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1 in palladium-induced metallate rearrangement wherein 1,2-migration of an alkyl or aryl group from bor
2 suggest a cohesive model of channel function wherein: 1) channel conductance and size selectivity are
3 depth recordings, we report here a sequence wherein: (1) convergent cortical downstates lead thalami
4 a different global glaucoma classification, wherein 146 of 617 (23.7%) of borderline classifications
5 that simulated approach-avoidance conflict, wherein 23 male and female human participants collected
6 interesting intersection of these materials wherein 2D graphenes are hybridized with 3D hydrogels to
7 luoroxindole (HOFox)-mediated glycosylations wherein 3,3-difluoro-3H-indol-2-yl (OFox) imidates were
9 or (555p) and a mosaic modern protein (151p) wherein 9 of the 30 coiled coil substitutions retain the
10 nas reinhardtii divides by multiple fission, wherein a 'counting' mechanism couples mother cell-size
11 icularly when a precision medicine paradigm, wherein a biomarker or gene expression pattern indicates
12 n of unactivated alkenes has been developed, wherein a cleavable bidentate directing group is used to
14 focused on the immittance function approach, wherein a library of analytical parameters can be comput
15 driven by the Nernst effect in bulk solids, wherein a magnetic field generates a Lorentz force on th
16 and concomitant immunity, suggesting a model wherein a parasite reservoir repopulates itself indefini
18 elopmental strategy in the Firmicutes phylum wherein a progenitor cell that faces starvation differen
19 turally related families is oligomerization, wherein a series of enzymatically catalysed reactions is
20 izures evolve into self-organized structures wherein a small seizing territory projects high-intensit
21 the development of a unique labeling method wherein a synthetic receptor probe for trimethyl lysine
23 ursor protein processing and support a model wherein Abeta production is amplified by plaque-induced
24 w HCV infections caused by released inmates, wherein about 90% of averted infections would have occur
25 tro using established Caco-2 cell monolayers wherein acrolein decreased barrier function and increase
27 ion is linked to pathologies such as cancer, wherein actively protruding filopodia, at the invasive f
29 we construct, to our knowledge, a new model wherein airway narrowing and closure dynamics are modula
30 supported a rate-determining AdE3 mechanism wherein alkyne activation by neutral ClBcat is concerted
31 e are then processed to sequencing libraries wherein all sequencing reads originating from each long
32 iangular Fe3 (mu3 -O) core induces a cascade wherein all three metal centers switch from high-spin Fe
33 al a partially rotated state of the ribosome wherein all three tRNA sites are occupied during transla
34 1 days in a flow perfusion bioreactor system wherein alpha-MEM (supplemented with 10% fetal bovine se
35 1 days in a flow perfusion bioreactor system wherein alpha-MEM (supplemented with 10% fetal bovine se
36 icial BiFeO3/SrRuO3/SrTiO3-heterostructures, wherein an altered environment at each interface, caused
37 aneous) hydrolysis of these same substrates, wherein an approximate 10(5)-fold difference in rates wa
38 a multielement method of LA-ICP-MS analysis wherein an array of chemical elements is simultaneously
39 tions are utilized in an open-ended approach wherein an endpoint is assayed during or after the biolo
40 free dendrimer nanoparticle vaccine platform wherein antigens are encoded by encapsulated mRNA replic
41 t of patterning of the Drosophila wing disc, wherein apically secreted Wingless (Wg) encounters its r
