ライフサイエンスコーパス: water solubility

1 alpha-helical conformations without loss of water solubility.

2 e in the environment because of their higher water solubility.

3 f adenosine receptor antagonists, is the low water solubility.

4 d volume slightly in excess of the predicted water solubility.

5 , with two propyloxyammonium side chains for water solubility.

6 of membrane-bound hydrogenases (MBHs), poor water solubility.

7 vel A 2A receptor antagonists with excellent water solubility.

8 amine sites per molecule, which resulted in water solubility.

9 equires facile provisions for imparting high water solubility.

10 d/or overall molecular properties related to water solubility.

11 ake and molecular properties associated with water solubility.

12 erial activities with significantly improved water solubility.

13 toxicity for substrate or aglycon, and good water solubility.

14 ly eliminated from the body due to increased water solubility.

15 ial redesign of the sequence so as to confer water solubility.

16 me increasingly lipophilic while maintaining water solubility.

17 e in water, while nitrone 4 exhibited a poor water solubility.

18 epare artemisinin O-glycosides with improved water solubility.

19 minimal aggregation in water, and excellent water solubility.

20 val in suspension, STAT3 phosphorylation and water solubility.

21 possessing greater bioactivity and improved water solubility.

22 s being nuclease resistant, can display good water solubility.

23 use of its difficult synthesis and very poor water solubility.

24 that would either act as prodrugs or confer water solubility.

25 croliter g(-1) min(-1), compatible with high water solubility.

26 e important property of measurable monomeric water solubility.

27 ure of these lipids is their relatively high water solubility.

28 th minimal cellular toxicity and appreciable water solubility.

29 tate, compared to PNQX, leading to increased water solubility.

30 s, rapid pharmokinetics, and relatively high water solubility.

31 and emission, high photostability, and good water solubility.

32 ent an effective method to overcome the poor water solubility.

33 including fluorescence, and their excellent water solubility.

34 des has been limited by its toxicity and low water solubility.

35 Both complexes show good water solubility.

36 verlooked in previous studies because of its water solubility.

37 produce operations are limited by their low water solubility.

38 through a change in chain conformation or in water solubility.

39 sibility and, after hydroxylation, long-term water solubility.

40 upramolecular polymer assemblies that retain water solubility.

41 nt grains, probably because of their limited water solubility.

42 /sulfonic acid derivative 3 showed excellent water solubilities.

43 lkali metal salts surprisingly displayed low water solubilities.

44 rrolo[2,3-d]pyrimidine (16c) (IC50= 3 nM and water solubility = 32 +/- 9 microg/mL at pH 7.4), was fu

45 gonists; however, they display uniquely high water solubility (43 mM for 11).

46 Sulfonated molecules exhibit high water solubility, a property that is valuable for many b

47 derivatives exhibit progressively increasing water solubility along with progressive decreases in cel

48 Less-oxidized oxygenated OA has the lowest water-solubility among all secondary OA factors, which a

49 eCF506 exhibits excellent water solubility, an optimal DMPK profile and oral bioav

50 Because of their low water solubilities and their tendency to persist and con

51 operties [color, porosimetry, crystallinity, water solubility and absorption, pasting properties, rec

52 The macrocycles have good water solubility and are readily characterized by standa

53 ) oligomers, as PEG substituents can improve water solubility and bioavailability, while retarding cl

54 +) ion binding and the glyco-moiety to bring water solubility and biocompatibility.

55 on cage was hydroxylated to provide improved water solubility and biodistribution.

56 ature at physiological pH, resulting in good water solubility and cell-permeability, (2) an alkyne gr

57 and Skp2, in HEK 293 cells, confirming good water solubility and cell-permeability.

58 development through optimized lipophilicity, water solubility and charged van der Waals surface area.

59 ave narrow polydispersity indices, to impart water solubility and chemical sensitivity toward targete

60 oss of side chains neutral sugars, increased water solubility and decreased molar mass.

61 As expected, the OH groups improved the water solubility and decreased the lipophilicity of the

62 ositive allosteric modulator (PAM) with good water solubility and demonstrating consistent activity a

63 nds of a short PEG chain, where PEG promotes water solubility and DHLA provides anchoring onto the QD

64 yl or pyrazin-2-ylmethyl congeners increased water solubility and enhanced affinity for the human SRI

65 This compound possessed high water solubility and exhibited good metabolic profiles.

66 ptide BBAT1 which possessed greatly improved water solubility and formed discrete trimers.

