ライフサイエンスコーパス: well-conserved

1 ry rarely and highlight that its function is well conserved.

2 tly, between these species, CESA motility is well conserved.

3 pecies but for which primary sequence is not well conserved.

4 the immediate Schiff base vicinity are very well conserved.

5 p), required for the catalytic activity, are well conserved.

6 structure of the archaeal NTD domain is very well conserved.

7 that the dual-functioning nature of MSH1 is well conserved.

8 ne methyltransferase has been evolutionarily well conserved.

9 d in relation to the eve stripes, are rather well conserved.

10 nt segmental chromosome duplications are not well conserved.

11 elatively early in vertebrate history and is well conserved.

12 roup of proteins involved in this pathway is well conserved.

13 ted, and consequently, hotspot positions are well conserved.

14 ioxygenase superfamily and is evolutionarily well conserved.

15 rosophila, midline expression of link is not well-conserved.

16 meres, telomeres and chromatin packaging are well-conserved.

17 ic enzymatic activity that is evolutionarily well-conserved.

18 ore maintaining the structural integrity are well-conserved.

19 edominantly expressed E1c variant revealed a well conserved 400 bp DNA region that contains five E-bo

20 The well-conserved 5'-isomiRs have several features, includi

21 alignment of KRs led to a hypothesis that a well-conserved 94-XGG-96 motif may be involved in contro

22 shown in 2011-2012 to be substantial against well-conserved A(H1N1)pdm09 and lineage-matched influenz

23 XCT contains a XAP5 domain and is well conserved across diverse taxa, suggesting it has a

24 tion antiporters, often at residues that are well conserved across gene families.

25 the chromosomal region containing TRM is not well conserved across mammals.

26 Although the major topoisomers were well conserved across many cell and tissue types, unique

27 contains HPV-neutralizing epitopes that are well conserved across numerous high-risk HPVs.

28 n a hydrophobic alpha-helical domain that is well conserved across several attachment glycoproteins.

29 stent with the breach cluster residues being well conserved across the HSP47 family.

30 esting that regulation of these receptors is well conserved across the two species.

31 results show that the expression of MORs is well-conserved across multiple mammalian species, indica

32 While the TERT protein is well-conserved across taxa, TR is highly divergent among

33 Rb), dissimilar to each other but especially well-conserved across the fungal lineage.

34 ment for ZipA suggesting that this atypical, well-conserved, actin homologue has a more critical role

35 SAMNs resulted structurally and magnetically well conserved after citrinin binding.

36 c damage, however, herpesvirus sequences are well conserved after reactivation from latency.

37 Although both pathways are relatively well conserved all the way from plants to invertebrates

38 on why large lipid transfer proteins have a well conserved alpha-helical domain, because we locate t

39 We also show that the normally well-conserved amino acid sequence of the autoproteolyti

40 with the phenotype in these families, affect well-conserved amino acids, and are predicted to be dama

41 Kdp system has a distinct arrangement and is well conserved among A. baumannii strains.

42 encoded by open reading frame 50 (Orf50), is well conserved among all known gammaherpesviruses and is

43 possess amino acid sequence motifs that are well conserved among all lipoyl protein ligases.

44 Although miRNA targets are well conserved among closely related species, they diffe

45 Some miRNAs are well conserved among different plant lineages, whereas o

46 However, trimer interfaces are well conserved among flaviviruses, so it is likely the d

47 way, which has been studied in detail and is well conserved among higher plants.

48 The C-terminal region of OPN is particularly well conserved among mammalian species, which suggests a

49 and the charge of the FcgammaRI FG loop are well conserved among mammalian species.

50 The Sema6D gene's (GT)n was also well conserved among mammals examined.

51 trol via morphogen gradients, are remarkably well conserved among numerous organisms (e.g., from mous

52 This binding site is not well conserved among PCs, and only a subset of these bac

53 he biophysical properties of the machine are well conserved among phylogenetically distant bacterial

54 Tyr(137) is well conserved among RAS orthologs and is part of a tran

55 e mitochondrial matrix in eukaryotes, and is well conserved among species.

56 e mitochondrial matrix in eukaryotes, and is well conserved among species.