42 An extensive cortical region was identified wherein area related positively to GCA in development.
43 ally, we propose a dual perspective approach wherein at any instant in the network evolution under at
44 ia coli (E. coli) appears to favor crosstalk wherein at least one of the cross-linked FFLs remains mo
45 ed similar sst2/sst5/D2 expression patterns, wherein BIM-23A760 inhibited the expression/secretion of
46 e structures reveal a truncated barrel fold, wherein binding of large peptide substrates is necessary
47 ur observations are consistent with pathways wherein both an excited state of the copper(I) carbazoli
48 unusual catalyst-controlled site selectivity wherein C-H alkenylation of five-atom heteroarenes can o
49 s through "hyperactive signaling junctions," wherein cAMP is locally delivered to PKA at supersaturat
51 omatic hydrocarbon (PAH)-contaminated media, wherein carcinogenic hazards are evaluated using a dose-
52 as based on that used by the previous study, wherein case Types I to IV defined increasing severity o
55 the transition between stage I and stage II, wherein cells first acquire different identities in the
56 t endocytic pathways exemplifies a mechanism wherein cells in tissues leverage multiple endocytic pat
58 cement of Iterative Exponential Growth (IEG) wherein chiral allyl-based IEG oligomers are subjected t
61 m the BLA and PL while rats performed a task wherein competing shock- and sucrose-predictive cues wer
62 tionships in other biomechanical subsystems, wherein complex hierarchical organization programmed fro
64 netically discontinuous replication process, wherein contacts within the replisome are continually br
65 eciated effect of chronic HFD on beta-cells, wherein continued DNA damage owing to persistent oxidati
67 e prepared from a room-temperature synthesis wherein crystallization of unhydrolyzed and valence-pure
68 The data collectively support a mechanism wherein CTCF serves to translate alphaKG-sensitive metab
69 has been thought to be inherently cytolytic, wherein CVB can escape from the infected host cell only
70 r, these results are consistent with a model wherein DDX1 acts as an RNA chaperone, remodeling the RR
71 em II structural transition leads to a model wherein DDX1 can act as an RNA chaperone, folding stem I
72 ctrometry (MS)-based glycoproteomic approach wherein deglycosylated peptides are analysed by LC-MS/MS
73 e studied the rotationally inelastic process wherein deuterium hydride (HD) (v = 1, j = 2) collides w
74 The intrauterine period is a critical time wherein developmental exposure can influence risk for ch
75 g for a diverse array of cellular processes, wherein differences in chain length, branching, and link
77 nstrate luminescent hyperbolic metasurfaces, wherein distributed semiconducting quantum wells display
80 pport a neurodevelopmental hypothesis of MDD wherein dysfunctional self-regulation is potentially ref
81 ine four conformational states of the trimer wherein each receptor-binding domain is either tightly p
82 We designed a questionnaire with 9 scenarios wherein each scenario compared a hypothetical patient wh
83 ty is rationalized from a two-step mechanism wherein each step occurs via maximal energy and orbital
84 alidated using CLEC12A knockout (KO) animals wherein EAE disease induction was delayed and reduced di
86 cofacial alignment at distances of 3.3-3.5 A wherein efficient spatial charge transfer can occur.
