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1 strokes, 369 occurred at age >/=80 years, of which 124 (33.6%) were in non-anticoagulated patients wi
2 ary Intervention) trial, a clinical trial in which 2,604 patients with chronic angina and incomplete
3 Central to this problem is the mechanism by which a brain region adjusts its activity according to t
5 ally pathogenic gene variants in families in which a person had multiple congenital malformations.
6 this hypothesis, we created a mouse model in which a portion of the sciatic nerve from one hind limb
7 demonstrate an lncRNA-mediated mechanism by which a transcriptional factor conveys a general chromat
8 fection in a cell.IMPORTANCE The pathways by which a virus enters a cell transform its packaged genom
9 ntroduce uses precast gelatin-based molds in which a whole mouse brain is embedded, flash frozen, and
10 d of density functional theory calculations, which account for the observed trends and levels of enan
11 termining migraine risk and characteristics, which accounts for sex differences, but there is also ev
12 ic transcripts of Alu transposable elements, which activate the NLRP3 inflammasome and additional dow
13 a new component of the signaling network by which activating mutations in the FGF receptor inhibit b
14 iferromagnetic corundum derivative Mn2MnWO6, which adopts the Ni3TeO6-type structure with low tempera
15 the C terminus functions as a toggle switch, which affects access of the NADPH substrate to the enzym
16 population of the second bright pipi* state, which affects the dynamics, acting mainly as a "doorway"
17 tified with 70% sensitivity and specificity, which after the incorporation of apolipoprotein epsilon4
18 potent vacuolar-type H(+)-ATPase inhibitors, which all inhibited LGR5 internalization by blocking cla
19 o-eat baby porridge was the only category in which all measured vitamin D concentrations were below t
20 ticulated in various approximation protocols which allow to achieve increasing levels of accuracy, it
21 in-independent malonate decarboxylase (MDC), which allows them to use malonate as the sole carbon sou
22 ity of the Sigma67TEQ-PCN, concentrations of which also decreased significantly between 1975 to 2014.
24 hondria, we demonstrate a novel mechanism by which antimycin-inhibited complex III generates signific
25 with causative changes in the DNA methylome, which appears relatively impervious to drought stress.
26 ronyl nitroxide (NN) biradicals is described which are conjugatively linked through p-ter-phenyl (PPP
27 ective target sites fall within two domains, which are conserved in sequence/structure indicating the
28 igation, forming RNA-DNA chimeric sequences, which are converted to a sequencing library for paired-e
30 r-sized synthetic vesicles, or polymersomes, which are internalized by binding to scavenger receptors
31 re the very early stages of protein folding, which are likely defined by intrinsic local interactions
33 ters, cyanoamides, dinitriles, etc., many of which are not readily accessible with alternative method
34 articularly affected include rice and wheat, which are primary sources of dietary protein for many co
35 umans: the classical inflammatory monocytes, which are rapidly mobilized upon inflammation in a CC-ch
39 igonucleotides can form G-quadruplexes (G4), which are stabilized by the hydrogen bonding of guanine
40 iseases such as Zika and chikungunya, all of which are transmitted by the disease vector mosquito Aed
41 ng) are enriched for regulatory variants, of which at least six (35%) alter transcription factor-DNA
42 n-circuit potential decay transients (OCVD), which attributes to its higher Voc and ff in comparison
43 summarize the existing literature concerning which autophagy proteins are capable of curvature recogn
44 let [UV-C] light except for C difficile, for which bleach and UV-C were used); bleach; and bleach and
45 ium disinfectant except for C difficile, for which bleach was used); UV (quaternary ammonium disinfec
46 her of two inhibitory regions, CBD and LAVP, which block substrate access to the substrate-binding gr
47 hibitors and decreased p53 protein turnover, which blocked their tumorigenic capacity through cellula
49 FindNeighbour2 are server-side applications which build, maintain, and persist either complete (for
51 tion, cleaves chem163S to generate chem158K, which can be further processed to the most active chemer
53 preferentially by oxidative phosphorylation, which can be maintained by bulk but not local monocarbox
54 or a soluble, versatile, HBC-based platform, which can be tailored by incorporation of electroactive
58 also agree with recent "magic ratio rules", which capture the role of connectivity in determining th
60 ents and to identify, with high reliability, which cases should be referred to an ophthalmologist for
61 nt is initiated by the PCGF3/5-PRC1 complex, which catalyzes chromosome-wide H2A lysine 119 ubiquityl
66 ures of the beta2AR reveals the mechanism by which Cmpd-15 modulates agonist binding affinity and sig
