ライフサイエンスコーパス: well-characterized

1 ein methylation on its function has not been well characterized.

2 unctions governing treatment outcome are not well characterized.

3 4 in the central nervous system has not been well characterized.

4 HF) with preserved ejection fraction is less well characterized.

5 ies, the parameters that govern NAGC are not well characterized.

6 opographical and laminar organization is not well characterized.

7 embryonic stem cell differentiation has been well characterized.

8 nd clinician staffing patterns have not been well characterized.

9 treated with 8-aminoquinolines has not been well characterized.

10 , an individual whose germline variants were well characterized.

11 g during CD4 T cell activation have not been well characterized.

12 and distribution of ER-PM junctions are not well characterized.

13 esistance in neighboring cancer cells is not well characterized.

14 gdom but their underlying mechanisms are not well characterized.

15 T lymphocyte functions during sepsis are not well characterized.

16 that regulates follicular melanocytes is not well characterized.

17 Th17 cell differentiation has remained less well characterized.

18 supramolecular structures of these SAMs were well characterized.

19 t cellular uptake by a mechanism that is not well characterized.

20 post-colonoscopy complications has not been well characterized.

21 uman leukocytes to MPLA and LPS has not been well characterized.

22 eading to enhanced TGF-beta activity are not well characterized.

23 of cells constituting this structure are not well characterized.

24 ty of differentially expressed genes are not well characterized.

25 cells are detected in the heart but are not well characterized.

26 in Drp1, but effects on IMM division are not well characterized.

27 nd migration of neural stem cells need to be well characterized.

28 xist; however, only a small number have been well characterized.

29 velopment in pacemaker patients has not been well characterized.

30 facilitate these enhanced properties are not well characterized.

31 otype correlations of these diseases are not well characterized.

32 (stromal) heterogeneity in TNBC has not been well characterized.

33 of comorbidities in patients with AD is not well characterized.

34 ements in natural environments have not been well characterized.

35 e role of Neo1 in endosomal recycling is not well characterized.

36 n and its contribution to infections are not well characterized.

37 ngth and aerobic and muscular fitness is not well characterized.

38 crobiota after the onset of arthritis is not well characterized.

39 for synthesis of PtdIns4P at the TGN are not well characterized.

40 cur through atypical mechanisms that are not well characterized.

41 ) arachidonate-derived eicosanoids have been well characterized.

42 aria in low-endemicity settings has not been well characterized.

43 idue in intrinsic KRAS function has not been well characterized.

44 n, if statistics of the volume variation are well characterized.

45 ility of this platform, but has not yet been well characterized.

46 se to the PfCSP C terminus (C-PfCSP) is less well characterized.

47 n inhibitory neurotransmission has been less well characterized.

48 varies depending on study cohort and is not well characterized.

49 lecular physiology of aneuploid cells is not well characterized.

50 function during bacterial infections is not well characterized.

51 R (ssUVR), a mixture of UVA and UVB, are not well characterized.

52 ore restricted type I latency, have not been well characterized.

53 aterials whose coactivated response has been well-characterized.

54 ose chemical communication systems have been well-characterized.

55 nic stem cells (mESCs) has been increasingly well-characterized.

56 hood HGG, a relatively rare disease, is less well-characterized.

57 y and outcomes of pediatric delirium are not well-characterized.

58 The well-characterized 3 generations of the Isle of Wight co

59 We used well-characterized 3T3-L1 murine adipocytes to demonstra

60 n cortex involved in bleb-driven motility is well characterized, a role for transcriptional regulatio

61 ease stages from desmoglein 2-mutant mice, a well characterized AC model.

62 ugh the canonical Notch signaling pathway is well characterized, accumulating evidence points to the

63 which ensure basic energy supply, have been well characterized, adaptation of root growth and develo

64 the nitrogen atom, which provide stable and well-characterized adducts with various Lewis bases.