57 e regions involved in these interactions are well conserved among the different HCV genotypes, these

58 The M. acetivorans vht promoter region is well conserved among the sequenced Methanosarcina specie

59 with the PTB domain of Numb through a region well conserved among vertebrate Kanks containing the NGG

60 ifferentiation of thrombocytes from HSPCs is well conserved among vertebrate organisms, positing the

61 lecular modeling indicates that this fold is well conserved among vertebrates.

62 ish embryo, lens organogenesis appears to be well conserved among vertebrates.

63 s are composed of more than 30 exons and are well conserved among vertebrates.

64 s of the protein, (R/N)(Y/F)(R/S)E(F/W), was well-conserved among AvrLm4-7 homologs.

65 f the sugar into a hydrophobic patch that is well-conserved among putative nucleotide-linked sugar di

66 er, their 5' untranslated regions are not as well conserved and all poorly characterized.

67 se iron import systems tend to be relatively well conserved and are promising vaccine targets, having

68 equence on IC and its interface with LC7 are well conserved and are, thus, likely representative of a

69 etworks between human and mouse PSCs are not well conserved and better resemble their respective blas

70 kable tripartite structure is evolutionarily well conserved and can be found in almost all sexually r

71 tides 2 through 7 of the toxbox sequence are well conserved and contain an invariant tract of four co

72 The HSR is evolutionarily well conserved and has been widely studied in bacteria,

73 tructural bases for stomatal development are well conserved and increasingly well understood in extan

74 subunit of eukaryotic RNase H2, RNASEH2A, is well conserved and similar to the monomeric prokaryotic

75 specific, secreted CEACAM16 is exceptionally well conserved and specifically expressed in the inner e

76 eam region of human and mouse PEG3, which is well conserved and thus predicted to harbor several cis-

77 rface, and ranks the waters according to how well conserved and tightly clustered they are in the set

78 ighly-relevant channels contain structurally well-conserved and characterized extracellular and trans

79 sential, sporulation-specific homolog of the well-conserved and essential SEDS (shape elongation, div

80 human and mouse teeth establishes this as a well-conserved and fundamental biological process direct

81 Feeding is arguably one of the most well-conserved and important adaptive behaviors across a

82 und in 5'-UTRs and non-coding RNAs, are less well conserved, and have no bioinformatic indicators of

83 that the Rab1-regulated secretory pathway is well conserved, and hemoglobin receptor trafficking foll

84 trary to expectations in that PINB is not as well conserved as PINA.

85 omosome passenger complexes (CPCs) exhibit a well-conserved association with the anaphase spindle and

86 wnstream ATGs in PB1-F2 plasmids lacking the well-conserved ATG start codon.

87 ent and niche-specific requirements for this well-conserved auxiliary factor.

88 gan identity genes are more diverse than the well-conserved B and C floral organ identity functions.

89 Although many basic cellular processes are well conserved between animals and plants, cell-to-cell

90 of PPIases is shallow, solvent-exposed, and well conserved between family members, making selective

91 While the RNA sequence of LncMyoD is not well conserved between human and mouse, its locus, gene

92 The synergies were well conserved between monkeys, with two of the synergie

93 Although TERT is well conserved between most organisms, TER is highly div

94 ree plant homeodomain (PHD) fingers that are well conserved between species but whose potential roles

95 subunit of ATP synthase, which is unusually well conserved between the 2 organelles and the only sha

96 of a novel structural site on Cdk2, which is well conserved between the cell cycle Cdks.

97 visiae The mechanism of protein synthesis is well conserved between yeast and other eukaryotes, and m

98 Since Ebp1 is well-conserved between mouse and chick, we switched to c

99 (LR) asymmetry (handedness, chirality) is a well-conserved biological property of critical importanc

100 Its presence is well conserved both in lower and higher eukaryotes.

101 revealed that miR-124, the most abundant and well-conserved brain-specific miRNA, was exclusively pre

102 ition of LlaGI and LlaBIII were structurally well-conserved but sequentially less-conserved.

103 clan CD of cysteine peptidases and contain a well-conserved C-terminal catalytic protease domain simi

104 hree point mutations altered residues in the well-conserved C-terminal motif or close to the glycine

105 acterial orthologs because of an additional, well-conserved C-terminal region.