67 tionary algorithm is proposed to train FCMs, which combines a dynamical multi-agent genetic algorithm
68 platform for perturbation analysis in vivo, which combines live imaging, real-time image analysis, a
69 away from half-filling, towards a regime in which complex many-body states are expected, and find th
70 ir) were rarely detected in the other river, which confirmed that lake sturgeon in the Detroit and St
71 n multiple major white matter fiber bundles, which connect the fronto-parietal control network and th
72 he proteinaceous polymers are the collagens, which constitute the fibrous matrix outside cells and wh
73 scovery of the first doubly charmed baryon , which contains two charm quarks (c) and one up quark (u)
74 highly tumorigenic glioma stem cells (GSCs), which contributes to tumor initiation and treatment resi
75 uman 28-day menstrual cycle hormone profile, which controls human female reproductive tract and perip
76 1-characteristic trafficking receptor CXCR3, which correlated with significant impairment of renal Tr
77 obtained that binds Shh with a KD of 170 nM, which corresponds to a 120-fold affinity improvement com
78 change in the bending modulus of the bilayer which could be associated with the dissolution of ordere
79 gher rates of ESRD than HIV-positive whites, which could be attributed to the APOL1 renal risk varian
80 tool for investigating brain glycosylation, which could be developed in to brain mapping application
82 could vary in different signaling pathways, which could be related to conformational selection, sign
84 can form rapidly under oxidized conditions, which could help explain low concentrations of organics
85 usal chain between these complex phenotypes, which could inform and prevent disordered eating problem
86 pid, reliable detection of short RNA regions which could open up new opportunities in transcriptome a
87 ects by combining daily global weather data, which creates exogenous variation in running among frien
88 re the most commonly reported environment in which de-escalation occurs, and nursing the disciplinary
89 this system, we have been able to establish which decorations underpin the formation of AVIs, the co
90 lectrical, and electromechanical properties, which delineate them from their bulk counterparts and al
91 c relationship with instantaneous frequency, which depends on the gating rates of the fast voltage-ga
92 h G. vaginalis and other anaerobic bacteria, which depleted tenofovir by metabolism more rapidly than
94 e neural circuits and synaptic mechanisms by which distinct populations of RVM neurons facilitate or
95 y in early-diverging Apicomplexan parasites, which do not divide by canonical binary fission but unde
98 hes effects of TL alterations on the rate at which ECs terminate from effects of the TL on the nucleo
99 and KIT form a positive regulatory loop, in which ectopic DNMT1 expression increases, whereas target
100 tes a considerable spontaneous polarization, which effectively tunes the electrical band bending of T
101 d fluorescence fluctuation imaging analysis, which employs statistical resampling to measure the Eph
102 ilable module of the popular PLUMED library, which enables the simultaneous determination of structur
103 cases are explained by mutations in TSEN54, which encodes a subunit of the tRNA splicing endonucleas
104 ed inactivating mutations of the RASA1 gene, which encodes p120 RasGAP (RASA1), a negative regulator
105 ss-of-function mutations in the MCOLN1 gene, which encodes TRPML1, cause the neurodegenerative lysoso
106 cated in one 15.5-Mb locus on chromosome 13, which encompassed the Bhmt gene and defined a potentiall
110 d potent BTK kinase inhibitor (CHMFL-BTK-11) which exerted its inhibitory efficacy through a covalent
112 ally motivated, Bayesian multitask approach, which explicitly models gene-centric dependencies across
115 structure and composition, abnormalities of which form the direct, pathophysiologic substrate for SC
116 ars compacta and the ventral tegmental area, which form the nigrostriatal, mesolimbic, and mesocortic
118 tor (IR) and mannose receptor C-type 1 (MR), which functions to clear endogenous mannosylated protein
119 levels impair interaction of p62 with Keap1, which further decreases Nrf2 function and antioxidative
120 groundwork for exploration of mechanisms by which gap junction nexus stability modulates intercellul
122 tivities were modeled by Bayesian inference, which had a top-down explaining-away effect that enabled
124 ring of herpes simplex virus type 1 (HSV-1), which has a large DNA genome, using synthetic genomics t
125 Our data suggest a highly disordered CUB, which has acquired a state similar to that of intrinsica
126 rmined whether a PCSK9 variant (rs11206510), which has been identified for early onset myocardial inf
127 quence with independent components analysis, which has been shown to have enhanced signal-to-noise ra
128 ecially for 20-hydroxyeicosatetraenoic acid, which has both vasoconstrictive and natriuretic actions.