87 of materials that can support angiogenesis, wherein endothelial cells from existing vasculature inva
88 ity across a range of pH's and temperatures, wherein enzyme-based sensors will not function, and in b
89 pted an in vivo mouse model expressing hPXR, wherein expression of hPXR in mice promotes M. tuberculo
90 ximal leading process nanoscale architecture wherein f-actin and drebrin intervene between microtubul
91 monstrate a feed-forward signaling mechanism wherein F-actin and integrin receptors drive contact for
92 d axis also generates regions of trait space wherein fitness is almost equalized, an outcome we term
93 s to develop a simpler experimental approach wherein flies could implement behavior that induces self
94 forming a Lowry protein assay in the device, wherein fluid flow was deactivated to allow individual r
95 Tie2 and initiates a positive feedback loop wherein FOXO1-driven ANG2 expression promotes vascular r
97 tions, a model of GenK catalysis is proposed wherein free rotation of the radical-bearing carbon is p
98 rm for preparing well-defined nanostructures wherein functionality such as catalysis can be incorpora
99 PPVs is used to realize a parallel pi-sheet, wherein further orthogonal assembly with helical motifs
100 by one of two modes: a likely ancestral mode wherein germ cells are induced during embryogenesis by c
101 auterine environment, to the postnatal state wherein granulocytes predominate to provide innate immun
102 vations support a model for Cas9 specificity wherein gRNA-DNA mismatches at PAM-distal bases modulate
103 ign element for multiparameter optimization, wherein >/=10-, 100-, or 1000-fold improvement in a vari
104 Here, we describe a somatic mouse model wherein H3.3(K27M) and Trp53 loss alone are sufficient f
105 grading capacity in the marine water column, wherein HCB associated with phytoplankton are better tun
106 far back as Aristotle's Historia Anima lium, wherein he identified five basic biological processes th
107 Pt, Pd) molecular architecture (M-(PM')n-M), wherein high-oscillator-strength NIR absorptivity up to
108 e host cell, leading to persistent infection wherein HIV-1 can remain transcriptionally silent in lat
109 ns support a model for native HIV-1 assembly wherein HIV-1 gag-pol mRNA localization helps to confine
110 uch as Portuguese are melodic or "sing-song" wherein identifying a word relies on what comes before a
111 These data reveal a signaling framework wherein IL-2-JAK-controlled pathways coordinate with IL-
113 biofilm formation in vivo We propose a model wherein impaired cellular respiration stimulates SaeRS v
114 nnervating the lower gastrointestinal tract, wherein in-vivo administration of ABX prevented toleranc
115 Oocyte fertilization represents a scenario wherein inappropriate responses to exogenous yet non-pat
116 apitulated in a mouse model of fungal asthma wherein infection during heightened allergic inflammatio
117 cidence mechanism of short-pass selectivity, wherein inhibition and suprathreshold excitation show gr
118 nation domain of lanthipeptide dehydratases, wherein insertions of secondary structural elements resu
119 negative feedback loop in M2 myeloid cells, wherein integrin beta3 signaling favored STAT1 activatio
121 These data support the design hypothesis wherein interligand steric interactions are employed to
124 -139-5p in two independent clinical cohorts, wherein it associated with poor recurrence-free survival
125 mation of the director configuration occurs, wherein it conforms to a unique splay-minimizing configu
126 e GPh is embedded in a basal ganglia circuit wherein it receives inhibitory input from both striosoma
127 hat this sensor is functional in live cells, wherein it reports forskolin-stimulated activity of AC.
129 pirical data ( approximately 2,100 species), wherein, large-seeded animal-dispersed species are large
130 ed the established relationship to splicing, wherein levels were directly correlated with splicing ef
131 cultural lands in the tropical forest biome, wherein lies the greatest potential to conserve or lose
132 Tip-enhanced Raman spectroscopy (TERS), wherein light is confined and amplified at the apex of a
133 aerosol particles in a contact-free manner, wherein measured scattering patterns are interpreted to
134 hermodynamic viewpoints of protein structure wherein mechanical clamps that mimic substrate or cosolu
135 nsistent with a bimodal inhibition mechanism wherein membrane binding of a second protein (a membrane
136 expression of an altered circadian waveform wherein mice in light/dark/light/dark (LDLD) cycles "bif
137 Here we demonstrate the use of fate mapping wherein microglia and monocyte-derived cells are endogen
139 enomic locations within developmental stages wherein monoallelic Ag receptor locus recombination is e
140 dynamics can result in habitat compression, wherein more colonists occupy a patch or locality than i
141 lt can be explained by a reinforcement model wherein movement errors influence decision-making, eithe
142 l determinant of cell persistence and growth wherein mTOR complex 1 (mTORC1) mediates a balance betwe
143 gs reveal a formerly uncharacterized feature wherein multiple copies of the amplicon congregate as tr
144 mber/size of emissive graphenic nanoclusters wherein multiscale modelling captures essential experime
145 ere further confirmed in a converse approach wherein MYB was overexpressed ectopically in a MYB-null
146 lial amyloidosis, a life-threatening disease wherein N-terminal protein fragments form fibrils in vit
148 tial "late-stage functionalization" exercise wherein natural products serve as the lead scaffolds.
