1                                              We discovered that: 
1) CD4(+) T lymphocytes exposed to H
 
     2                                    From this 
we discovered that 20% DMC is necessary to reverse the s
 
     3 gh screening 3,983 Escherichia coli mutants, 
we discovered that 29 bacterial genes, when deleted, inc
 
     4                                              We discovered that 440 DMRs of 648 genes were hypermethy
 
     5                                        Here, 
we discover that a small moving disk, simulating the swe
 
     6                                        Here, 
we discovered that a combination of type I interferon (I
 
     7 strained virtual reality system for rodents, 
we discovered that a new experience increased firing of 
 
     8                         Using this approach, 
we discovered that a pair of two-pore potassium channel 
 
     9                                              We discovered that a select population of so-called "ind
 
    10                                              We discovered that a small percentage of nonprostatic ca
 
    11                            During this work, 
we discovered that a standard, unmodified lentiviral vec
 
    12 is (Arabidopsis thaliana) as a model system, 
we discovered that a transgene exogenously expressing hi
 
    13                                              We discovered that A673V mutation shifted the BACE1 clea
 
    14                                              We discovered that A673V mutation, the only recessive AD
 
    15 gy, biochemistry, and biophysics techniques, 
we discover that ACT has intrinsic phospholipase A (PLA)
 
    16                                              We discovered that adding fluorescent proteins to the C-
 
    17                                        Here, 
we discovered that adeno-associated viruses (AAV1 and AA
 
    18        Using an inducible expression system, 
we discovered that age-onset phenotypes caused by (PR)50
 
    19                                              We have discovered that agelastatin alkaloids are potent
 
    20 ly, despite their striking visual diversity, 
we discovered that all architectures could be described 
 
    21                                              We discovered that all nontransverse patterns share a co
 
    22                                              We have discovered that although the svb promoter respon
 
    23                                         Here 
we discover that amongst different developmental stages,
 
    24                                              We discover that an independent RhoA pacemaking oscillat
 
    25 i biofilms and the lytic phage T7 as models, 
we discovered that an amyloid fibre network of CsgA (cur
 
    26                    Using in silico modeling, 
we discovered that anisotropic proliferation might expla
 
    27                                              We discovered that another E2, ubc-3, interacts genetica
 
    28                                              We discovered that anti-LINGO-1 antibody-promoted OPC di
 
    29                                        Here, 
we have discovered that AP1 and AP2 cotraffic with HCV p
 
    30                                              We discovered that around half of known type 2 diabetes 
 
    31                                Surprisingly, 
we discovered that attentional enhancements of populatio
 
    32                                              We discover that attributes that describe the spatial st
 
    33                                In this study 
we discovered that atypical E2Fs control tumor angiogene
 
    34           Using an immunoproteomic approach, 
we discovered that autoantibodies against the cell-cycle
 
    35                                 As a result, 
we have discovered that B1 and VRK2 target a common set 
 
    36                                         Here 
we discover that BAP1 localizes at the endoplasmic retic
 
    37 marrow mesenchymal progenitor cell line ST2, 
we discover that BMP2 induces not only genes commonly as
 
    38                                              We discovered that both inbred and outbred rats could sh
 
    39           Using MMP9 and CCL2 knockout mice, 
we discovered that both molecules partially contributed 
 
    40 an siRNA library targeting DSB repair genes, 
we discover that BRCA2 depletion enhances Chk1-dependent
 
    41                               In this study, 
we discovered that BRD4 is hyperphosphorylated in NUT mi
 
    42                                         Here 
we have discovered that burning coal also produces large
 
    43 d approximate Bayesian computation analyses, 
we discovered that C. ciliata first invaded the east coa
 
    44                               In this study, 
we discovered that C646, a reversible p300 inhibitor, do
 
    45                                              We discovered that cardinal GABAergic neuron types are d
 
    46 extensive growth inhibition experiments, and 
we discovered that cell size at replication initiation p
 
    47                                              We discover that CEP19 is recruited to the ciliary base 
 
    48                                              We discovered that CHD1 loss alters H3K4me3 and H3K36me3
 
    49 terally implanted with a CI electrode array, 
we discovered that CI stimulation was surprisingly ineff
 
