ライフサイエンスコーパス: weaken

1 on, NADW nearly collapses, while AABW mildly weakens.

2 ing the 2000s as the overturning circulation weakened.

3 OFF levodopa, this link with acceptance was weakened.

4 diction is violated, memory for that item is weakened.

5 added as an effect, ~65% of connections were weakened.

6 on in the auditory cortex is strengthened or weakened.

7 rengthening followed by substantial velocity weakening.

8 el prevented surface AMPAR loss and synaptic weakening.

9 shening, and suggest a possible link to AMOC weakening.

10 uid at the Nankai Trough restrains the fault weakening.

11 of drug resistance in cases of drug pressure weakening.

12 quences of prediction error go beyond memory weakening.

13 rriving during the Up state undergo synaptic weakening.

14 nd that this function was reduced due to the weakened ability of AcMFT-FD to activate the downstream

15 We conclude that a weakened ability of the amblyopic eye to modulate cortic

16 principle be used both to strengthen and to weaken affinities (leading in this case to infra-affinit

17 demonstrate that MV-associated VEGF90K has a weakened affinity for Bevacizumab, causing Bevacizumab t

18 ivity in a given channel is both boosted and weakened after a systematic pattern over neighboring cha

19 urs and which chemical bonds are altered and weakened after hydration.

20 A significantly weakened Ag-specific recall cytokine production response

21 Meltwater stored in ponds and crevasses can weaken and fracture ice shelves, triggering their rapid

22 g the Little Ice Age, when the subpolar gyre weakened and shifted westward promoted by atmospheric bl

23 that results in skeletal and cardiac muscle weakening and early death.

24 induced activity from these waves indicate a weakening and eventual failure of their source.

25 ular materials and the interplay of damping, weakening and inertial effects in bulk metallic glasses

26 er's disease (AD) is attributed to pervasive weakening and loss of synapses.

27 Our results suggest that strain weakening and resultant shear localization likely occur

28 ter convection depths since the mid-1990s, a weakening and retraction of the subpolar gyre and an ass

29 of fault materials and simulations of fault weakening and rupture propagation.

30 ncreased stratification goes together with a weakening and shoaling of the interhemispheric overturni

31 ses: as population size decreases, selection weakens and genetic drift grows in importance.

32 Therefore, in the context of weakened antiviral resistance, vulnerability to IAV dise

33 /-30 %, depending on whether they enhance or weaken aromatic delocalization.

34 y is moderate in patients with </=1 RFs, but weakens as RFs accumulate, especially in diabetics.

35 opic friction of particulate materials often weakens as the flow rate is increased, leading to potent

36 ature dependence of peak impulse latency was weakened at temperatures above 30 degrees C suggesting a

37 surface defects and is likely facilitated by weakened Au-Au interactions due to bonding with the acet

38 to achieve enhanced forward scattering with weakened backward scattering in plasmonic thin film sola

39 veals an infection containment strategy that weakens bacterial fitness and could be a blueprint for a

40 t is assumed that synaptic strengthening and weakening balance throughout learning to avoid runaway p

41 m the presence of basally migrating GC and a weakened basal lamina, whereas GC migration was minimal

42 creased by light irradiation, resulting from weakened binding of the thiol layer to the metal surface

43 ther residue except Tyr or Phe significantly weakens binding of the antibody to IL-6, as was also obs

44 (N171D, N171E) at this position dramatically weakens block.

45 HiC shows that BRD2 depletion weakens boundaries co-occupied by CTCF and BRD2, but not

46 This weakened braking limits the diagnostic power of gyrochro

47 inding of cGMP to pacemaking ion channels is weakened by a slower internal conformational change.

48 The labile memory could then be weakened by an extinction protocol or strengthened by re

49 diated by N-methyl-d-aspartate receptors and weakened by cAMP-PKA-potassium channel signaling in dend

50 we are faced with a regulatory system that, weakened by decades of limited resources, has fallen sho

51 a catch bond (a bond strengthened instead of weakened by force) drives mechanosensitivity of the flag

52 ears to be enhanced by some coinfections and weakened by others.

53 ystems where the anomeric effect is severely weakened by polar solvents.