65 nfirm the high anti-fungal activity of these well-characterized agents mediated by their interaction

66 This test was performed using a pair of well-characterized agonists for members of the 5-HT2 cla

67 econd, we conducted FASS-LTP analysis in two well-characterized Alzheimer's disease (AD) mouse models

68 with and functions for MT motor proteins are well characterized and extensively reviewed for many vir

69 nses are generated against solid cancers are well characterized and knowledge of the immune evasion p

70 The humanized organ bone model has been well characterized and validated and allows dissection o

71 Due to its well-characterized and highly conserved structure, as we

72 cells with new ones, preferably cells from a well-characterized and unlimited source of human insulin

73 d cells from patients with DBA have not been well characterized, and the mechanisms underlying the er

74 However, presently, most lncRNAs are not well characterized, and their regulatory mechanisms rema

75 detected.IMPORTANCE Poxviruses, unlike many well-characterized animal DNA viruses, replicate entirel

76 in two independent clinical trials of MDD, a well-characterized animal model of depression, and post-

77 Our studies of a well-characterized antigen demonstrate that MAbs against

78 One host defense peptide with well-characterized antimicrobial activity is the human c

79 Ab and the occurrence of superinfection in a well-characterized, antiretroviral therapy (ART)-naive,

80 NA (dsRNA)-activated protein kinase (PKR), a well-characterized antiviral protein that inhibits cap-d

81 The well-characterized apoplastic effector EPIC1, a cysteine

82 Fentanyl is well characterized as an anesthetic, but the basic physi

83 While circadian entrainment by light is well characterized at the molecular level, mechanisms th

84 ribution of CRF receptor expression has been well characterized at the mRNA level, the localization o

85 rticularly with respect to adenosine, is not well characterized because of challenges in blood gas co

86 s, force fields, and modeling innovations on well-characterized benchmark systems, and we lay out our

87 Well-characterized BMCs include carboxysomes for CO2-fix

88 el shows a substantially better fit to three well-characterized bNAb lineages than the standard GY94

89 way polarizes stationary epithelial cells is well characterized, but how PCP signaling functions to r

90 t form the bulb of caveolae are increasingly well characterized, but less is known about the contribu

91 The pathways for disulfide formation are well characterized, but our understanding of how non-nat

92 hat promote adipose tissue thermogenesis are well characterized, but the limiters of energy expenditu

93 he current study investigated the effects of well-characterized butyrate-producing bacteria Clostridi

94 Results suggest IM distributions are well characterized by a Gaussian model and separation ef

95 me between successive puffs, are found to be well characterized by a probability density function inv

96 ensitized states that are starting to become well characterized by electrophysiological and biophysic

97 rus is a very rare anomaly which can be very well characterized by magnetic resonance imaging (MRI).

98 e of the larger peptides that are often less well characterized by traditional collision-based activa

99 found that the structure transformations are well-characterized by pronounced difference in SPR spect

100 re searches revealed that in addition to the well-characterized C2O4(2-) oxalate in Li2C2O4 viable co

101 The well-characterized caerulein model of CP was used to ass

102 contrived specimens were prepared by seeding well-characterized carbapenem-susceptible and -nonsuscep

103 significant alterations in the expression of well characterized cellular proliferation and apoptosis

104 Glutamate receptors are well characterized channels that mediate cell-to-cell co

105 One particularly well-characterized circuit regulating innate immunity, t

106 describe three virus panels, chosen from 200 well-characterized clade C envelope (Env)-pseudotyped vi

107 Here we find that in addition to these well-characterized classes, nearly all of the remaining

108 transcriptomes of 68 pediatric patients with well-characterized clinical phenotype to identify transc

109 magnetic resonance imaging study in a large, well-characterized clinical sample at a research clinic

110 Sleep loss produces well-characterized cognitive deficits, although there ar

111 This well-characterized cohort of 1415 patients with schizoph

112 ictors of 9 modifiable CVD risk factors in a well-characterized cohort of 20,625 middle-aged French w

113 ith TERT mRNA expression and outcome using a well-characterized cohort of 27 patients with melanoma (

114 We evaluated the long-term risk of SMNs in a well-characterized cohort of 5-year CCSs, with a particu

115 ma cytokine correlates of TB recurrence in a well-characterized cohort of HIV-infected individuals on

116 Using a well-characterized cohort of patients with biopsy-proven

117 nt stem cells were derived from a clinically well-characterized cohort of three individuals with nons

118 ease-driven replication capacity using large well-characterized cohorts in Africa and the Americas.