67 The resulting compounds have better water solubility and generally lower log P values and me

68 ed or charged, dramatically increasing their water solubility and greatly altering the film propertie

69 rge percentage of drug compounds exhibit low water solubility and hence low bioavailability and thera

70 g to a release dynamics dependent on the low water solubility and high hydrophobicity of felodipine.

71 ave limited clinical utility because of poor water solubility and high systemic toxicity.

72 Derivative 18 showed water solubility and higher metabolic stability than 5 i

73 d by pyridine and pyrazine not only enhances water solubility and hydrogen bonding capacity as expect

74 ad-spectrum anti-tumor effects, but its poor water solubility and incompetent targeting property larg

75 < 0.05) with physicochemical parameters like water solubility and log KOW.

76 However, its poor water solubility and low oral bioavailability (F) in rat

77 hurdle; however, its use is limited by poor water solubility and low permeability.

78 active ASBT inhibitor while also increasing water solubility and maintaining potency.

79 philic (cLogD = 5.01), which compromises its water solubility and may adversely affect its pharmacoki

80 x, which was manifested in moisture content, water solubility and mechanical properties of the result

81 rtebrates and fish toxicity data, as well as water solubility and melting point values, were collecte

82 e yielded CDs with high photostability, good water solubility and minimum by-products.

83 To enhance the water solubility and oral bioavailability of DCK analogu

84 To increase water solubility and oral bioavailability, the N,N-dimet

85 ied to enhance hydrolysis included increased water solubility and polyester hydrophilicity as well as

86 hyl-4-methyl-DCK (4a), it provides increased water solubility and possible linkage to other moieties.

87 detection limit (30 nM for Cys), appreciable water solubility and rapid response time (within 2 min f

88 rrocene fragment leads to the improvement of water solubility and reactivity in vitro but also decrea

89 as a pharmacokinetic modifier to improve the water solubility and renal clearance of three hydrophili

90 and tri-PEG chlorin conjugates increased the water solubility and sensitivity to hydrolysis and uptak

91 comparison to ABT-526, ABT-510 has increased water solubility and slower clearance in dog and monkey.

92 Water solubility and small particle size is achieved wit

93 ed a notably increase of Vitamin A Palmitate water solubility and stability in front of those variabl

94 mental organic contaminants due to their low water solubility and strong sorption onto organic/minera

95 Its poor water solubility and the lack of distribution to the ske

96 lts in a significant improvement of both the water solubility and the microsomal stability.

97 All five containers exhibit good water solubility and weak self-association (Ks </= 624 M

98 d with functional terminal groups to promote water-solubility and biocompatibility of quantum dots (Q

99 Nevertheless, its use is limited by its poor water-solubility and chemical instability.

100 However, the poor water-solubility and low bioavailability of carotenoids

101 and low background fluorescence, shows good water-solubility and stability, and exhibits no sign of

102 (library of compounds 3) included to promote water-solubility and to allow incorporation of probes vi

103 nal bulk material, biodegradation, maturity, water solubility (and oil:water emulsion behavior), depo

104 dvantages over other epothilones in terms of water solubility, and can serve as a readily functionali

105 such as ultrasmall size, low toxicity, good water solubility, and near infrared (NIR) fluorescent em

106 yite and ringwoodite in particular have high water solubility, and recent high pressure experiments s

107 rehalose moiety to promote biocompatibility, water solubility, and stability against aggregation, ami

108 order to generate inhibitors with acceptable water solubility, and this often resulted in a loss of p

109 resemble protein receptors in size, complete water-solubility, and tailored binding sites in their hy

110 ached through an amide bond and examined for water solubility, antitumor activity, and propensity to

111 to its small size ( approximately 15kDa) and water solubility, appears readily in the blood-stream fo

112 Ribbon structures with high water solubility are obtained.

113 ic solution model predicts that species with water solubility as low as 10(-4) g L(-1) contribute to

114 Results for water solubility assays demonstrated clear differences b

115 high setback and breakdown viscosities, high water solubility at 85 degrees C but low swelling volume

116 -pyridylcarbamoyl moiety that conferred good water solubility at low pH (<4.0) but poor solubility at

117 lic Newkome-type dendrons provide sufficient water solubility at slightly basic conditions.

118 wing changes occurred for both samples; cold water solubility (at 25 degrees C) increased, water abso

119 nal therapeutic agents, including their poor water solubility (at least, for most anticancer drugs),

120 hylene glycol) moiety, resulting in improved water solubility, binding affinity, and agonist potency.