54 rent targets can be controllable enhanced or weakened by rational design of interface potential barri

55 When the forces are weakened by taxol treatment, the outer kinetochore expan

56 Further, we find that adhesion forces are weakened by the presence of natural organic matter (NOM)

57 individuals could behave unpredictably or be weakened by their state of stress (rendering aggression

58 Multiple bond weakening by the addition of strong pi donors has the po

59 yey materials from the Japan Trench, dynamic weakening by thermally pressurized fluid is greater at t

60 ss of genes that encode RNA splicing factors weakens cancer cells in a way that could be exploited by

61 ing climate for tropical forests may yield a weakened carbon sink from both decreased GPP and increas

62 ) and gross primary production (GPP) to this weakened carbon sink.

63 Weakened cardiac contractility in vivo in alcoholic anim

64 ty further suppresses long-lasting sparks by weakening CICR.

65 in moisture which is partially mitigated by weakening circulation.

66 fibers produced by high thrombin resulted in weakened clot architecture as analyzed by magnetic tweez

67 igher ECS estimates are directly linked to a weakened cloud-phase feedback arising from a decreased c

68 We sought to develop a dual approach for weakening cocaine memories through phosphoproteomic iden

69 n in cells and in vitro The S3D substitution weakens cofilin binding to filaments, and it is presumed

70 in why genetic insults to the alpha4 subunit weaken cognitive and attentional abilities.

71 rity between species had little influence in weakening competition.

72 nterface mobility, thereby strengthening and weakening complex formation, is described.

73 Specifically, misprediction weakens connections in the representation to features sh

74 odiversity, fertility and plant productivity weaken considerably, probably as a result of a reduction

75 00 CE after which the solar-climate coupling weakened considerably.

76 Weakening correlations with socioeconomic factors show a

77 We show that velocity weakening, corresponding to a nonmonotonic behavior in t

78 of sufficient source strength to overcome a weakened current sink to depolarize Vm and trigger actio

79 in vivo, whereas mutation to lysine gives a weakened dimer that is functional in vivo, indicating th

80 Unexpectedly, this weakened dimerization elicits more sustained EGFR signal

81 , habit suppression correlated solely with a weakened direct pathway output.

82 above a warm open sea, the majority of them weaken due to atmospheric and oceanic environments unfav

83 Ia synapses influences their maintenance or weakening during later development and that heterosynapt

84 cur synchronously when the upstream Kuroshio weakens during winter.

85 American Gap Winds (CAGW), which intensify (weaken) during El Nino (La Nina), producing low-level an

86 AR in enzalutamide-resistant PCa cells with weakened effects on nuclear HDACI targets.

87 e dramatically reduced (ER81(-/-) knockout), weakened (Egr3(-/-) knockout), or strengthened (mlcNT3(+

88 This bond weakening enables spontaneous dihydrogen evolution upon

89 ses spontaneous activity of PFC neurons, and weakens encoding of task rules by dorsomedial PFC neuron

90 on, some of these activator sites were lost, weakening enhancer activity.

91 vorable experimental binding affinity due to weakened enthalpy.

92 This in vivo selectivity depended on the weakening EPO mutation, fusion to the RBC-specific antib

93 synapse in the hippocampus is substantially weakened, even though this form of synaptic plasticity i

94 ed silent synapses were likely eliminated to weaken excitatory inputs to D2-type neurons.

95 uring a positive PDO phase, however, the KEC weakens facilitating the neonates to swim north of the T

96 earing (clay content </=3 wt.%) micro-layers weaken faster than calcite gouges or mixed calcite-phyll

97 c) glutamatergic transmission is selectively weakened following acute sleep deprivation, whose restor

98 itioned psychomotor activation, which may be weakened following extinction (EXT) learning.

99 These low-energy excitations, which get weakened for temperatures above 350 K but persist at lea

100 en the slip surface is characterized by rate-weakening friction and its lateral dimensions exceed a c

101 flash heating but not with widely used slip-weakening friction laws.

102 ion Rating Scale scores were correlated with weakened functional connectivity of the medial orbitofro

103 of this phenotype in the patients themselves weakens genetic inference on risk for psychosis.

104 orted geological evidence for a link between weakened geomagnetic field and climatic cooling.

105 where Cbln1 deletions impair sociability and weaken glutamatergic transmission.