130 cularly in Gram-negative hospital pathogens, which has led to renewed efforts in antibiotic drug disc
131 an emerging 'respectful modeling' framework which has two key aims: (i) respecting the models themse
132 bscure class of cyclooctatetraenyl radicals, which have been impossible to access through classical s
133 diates have unique and interesting features, which have been partially revealed through spectroscopic
134 other 14 known galectins in mammalian cells, which have dimeric or tandem-repeated CRDs enabling mult
135 ttentional modulation and mutual inhibition, which have distinct selectivity (feature vs. eye of orig
136 es that of commercial homogeneous catalysts, which have dominated this important industrial process f
137 llected in Africa belong to Indian Assam tea which have likely originated from India and/or Sri Lanka
138 ,Y-substituted 2,6-(pyrazol-1-yl)pyridines], which have produced 16 SCO-active [Fe(II)(bpp(X,Y))2](Z)
141 part to epigenetic reactivation of ERalpha, which in turn increases TAM-dependent anti-estrogen chem
142 follows its own specific substrate gradient, which in turn is produced by the preceding enzymatic rea
143 bution that creates large coherency strains, which in turn may promote crack initiation under load.
144 ored Wnt-Frizzled and Wnt-SFRP interactions, which, in turn, may reveal further Wnt signaling pathway
145 served mitochondrial targeting domain (MTD), which, in unstressed conditions, is inhibited by intramo
146 30 were included in our study, only eight of which included detection of hepatitis D virus RNA among
148 tary masses along with clinical correlation, which includes early involvement of ACTH and TSH and a r
149 ntified using the National Cancer Data Base, which includes more than 70% of patients newly diagnosed
150 myogenesis -related gene expression pattern which includes myogenin and Myf5 up-regulation and Cycli
151 constriction ("waist formation"), pulsation-which increases waist longitudinal stresses-and transver
152 coupling in In0.75 Ga0.25 As quantum wells, which indeed can be tuned by the indium composition, sug
153 ons of the two N-oxyl radicals with toluene, which indicate that the HAT process is characterized by
154 tion temperature of 320.16+/-0.35 degrees C, which indicated that there was good thermal stability of
155 oss-linking of F57Bpa with KCNQ1 was slowed, which indicates that KCNE1 is displaced within the chann
156 veloped a new mouse model, PMN(DTR) mice, in which injection of diphtheria toxin induces selective ne
157 re both accompanied by cell-wall remodeling, which involves the INFLORESCENCE DEFICIENT IN ABSCISSION
158 ition-based model, and termed as dMAGA-FCMD, which is able to deal with large-scale FCMs with up to 5
159 h, a variant of the classic de Bruijn graph, which is aimed at 'detecting and genotyping simple and c
160 mmonly known as the green peach aphid (GPA), which is an important phloem sap-consuming pest of more
161 to high energies (>10 kilo--electron volts), which is ascribed to an accretion disk corona of energet
162 ry skin diseases including chronic urticaria which is associated by increased IL-31 serum levels.
