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1                                                             We excluded studies based on design, target population, and o
2                                                             We excluded studies based on high-risk or clinical population
3                                                             We excluded studies concerning indwelling vascular catheters,
4                                                             We excluded studies containing mixed cohorts of migrants and
5                                                             We excluded studies done in high-income countries.
6                                                             We excluded studies evaluating cross-linking for nonectatic i
7                                                             We excluded studies focusing on special populations, infants
8                                                             We excluded studies if children were only tested at birth.
9                                                             We excluded studies if continued cannabis use or discontinued
10                                                             We excluded studies if more than 20% of participants were mil
11                                                             We excluded studies if they contained duplicate data from the
12                                                             We excluded studies if they included central venous catheters
13                                                             We excluded studies in high-income countries, those involving
14                                                             We excluded studies in high-income countries, those involving
15                                                             We excluded studies in patients with chronic obstructive pulm
16                                                             We excluded studies in patients with treatment resistance, fi
17                                                             We excluded studies in which malaria in pregnancy was not con
18                                                             We excluded studies in which recruitment was not consecutive,
19                                                             We excluded studies investigating the use of whole blood or h
20                                                             We excluded studies limited to patients with acute myocardial
21                                                             We excluded studies of deliberate overdose and depression in
22                                                             We excluded studies of only patients with a prodrome or solel
23                                                             We excluded studies of patients with extrapulmonary tuberculo
24                                                             We excluded studies of supplements, children, or individuals
25                                                             We excluded studies of vaccinations in investigation or devel
26                                                             We excluded studies performed in non-developed countries, and
27                                                             We excluded studies restricted to hospitalised patients or sp
28                                                             We excluded studies that combined LRH and RRH without supplyi
29                                                             We excluded studies that did not (1) dichotomize neurologic o
30                                                             We excluded studies that did not allow comparison between mor
31            For the mortality and diagnostic value searches, we excluded studies that did not include an effect estimate o
32                                                             We excluded studies that did not include supervised schizonti
33                                                             We excluded studies that did not use both minor and major det
34                                                             We excluded studies that focused exclusively on treatment-res
35                                                             We excluded studies that had been conducted only in children
36                                                             We excluded studies that included pediatric or hospitalized p
37                                                             We excluded studies that only measured faecal indicator bacte
38                                                             We excluded studies that reported only the current prevalence
39                                                             We excluded studies that scored less than 3 points.
40                                                             We excluded studies that used selected samples or were only q
41                                                             We excluded studies that were not in humans, or reported only
42                                                             We excluded studies that were not published in English.
43                                                             We excluded studies using non-human samples and antimicrobial
44                                                             We excluded studies whose population of interest was neonatal
45                                                             We excluded studies with <50 patients with a single disease e
46                                                             We excluded studies with an active control agent (which might
47                                                             We excluded studies with an unclear or closed population samp
48                                                             We excluded studies with fewer than 15 patients.
49                                                             We excluded studies with fewer than 50 patients.
50                                                             We excluded studies with pharmacological or device-based inte