106 Autophagy is a well-conserved catabolic process essential for cellular

107 me that all occipital tissues participate in well-conserved cell movements.

108 in their ability to dissect more than a few well-conserved cell populations across a tumor data set.

109 cell-surface protein families, overlaid on a well-conserved cell template.

110 tin immunoprecipitation assays have revealed well conserved cis-elements for FoxOs and Clock/Bmal1 in

111 are not conserved between kingdoms, CK2 is a well-conserved clock component modulating the stability

112 larly perform saturation genome editing of a well-conserved coding region of an essential gene, DBR1,

113 ex conservation follows one of three models: well-conserved complexes, complexes with a conserved cor

114 While many are familiar with actin as a well-conserved component of the eukaryotic cytoskeleton,

115 inally, we identify 183 complexes containing well-conserved components and uncharacterized proteins w

116 Well conserved consensus sites at lysine 122 and 275 in

117 The promoters of MHC class I genes contain a well-conserved core module, the W/S-X-Y motif, which ass

118 ulin acetyltransferase displays a relatively well-conserved cosubstrate binding pocket but is unique

119 A second well-conserved CRIP homologue functions in multiple valv

120 tudies demonstrate that mutation of a single well-conserved cysteine residue in the C(3)HC(4) zinc RI

121 forces that are modulated by the presence of well-conserved cytoplasmic charged residues, the removal

122 These lie in a small, well-conserved cytoplasmic domain of FlhA, located betwe

123 ming cysteines critical for Tg function, are well conserved despite overall divergence of amino acid

124 Our results show that genes with well-conserved developmental functions can be re-used at

125 Planar cell polarity (PCP) signalling is a well-conserved developmental pathway regulating cellular

126 Besides the well-conserved DNA repair machineries, organisms thrivin

127 Ebp1 is a well-conserved DNA/RNA binding protein that is implicate

128 and herpesviruses consist of a structurally well conserved dodecameric portal at a special 5-fold ve

129 An RWD domain is a well conserved domain found through bioinformatic analys

130 n addition, atom and electron economies were well-conserved during this CRC reaction.

131 tiated mesodermal cells is controlled by two well-conserved E box elements in the large first intron.

132 emerteans, and polyclad flatworms) display a well-conserved early developmental program called spiral

133 ombinant human rhinoviruses that display the well-conserved ELDKWA epitope of the membrane-proximal e

134 A well-conserved, eukaryotic-like Ser/Thr membrane kinase

135 Leu-27 is evolutionarily well conserved even though it is exposed in the monomeri

136 easure of steady-state network function, was well conserved even when all parameters were rounded to

137 Midasin contains a well conserved extension region upstream of the MIDAS do

138 , the Arabidopsis KIN17 homolog belongs to a well-conserved family of essential eukaryotic nuclear pr

139 The rhomboids are a well-conserved family of intramembrane serine proteases,

140 POT transporters represent an evolutionarily well-conserved family of proton-coupled transport system

141 , their 3D relationships are considered, and well-conserved (feedback-like) functions are estimated.

142 states, and DNA methylation preferences are well conserved for TF-occupied sequences.

143 The well conserved formin homology 1 and 2 domains were orig

144 entify a family of Glut4EF proteins that are well conserved from Drosophila to humans and find that m

145 lineages, including that of rodents, but is well conserved from Drosophila to man and is likely to h

146 hagocytosis of corpses of apoptotic cells is well conserved from worms to mammals.

147 r misfolded protein disposal pathway that is well conserved from yeast to mammals.

148 merging from such structures may distinguish well-conserved from recently developed host-microbial in

149 d by one or more databases, suggesting their well-conserved functions.

150 of the Fur box established the existence of well-conserved Fur boxes in the promoters of numerous kn

151 AEBP2 is an evolutionarily well-conserved gene that is found in the animals ranging

152 Recently, the well-conserved general AA control non-derepressing syste

153 e set is supported by its tight overlap with well-conserved genes and its enrichment for core biologi

154 nment of different Cxs shows the presence of well conserved glutamate residues in the C terminus of T

155 s a single Endos protein with a surprisingly well-conserved Gwl target site.