163 wound infections, and cystic fibrosis (CF), which is caused by mutations of the cystic fibrosis tran
164 epresents a different class of 2D materials, which is characterized by low symmetry having 1D metalli
165 billion of economic productivity every year, which is comparable to recent acute epidemics, including
166 n shown to reduce cortical dopamine release, which is critically involved in the reinforcing effect o
167 in (IL)-33 released from breast tumor cells, which is crucial for the induction of IL-13(+) Th2 cells
168 on macrophages, hepatocytes, and adipocytes, which is distinct from the effect of STING activation by
169 ssembling the functional polymerase complex, which is essential for the replication and transcription
170 these synapses leads to initial depression, which is followed by steady-state responses that are fre
171 of an ultrathin titanium nitride (TiN) film, which is incorporated in a gated TiN/SiO2/Ag plasmonic h
176 equivalent to 6.5 x 10(-11) mol m(-2) s(-1), which is over an order of magnitude greater than the rat
178 C-terminus early in the maturation process, which is progressively removed as maturation proceeds.
179 tive gibberellin, GA1, by UV-B in this zone, which is regulated, at least in part, by the expression
180 fibronectin extra domain A isoform (FnEDA), which is relatively restricted in distribution to sites
182 SP at the soma of CA2 compared with CA1 PNs, which is sufficient to drive action potential output fro
183 effect of the HIV-1 auxiliary protein, Nef, which is suspected of extracellular release by infected
184 fy the heritability of set-point viral load, which is the fraction of variation in this phenotype att
185 -dependent plasticity, but the mechanisms by which it controls vesicle fusion and plasticity are not
189 ten require several days of turnaround time, which leads to compromised clinical outcome and promotes
190 he crystal packing would improve solubility, which led to a change from N-methylpyridone to a tetrahy
191 ication of target-specific oligonucleotides, which limits genetics and genomics research on many spec
192 nosis is time-consuming and labor-intensive, which limits the treatment efficiency especially when th
193 flakes due to the reduced contact resistance which mainly resulted from direct contact between the lo
196 -2 expression and this negativity: a finding which may also be relevant for clinical imaging of other
197 create stretches of phosphorylated residues, which may be a means to amplify signals or stabilize a p
198 odulate N2O accumulation in denitrification, which may contribute to further design strategies to con
199 Hence, an anatomic substrate is present, which may enhance the occurrence of EBW during atrial fi
200 e transition between the two configurations, which may give rise to disease-associated repeat expansi
201 in order to influence experimental efforts, which may in turn influence the outcome of cellular diff
202 s generates sparse and orthogonal AP firing, which may support sparse coding during hippocampal infor
203 diated by an inability to recruit the dlPFC, which mediates the cognitive control needed to overcome
204 nclusion, our results suggest a mechanism in which MEF2 transcriptional activity is differentially re
205 In this review, we discuss the extent to which membranes are naturally curved at each of the cell
206 g conditioned place preference and a task in which mice learn associations between cues and food rewa
208 clusion, CMMPs act as 'synthetic stem cells' which mimic the paracrine and biointerfacing activities
209 ions, but also serves as a potential drug by which modulation of neural glycan biosynthesis and thus
210 enic population of human melanopsin-ir RGCs, which most likely are involved in different functions.
211 hat introduction of the pdm2009 H1 virus, to which most of the broadly prevalent, neutralizing antibo
212 rrently no validated biomarkers that predict which mRCC patients will benefit from antiangiogenic the
213 oteins induced by RBM3 and the mechanisms by which mRNAs encoding cold shock proteins escape cooling-
214 ntestinal tract is a highly complex organ in which multiple dynamic physiological processes are tight
215 d uncover a PDL1-dependent mechanism through which MZB cells use their innate immune properties to li
216 hydrolysis state of KaiC create a hub around which nighttime signaling events revolve, including inac
218 study, we aimed to define the mechanisms by which noninflammatory SF modulate Th cell responses and
219 ny gastrointestinal and hepatic diseases for which obesity is the direct cause (eg, nonalcoholic fatt
220 ocardium, and observed a fourth mechanism in which PECs migrate along the surface of the inflow tract
221 induces changes in the filter conformation, which play a key role in defining both selectivity and p