106 To weaken GroEL(SR)-GroES interaction in a controlled manne

107 rupts the electrostatic interactions of K16, weakens H4 tail-acidic patch binding, and significantly

108 tion of histone H3 threonine 118 (H3 T118ph) weakens histone DNA-contacts, disrupting the nucleosome

109 , and fine tunes the electronic structure to weaken hydrogen adsorption toward the optimum region.

110 Incubation at 0 degrees C, which globally weakens hydrophobic interactions, causes gradual and rev

111 We show that the buffer weakens (i.e. greater potential for more powerful typhoo

112 ults suggest that, even when climate forcing weakened, ice-sheet retreat continued.

113 elation of rC with climate was significantly weakened if removing the effects of soil properties and

114 Whereas Tiam1 genetic deficiency weakens IL-17A expression partially and inhibits the dev

115 smission onto striatal projection neurons is weakened in mutant mice lacking the SH3 and multiple ank

116 nt trapping mechanism, residual trapping, is weakened in rocks with a mixed wetting state typical of

117 These effects are weakened in temporally irregular sensory streams.

118 ; and also show strengthening in tension but weakening in compression with decreasing wire diameter.

119 The results imply that the frictional weakening in granular materials and the interplay of dam

120 odel simulations results in a 20-40 per cent weakening in the Kuroshio Extension Jet.

121 Two IN substitutions (T124N/T174I) directly weaken inhibitor binding at the dimer interface of the c

122 changes in the hail size spectra may imply a weakened intensity of hailstorms in China in recent deca

123 tions from SI to MP were not associated with weakened interspecific reproductive barriers or loss of

124 d have attributed this functional decline to weakened intracortical inhibition, especially GABAergic

125 suberoylanilide hydroxamic acid (SAHA), with weakened intrinsic pan-HDACI activities, to target HSP90

126 Current strategies used to weaken ionic interactions can enhance the power of SCs,

127 Because this membrane weakening is hypothesized to facilitate parasite egress

128 data indicate that the induction of synaptic weakening is under postsynaptic control, as it can be pr

129 miR-30c targets the 3'-UTR of Tnrc6a mRNA to weaken its function.

130 d not interfere with POMP10 localization, it weakened its interaction with the OM.

131 urthermore, phosphorylation of the PCF11 CID weakens its interaction with Pol II.

132 marine proxy reconstructions, which suggest weakened Labrador Sea Water formation and gyre strength

133 cooperativity and coordination induced bond weakening likely contribute to dihydrogen formation.

134 , which compromises S3D cofilin's ability to weaken longitudinal filament subunit interactions.

135 t molecule bound the M1 protein potently and weakened M1-M1 self-association.

136 te that models that incorporate dramatically weakened magnetic braking for old stars can--unlike exis

137 the MBON in these DAN>MBON synapses and can weaken memory recall.

138 errant mitotic checkpoint gene expression, a weakened mitotic checkpoint, and an increased frequency

139 correlations are maximal at half-filling and weaken monotonically upon doping.

140 Alongside a weakening monsoon circulation, the locally available moi

141 We observe a weakened N identical withC bond and enhanced reactivity

142 Significantly, the weakened N-H bonds in ((iPr)PDI)Mo(NH3)2(eta(2)-C2H4) en

143 Finally, DREADD-mediated OFC inhibition weakens new action-outcome memory.

144 Here we show that CH bond weakening occurs in alkoxide anions as a consequence of

145 n cause for muscle dysfunction, fatigue, and weakening of athletic ability.

146 binding to low-coordinated Cu atoms and the weakening of binding of Cu to neighboring atoms help dri

147 der of the central bridging bond and overall weakening of bonds in the dark state, which is supported

148 in F-actin and E-cadherin at junctions and a weakening of cell-cell adhesion.

149 ends on intercellular junctions, because the weakening of cell-cell interactions in an alpha-catenin

150 her occurrences correlates strongly with the weakening of East Asian summer monsoon which is the prim

151 Social defeat caused a weakening of functional connectivity between these two a

152 This enhancement coincides with a weakening of glutamatergic inputs, resulting in a signif

153 r together with conditions for more probable weakening of hurricanes near the United States coast.

154 e in neutralization sensitivity results from weakening of intramolecular interactions that maintain E

155 the aggregates of small sizes, and a partial weakening of larger blocks.

