ライフサイエンスコーパス: weak base

1 colored allenic structure upon addition of a weak base.

2 les was corrected with low concentrations of weak base.

3 but not by inducing exchange or acting as a weak base.

4 nts is abnormally sensitive to inhibition by weak bases.

5 anic compounds (IOCs) such as weak acids and weak bases.

6 fficking defects, which can be alleviated by weak bases.

7 nal evidence that carbon nanotubes behave as weak bases.

8 sensitive to pH in the manner observed with weak bases.

9 role in renal secretion of a broad array of weak bases.

10 proton pumping but not by endosome-targeted weak bases.

11 ubating CF respiratory epithelial cells with weak bases.

12 acid (HPTS) and changed using weak acids and weak bases.

13 e pH that favors accumulation of cations and weak bases.

14 rong bases (0.2 and 0.5 M KOH) and best with weak bases (0.01 and 0.2 M KOH).

15 Incubating unfertilized sea urchin eggs in weak bases activates nuclear centering, DNA synthesis, a

16 , but later experiments indicated that these weak bases also lead to increases in reduced pyridine nu

17 sassembly, since treatment of cells with the weak base ammonium chloride diminished the apoptotic res

18 Incubation of HeLa and CHO cells with the weak base ammonium chloride or the ionophore monensin, w

19 manner by treatment with the lysosomotropic weak base ammonium chloride, which raises intravesicular

20 n A and bafilomycin A1 or the lysosomotropic weak base ammonium chloride.

21 ning two effective buffering components: one weak base and one weak acid which have similar pKa at 25

22 rtments are not dependent on the presence of weak bases and are not inhibited by bafilomycin A1.

23 her perturbants of intraorganelle pH such as weak bases and inhibitors of V-type ATPases.

24 excess unlabeled transferrin and reduced by weak bases and metabolic inhibitors.

25 te intravesicular trapping of chloroquine (a weak base) and do not account for reduced drug accumulat

26 odified dibenzylideneacetone (dba) ligand, a weak base, and a strong oxidant are critical for obtaini

27 g acid cation exchangers and strong base and weak base anion exchangers were evaluated as stationary

28 vant to the protonation and sequestration of weak base anticancer drugs such as doxorubicin.

29 In this issue of Neuron reveal that weak base antipsychotic drugs inhibit presynaptic functi

30 acids, where dissociation is suppressed, and weak bases as cations is possible.

31 ements, however, show that these amphipathic weak bases bind to phospholipid vesicles at the same con

32 The buffers in use contain a weak acid or weak base buffered by a compound with a dissimilar pK.

33 Exposure to weak bases can also inhibit aggregation and cell-type sp

34 n of proton donors in the form of protonated weak bases can be highly beneficial; (iii) the addition

35 demonstrate that the addition of aniline (a weak base) can control the acidity of PEDOT:PSS and enha

36 owing to the presence of hydronium ions and weak base cations.

37 e a cytotoxin, VacA, that in the presence of weak bases, causes osmotic swelling of acidic intracellu

38 e presence of an excess concentration of the weak base, CH(3)COOLi.

39 ontained a significant, additional amount of weak base character, about the same as the strong base i

40 Weak base chemotherapeutic drugs (e.g., anthracyclines a

41 to favor metastatic spread and resistance to weak base chemotherapeutic drugs.

42 orts that tamoxifen causes redistribution of weak base chemotherapeutics from acidic organelles to th

43 Drug-resistant cells sequester weak base chemotherapeutics in acidic organelles away fr

44 proto-ionophore monensin (10 microM) and the weak base chloroquine (40 microM) inhibited activation.

45 The weak base chloroquine strongly inhibited (125)I-gp120 pr

46 MHC class I molecules was insensitive to the weak base chloroquine, but was blocked by peptide aldehy

47 tments that raise intragranular pH, e.g. the weak base chloroquine, the ionophore monensin and the va

48 ethyl aminomethane acts by increasing plasma weak base concentration and weak cations.

49 It has also been shown that the weak base Cs2CO3 can be employed with ligand 3, allowing

50 The use of the weak base Cs2CO3 in Pd-catalyzed carboamination reaction

51 Dowd and colleagues have proposed that a weak base (cysteine) produces a strong base (oxygenated

52 cultured mammalian cells in the presence of weak bases (e.g., ammonium chloride), VacA induces the f

53 Similarly, amphipathic weak bases (e.g., sphingosine) that reverse the negative

54 o a cocurrent receptor stream of water (or a weak base, e.g., dilute hydroxylamine), flowing through

55 These results support the idea that weak bases exert their effects by inhibiting acidificati

56 n analysis (MSFIA), with a selective resin ((weak base extraction chromatographic (WBEC) resin) enabl

57 Weak base functional groups were not required for high a

58 ication of CO2 at constant pHo or removal of weak bases, greatly increased phasic contractions.

