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1 8 weeks induced extensive hepatic fibrosis, whereupon 1D11 dosing was initiated and maintained for 8
2 ication is frequently not achieved with MTD, whereupon a de facto goal of longer-term tumor control i
3 ase E1 to an A/T-rich origin of replication, whereupon a dihexamer forms, resulting in DNA replicatio
4 ors on the cell surface and is internalized, whereupon a pH drop in the endosome (pH approximately 5.
6 to relatively common anionic phospholipids, whereupon a two-dimensional search is initiated by the C
8 lceramide in live cells or in mouse tissues, whereupon an HPLC assay enabled detection and quantifica
9 ifferent time points for 14 days post injury whereupon animals were killed and cerebral tissue analyz
11 e membrane to the inner part of the cytosol, whereupon another diffusion-trapping mechanism involving
12 -6 days until the development of TIC and MR, whereupon biplane videofluoroscopy and transesophageal e
13 l effect on proMMP-2 activation was observed whereupon blocking ERK1/2 phosphorylation promoted proMM
15 iferative basal cells of mammalian epidermis whereupon cell division, transmembrane planar cell polar
16 niform stimuli trigger a symmetric response, whereupon cells stop and round up; then localized patche
17 ected to non-surgical periodontal treatment, whereupon changes in salivary CSF-1, IL-34, and MMP-8 le
18 he Arg(234)-Glu(446) salt bridge is released whereupon conformational changes occur that activate the
19 pillomavirus virion uncoats in the endosome, whereupon conformational changes result in a dissociatio
20 xin internalization into acidified vesicles, whereupon cryptic segments from within the 1,050-aa tran
21 until replacement of the final alpha-helix, whereupon cyclopropanation and branching activity compet
22 d of the peptide cation and reagent dianion, whereupon dehydration of the complex via collision-induc
23 sm after fusion of viral and host membranes, whereupon dynein-dependent trafficking along microtubule
24 ability of mitotic kinetochores to biorient, whereupon each sister kinetochore forms microtubule (MT)
25 ral specificity to DNA junctions as a dimer, whereupon each subunit cleaves a phosphodiester bond of
26 urgent need for early diagnosis in medicine, whereupon effective treatments could prevent irreversibl
27 was applied underwater to various substrates whereupon electrostatic complexation, phase inversion, a
28 itical role in bringing Gab2 to FcepsilonRI, whereupon Gab2 becomes tyrosyl-phosphorylated in a Syk-d
29 bitat lead to extinction of the specialists, whereupon generalists invade from the uniform habitat, a
30 ng of the human papillomavirus (HPV) capsid, whereupon host cyclophilins facilitate the release of mo
31 This run-down was prevented by okadaic acid, whereupon ICl,CaMK remained near its maximum value for >
32 omes of hematopoietic and parenchymal cells, whereupon IgG is diverted from degradation in lysosomes
33 . aureus to facilitate bacterial attachment, whereupon infected or sterile catheters were stereotacti
34 mice unless the mice were stratified by age, whereupon inverse correlations between memory and Abeta(
35 mine, and N-glycolylglucosamine 6-phosphate, whereupon irreversible de-N-glycolylation of the latter
36 recruited by DNA-binding activator proteins, whereupon it alters chromatin structure to increase prei
37 alize from the nucleolus to the nucleoplasm, whereupon it binds replication protein A and inhibits DN
38 es phosphorylated in a lck-dependent manner, whereupon it can directly recruit p85 adaptor subunits o
41 s the star to evolve back into a cool giant, whereupon it experiences renewed mass ejection before re
42 by increases in the cellular AMP:ATP ratio, whereupon it functions to help preserve cellular energy.
43 after a precipitous drop in ambient oxygen, whereupon it induces the expression of diverse gene fami
44 lls and released from apoptotic tumor cells, whereupon it interacts with the complement C5a receptor
45 that is induced upon bacterial colonization whereupon it is expressed in the ileum and colon, region
46 consumption may peak between 2015 and 2020, whereupon it is likely to drop by up to 40% until 2050.
48 es in the nucleus after rapamycin treatment, whereupon it primes the phosphorylation of the RNA polym
49 DC subsets efficiently internalize CLEC12A, whereupon it quickly translocates to the early endosomes
50 ium or H2 as the sample was heated to 523 K, whereupon it reacted with oxygen of the support to give
52 d/hook-type proteins before hook completion, whereupon it switches specificity to recognize filament-
53 on with receptor I, which phosphorylates it, whereupon it translocates into the nucleus presumably to
54 erefore subjected ribose to these conditions whereupon it was partially converted to 2-deoxyribose.