156 trates, the result was the same: NGF-induced weakening of MII-dependent restraint led to dynamic micr

157 nt assembly kinetics, and caused significant weakening of networks.

158 tition between overlapping memories leads to weakening of nontarget memories over time, making it eas

159 that this executive order will result in the weakening of our country and bolstering of our enemies.

160 mory reactivation promotes strengthening and weakening of overlapping memories based on their associa

161 Conversely, the weakening of replication origins in repetitive regions s

162 h muted interatomic interaction induced by a weakening of resonant bonding.

163 cortex, and find that Up states promote the weakening of subthreshold synaptic inputs, while suprath

164 ions in composition and signaling, including weakening of synapses through removal and dephosphorylat

165 oundaries, and SMARCA4 knockdown resulted in weakening of TAD boundary strength.

166 During 3.8-3 Ma, we suggest a weakening of the AMOC in line with the global cooling tr

167 quency during 2005-2015 is associated with a weakening of the Atlantic Meridional Overturning Circula

168 A major driver for the YDS climate was a weakening of the Atlantic Meridional Overturning Circula

169 found under thermal activation indicating a weakening of the Au-CO bond and a change in the mechanis

170 h a nearly equal contribution from a further weakening of the biological pump and rising ocean temper

171 iameter and wall thickness were reduced, the weakening of the calcified tissue and the geometric comp

172 Our record shows a remarkable weakening of the EASM strength since the 1880s, which ma

173 osteolytic lesions and prevented mechanical weakening of the femur and tibia.

174 new data, which indicate an extremely rapid weakening of the field (losing approximately 27% of its

175 s playing a key role in the link between the weakening of the geomagnetic field and climatic cooling.

176 The weakening of the geomagnetic field causes an increase in

177 Here, we show that recent ice reductions, weakening of the halocline, and shoaling of the intermed

178 otion and a displacement of helix 5 due to a weakening of the interaction between the active site and

179 We found that deforestation results in weakening of the ISMR because of the decrease in evapotr

180 Periodic weakening of the NAO caused drought in the regions of or

181 Weakening of the NAO in the instrumental record of the N

182 by motor neuron dysfunction and progressive weakening of the neuromuscular junction (NMJ).

183 r redox potential of copper and the enhanced weakening of the O-O bond from the higher electron densi

184 tralasian Intertropical Convergence Zone and weakening of the Pacific Walker circulation (PWC) betwee

185 tease levels and activity that could augment weakening of the sarcolemma through greater degradation

186 e numerical simulation results confirmed the weakening of the UHI intensity due to PM2.5 via the high

187 Continued weakening of the upper-ocean overturning is likely to st

188 ion density is the Hyperstage-1 GIC state, a weakening of the van der Waals coupling between adjacent

189 ngest next to cryptic exons and that gradual weakening of these motifs contributes to the evolutionar

190 ted hemispheric-scale climate change-induced weakening of vertical mixing may have acted to amplify t

191 Although fluorescence emission was weakened or even canceled upon introduction of two or th

192 ied by loss of S-RNase, smaller flowers, and weakened (or absent) interspecific pollen-pistil barrier

193 the emergence and development of technology, weakening our evolutionary models [3].

194 exposure potentiated output of D1-MSNs, but weakened output of D2-MSNs, occluding LTP and LTD at the

195 in two experimental studies, we showed that weakening participants' belief in free will leads to a r

196 Phosphorylation of MDMX at Tyr99 weakens peptide binding by approximately two orders of m

197 CF, and thus promotes hyper-inflammation and weakens phagocytosis.

198 We observed a pronounced correlation between weakened predicted SD-aSD interactions and reduced trans

199 to radicle protrusion, as well as endosperm weakening prior to its rupture.

200 ed fault-forming sediments, contrasting with weakening proposed for the shallow Tohoku-Oki 2011 ruptu

201 pothesize that strong folding of nascent RNA weakens R-loops and hence decreases mutagenesis.

202 Notably, BRCA1-BARD1 mutants with weakened RAD51 interactions show compromised DNA joint f

203 y antiaromaticity or disrupt aromaticity are weakened, relative to analogues lacking full pi-circuits

204 nflammatory responses, leading to an overall weakened response to infection.