119 logue of human iPSC lines, arguably the most well characterized collection to date.

120 A well-characterized collection of mecC-positive S. aureus

121 this analytical framework to larger and less well-characterized connectomes.

122 report the pro-inflammatory effect of ImI, a well characterized conotoxin that inhibits alpha7 nAChRs

123 lidation of 13 anti-ERbeta antibodies, using well-characterized controls and a panel of validation me

124 two Cdc20 molecules, one (Cdc20(M)) through well-characterized, cooperative binding to Mad2 and Mad3

125 osphorylation by protein kinase A (PKA) is a well-characterized CREB activation mechanism.

126 n a model artificial community consisting of well-characterized cultured diatoms (Phaeodactylum trico

127 intracellular signaling of jasmonate (JA), a well-characterized defense hormone.

128 titutively accumulate greater amounts of two well-characterized defensive compounds, the volatile (E)

129 typical recrystallization boundary through a well-characterized deformation matrix.

130 f the pathogenesis of N. gonorrhoeae using a well-characterized DeltapilT mutant.

131 ough healthy mossy fiber synapses in CA3 are well characterized "detonator" synapses that potently dr

132 tervention trials that tested the effects of well-characterized DFs on appetite ratings or energy int

133 tors in cancer, available therapies for this well-characterized disease remain inadequate, prompting

134 r performance of the new method for not only well-characterized diseases but also new ones.

135 Here we demonstrate, using a well characterized Drosophila melanogaster malignant tum

136 Taking advantage of a well characterized Drosophila neural circuit, we discove

137 docking and in vitro directed evolution in a well-characterized drug-sensitive yeast model, we determ

138 Thalamic relay neurons have well-characterized dual firing modes: bursting and tonic

139 ants, somatic insertions are among the least well characterized due to challenges with interpreting s

140 ngineered and immortalized HEK293 cells with well-characterized electrical properties and the ability

141 The flg22 flagellin peptide, a well-characterized elicitor of plant basal immunity, did

142 ately account for the risks of perchlorate-a well-characterized endocrine-disrupting chemical-to vuln

143 The study tested 100 well-characterized Enterobacteriaceae, Acinetobacter bau

144 pulation of electron degrees of freedom in a well-characterized environment.

145 intermediates in the catalytic cycle of this well-characterized enzyme have been proposed on the basi

146 rs in vitro, indicating an independence from well-characterized ephrinB2/B3, sialic acid and CD150-me

147 Concomitant with these well-characterized events is the acquisition of a mature

148 tutes a notable exception, with virtually no well-characterized examples known to date.

149 The scope of this review has been limited to well-characterized examples of copper-oxygen species but

150 ocomotion strategies for steady swimming are well characterized, far less is known about acceleration

151 LET-99 is well characterized for generating the asymmetric cortica

152 chanism, also termed selective autophagy, is well characterized for invasive bacteria but remains poo

153 The intact SAGA complex has been well characterized for its function in transcription reg

154 this contraction of the PAS domain, which is well characterized for the isolated domain, is the signa

155 The trafficking kinesin proteins (TRAKs) are well characterized for their role in lysosomal and mitoc

156 nd degree of genetic mosaicism have not been well-characterized for most species, limiting our abilit

157 tivation of inflammasomes in addition to its well-characterized function as an endogenous second mess

158 e the mycobiome in lungs of individuals with well-characterized fungal disease.