121 es can be modified not just to improve their water solubility but also to enable these versatile nano

122 lternative to improve curcumin stability and water solubility but curcumin concentration inside the n

123 The presence of the PEG group improved water solubility by 50-fold compared to the unsubstitute

124 ctivities similar to that of 8a and enhanced water solubility (ca. 1 mg/mL).

125 We now report that water-solubility can be achieved by inserting an amino f

126 the dipolarophile is overcome by decreasing water solubility causing changeover to on-water conditio

127 ful as sulfofluoresceins have more favorable water solubility characteristics than fluoresceins that

128 eutical ingredient is compromised by its low water solubility, chemical stability, and bioavailabilit

129 MT starches were characterised by thickness, water solubility, colour, opacity, mechanical properties

130 showed 3 orders of magnitude improvement in water solubility compared to the gold-standard (N-MePhe)

131 Water solubility decreases with a decrease in the radius

132 ackbone hydrogen bonds decreased polypeptide water solubility dramatically and accelerated the nanose

133 s is currently limited because of their poor water-solubility, high melting point, chemical instabili

134 s is currently limited because of their poor water-solubility, high melting point, low bioavailabilit

135 brates, odorant sorptiveness--volatility and water solubility--imposes physicochemical constraints on

136 mined temperature and pressure dependence of water solubility in magma reveals that, for many ascent

137 e required pharmaceutical properties of good water solubility (in weak acid) and stability at ambient

138 ajor component of CPM, demonstrated very low water-solubility, in contrast with the modestly water-so

139 Water solubility increased while water absorption reduce

140 and pasting properties were increased, while water solubility index (WSI), total phenolic content (TP

141 pH and NaCl concentration, on six responses: water solubility index (WSI), water absorption capacity

142 easing the water-holding capacity, swelling, water solubility index, and cation-exchange capacity and

143 expansion, specific volume, hardness, color, water solubility index, and water absorption index] and

144 ncrease in its water absorption capacity and water solubility index.

145 Unlike its parent compound with low water solubility, intraperitoneally administered ZWC is

146 Water solubility is imparted to the dendrimers via a pal

147 of self-assembly and for applications where water solubility is required.

148 r toxicity is significantly lower, and their water solubility is up to 5000-fold higher than that of

149 The enhanced water solubility, its fast and efficient switching behav

150 a DNA model suffers from the compound's low water solubility, its lack of reactive oxygen sites, and

151 The water solubility, long-term storage and UV-light stabili

152 The low cost, water solubility, low toxicity and stabilizing propertie

153 s is currently limited because of their poor water-solubility, low bioavailability and chemical insta

154 lent metals and the core enzyme coupled with water solubility makes tetracyclines potential candidate

155 zed on both ends and were shown to have high water solubility, making them compatible with biological

156 However, ovomucin's limited water solubility might restrict its future applications.

157 a pharmacophore on the inhibition potencies, water solubilities, octanol/water partition coefficients

158 was evaluated on their inhibitor potencies, water solubility, octanol/water partition coefficients (

159 However, poor water solubilities of some of the other compounds preclu

160 n nitro groups and also tend to increase the water solubilities of the peptidomimetics.

161 Finally, the water solubility of a key intermediate necessitated the

162 es of these SWNT graft copolymers indicate a water solubility of about 5 mg/mL, and atomic force micr

163 Water solubility of AN was significantly improved upon c

164 limited volume of the nasal cavity and poor water solubility of anti-epileptics restrict absorption,

165 with the relatively low myosin affinity and water solubility of blebbistatin.

166 the carnosine, probably because of the high water solubility of carnosine and its homologues; cookin

167 However, the low stability and the low water solubility of certain vitamins make difficult thei

168 used as a complexation agent to improve the water solubility of cis- and trans-clomiphene without af

169 erial sciences, the low polarity and limited water solubility of commonly used cyclooctynes represent

170 f a novel prodrug approach for improving the water solubility of drugs containing a tertiary amine gr

171 tion, overcome drug resistance, and modulate water solubility of etoposide (1) analogues.

172 in B3) as a hydrotropic agent to enhance the water solubility of flavin mononucleotide.

173 26 h had a log P value of 4.9 and water solubility of greater than 10 mg/mL.

174 interactions, which are assisted by the low water solubility of guanine as compared to the other nuc

175 ty, and favorable relative influences on the water solubility of HPY conjugates are complementary to

176 The volatility and limited water solubility of linalool is a critical issue to be s

177 The water solubility of lyotropic liquid crystals (LCs) make

178 s limited due to lack of any charge and poor water solubility of molecules.