55 damaged mitochondria in response to stress, whereupon its binding partner, Cdc48, contributes to mit
56 hR recruit the P-TEFb to the cyp1a1 promoter whereupon its kinase subunit phosphorylates the RNA PII
57 generated an average charge state of 5.88+; whereupon, liquid chromatography/electrospray ionization
58 e transcription factor IRF3 to the promoter, whereupon MafB acted as a transcriptional antagonist, im
59 bridges (as many as 18 for specific binding) whereupon many of the unmasked charged groups hydrate an
62 s triggers the cells to reactivate the virus whereupon most are killed by CTL(IEs) before they can re
63 ctivated with 10 ng/ml LPS for various times whereupon N-acetylcysteine (30 mM) and alpha-tocopherol
64 ited to separate and purify target analytes, whereupon plutonium and neptunium were simultaneously is
65 by rnc) cleaves the pnp untranslated leader, whereupon PNPase represses its own translation by an unk
66 h MPO and PON1 interact during inflammation, whereupon PON1 binding partially inhibits MPO activity,
69 FcgammaRIIb to promote SHIP phosphorylation, whereupon SHIP binds to Shc and dissociates from Fcgamma
70 xylates, with 3-cyanochromones is described, whereupon spirochromenofuran derivatives 5 or 6 were obt
71 n=50) or a severe AMI (anterior AMI; n=50), whereupon surviving animals (n=36 moderate, n=33 severe)
72 umpy forms" until entry into the tsetse fly, whereupon TbPTP1 is inactivated and major changes in par
74 olved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine i
75 using the polarizable continuum model (PCM), whereupon the activation of the C-CN bond was found to b
76 (TTF*+) or dicationic (TTF2+) counterparts, whereupon the alpha-CD ring, moves along the dumbbell to
78 chanism is a weak base "ion-trapping" effect whereupon the basic drug is concentrated in the acidic f
80 ent network that eventually fills the gland, whereupon the buds shrink in size and become mitotically
82 expansion of the ductal cells as a monolayer whereupon the cells were overlaid with a thin layer of M
83 sine, is then added to the reaction mixture, whereupon the DNA molecules bind electrostatically to th
84 0.06), through the spin transition of iron, whereupon the elastic moduli exhibited up to 25% softeni
85 of an intrahelical, fully base-paired oxoG, whereupon the enzyme promotes extrusion of the target nu
86 dc42 localizes the exocyst to primary cilia, whereupon the exocyst targets and docks vesicles carryin
87 localizes the exocyst to the primary cilium, whereupon the exocyst then targets and docks vesicles ca
89 obalamin-colchicine prodrug by cancer cells, whereupon the hydrazone linker undergoes hydrolysis in t
90 on sampling-leads to a randomized algorithm whereupon the kernel induces a probability distribution
91 ome fixed when environment variation is low, whereupon the mean fitness in the population is higher t
92 transiently translocated into the ER lumen, whereupon the NST domain is glycosylated to yield an ina
93 host plasma membrane and enters the cytosol, whereupon the P8 shell disassembles and the polymerase c
94 DMB were soaked in nicotinate mononucleotide whereupon the physiological reaction occurred in the cry
95 ypeptide that is imported into mitochondria, whereupon the pre-sequence is proteolytically removed to
96 naffected until [Zn] increased to 20 microM, whereupon the radius of gyration, RG, values increased f
97 r specifically binds methyl epoxyfarnesoate, whereupon the receptor homodimerizes and changes tertiar
98 iably deprotonated at physiological pH also, whereupon the resultant thiolate nucleophile may play an
99 ith a time constant of approximately 500 fs, whereupon the retinal rapidly twists and encounters a se
100 ugh the RAC1-NADPH oxidase 1 enzyme complex, whereupon the senescent cells express an antifibrosis ge
101 pplied strain until a mechanical yield point whereupon the stress cannot increase anymore, afterward
102 portal that is embedded in the capsid wall, whereupon the structure of the portal and its interactio
103 pattern by 96 hours postfertilization (hpf), whereupon the temporal pattern of neuroD expression in c
104 ion by recruiting Csk to active Src kinases, whereupon their activities and consequent c-myc inductio
105 equired for maintaining the tumor phenotype, whereupon there is a switch from a gene expression progr
106 ss activated to differentiate to adipocytes, whereupon these cells reduce expression of several prote
107 until induced during regeneration or aging, whereupon they become Notch1-dependent and fail to fully
108 activated by an associated tyrosine kinase, whereupon they dissociate from the receptor and dimerize
109 d into a mammalian skin by a sandfly vector, whereupon they encounter increased temperature and toxic
110 nt female changes in habitat use across time whereupon they increasingly relied on steeper post-glaci
111 d Jag1 expression in hepatic stellate cells, whereupon they interacted with hepatic progenitor cells
113 the chromosomes reached the cell periphery, whereupon they often somersaulted and returned to the ce
114 ken end until they encounter a chi sequence, whereupon they produce a 3' single-stranded DNA tail ont
115 eria until the insect tissues are exhausted, whereupon they reassociate and leave the cadaver in sear
116 y activation of endogenous adenylyl cyclase, whereupon they receive stimulation from adjacent PE via
117 r onto the biomolecule-containing particles, whereupon they were sampled into the inlet of our spectr
118 ity to efficiently infect immature human DC, whereupon those DC were observed to undergo rapid activa
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