205 sis, the bilayer-cytoskeleton interaction is weakened, resulting in substantial increase of the tensi

206 nts reveal distinct behaviors in response to weakening retinal drive, providing insight into the natu

207 rks synergistically with 2'-O-methylation to weaken RNA affinity by 200-fold and lower ATPase activit

208 we have found that formamide preferentially weakens RNA related processes in vivo.

209 ge with the Arg95 guanidinium group, thereby weakening RNase III engagement of product.

210 mutants in RNA 3' processing complex display weakened seed dormancy in parallel with defects in DOG1

211 In small populations, weakened selection against slightly-deleterious mutation

212 itially generated by homolytic cleavage of a weakened Si-H bond of a hypercoordinated silicon species

213 nt predictions and to shield it from further weakening.SIGNIFICANCE STATEMENT Competition between ove

214 We report that these robust bonds can be weakened significantly by increasing the number of multi

215 nical outcomes, including bone loss that may weaken skeletal or periodontal strength.

216 than 18 years and lower socioeconomic status weakened slightly between Natsal-2 and Natsal-3.

217 Mechanical forces can strengthen (catch) or weaken (slip) bonds between biological molecules.

218 dox of increased extreme rainfall events and weakened slower-time-scale components is not yet reporte

219 degraded soils was obviously decreased with weakened soil enzyme activities when compared to the hea

220 Average polyandry independently weakened some measures of sexual selection and crucially

221 n-binding site from the SPB component Spc110 weakens SPB-microtubule attachment in vitro and sensitiz

222 nase, such as the CDC2-like kinase 1 (CLK1), weakens splice-site selection.

223 eats but that extension of glucose by xylose weakens stability, explained by the binding of the glyca

224 e (AD) include surface AMPAR loss, which can weaken synapses.

225 AMPARs to promote their internalization and weaken synaptic strength, similar to what occurs in Nedd

226 els of CMT2D, we sought to determine whether weakened synaptic transmission at the neuromuscular junc

227 apses, an important synaptic plasticity that weakens synaptic strength.

228 ) report that dopamine depletion selectively weakens thalamic but not cortical afferents onto these n

229 on-related mechanism, in which Rh doping can weaken the (Ir Jeff = 1/2)-(O 2p) orbital hybridisation

230 , without affecting its fusogenicity, and to weaken the ability of the virus to replicate specificall

231 Stochastic variation in precipitation may weaken the average strength of biotic interactions over

232 otic use in a child during breastfeeding may weaken the beneficial effects of long breastfeeding dura

233 tion state: iron donates electron density to weaken the C-N bond undergoing cleavage.

234 rediction using the antibiotic vancomycin to weaken the cell wall.

235 tubule length and lifetime, and consequently weaken the driving force for alignment.

236 n modes: these vibrational modes effectively weaken the exciton-environment interaction, due to the n

237 fisheries productivity are unclear and could weaken the food security of hundreds of millions of peop

238 mitigating the hypoxic regions of tumors to weaken the hypoxia-driven pathways and inhibit tumor gro

239 e 5' UTR of acrA mRNA that could potentially weaken the inhibitory RNA secondary structure, allow for

240 toxic to cells; however, the intruding SEDs weaken the membrane's integrity.

241 ish to rid themselves of a phantom limb must weaken the neural representation of the absent limb.

242 he co-adsorbed alkali cations along the step weaken the OH adsorption at the step sites, causing a po

243 The results suggest that benign conditions weaken the scope for senescence to evolve and that the d

244 at the robustness-oriented optimization will weaken the small-world effect and vice versa.

245 Naltrexone also weakened the associations between subjective craving and

246 ely, depleting macrophages in fibrotic liver weakened the hepatoprotection and gave rise to exacerbat

247 Of note, EGF signaling weakened the interaction of CAR DBD T38D with CAR LBD, c

248 d cyclonic eddy impingement during 2002-2013 weakened the Kuroshio transport, moving it closer to the

249 in which the positive effect of debris area weakened the negative effect of barnacle cover.

250 nvironment of the Barbados region in summer, weakening the connection between the regional biases and

251 Strikingly, weakening the diffusion barriers that separate the ER me

252 ve increased outgassing of natural CO2, thus weakening the global CO2 sink.