151 source for GroEL dependence is frustration, wherein not all interactions in the native state are opt
152 d by using generalized linear mixed modeling wherein observations were nested for each radiologist ov
153 an unusual cationic sub-lattice arrangement wherein octahedral sites, which serve as bridges for cat
155 res are frequently performed as overlapping, wherein one surgeon is responsible for 2 procedures occu
156 formation of dinuclear palladium complexes, wherein only a single metal center is directly involved
157 current spintronic studies and technologies wherein only one spin species could be handled at a time
158 the case of chronic myeloid leukemia (CML), wherein our model recapitulated the clinical history of
159 1/parkin-dependent vesicle transport pathway wherein oxidized or damaged mitochondrial content are se
161 ion analyses were consistent with a scenario wherein parents with low childhood SES had current famil
162 severe form of dyskeratosis congenita (DC), wherein PARN deficiency leads to human telomerase RNA in
163 entify a time window in early postnatal life wherein partial amputation culminates in a localized reg
165 en-label period of the trial is in progress, wherein patients still on treatment at the end of the do
166 ugh relatively long-lived late intermediates wherein peptidyl-tRNA enters the P site of the small rib
167 ghbouring patches through spatial contagion, wherein perceived quality of one patch can extend beyond
168 blend of crosslinking acrylate and urethane, wherein phase separation induces the spontaneous, direct
169 based multichromophoric hydrogelator system, wherein pi-electron units with different inherent spectr
171 oks, collectively called Historia Plantarum, wherein plant forms are categorized into annual herbs, h
172 d an adaptable central lipid-filled chamber, wherein polytopic membrane-proteins could fold, sheltere
173 e provide a comprehensive synaptic framework wherein presynaptic KOR inhibition decreases the excitat
174 near-physiological organoid culture system, wherein primary human healthy liver cells form long-term
175 clearly identify a quasi-equilibrium regime wherein production rates increase until they equal the i
176 o current restrictive transfusion practices, wherein raising hemoglobin could reduce the risk of isch
177 we explore some perspectives for the future, wherein recent work in the immunology field clearly demo
178 capture assay for anti-HDV immunoglobulin G wherein recombinant HDV delta antigen is printed by micr
179 Our results illustrate a new mode of sensors wherein redox active recognition units are voltage-activ
181 dent, an observation consistent with a model wherein Rev self-association acts to transiently mask th
182 sociated molecular pattern-sensing pathways, wherein sensing of host-derived DNA limits immune-mediat
183 ween positive and negative affective states, wherein several neurochemicals converge and interact to
184 onsistent with a 'differential fusion' model wherein sexual selection reduces rates of fusion among l
185 n a bow-tie regulatory architecture [9, 10], wherein sexual, positional, temporal, and lineage inputs
188 growing demand for C-H alkylation reactions, wherein sp(3) C-H bonds are replaced with sp(3) C-alkyl
189 the basis of programmable molecular systems, wherein specific input sequences create distinct outputs
190 H3K36me3 is further responsive to splicing, wherein splicing inhibition led to a redistribution and
192 nanostructured composite has been developed, wherein stacked lamellas of 1D vanadium pentoxide nanofi
193 tive SLII adopts a locally compact structure wherein stacking interactions in a conserved 5'-AUAGC-3'
194 e establish a "two-hit" stress model in mice wherein stress at a specific postnatal period increases
195 ductivity to the cluster rattling mechanism, wherein strong optical-acoustic phonon scatterings are d
196 se data support a model for native infection wherein structural features of the gag-pol mRNA actively
197 d to contrast with the behavior in pure ILs, wherein structural relaxations and the associated times
199 more complex three-component configurations wherein symmetric and broken sets are not yet mixed and
200 dingly, we used a glyco-engineering approach wherein synthetic CD22 ligands linked to lipids are inse