156 domain within a short tract that includes a well conserved His-Gly motif, where mutations have been

157 iB from N. gonorrhoeae and E. coli reveals a well-conserved homodimeric structure consisting of two o

158 Defects in the well-conserved human homologue could play a similar role

159 ion of TAD) upon binding to TAZ1 through its well-conserved hydrophobic sites in a series of grooves

160 more, BIR mutations that abrogate binding of well-conserved IAP antagonists did not affect Op-IAP3's

161 This epitope is well conserved in all 16 subtypes of the HA protein of i

162 (Ub) is a small protein of 8.5 kDa, which is well conserved in all eukaryotes.

163 The dimer interface is well conserved in all known A33 sequences, indicating an

164 mpetence regulators SigX, ComR, and ComS are well conserved in both groups.

165 These functions are well conserved in CCTs across diverse phyla, although th

166 ting in cauliflower mosaic virus RNA and are well conserved in cIAP2 orthologs.

167 This region is well conserved in CodY homologs.

168 these regulators (termed reference TFs) are well conserved in Desulfovibrionales, while the remainin

169 clase (AC) IV (encoded by BB0723 [cyaB]) are well conserved in different species of Borrelia.

170 components of mRNA export machinery are not well conserved in divergent supergroups.

171 cap-mediated snRNP import in humans, is not well conserved in flies.

172 TAGteam motifs are present and well conserved in highly bound regions, and are associat

173 RHEX is well conserved in Homo sapiens and primates but absent f

174 ression level of their gene content, and are well conserved in induced pluripotent stem cells derived

175 a small protein of unknown function that is well conserved in low-GC Gram-positive bacteria.

176 While the imprinting status of genes is well conserved in mammals, clear estimates for the degre

177 The carrageenan utilization system is well conserved in marine Bacteroidetes but modified in o

178 Further, TBC-domain architecture has been well conserved in modern eukaryotes.

179 osS/DosT, an oxygen and redox sensor that is well conserved in mycobacteria.

180 e largely conserved, alternative splicing is well conserved in only a subset of tissues and is freque

181 r analysis indicates that VLRC sequences are well conserved in sea lamprey (Petromyzon marinus), L. c

182 The majority of these residues are well conserved in the AraR orthologs in Bacteroidetes.

183 e mechanism of IPS recognition is remarkably well conserved in the eukaryotic kingdom, as mammalian a

184 the immunoglobulin superfamily, but are less well conserved in the fibronectin type III (fnIII) super

185 tes +1 to +4 in the S. coelicolor enzyme are well conserved in the M. tuberculosis enzyme so their id

186 While residue S375 is well conserved in the majority of group M HIV-1 isolates

187 ifs in the N terminus of VGLUT1 that are not well conserved in the other isoforms.

188 mal RNAs [rRNAs] and ribosomal proteins) are well conserved in the plastid ribosome, little is known

189 These residues are well conserved in the T antigens from the polyomaviruses

190 tructural and electronic characteristics are well conserved in their stacked form, possibly due to th

191 g that cpDNA architecture has been extremely well conserved in these deep-branching lineages of green

192 ological features of the locomotor drive are well conserved in vertebrates.

193 elda and single-minded midline expression is well-conserved in Drosophila, midline expression of link

194 This residue is well-conserved in other DJ-1 homologues, including two (

195 ) s(-1)) and show that molecular markers are well-conserved in the bulk of solid BBA particles but un

196 Sets of R2R3 and R1R2R3 orthologs are well-conserved in three Phytophthora species.

197 Well-conserved infrastructure may be useful for Agrobact

198 The Oxa1 protein is a well-conserved integral protein of the inner membrane of

199 It contains an exceptionally well-conserved interface that docks the MELT(P) sequence

200 Circadian rhythms are generated by well-conserved interlocked transcriptional feedback loop

201 es contain four half-cysteine residues and a well-conserved Leu(65)-Ser(66) reactive site, typical fo

202 nt, rodent models hold promise in dissecting well-conserved limbic circuits.

203 peptidase (Spase) cleavage site along with a well conserved lipobox motif.