179 tostatin (SRIF-14), we sought to improve the water solubility of our glycosides.

180 The water solubility of PA2808 showed a marked increase comp

181 Here we take advantage of the water solubility of pradimicin S (PRM-S), a sulfated glu

182 ability of phytoglycogen (PG) to improve the water solubility of quercetin (QC).

183 Therefore, achieving water solubility of quinoxalinediones without loss of se

184 Due to poor water solubility of SMART compounds, co-solvent delivery

185 d weakly basic pyridine moiety increased the water solubility of some analogues.

186 The high water solubility of TcO4(-) (11.3 mol L(-1) at 20 degree

187 The glycinate ester moiety increases the water solubility of the 10,11-methylenedioxy analogues 4

188 The low water solubility of the A(2)1 salts is attributed to the

189 This method takes advantage of the low water solubility of the CHCA compared to its alkali salt

190 acyl chains, were synthesized to improve the water solubility of the corresponding gadolinium complex

191 in 4x and 5x) is sufficient to increase the water solubility of the corresponding synthetic analogue

192 In an effort to increase the potency and water solubility of the molecule, a structure-activity r

193 ion products mainly due to the extremely low water solubility of the organosiloxanes, low volatility

194 ater" environment, defined by the absence of water solubility of the reactants, has been reported to

195 ction limit concentrations decrease with the water solubility of the VOCs.

196 The low water solubility of these BBB shuttles has, however, pre

197 The objective was to increase the water solubility of Vitamin A Palmitate and its stabilit

198 This study on the water-solubility of OA factors provides insights for int

199 The water-solubility of OA factors, resolved with Positive M

200 em for direct and online characterization of water-solubility of organic aerosol (OA) by coupling a P

201 at are adjustable to specific needs, such as water solubility, on a very late stage of the multistep

202 arrier amount had biggest impacts on product water solubility, pigments degradation and yield, respec

203 Its low water solubility, potential toxicities and undesirable s

204 omega-carboxyl group was expected to improve water solubility relative to 1 or 2.

205 This, along with improved water solubility, resulted in compounds with enhanced bi

206 This, along with improved water-solubility results in compounds with enhanced biol

207 This, along with improved water solubility, results in compounds with enhanced bio

208 several charged residues aimed at improving water solubility seems to have led to the possible forma

209 zwitterion structure is tailored to decrease water solubility, stabilize emulsion droplets, and promo

210 conjugates displayed comparable or superior water solubility than native betaLg and betaLg/CA.

211 ose starches had higher moisture content and water solubility than the native high amylose starch fil

212 t tumor cells over normal cells with greater water solubility than triptolide.

213 ty of this compound class is limited by poor water solubility that can be attributed to the high ener

214 iable fraction of constituents with very low water-solubility that inhibited droplet growth through a

215 To increase water solubility, the hydrophobic C4-phenylamino substit

216 Due to their moderate water solubility, the majority of the environmental burd

217 es are highly hydrophobic with extremely low water-solubilities, thereby making them difficult to stu

218 ons, this double-wall chemistry enabled high water solubility through carboxylic acid functional grou

219 ins the C50-prenyl unit that shows very poor water solubility; thus, this chemical characteristic of

220 One construct showed the highest water solubility to a concentration of up to 4mg/ml in t

221 ssed a sufficient balance of polyvalency and water solubility to achieve crosslinking and establish a

222 Imparting water solubility to Gd@C(60) permits its evaluation as a

223 fonation is prized for its ability to impart water-solubility to hydrophobic molecules such as dyes.

224 x of subducting slabs) rises out of the high-water-solubility transition zone (between the 660 km and

225 ulated into NPM with significantly increased water solubility (up to 500 times).

226 The Si QDs were passivated for water solubility via two different methods: hydrosilylat

227 Water solubility was achieved through the addition of br

228 NAD(P), although high nicotinamide analogue water solubility was found to be a necessary trait for y

229 Water solubilities were lower (p<0.05) in films incorpor

230 ing NGO-PEG-SN38 complex exhibited excellent water solubility while maintaining its high cancer cell

231 This modification resulted in improved water solubility while retaining AK inhibition potency.

232 -azaindenoisoquinolines demonstrate improved water solubility without any decrease in Top1 inhibitory

233 fixed distance, the nanofibers exhibit high water solubility, without any signs of intramolecular tr