    50                       METHODS AND In humans, 
we discovered that clinical reperfusion after myocardial
 
    51                                              We discovered that co-infection of murine surgical wound
 
    52 als in the pathway by activating PP2A(Cdc55) 
We discovered that constitutively active Pkc1 can drive 
 
    53                                              We discovered that copper released from corrosion of plu
 
    54  variable copy numbers of an EGFP transgene, 
we discovered that CRISPR knockout is relatively insensi
 
    55 topic tumor implant models of breast cancer, 
we discovered that CXCR7(DeltaEND/DeltaEND) mice had sig
 
    56 emic crystallography, in the course of which 
we discovered that d-ShK has a near-background IC50 valu
 
    57                                 Importantly, 
we discover that DCC, a guidance cue receptor, controls 
 
    58                             Mechanistically, 
we discovered that DDB1 enhances FOXO1 protein stability
 
    59                             Of significance, 
we discovered that decayed (111)In-MSN complexes exhibit
 
    60                                 Furthermore, 
we discovered that deuteration of C10 promotes the forma
 
    61 g transcriptomics and bioenergetic analysis, 
we discovered that DF induces glycolysis and reduces mit
 
    62                                              We discovered that DHF/DSS patients respond to infection
 
    63                                 Furthermore, 
we discovered that DLX1 and DLX2 function as direct tran
 
    64                                        Here, 
we discovered that dual inhibition of the SHH and CXCR4 
 
    65 s points in a high-dimensional linear space, 
we discovered that each face cell's firing rate is propo
 
    66 d optogenetic/pharmacological manipulations, 
we discovered that EC received auditory input primarily 
 
    67                                              We discovered that effective cART restored the number of
 
    68                                              We have discovered that Egr2 and 3 are potent inhibitors
 
    69                                 Importantly, 
we discovered that endocannabinoid/mGlu5-mediated LTD in
 
    70                                              We discovered that endorepellin-induced autophagic flux 
 
    71                                              We discovered that endothelial IL-33 expression was stim
 
    72                                              We discovered that erythrocytes suppressed neutrophil ac
 
    73                             Mechanistically, 
we discover that excessive Krz, the Drosophila beta-arre
 
    74                                              We discover that extrapolating the macroscopic idealizat
 
    75                                              We discovered that FBMNs seem remarkably resilient to a 
 
    76                                        Here, 
we discovered that female mouse embryos lacking Coup-tfI
 
    77                                              We discover that fibrils accumulate towards the hot side
 
    78                             Mechanistically, 
we discovered that five bacterial mutants promote longev
 
    79 reconstituting Search-Capture-Pull in vitro, 
we discovered that formin Cdc12 is a mechanosensor, wher
 
    80                                              We discovered that FXR1P-deficient aNSCs have altered ex
 
    81                                              We have discovered that GAS uses a previously unknown pe
 
    82                                     Finally, 
we discovered that Gbb38 is produced when processing at 
 
    83                                     Further, 
we discover that genus richness today does not match the
 
    84 testinal tract in mice infected with Giardia 
We discovered that Giardia's colonization of the small i
 
    85 cing experiments in fetal or postnatal mice, 
we discover that Gli1(+) cells progressively produce ost
 
    86 unctional penicillin binding protein PBP A1, 
we discovered that GpsB influences lysozyme resistance o
 
    87 wed by validation via RT-PCR and immunoblot, 
we discovered that granzyme A (GrmA), a serine protease 
 
    88 ed cell model of osteoclast differentiation, 
we discovered that H3NT proteolysis is selectively targe
 
    89                                              We discovered that HDAC1 activates PU.1 gene transcripti
 
    90                                 Importantly, 
we discovered that HIV induces expression reversal of mo
 
    91                                        Here, 
we discover that HMMR acts at centrosomes in a PLK1-depe
 
    92                                              We discovered that HOCl and HOBr work almost interchange
 
    93           Refuting previous theory, however, 
we discovered that homogeneously distributed resources s
 
    94                                              We discovered that IFN-gamma enhanced bacterial replicat
 
    95                                              We discovered that IFNgamma is captured by phosphatidyls
 
    96                                              We discovered that IMP3 binds avidly to SNAI2 (SLUG) mRN
 
    97                                              We discovered that imposing a time-restricted feeding (T
 
    98                               In this paper, 
we discover that in association with the polyamorphism o
 
    99                                              We discovered that in budding yeast, kinetochore inactiv
 
   100                                         Here 
we discovered that, 
in amyloid precursor protein (APP)/p
 
   101 pled with mass spectrometry and immunoblots, 
we discovered that inactive, unphosphorylated CPC intera
 