204 by pulse radiolysis that the mutation of the well-conserved lysine 48 into isoleucine in the SOR from

205 Members of the well-conserved mannose receptor (MR) protein family have

206 beta/SMAD4/IRF6 signaling cascade might be a well-conserved mechanism in regulating multiple organoge

207 for thioredoxin-like 5) is an evolutionarily well-conserved member of the thioredoxin (Trx)-fold prot

208 t of 'index' orthologs representing the most well-conserved members of each ATGC-COG, the phylogeneti

209 ich fold as higher-plant PsbP and contains a well-conserved metal (zinc)-binding site that is also pr

210 Endospore formation (sporulation) is a well conserved microbial developmental strategy in the F

211 y of 141 conditional miRNA sponges targeting well-conserved miRNAs in Drosophila.

212 Among well-conserved miRNAs, we observed unexpected cases of c

213 utL homologs from bacteria to humans contain well-conserved N-terminal and C-terminal domains.

214 in yeast and human proteins, confirming the well-conserved nature of these systems.

215 e nuclear/cytosolic exosome decay complex is well conserved, neither nucleus-specific activators nor

216 Here we examine the evolutionary history of well-conserved nitrogen-assimilating enzymes to determin

217 Although GSK3 orthologs are well-conserved, none of them have been functionally char

218 We identified cacn-1/cactin, a well-conserved, novel regulator of cell migration in a g

219 re in the Rad2/XPG family and insights how a well-conserved nuclease core acquires versatility in rec

220 ed miRNAs have the same functionality as the well conserved ones.

221 KS, respectively), which are found within a well-conserved operon that may lead to the production of

222 os, which varied over a fourfold range, were well conserved over these durations.

223 ssyn, is HERV-derived, placenta-specific and well-conserved over simian evolution.

224 ditis elegans filamin ortholog, FLN-1, has a well conserved overall structure, including an N-termina

225 r findings provide mechanistic insights on a well-conserved pathway of PP regulation that is critical

226 th mutants, indicative that they are part of well conserved pathways and likely, therefore, to be opt

227 estigation determined that expression of the well-conserved penicillin-binding protein (PBP) 1A, prev

228 structure of the RMI core complex bound to a well-conserved peptide from FANCM shows that FANCM binds

229 e bacterial cell, which is dealt with by the well-conserved phage shock protein (Psp) system in a hig

230 Myomaker, encoded by Mymk (Tmem8c), is a well-conserved plasma membrane protein required for myob

231 Surprisingly, while track polarity is well conserved, polarity is nonetheless functionally dis

232 We found that PIP(2) bound to the well conserved polybasic patch of the C2B domain with an

233 e-directed mutagenesis revealed specific and well-conserved posttranslational modifications (PTMs), i

234 sults demonstrate the evolvability of even a well-conserved process and suggest that changes in chrom

235 Endocytosis is a well-conserved process by which cells invaginate small p

236 dings that show peroxidase enzymes possess a well-conserved profibrogenic capacity to stimulate the m

237 Homologues of this well conserved protein are found within diverse phyla in

238 de evidence for the methylation of Rpl1ab, a well conserved protein forming the ribosomal L1 protuber

239 The alpha isoforms express a well conserved protein kinase A consensus site, which is

240 A well-conserved protein complex named ClpP (caseinolytic

241 The eukaryotic RNA exosome is a well-conserved protein complex with ribonuclease activit

242 LsrS appears to be a well-conserved protein that is present in many streptoco

243 ed N-terminal, DNA-binding domain and a less well-conserved protein-binding domain.

244 Their modular structure and well-conserved protein-DNA interface allow the developme

245 vidence suggests an important role for these well-conserved proteins in multiple processes and raises

246 aenorhabditis elegans germ line utilizes the well-conserved RAS-ERK signaling pathway in multiple dif

247 at while there are dramatic differences from well-conserved RCC1 proteins, TgRCC1 associates with chr

248 CRY couples to membrane depolarization via a well conserved redox sensor of the voltage-gated potassi

249 A well-conserved region called the magnetosome island (MAI

250 a mutations and four polymorphisms affecting well-conserved regions of Poldelta or Polepsilon.