159 ve developed genetic techniques to study the well-characterized fusellovirus Sulfolobus spindle-shape

160 us limiting role of two genes, including the well-characterized gene, dicer, and a probable uncharact

161 ssing has been difficult, in contrast to the well-characterized genes involved in the melanogenesis p

162 ed by published literature and annotation of well-characterized genes.

163 ted through the use of reference standards - well-characterized genetic materials or synthetic spike-

164 In this paper, we re-sequenced a well characterized genome, the Saccharomyces cerevisiae

165 doscopic therapies can benefit patients with well-characterized GERD.

166 resulting from proteolytic digestion of the well-characterized glycoproteins bovine ribonuclease B,

167 tual biorepository strain catalogue includes well-characterized gram-positive and gram-negative bacte

168 Most well-characterized growth-defense trade-offs stem from a

169 ce spectroscopy was also used to study three well-characterized HAMP mutational phenotypes: those tha

170 na attenuata, an ecological model plant with well-characterized herbivore interactions to characteriz

171 33 adolescent and young adult patients with well-characterized histories of treatment-refractory dep

172 ial for islet cell differentiation have been well characterized; however, because they are often expr

173 Well-characterized human pluripotent stem-cell-derived v

174 -approved cancer drugs against a panel of 60 well-characterized human tumor cell lines (NCI-60) to un

175 observations in sphingolipid metabolism to a well-characterized Huntington's disease pathway.

176 The EZ was well characterized in 29 patients; 26 had an EEG-fMRI GM

177 nderlying differentiation pathways have been well characterized in cells formed during embryogenesis,

178 GC synthesis has been well characterized in healthy skin, but the pathological

179 es and immune complex formation has not been well characterized in humans.

180 phoid cells (ILC2s), with these latter being well characterized in mice but less so in human subjects

181 Membrane phase behavior has been well characterized in model membranes in vitro under the

182 As themselves and small RNA pathways are not well characterized in other land plants such as lycophyt

183 sh them from the canonical OCP that has been well characterized in Synechocystis, denoted hereafter a

184 r detachment for retinal gene therapy is not well characterized in those with relatively preserved ce

185 The risk for skin cancer has been well characterized in white organ transplant recipients

186 ng induced systemic resistance (ISR), is not well characterized in whitebark pine, narrowing the curr

187 de immunotherapy; however, this has not been well-characterized in human cancer patients.

188 nics of DNA replication and cell cycling are well-characterized in model organisms, but less is known

189 While virus growth dynamics have been well-characterized in several infections, data are typic

190 Although many of these enzyme families are well-characterized in terms of function and substrate sp

191 han 1100 proteins in the peripheral blood of well-characterized IPF patients and normal volunteers.

192 henylpyridine by an iron(I) species, to give well-characterized iron(II) products.

193 AKAP150, the most well-characterized isoform, plays an important role in s

194 Although not well characterized, it continues to play an integral rol

195 of the homologous recombination machinery is well characterized, it is not known how its presence at

196 trikingly, BTB-1 binding is close to that of well-characterized Kif11 inhibitors that block tight mic

197 though the role of B cells and antibodies is well characterized, knowledge regarding T cells is limit

198 contributions beyond nociception are not yet well characterized, leading to a predominant focus on no

199 ion stimulated by Hp(2-20) and Ac(2-26), two well-characterized ligands for FPR2 in GC cells.

200 short-chain fatty acids have been previously well characterized, little is known about the contributi

201 Although gain mechanisms are well characterized, little is known about the cortical p

202 Whereas sites of CTCF interactions are well characterized, little is known on how long CTCF bin

203 atory response that directly counteracts the well-characterized loss of t-tubule complexity and reduc

204 eplica-exchange MD (REMD) simulations of the well-characterized LOV protein Vivid (VVD) demonstrate t

205 functional in supporting the degradation of well characterized luminal and membrane substrates.