   102 s unlikely to be coded via time information, 
we discovered that information from the individual harmo
 
   103 tion of Atoh1 modulates its effects in vivo, 
we discovered that inner ear hair cells are much more vu
 
   104                                              We discovered that integrin alpha 1 (ITGA1) is frequentl
 
   105                               In this study, 
we discovered that intracerebroventricular infusion or l
 
   106                                Surprisingly, 
we discovered that intrinsically active MEK variants can
 
   107         Using RNA sequencing in macrophages, 
we discovered that IRE1 regulates the expression of many
 
   108 ogy, liver damage assays and transcriptomics 
we discovered that iron deficiency arising from KCNE2-de
 
   109                     Investigating mechanism, 
we discover that irrespective of cellular origin, lineag
 
   110 thogen that elicits protective immunity, but 
we discovered that it can nonetheless disrupt intestinal
 
   111                                              We discovered that it was not the N termini, but the loo
 
   112                                        Here, 
we discovered that KCNQ2/3 channels isoform-specifically
 
   113                                              We discovered that KIF1Bbeta is required for nerve growt
 
   114                                 Importantly, 
we discovered that knocking down MYST3 resulted in profo
 
   115 hat combine potential leaders and followers, 
we discover that leader-follower dynamics emerge from th
 
   116                                In this work, 
we discovered that light scattering of metal nanoparticl
 
   117                                  Remarkably, 
we discovered that linker histone H1 phosphorylated at S
 
   118                                     Finally, 
we discovered that low-temperature incubation increased 
 
   119 ein expression profiling and bioinformatics, 
we discovered that many months after TKA, the fibrotic j
 
   120 lance, a feature shared by all three models, 
we discover that MAPK pathway inhibition impinges unique
 
   121                                              We discovered that mechanically induced intercellular Ca
 
   122  is, stimulated Raman scattering microscopy, 
we discovered that metabolism of palmitate, a prevalent 
 
   123                                              We discover that MIC60 performs dual functions to mainta
 
   124                                              We discovered that mice haploinsufficient for the SMS ca
 
   125                               In this study, 
we discovered that mice with mutations in retinol dehydr
 
   126                               Ten years ago, 
we discovered that microbiota composition controls intes
 
   127                                 Furthermore, 
we discovered that miR858-mediated silencing of MYB83 is
 
   128 sing northern blotting during these studies, 
we discovered that miRNA-length probes can have approxim
 
   129                                              We discovered that moderate heating (MH) at 43 degrees C
 
   130                                        Here, 
we have discovered that moesin is translationally regula
 
   131                                              We discovered that molten Li metal can infuse into the s
 
   132                                              We discovered that morc-1 is essential for transgenerati
 
   133                               Interestingly, 
we discovered that most differentially expressed genes w
 
   134                                              We discovered that mountain gorillas are widely infected
 
   135                                              We discovered that MTA1 represses DNMT3a expression via 
 
   136                                         Here 
we have discovered that MTA1 is a novel corepressor of s
 
   137 ls and PI3K/Akt/mTOR signaling in zebrafish, 
we discovered that mTOR kinase activity in oligodendrocy
 
   138                         In a previous study, 
we discovered that multi-drug resistance is common in ba
 
   139                                              We have discovered that mutations in a tRNA gene, aspT, 
 
   140                                         Here 
we discover that NAD(P)H oxidase 4 (NOX4), an enzyme kno
 
   141 ur newly generated CD11a-mYFP knock-in mice, 
we discovered that naive CD8(+) T cells reserve a signif
 
   142                                 Furthermore, 
we discovered that natural antisense transcripts (NATs) 
 
   143                                              We discovered that net leaf flushing of the canopy layer
 
   144                                     Further, 
we discovered that neural activity in the bat SC changes
 
   145                                              We discovered that neural excitability operates under a 
 
   146 ell characterized Drosophila neural circuit, 
we discovered that neurons lacking FMRP take up dramatic
 
   147                                        Here, 
we discover that neurotrophin 4 (NT4) plays an essential
 
   148 ening, combined with transcriptome analysis, 
we discover that nicotinamide (NAM) ameliorated disease-
 