251 A phosphorylation event of a well-conserved RelA(Ser276) is prerequisite for the form

252 Well conserved residues were highlighted, and the potent

253 athways, we performed an in vivo analysis of well-conserved residues in Msh3 that are hypothesized to

254 These amino acid substitutions affect well-conserved residues in the prodomain and in the pept

255 Across diverse vertebrate species, TRIO is a well-conserved Rho GTPase regulator that is highly expre

256 d Drosophila melanogaster demonstrates how a well-conserved RNA-binding domain and cognate binding se

257 TDP-43 is a well-conserved RNA-binding protein known to regulate alt

258 There are no well-conserved secreted polysaccharide-degrading enzymes

259 of seven transmembrane helices that contain well-conserved sequence motifs, indicating that they are

260 Our findings highlight a well-conserved series of events that we demonstrate can

261 lates the mTOR binding partner raptor on two well-conserved serine residues, and this phosphorylation

262 Notch is a well-conserved signaling pathway and its function in cel

263 of a sensor kinase that typically has three well-conserved sites of phosphorylation: autophosphoryla

264 essential regulator of that decision is the well conserved Slit-Robo signaling pathway.

265 icularly profound in light of the apparently well-conserved staggered cross-heme wire structural moti

266 d subsequent release of Nle1 by midasin is a well conserved step in the ribosome maturation pathway i

267 inhibition in matrix-attached cells resemble well-conserved stress responses to nutrient and growth f

268 ies widely among insects, in contrast to the well-conserved structure of legs.

269 Based on the well-conserved structure, multiple programs were develop

270 ion-coupled repair (TCR) is an important and well-conserved sub-pathway of nucleotide excision repair

271 lification, and these events' linkage to the well-conserved subsequent asymmetric transcriptional cas

272 e and yeast Srv2/CAP homologs are remarkably well conserved, suggesting that the same activities and

273 d evolutionarily distant algal phots is less well conserved than previously thought.

274 ce for sites which are more exposed and less well conserved than random.

275 One element was so well conserved that a similar mouse Hox cluster sequence

276 These sites are less well-conserved, therefore allosteric ligands have greate

277 Although generally well-conserved, they exhibit important differences.

278 ause regulation of mitotic entry by Cdc25 is well conserved, this mechanism may provide a widespread

279 e-step enzymatic pathway, which is generally well conserved throughout all gram-negative bacteria.

280 characterized Protein Family 0016, which are well conserved throughout evolution and share characteri

281 The Nrf2 transcription factor is well conserved throughout metazoan evolution and serves

282 mino acid level, PCPs for both proteins were well conserved throughout the FVs.

283 This hydrophobic core was well conserved throughout the m02 family, thereby indica

284 However, this capability also depends on a well-conserved toolkit of different molecular mechanisms

285 Elp3 is the catalytic subunit of the well-conserved transcription Elongator complex; however,

286 ich could be explained by the existence of a well-conserved tryptophan at position 375 (Trp 375) in H

287 LMW-PTPs, the phosphorylation status of two well conserved tyrosine residues, typically located in t

288 wo residues, T1609 and S1618, located in its well-conserved ubiquitination-dependent recruitment (UDR

289 crown area-to-diameter allometry exponent: a well-conserved value across tropical forests.

290 Mammalian DREAM is well conserved with Drosophila and Caenorhabditis elegan

291 l priming mechanisms, these proteins are not well conserved with heterodimeric (p48/p58) primases in

292 e amino acid sequences of S. aureus PSMs are well conserved with two exceptions, one of which is the

293 The MAR family of transcription factors is well conserved, with members playing central roles in pa

294 ld multicellular diversity are proving to be well conserved within lineages, generating interest in t

295 erine-rich tract (SRT) of VZV IE62, which is well conserved within the alphaherpesviruses, is needed

296 Gene colinearity in the region is well conserved within the genus Zea.

297 ding network around the cis-peptide bond are well conserved within the metallopeptidase subfamily M9B

298 lored microbial interactomes and to focus on well-conserved yet uncharacterized interactors for furth

299 t chromosome synteny in Lepidoptera has been well conserved, yet the number of haploid chromosomes va

300 wo high affinity (K(d) approximately 20 nm), well conserved Zn(2+)-binding sites near its N terminus,