206 the combined LYT EIA using samples from 471 well-characterized Lyme patients and controls.

207 oup is composed of PRD1 and nearly identical well-characterized lytic viruses, the second one include

208 odels mimicking human pathogenesis have been well characterized, many of these experiments use intrap

209 new materials, as well as the engineering of well-characterized materials for the repurposing in appl

210 Despite its well-characterized mechanism of action on several establ

211 formed a screen of 1120 small molecules with well-characterized mechanisms of action to detect those

212 evolved a novel biological function through well-characterized mechanisms.

213 ty to repress new targets, including LIFR, a well-characterized metastasis suppressor.

214 Here, we report that in addition to the well-characterized middle region of MAD1 containing the

215 cough responses in a group of patients with well-characterized mild-to-moderate asthma compared with

216 phila midgut, a hierarchically organized and well characterized model for stemness analysis.

217 Here, we use the well-characterized model of the Pax9(-/-) mouse, which d

218 microscopy techniques, transgenic lines and well-characterized molecular markers, have made histolog

219 Using the well-characterized mouse atherosclerosis models of Apoe(

220 In a well-characterized mouse model for DM1 (HSALR mice), act

221 anglionic eminence (MGE, CGE) were made in a well-characterized mouse model of status epilepticus-ind

222 cinogenesis in in vitro keratinocytes and in well-characterized mouse models in which antitumor effic

223 715 and its derivative Cpd-5, but not to the well characterized Mps1 inhibitor, reversine.

224 ubstrate adaptor atrogin-1 is among the most well-characterized muscle atrogins.

225 The well-characterized mycorrhizal tomato (Solanum lycopersi

226 nts of the Phe-53 residue, which maps to the well-characterized negative regulatory region of MEK1.

227 Despite the importance of these two well characterized neuron types in maintaining metabolic

228 to the nucleus that differ from conventional well-characterized NLSs from mammals and yeast.

229 ALCL), the vast majority of which harbor the well-characterized nucleophosmin (NPM)-ALK fusion protei

230 The recent expansion of well-characterized O-mannosylated mammalian proteins bey

231 Proteomes of even well characterized organisms still contain a high percen

232 A blind study was conducted on a well-characterized panel of 279 human sera from the CDC,

233 y over time in the vulval precursor cells, a well-characterized paradigm of epidermal growth factor r

234 and analyzing genome-wide molecular data on well-characterized patient material.

235 on of animal models and sera from clinically well-characterized patients, we have demonstrated that t

236 Our studies utilized the well-characterized Pax9(-/-) mouse model with a consiste

237 Here, we have employed two well-characterized Pdx-1CreLSL-Kras(G12D) and Pdx-1CreLS

238 ned by two microarray platforms applied on a well-characterized pediatric asthma cohort.

239 We have used a novel approach to study three well-characterized permeability and absorption marker dr

240 essing mutant LRRK2, which occurs before the well-characterized phenotype of dendritic shortening.

241 ectroscopy as an analytical tool to generate well-characterized phosphorylated Tau samples and show t

242 ty (1-3% relative uncertainty) of previously well-characterized polymer microbeads and subsequently a

243 A well-characterized post-translational consequence of pat

244 hosphatases represents the most prolific and well-characterized posttranslational modification known.

245 e and female wild-type and TgF344-AD rats, a well-characterized preclinical AD model, were administer

246 Unlike well-characterized proangiogenic functions of endothelia

247 by comparison with related and comparatively well-characterized processes such as corrosion of iron i

248 PR3 has a number of well-characterized proinflammatory functions, including

249 Our findings from a large, well-characterized prospective cohort provide compelling

250 of oncogenic gene fusions among a clinically well-characterized, prospectively collected set of 278 p

251 Even though the NDH-1 complex is a well-characterized protein complex in the thylakoid memb

252 ting <SASA> measurements was tested by using well-characterized protein models.