   149                                         Here 
we have discovered that norcoclaurine synthase from Thal
 
   150                                              We discovered that normalized powers of the right BNST d
 
   151                                              We discovered that not only does vaccination provide hig
 
   152                                   Previously 
we discovered that, 
once Six2-expressing nephron progeni
 
   153             Using the cryoEM method MicroED, 
we discover that one segment, 19-29 S20G, forms pairs of
 
   154                                              We discovered that one autism-associated de novo mutatio
 
   155                                              We discovered that osteosarcoma cells (SJSA) are natural
 
   156                                              We discovered that overexpression of the nucleotide exch
 
   157                                 Furthermore, 
we discovered that p17 binds to and inhibits the CDK2/cy
 
   158                                              We discovered that pancreatic EVs from healthy patients 
 
   159                                Unexpectedly, 
we discovered that pasteurization of A. muciniphila enha
 
   160                        In the current study, 
we have discovered that PDK4 is a short lived protein (t
 
   161                                              We discovered that pDNA-IL-10 treatment reduces remifent
 
   162                                              We discovered that PEBP1, a scaffold protein inhibitor o
 
   163                                              We have discovered that PEG3 is an upstream transcriptio
 
   164                                              We discovered that perhexiline, an antiangina agent that
 
   165                                              We discover that phosphorylation on serine 687 regulates
 
   166                                              We discovered that place fields in hippocampal area CA1 
 
   167                         Using this approach, 
we discovered that plasma membrane-bound respiratory syn
 
   168                                      Second, 
we discovered that PNs receive more synapses from ipsila
 
   169 atively well documented on some ice shelves, 
we have discovered that ponds often form part of widespr
 
   170 Using a Gene Set Enrichment Analysis (GSEA), 
we discovered that poorly differentiated breast cancers 
 
   171                                              We discovered that populations of spheroids with a diame
 
   172                                     Notably, 
we discovered that PR physically associated with the Pol
 
   173                                              We discovered that, 
prior to seroconversion, an early po
 
   174                               Significantly, 
we discovered that PRMT5 displays positive cooperativity
 
   175                  Through empirical modeling, 
we discovered that properly designed creation projects m
 
   176                                        Here, 
we discovered that PRRSV antagonizes the JAK/STAT3 signa
 
   177                                              We discovered that Qki is a major regulator of NSC stemn
 
   178                                              We discovered that RAMPs and GPCRs tend to have ortholog
 
   179                                       First, 
we discovered that RASSF4 regulates store-operated Ca(2+
 
   180                                 Importantly, 
we discover that receptor tyrosine kinase AXL is a trans
 
   181                                              We discovered that Reelin regulates several phosphorylat
 
   182                                              We discovered that resistance to chemotherapeutic drugs 
 
   183                                              We discovered that resistance to sonication is a reliabl
 
   184 porters to map protein-protein interactions, 
we discovered that RI binds directly and selectively to 
 
   185                                              We discovered that RNAi is less effective in zebrafish a
 
   186                                              We discovered that robustness of a microbial population 
 
   187                                              We discovered that RSV infection induces a complex of br
 
   188                                     Further, 
we discovered that Rv2466c lacks oxidase activity; rathe
 
   189 ious reports of S100A4 as a reporter of EMT, 
we discovered that S100A4 is an upstream regulator of th
 
   190          Furthermore, using pulldown assays, 
we discovered that Sam68 is a possible trans-acting fact
 
   191 ng human intestinal epithelial cells (IECs), 
we discovered that SCFAs, particularly butyrate, enhance
 
   192                                         Here 
we discovered that sea lamprey (Petromyzon marinus), a r
 
   193                               In this study, 
we discovered that selective upregulation of p39 is the 
 
   194  within this coarse functional organization, 
we discovered that sensory and motor neurons are comingl
 
   195                                              We discovered that sHsps, which form large oligomers (Hs
 
   196 m one lung and two pancreatic cancer models, 
we discover that significant intratumoral and intertumor
 
   197                                              We discover that similar evolutionary events occur in mo
 
   198                                              We discovered that skin biopsies obtained during asympto
 
   199                                        Also, 
we discover that Smurf1 directly binds to the kinase dom
 
   200                                              We discovered that SNr neurons express the sodium leak c
 
   201                                     Finally, 
we discovered that solutions based only on surrogate inf
 
   202 tatus under chronic inflammatory conditions, 
we discovered that sorting nexin 9 (SNX9), a protein tha
 