59 wing in vivo administration, supporting the "weak base hypothesis" that amphetamine reduces synaptic

60 Varenicline was trapped as a weak base in acidic compartments and slowly released, bl

61 e reduced accumulation of protonated CQ as a weak base in the digestive vacuole of the erythrocyte-st

62 Lactone enols are moderately weak bases in water with pK(BH) in the range of 3.9-8.1,

63 Some organic weak bases induce a detachment from inner lysosomal memb

64 The pathway by which weak bases influence development is not understood.

65 itic chloroquine accumulation mechanism is a weak base "ion-trapping" effect whereupon the basic drug

66 ng development, and the accumulation of this weak base is believed to be responsible for inhibiting f

67 eceptors, we examined whether [(11)C]dLop, a weak base, is ionically trapped in acidic lysosomes.

68 First, as a lipophilic weak base, it partitions into acidic vesicles, resulting

69 ituents, a Cu(I) carboxylate complex and the weak base KOAc.

70 the ammonium analog [(14)C]methylammonium, a weak base, led to the proposal that members of this fami

71 e-supported palladium(II)-aryl complex and a weak base, lysine amino groups underwent C-N bond format

72 ched by the addition of a membrane-permeable weak base, methylamine.

73 lds of the desired compounds, along with the weak base, NaOAc, in anisole at 120 degrees C.

74 In contrast, a weak base (NH3) changes pHo with reverse dependence on t

75 Application of the weak base NH4Cl alkalinized the cytosol and caused a dos

76 inhibited from entering cells by either the weak base NH4Cl or the cysteine proteinase inhibitor E-6

77 operty was demonstrated using lysosomotropic weak bases (NH4Cl, chloroquine, or methylamine) that inc

78 a2+]i induced by nigericin, monensin, or the weak base, NH4Cl, in the nominal absence of extracellula

79 3.9-8.1, whereas the lactones are extremely weak bases of pK(BH) in the range of -10.5 to -17.4.

80 parations of both nucleobases and weak acids/weak bases on these gradient stationary phases have been

81 However, most tests of neutrality are weak, based on static system properties such as species-

82 f intracellular compartments (lysosomotropic weak bases) on the infection and replication of Sindbis

83 Alkalinization with weak bases or by removal of CO2 inhibited contractions.

84 everse Watson-Crick orientation, and forms a weak base pair with a thymine of the opposite strand.

85 possible contribution to specificity is the weak base pairing and inherent instability of damaged si

86 ents with reporter assays, we establish that weak base pairing in both seed and 3' regions is require

87 able DNA stabilizing ability for maintaining weak base pairing interactions to facilitate primer exte

88 SOM sorption for weak bases (pK(a) 4.5-7) was stronger at pH 4.5 than at

89 Hydrolysis by weak base renders AE permanently non-chemiluminescent.

90 Exposing cells to a weak base such as primaquine increases the pool of inter

91 total alkalinity of a sample that contains a weak base such as Tris (pK(a) = 8.2) is presented here f

92 of traditional mixed superacids to protonate weak bases such as CO2 can be traced to a competition be

93 eaction proceeds under mild conditions using weak bases such as Cs(2)CO(3) or K(3)PO(4).

94 grow in the presence of ammonium chloride, a weak base that blocks acid-dependent proteolysis of vira

95 grow in the presence of ammonium chloride, a weak base that blocks acid-dependent proteolysis of vira

96 Ammonium chloride (AC) is a weak base that blocks disassembly of reovirus virions by

97 d in cells treated with ammonium chloride, a weak base that blocks viral disassembly.

98 se removal is also blocked by chloroquine, a weak base that neutralizes the acidic pH of the vacuole.

99 For a weak base that was tested in eluent pH either above or b

100 All of these compounds are weak bases that accumulate in the acidic space generated

101 VMAT1-independent mechanism; they may act as weak bases that passively permeate secretory vesicle mem

102 LysoSensors are cell-permeable weak bases that selectively accumulate in acidic vesicle

103 Moreover even in the absence of added weak bases these mutants are delayed in aggregation and

104 A pyridine N-oxide acts as a weak base to facilitate the formation of an alkynylgold

105 a strong base to recover xanthophylls and a weak base to recover astaxanthin--should be used for max

106 acetone, pyrrole, indole, or acrolein and a weak base to stereoselectively form 1,2-dihydropyridine

107 obenzene and in the presence of K(3)PO(4) as weak base, to afford the corresponding unsaturated amino

108 The weak bases trimethoprim and 4-phenylpyridine showed a si

109 ge in pHi was neutralized by addition of the weak base trimethylamine (TMA).

110 superfusion with 3 mM concentrations of the weak bases trimethylamine (TMA), ammonium chloride (NH4C

111 ixture of particles coated by weak acids and weak bases under externally controlled oscillations of p

112 utral reference compound, (v) the protonated weak base was strongly affected by different electrolyte

113 Trapping of weak bases was utilized to evaluate stimulus-induced cha

114 Among weak bases we screened, catalytic (10-20 mol %) 1,4-diaz

115 measurements, whereas release of fluorescent weak bases, which accumulate selectively within eosinoph

116 acid, the presence of low concentrations of weak base will prevent the effect of stray light.

117 Chloroquine (CQ) is a lysosomotropic weak base with over 60 years of clinical use for the tre

118 A cancer candidate, compound 1, is a weak base with two heterocyclic basic nitrogens and five

119 Hexafluorotropone was found to be a very weak base, with a conjugate acid pK(a) of -6.2 +/- 0.5.