253 One well-characterized protein responsible for regulating bo

254 untington disease and Alzheimer disease, are well-characterized proteinopathies, cardiac diseases hav

255 tinal tract, regulate intestinal motility, a well-characterized reflex controlled by enteric neurons.

256 es and differences between the HD RGCs and a well characterized RGC with a comparably small receptive

257 Thus, in addition to their well-characterized role in pro-inflammatory responses, k

258 citatory neurotransmitter glutamate and have well-characterized roles in the nervous system.

259 lly rich data set provides a psychiatrically well-characterized sample of unprecedented size (n=1616)

260 ng low amounts of purified, synthetic DNA in well characterized samples under identical reaction cond

261 Well-characterized samples from RT-PCR-confirmed patient

262 The well-characterized Scl1 proteins of S. pyogenes show a d

263 nvestigated here their interactions with the well-characterized Scribble binding partner beta-PIX, a

264 , we show here ferroelectric hysteresis from well-characterized single crystals at low temperature (s

265 of chemical analytes, in streamwater from 35 well-characterized sites (3 reference and 32 impacted) a

266 he long-term durability of CEIM has not been well characterized, so the frequency and duration of sur

267 the cancer cell-surface sialylation are not well characterized, specifically in bona fide human dise

268 Here, we employed LAESI-MS to explore the well characterized symbiosis between soybean (Glycine ma

269 proach by measuring specific affinity of two well-characterized systems, the fluorescently labeled so

270 Most of the well-characterized target transcripts of FMRP are synapt

271 urin (RCAN1), an inhibitor of calcineurin, a well-characterized tau phosphatase.

272 of full-length Akt3 isoform (Akt3/+S472) is well-characterized, that of Akt3/-S472 isoform remains u

273 proinflammatory responses of macrophages are well characterized, the components that regulate macroph

274 ation of osteoblast differentiation has been well characterized, the factors that regulate differenti

275 T cell metabolism, diabetes and obesity are well characterized, the function of D-mannose in T cell

276 While the G-quadruplexes have been well characterized, the i-motifs have not been investiga

277 structures of model fusion systems have been well characterized, the intermediate structure(s) formed

278 anges occurring during T cell activation are well characterized, the metabolic demands of differentia

279 concentrations lethal for bacteria is often well characterized, the role of antibiotics at much lowe

280 nse in patients with celiac disease has been well characterized, the role of regulatory T (Treg) cell

281 r processing and expression of fear has been well characterized, the top-down control of this circuit

282 circuits controlling energy homeostasis are well-characterized, the signals controlling the relay of

283 ribution of these to appetite control is not well characterized.The influence of specific DF characte

284 circuits in the stomatogastric ganglion are well characterized, their anatomical distribution as wel

285 ower limits) whose distributional shifts are well characterized, this species provides clear expectat

286 Well-characterized time scales elucidating the EP effect

287 The lac repressor (LacI) is a well characterized transcription factor that regulates t

288 The tumor suppressor p53 is a well-characterized transcription factor that can bind ge

289 trogen fixation that is mediated by a set of well-characterized transition-metal complexes.

290 potential biotechnological tools beyond the well-characterized Type II Cas9 systems.

291 observed at high temperatures, including the well-characterized ubiquitin A state, and two solution s

292 Abeta (1-40) and Abeta (1-42) have been well characterized under various solution conditions, in

293 ble enzymes involved in photorespiration are well characterized, very few membrane transporters invol

294 3 can be maintained by replacing it with the well-characterized viroporin influenza A virus (IAV) mat

295 However, this approach is restricted to well-characterized viruses with known immunogenic/protec

296 nanostructures must be carefully studied and well characterized what require analytically useful and

297 ty of this RNA binding activity has not been well characterized, which limits the ability to validate

298 blood meals supplemented with allopurinol, a well-characterized XDH inhibitor.

299 egions that regulate fluid satiation are not well characterized, yet are essential for understanding

300 telomere length (TL) and aortic stiffness in well-characterized, younger and older healthy adults, wh