   203                                              We have discovered that specific promoter regulatory ele
 
   204 ing high-resolution imaging in living cells, 
we discover that spindle movement is regulated by change
 
   205                                              We discovered that SPNs are surprisingly resistant to ce
 
   206  a transcription-normalized reporter system, 
we discovered that stop codon readthrough is heterogeneo
 
   207                                              We discovered that suramin (C51H40N6O23S6) bound to TIMP
 
   208                                              We discovered that surface water on Cu plays a key role 
 
   209                                              We discovered that SynII affects the time course of GABA
 
   210                                              We discovered that target transcripts of a high-confiden
 
   211  Using a cell-based prion propagation assay, 
we discovered that tau prion replication is suppressed b
 
   212                            Using this probe, 
we discover that the apoptotic caspases are O-GlcNAcylat
 
   213 vely track lipid synthesis and mobilization, 
we discover that the BMP signaling mutants have increase
 
   214                                              We discover that the C. albicans transcription factor Ca
 
   215                                              We discover that the chloride intracellular channel prot
 
   216                                              We discover that the diabetes gene Clec16a encodes an E3
 
   217                             Mechanistically, 
we discover that the enzyme converting methionine to S-a
 
   218                                        Here, 
we discover that the pluripotency-associated pioneer fac
 
   219       From the analysis of the trajectories, 
we discover that the potential that directs the rotating
 
   220                               In this study, 
we discovered that the 3C(pro) proteins from CV-A16, CV-
 
   221                                              We discovered that the alleles causing splicing defects 
 
   222                 Using multimodal approaches, 
we discovered that the anatomy of the corticospinal trac
 
   223 hat YY1 transcriptionally regulates ATP6V1A, 
we discovered that the ATP6V1A core promoter region cont
 
   224  microbeam in the path of an advancing axon, 
we discovered that the beam acts as a repulsive guidance
 
   225 screen targeting endogenous gene expression, 
we discovered that the beta2-adrenoreceptor (beta2AR) is
 
   226      During the course of their development, 
we discovered that the capacity of a PROTAC to induce de
 
   227                                              We discovered that the CDK-8 Mediator kinase module acts
 
   228                                              We discovered that the combination of cysteine or other 
 
   229                                              We discovered that the combination synergistically kille
 
   230 tures of Btk inhibitors bound to the enzyme, 
we discovered that the compounds can be classified by th
 
   231                                              We discovered that the CYP-derived lipid metabolites epo
 
   232                                     Finally, 
we discovered that the degradation of few-layer BP flake
 
   233                                              We discovered that the distributed network known as the 
 
   234 nt machinery without an impact of selection, 
we discovered that the distribution of human rearrangeme
 
   235                                      Herein, 
we discovered that the earth-abundant aluminum oxide (Al
 
   236 is of the resulting N-glycosylation pattern, 
we discovered that the enhanced rhEPO sialylation could 
 
   237                                      Second, 
we discovered that the evaporation-driven microscopic fl
 
   238 or the maturation barricade in Mus musculus, 
we discovered that the exosome complex is a vital determ
 
   239                                              We discovered that the fruit fly olfactory circuit solve
 
   240              Using transcriptomic profiling, 
we discovered that the gene expression for regulating en
 
   241                                   Previously 
we discovered that the gene Mgat3 encoding the glycosylt
 
   242                                              We discovered that the growth displayed a spiral pattern
 
   243                 Utilizing a novel CSC model, 
we discovered that the HDACs, HDAC1 and HDAC7, are speci
 
   244                               In this study, 
we discovered that the human Piwil 2 (Hili) protein can 
 
   245 nd unbiased functional screening approaches, 
we discovered that the Id family of helix-loop-helix pro
 
   246                        In this investigation 
we discovered that the initial transformation in the bio
 
   247 cence in cultured mouse hippocampal neurons, 
we discovered that the kainate receptor subunit GluK2 an
 
   248                                              We discovered that the key factors used to produce high 
 
   249                                              We discovered that the knock-out of HO in P. berghei is 
 
   250                                   Meanwhile, 
we discovered that the MEK/Erk signaling pathway played 
 
   251 in antibody (scFv) delivery format (SS-TR3), 
we discovered that the membrane-tethered cytokine had a 
 
