1 Here
we disclose a 7-nitrobenzo-2-oxa-1,3-diazole (NBD)-based
2 In this Communication,
we disclose a catalytic, highly enantioselective (up to
3 Here,
we disclose a class of phosphines that enable the Ni-cat
4 Herein
we disclose a conceptually novel organocatalytic approac
5 In the process,
we disclose a detailed DFT study of equilibrium geometri
6 We disclose a detailed examination of a thermally induce
7 Herein
we disclose a detailed SAR study that led to the biaryl
8 Herein
we disclose a detailed study examining the structure of
9 Herein
we disclose a facile method for the preparation of (co)p
10 Herein,
we disclose a facile way to realize designed micropatter
11 We disclose a facile, aerobic, transition-metal-free, di
12 Herein,
we disclose a full account of the syntheses, structure-a
13 Here,
we disclose a general and reliable reaction manifold for
14 Herein,
we disclose a general strategy for aliphatic gamma-C(sp(
15 Herein,
we disclose a general strategy for precise tuning of loo
16 In this communication,
we disclose a generalizable strategy for developing agen
17 We disclose a highly specific dual FMS and KIT kinase in
18 In this work,
we disclose a metal-ion-mediated strategy to assemble tr
19 Here
we disclose a method to bond graphene and single-walled
20 In this paper,
we disclose a mild, selective, and convenient method for
21 Here
we disclose a modular synthesis of pleuromutilins by the
22 Herein,
we disclose a new alkene carboacylation reaction initiat
23 We disclose a new high-yielding and highly enantioselect
24 Herein,
we disclose a nitrogen complexation strategy that employ
25 Herein
we disclose a novel aminooxygenation of oxindoles with n
26 In this study,
we disclose a novel immune-regulatory role for DA: inhib
27 Here
we disclose a novel ligand design based on the privilege
28 Herein
we disclose a novel method for the facile transfer of pr
29 We disclose a novel pathway to beta-cell death involving
30 We disclose a novel series of indenopyrazole-based cycli
31 In this article,
we disclose a novel series of substituted 4-benzyl-2 H-p
32 Herein
we disclose a previously underappreciated aspect of aryl
33 We disclose a protocol for the palladium-catalyzed ortho
34 Herein,
we disclose a semisynthetic, catalytic approach for stru
35 Herein
we disclose a series of ACC inhibitors based on a spiroc
36 Here,
we disclose a series of experiments that elucidate the m
37 In this report,
we disclose a series of potent and highly selective JNK
38 Here
we disclose a simple route to nanoscopic 2D woven struct
39 We disclose a strategy for Ni-catalyzed dicarbofunctiona
40 Herein,
we disclose a strategy that harnesses an intramolecular
41 Herein,
we disclose a synthetic route that allows access to eith
42 Herein
we disclose a systematic study of a single CH HB by usin
43 Herein,
we disclose a template-assisted method for the regiosele
44 s siderophore biosynthesis protein B (AsbB),
we disclose a three-dimensional model of a nonribosomal
45 In this report,
we disclose a very efficient catalytic protocol for site
46 Recently,
we disclosed a (bpy)Cu(I)/TEMPO/NMI catalyst system (NMI
47 Recently,
we disclosed a new class of HCV polymerase inhibitors di
48 We disclosed a principle controlling Sirt1 activity and
49 otting and confocal fluorescence microscopy,
we disclosed a robust increase in the expression of geph
50 Here
we disclose an efficacious hybrid molecule 4-(5-Amino-1,
51 We disclose an efficient and operationally simple protoc
52 In this paper,
we disclose an efficient one-pot procedure for the prepa
53 Herein
we disclose an improved synthesis into the oxazepine and
54 Here,
we disclose an integrated microfluidic emulsion creamer
55 Herein
we disclose an organocatalytic aryl-aryl bond-forming pr
56 Herein,
we disclose an unprecedented in vivo reduction process t
57 We disclose an unprecedented isomerization of some spiro
58 We disclose by classical molecular dynamics simulations
59 Here,
we disclose chemical processes that result in formation
60 We disclose compartmentalized corelease of glutamate and
61 Herein
we disclose extensive structure-activity relationship an
62 We disclose here a new class of kinase inhibitors, obtai
63 We disclose here a new highly efficient and versatile ro
64 We disclose here for the first time the curative activit