253 n maternal transmission of wMel, potentially weakening the integration of this strain into a mosquito

254 -odd orbital-symmetry rule and predicts that weakening the interaction between G blocks exaggerates t

255 ved the Kuroshio away from northeast Taiwan, weakening the Kuroshio intrusion onto the East China Sea

256 and lengthened in the GOFs, strengthening or weakening the linker/TRP helix latch, respectively.

257 ing moisture content, have weaker effects in weakening the off-equatorial monsoon circulation than th

258 acclimate to altered temperatures, however, weakening the positive feedback of plant respiration to

259 uatorial ones, and so do the SH eruptions in weakening the SH monsoon, because the equatorial eruptio

260 c teleconnection to the North Pacific, which weakens the Aleutian low and subtropical North Pacific w

261 zation of the Ig20 structure that supposedly weakens the autoinhibition.

262 elongation of the covalent Nb-Se bond, which weakens the covalent interaction and enhances the ionici

263 at phosphorylation of residues S650 and S975 weakens the E2F4 transactivation domain binding.

264 ylation in hepatocytes and adipocytes, cGAMP weakens the effects of glucagon on stimulating hepatocyt

265 We report that chronic hyperglycemia weakens the endogenous antioxidant response, and the con

266 n) with a primary amide group (Q side chain) weakens the hydrophobic interaction generated by the six

267 e show that depletion of Naa50 in HeLa cells weakens the interaction between cohesin and its positive

268 a charged residue at the interface (Arg-103) weakens the interface significantly, whereas effects are

269 s limited by the rate of zinc release, which weakens the RsrA-sigma(R) complex by accelerating its di

270 Pds5 binding to Scc1 weakens the Scc2-Scc1 interaction.

271 nd hear /ba/ (illusion-ba), the visual input weakens the weighting of the phone /f/ representation.

272 canically induced cooling in tropical Africa weakens the West African monsoon, and the resulting atmo

273 function of antitumor lymphocytes, possibly weakening their therapeutic effects.

274 ation of the three PKC phosphorylation sites weakens their interaction.

275 eased by the activity of common fungi, which weaken these zones by degrading non-lignified pericarp c

276 d immunoglobulin (Ig) domains of Gpr124, and weakening this interaction by targeted mutagenesis reduc

277 he filament surface, whereas phosphorylation weakens this stabilization and binding of the heads to t

278 incontinence (SUI) to augment and strengthen weakened tissue.

279 hibit conventional use-dependent depression, weakening to a greater extent as the firing frequency is

280 Enemy Constraint Hypothesis, which predicts weakened top-down effects on mesopredators towards the e

281 Given a weakening trend in springtime zonal winds, this lagged r

282 Both strengthening and weakening trends with decreasing diameter have been obse

283 -associated TRPP2 mutant T448K significantly weakened TRPP2 homomeric assembly but had no obvious eff

284 fusal; and failure to permit overrules could weaken trust in the donation system.

285 sed response gain, while Pvalb+ inactivation weakened tuning and decreased information transfer, impl

286 ing trend in the mean monsoon rainfall and a weakening variance of its low-frequency ISO (LF-ISO) cyc

287 erial aging is a prominent factor leading to weakened vasodilatory action of estrogenic compounds.

288 predisposed to vascular diseases because of weakened vessel walls under stress conditions.

289 negative AMO state, there is an anomalously weakened Walker circulation over the tropical Pacific th

290 with the looped-out alignment facilitated by weakened Watson-Crick and reversed non-canonical flankin

291 rom neuron A to neuron B is strengthened (or weakened) when A fires before (or after) B within an opt

292 n reduced bone formation and subsequent bone weakening, which leads to a number of conditions such as

293 ow-wave activity might bias synapses towards weakening, while preserving the synaptic connections wit

294 the central tropical Pacific as trade winds weaken with global warming.

295 Bay were synchronous, but their correlations weakened with distance from the ocean.

296 These activations weakened with oxytocin and vasopressin administration su

297 poor myofiber repair and progressive muscle weakening with age.

298 ons had a similar influence, which gradually weakened without reinforcement.

299 ng that includes wrinkles, pigmentation, and weakened wound healing ability.

300 In particular, we characterize a weakening zone that forms near the moving crack tips usi