   252                                  Remarkably, 
we discovered that the myosin I protein in fission yeast
 
   253                                    Moreover, 
we discovered that the noisy spiking is linked to a high
 
   254             Using the gnotobiotic zebrafish, 
we discovered that the normal expansion of the pancreati
 
   255 ads that map uniquely onto the human genome, 
we discovered that the overwhelming majority of intronic
 
   256    Once segregated findings were configured, 
we discovered that the patient's role in bedside handove
 
   257                                              We discovered that the PDZ domain-containing protein Sip
 
   258                                              We discovered that the placement of a single side chain 
 
   259                                              We discovered that the presence of cholesterol, LDLR-med
 
   260                                              We discovered that the structural sampling of the substr
 
   261                                        Here, 
we discovered that the Target of Rapamycin (TOR) kinase 
 
   262                                     Finally, 
we discovered that the termination of integrin tension i
 
   263                                              We discovered that the thalamus contributed proportionat
 
   264                                              We discovered that the trajectory of gyrification during
 
   265 ers and repressors of cardiac reprogramming, 
we discovered that the zinc finger transcription factor 
 
   266                                         Here 
we have discovered that the bovine papillomavirus 1 (BPV
 
   267                                              We have discovered that the calcium-binding protein nucl
 
   268                                              We have discovered that the translocation of surface Glu
 
   269                                     Further, 
we discovered that these differences require the Type II
 
   270                                    Moreover, 
we discovered that these distinct functions of mTOR are 
 
   271 ng T-cell activation in long-term survivors, 
we discovered that these individuals were enriched in ne
 
   272 siblings with isolated cleft lip and palate, 
we discovered that they share a novel missense mutation 
 
   273                                        Here, 
we discover that this process depends on the HECT E3 ubi
 
   274 g (NGS) analysis of nucleotide polymorphisms 
we discovered that this group of viruses generates enhan
 
   275                               Interestingly, 
we discovered that tightening of ER-mitochondria contact
 
   276                                              We have discovered that transformations involving the ao
 
   277                                     Finally, 
we discovered that treatment of mycobacteria with ethamb
 
   278 ted PTP1B inactivation by H2O2 Intriguingly, 
we discovered that TrxR1/NADPH directly protects PTP1B f
 
   279                                              We discovered that two Bacillus subtilis biofilm communi
 
   280                                        Here, 
we discovered that two Drosophila slit diaphragm protein
 
   281 using the approach of in utero gene transfer 
we have discovered that Ulk4 plays a key modulatory role
 
   282 tent screen (HCS) of >9,000 small molecules, 
we discovered that UNC0638 and UNC0642-two selective inh
 
   283 ron diffraction and meta-dynamic simulation, 
we discovered that under high pressure, acetylene molecu
 
   284                                    Recently, 
we discovered that unlike undecaprenyl diphosphate synth
 
   285 m cells undergoing neuronal differentiation, 
we discover that up to 20% of AS exons exhibit bimodalit
 
   286 of-function approaches in vitro and in vivo, 
we discovered that UPF3A acts primarily as a potent NMD 
 
   287                                              We discovered that UPF3B (i) interacts with the release 
 
   288                                Additionally, 
we discovered that using glucose as the sole carbon sour
 
   289                                              We discovered that value information influences adverse 
 
   290                                              We discovered that VIPAR, with its partner proteins, reg
 
   291      Using a phospho-kinase screening array, 
we discovered that WA increased phosphorylation of ERK a
 
   292                                        Here, 
we discovered that WHAMM interacts with alphabeta-tubuli
 
   293                                              We discovered that wheat bran flakes have a 'rough' and 
 
   294                                              We discover that whereas cell divisions drive tissue exp
 
   295                                              We discover that while unbound PD-1 exhibits a hard-to-d
 
   296 nscriptional control also exists in vivo, as 
we discovered that wild-type mice in the fed state incre
 
   297                                 Using PKPro, 
we discovered that XNA polymerases function with rates o
 
   298                                              We discovered that yeast has a recycling route from endo
 
   299                                     Finally, 
we discovered that ZIKV structural proteins (E, prM, and
 
   300 ce deficient in the ZIP14 metal transporter, 
we have discovered that ZIP14 is essential for manganese