201 n of mRNAs activated under short-term stress wherein TC recycling is attenuated by eIF2alpha phosphor
202 We also construct an antiparallel pi-sheet, wherein terminal PPV blocks are adjacent to a flexible c
204 g sites within the large and small subunits, wherein the 6'-hydroxyl substituent in ring I serves as
205 Ruminococcus gnavus is a human gut symbiont wherein the ability to degrade mucins is mediated by an
208 flow-cytometric host cell reactivation assay wherein the activity of several enzymes [four BER-initia
209 m involving two catalytic cycles is proposed wherein the alternating copolymerization proceeds via in
210 have a well-established modular architecture wherein the antigen-binding site residing in the antigen
212 vskites are solution-processed quantum wells wherein the band gap can be tuned by varying the perovsk
214 high as 4 bit/s/Hz over 16 m in free space, wherein the BLD carried QAM-OFDM data stream remains its
215 ic investigations support an ionic mechanism wherein the bromochloride serves as an enantioenriched b
217 of endogenous protein assemblies-i.e., those wherein the component proteins are expressed at endogeno
218 new framework to assess network robustness, wherein the connectivity of the affected nodes is also t
219 an ortho- substituent in the N-phenyl moiety wherein the corresponding expected 3'-phenyl-1'H-spiro[i
220 o-tumor role for CXCR3 in lung immunobiology wherein the CXCR3 axis drives both the anti-tumor effect
221 APCs), can undergo asymmetric cell division, wherein the daughter cell proximal to the APC is more li
223 redox catalysis as a platform to selectivity wherein the discrepancy in oxidation potentials between
224 sequence triggers structural transformation wherein the domains dissociate and RfaH refolds into a N
225 lline G-quadruplex-based organic frameworks, wherein the electron donors and acceptors form ordered,
226 s in an unusual intramolecular PCET process, wherein the electron travels to a proximal radical catio
227 rasts with classical organoboron derivatives wherein the element is in the +III oxidation state.
228 me elongation, GSCs form asymmetric spindle, wherein the elongated mother centrosome organizes consid
230 signaling in neurons, highlighting examples wherein the fundamental cell biological processes of pro
231 these arrangements exhibit a common feature wherein the gamma-CD moiety interacts with the Dawson-ty
232 elds an extended range of short-range order, wherein the growth of magnetic correlations with decreas
233 lbeta.DNA.dNTP) for both extension contexts, wherein the incoming nucleotide is bound in either the c
234 nticated reactive iron(V)oxo units (Fe(V)O), wherein the iron atom is two oxidation equivalents above
235 nd possible manifestation of generalization, wherein the knowledge or skills acquired via training, d
236 ormation and a distinct, second conformation wherein the last beta-strand is retracted to extend the
237 ion occurs through an induced-fit mechanism, wherein the ligand promotes a primary nucleation binding
238 The receptor adopts an extended conformation wherein the linker and N3 domains pack against each othe
239 is achieved by a short-circuiting mechanism wherein the LRR domain selectively blocks productive ami
240 ign strategy applies to any materials system wherein the mechanical properties are controlled by the
241 ent of an alternative class of CA inhibitor, wherein the medicinal chemistry pedigree of primary sulf
243 n together, our findings provide a mechanism wherein the multimeric states of both Mff and Drp1 regul
244 ubstitution by a "soft"-nucleophile pathway, wherein the nucleophile attacks the allyl group external
245 aterial, an optical Janus effect is created, wherein the observed reflected color is different on one
246 e observations, we develop a summative model wherein the P-body assembly phenotype of a given mutant
247 scribe a series of novel triazolopyrimidines wherein the p-SF5-aniline was replaced with substituted
248 we delineate a sex-specific neuronal circuit wherein the P1 neurons encoding increased courtship driv
249 is, in part, because of an oligogenic cause, wherein the pathogenic variants do not cosegregate with
250 Seven trials had prebaseline assessments wherein the patients knew that they were not receiving t
251 states according to the outside environment, wherein the perception of salient stimuli prompts vigila
