-3) and moderate (WHZ <-2) wasting would be <120 and <125 mm for ages 6-24 mo, <125