65 T) from a small sample of the same material,
we disclose here the preliminary work directed toward th
66 We disclose herein that the clinical candidate (+)-SJ733
67 We disclose herein the development of functional and hig
68 We disclose herein the discovery of a new class of non-b
69 We disclose hundreds of commercially available activity-
70 We disclose in this paper a ligand-based drug design app
71 In this report,
we disclose LLY-507, a cell-active, potent small molecul
72 In conclusion,
we disclose novel tentative evidence for the involvement
73 Herein,
we disclose our novel MS-based quantitative proteomics s
74 Here,
we disclose SAR investigation and ADME/PK optimization l
75 ne receptors are peptides, but in this study
we disclose small-molecule ligands that are able to acti
76 Herein,
we disclose structurally diverse small molecule inhibito
77 Here
we disclose structures and biological activity of the en
78 Herein,
we disclose studies aimed at determining the origin and
79 Herein,
we disclose that compounds having the O-glycosidic bond
80 For the first time, to our knowledge,
we disclose that IL-2 induces monocyte-derived hDC's fun
81 Herein
we disclose that kinetics studies indicate the reaction
82 Herein,
we disclose that such Au(III) complexes can undergo faci
83 We disclose that this metabolic reduction can be greatly
84 Hybridization and Long Distance Inverse-PCR
we disclosed that these transcripts result from a genomi
85 Furthermore,
we disclosed that this proteolytic activity is metal ion
86 Additionally,
we disclose the co-crystal structure of our inhibitor se
87 We disclose the conformational transition of Cas9 from i
88 Herein,
we disclose the construction of aromatic nitriles via di
89 Here,
we disclose the design and validation of a high-throughp
90 We disclose the design of a novel series of cyanoguanidi
91 In this paper,
we disclose the detailed phenomenon of sublimation on th
92 Herein
we disclose the discovery of a new class of positive all
93 Here,
we disclose the discovery of a very potent and selective
94 In addition,
we disclose the efficacy of 4a in a mouse EAE model, whi
95 Herein
we disclose the evolution of this chemotype to address t
96 We disclose the first catalytic activation of carbohydra
97 Herein,
we disclose the first examples of the sigma-bond metathe
98 Here
we disclose the first high resolution cocrystal structur
99 Herein,
we disclose the first light-controlled, cobalt-catalyzed
100 Herein,
we disclose the first metal-free synthesis of primary ar
101 We disclose the first small molecule histone deacetylase
102 Herein,
we disclose the first solution to the problem of ECA of
103 Herein,
we disclose the first total syntheses of three members,
104 Here
we disclose the first total synthesis and structural con
105 We disclose the first total synthesis of stachybotrin C,
106 Herein,
we disclose the first total synthesis of this highly str
107 Herein,
we disclose the first X-ray crystal structures of inhibi
108 In this, a full account,
we disclose the first- and now second-generation synthes
109 We disclose the pharmacological properties of the novel,
110 Furthermore,
we disclose the proinflammatory potential of NKG2C(brigh
111 Herein
we disclose the results of our investigations regarding
112 We disclose the role of miR-708-KPNA4-TNF axes in PCa me
113 Guided by mechanistic studies,
we disclose the selective trapping of formaldehyde by in
114 We disclose the source code of our simulation.
115 Herein,
we disclose the syntheses and reactivity of three Ntau-i
116 In this paper
we disclose the synthesis of the model adducts N(6)-(1-p
117 Herein
we disclose the use of property and structure-based drug
118 In this article,
we disclose the various routes and strategies we had to
119 In this paper
we disclose the X-ray structure of a complex between cat
120 Recently,
we disclosed the discovery of Boceprevir, SCH 503034 (1)
121 Recently,
we disclosed the first highly Z-selective isomerization
122 Previously,
we disclosed the role of Cav1.2 alpha1 in mouse and huma
123 Herein,
we disclosed the structure-activity relationships of a s
124 We disclosed therein a new reaction of reductive isomeri
125 We disclose these dynamics by investigating three symmet
126 Here
we disclose VH298, a potent VHL inhibitor that stabilize