253 Amputation rate was improved more in trials wherein the prevalence of diabetes mellitus was high.
254 associated with calcium-transient alternans, wherein the probabilistic nature of dyad activation and
256 troduce a new technology based on biomimicry wherein the protein-protein interfaces of two different
257 an impedance-derived capacitance methodology wherein the redox probe is contained in the receptive la
259 to an integration engine and database server wherein the scores were calculated and stored without vi
260 anism referred to as reversible disassembly, wherein the soluble catalytic sector, V1, is released fr
262 nalysis point to a dual role of the catalyst wherein the thiourea moiety of the catalyst is engaged i
263 ctures using chemical vapor deposition (CVD) wherein the top layers are relatively smaller in size th
264 gene name(s) does not work well on datasets wherein the vast majority of their content is numeric.
265 but also the unique architecture of TRPMLs, wherein the voltage sensor-like domain is linked to the
266 -A diversified in a co-evolutionary process, wherein their prymnesiophyte partners acted as a barrier
267 ivery selectivity specifically to the heart, wherein therapeutic drug levels can be maintained over t
268 sults reveal a novel chaperone-like activity wherein these MDPs specifically target misfolded amyloid
269 ave witnessed another technological advance, wherein these two powerful modalities have been physical
270 is also observed in sugar transporter genes, wherein, these genes have undergone positive selection i
271 ein kinases lies in their dynamic structure, wherein they are able to modulate cellular signaling by
273 s and parasites exist in diverse communities wherein they interact with other species, spanning the p
274 ist classes of computationally hard problems wherein this paradigm is fundamentally inefficient.
275 vel sequential one-pot, three step protocol, wherein three new carbon nitrogen bonds are formed in co
276 cting staphylolytic peptidoglycan hydrolases wherein three unique antimicrobial activities from two p
277 le manifestation of learning generalization, wherein training on one task produces an immediate boost
279 d potassium channels, we engineered chimeras wherein transmembrane regions of TRPV1 were transplanted
281 a faces the problem of multiple comparisons, wherein true signals are difficult to detect on the back
282 ly, in the TS1 TCR transgenic model of GVHD, wherein TS1 CD4 cells specific for a model minor histoco
283 ce that it is a genetically advanced lesion, wherein tumor cells carry many of the genetic changes fo
285 Here we propose and test a "proximity model" wherein two females that vary in their relative attracti
286 4a exhibits a hexanuclear cluster structure wherein two monomer-of-trimer units are linked by a genu
287 stable solar cells using a ternary approach, wherein two non-fullerene acceptors are combined with bo
288 xes with particular photo-physical property, wherein unique donors are combined with a single metal a
289 a role for UPF1 in regulated protein decay, wherein UPF1 acts as an E3 ubiquitin ligase to repress h
290 Our findings support a conceptual model wherein variable climatic conditions dominate recent phy
291 gating of controlled radical polymerization wherein various combinations of three stimuli were requi
292 onship between ENSO and southeast Asian SATs wherein virtually all April extremes occur during El Nin
293 gm while undergoing functional neuroimaging, wherein visual cues were paired with either an aversive
295 poral gas-phase ion population manipulation, wherein we collapse ion distributions in ion mobility (I
296 l angiographic features (junctions, lengths) wherein we observed significant global (both hemispheres
297 ablished a model of premalignant lung cancer wherein we treated human bronchial epithelial cells (HBE
298 e develop and apply an intermediate approach wherein we use stand-level tolerances of environmental s
299 ling risk factor for mood-related illnesses, wherein women represent the majority of those affected b
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