222 A had increased intraepithelial neutrophils, which positively correlated with FEV1 %predicted (r = 0.
224 e consistent with population genetic theory, which predicts that deleterious mito-nuclear interaction
225 increased the number of circulating B cells, which produced elevated amounts of tumor necrosis factor
227 peripheral T follicular helper (pTfh) cells, which provide help to B cells for developing into Ab-sec
228 for genes SPAD follows a beta distribution, which provides a good description of empirical data and
229 of visual areas, dubbed the ventral stream, which rapidly computes object representations that are b
231 natural killer (NK) cell populations, one of which recirculates while the other is tissue resident.
232 he use of the licensed antibody palivizumab, which recognizes site II on both the pre-F and post-F pr
234 nases, such as the LIM domain kinase (LIMK), which regulates actin activity through phosphorylation o
235 story datasets for small-scale societies for which reliable age records are difficult to acquire.
236 the Debye screening layer of an electrolyte, which represents a key physicochemical surface property
237 lator of hermaphroditic cell identity tra-1, which represses the transcription of dmd-3 in hermaphrod
238 uipment such as readers and imaging systems, which require intensive and time-consuming procedures.
239 (9) cfu mL(-1) and 103.97 x 10(7) cfu mL(-1) which resulted in detection limits of 1.99 x 10(4) cfu m
240 7 antibody that stimulates the CD27 pathway, which results in T-cell activation and antitumor activit
241 nt using (13)C-diazomethane" ((13)C-TrEnDi), which results in the methyl esterification of all acidic
243 ts in La1.6-x Nd0.4Sr x CuO4 under pressure, which reveal a large and unexpected shift of p* with pre
244 signals can stimulate angiogenesis, both of which stimulated SRC-2 expression in vitro Furthermore,
245 ested this model using cued recall tasks, in which subjects had to memorize object arrays composed of
246 ions (commonly referred to as sex hormones), which substantially influence many aspects of metabolism
247 senescence in vascular sprouts and vessels, which suggests that pathologic outcomes of centrosome ov
248 ked in open and closed states, respectively, which suggests that their actions are mediated mainly by
252 valency model posited in mammalian cells, in which the coexistence of H3K4me3 and H3K27me3 at develop
253 ts with suspected acute coronary syndrome in which the diagnosis was adjudicated according to the uni
254 P shows an inactive form of the tetramer, in which the dimer pairs are rotated by 18 degrees relative
256 is an open-label, 2-cohort clinical trial in which the first cohort assessed for the safety and effic
257 origami technology and colloidal science, in which the former allows for rapid and robust synthesis o
259 nd polymer and to characterize the degree to which the segments of the nanoparticle-wrapping polymer
261 onalized with polyclonal anti-M1 antibodies, which then serve to identify the universal biomarker for
267 lization of medical education-the process by which trainees in any region gain access to internationa
268 dies must therefore rely on patient samples, which typically display a low proportion of parasites an
269 is built upon studies of diatomic molecules, which typically have electronic states that are relative
270 originates from semi-coherent precipitates, which unavoidably exhibit a heterogeneous distribution t
271 reviously described hemocompatibility score, which uses 4 escalating tiers of hierarchal severity to
272 ed the method of elastic net regularization, which uses repeated internal cross-validation to select
273 beta or with a rapamycin-inducible system in which various phosphatidylinositol phosphatases were rec
274 azole imidazole and triazoles are described, which vary in the linker between the biaryl pyrazole and
276 eads to an extreme form of eye dominance, in which vision through the nondominant eye is degraded.
278 sulin, and GIP concentrations after surgery, which was accompanied by a marked augmentation of pancre
279 ts were found to possess an expanded allele, which was associated with a reduction in the quality of
280 r gain- or loss-of-function changes, part of which was attributable to cysteine-mediated dimer format
281 el fits the observed GPP well (R(2) = 0.79), which was confirmed by other model performance checks th
283 lowing silver nanoparticle (Ag NP) exposure, which was dependent upon key physicochemical properties.
285 follicles were strongly positive for IL-15, which was primarily presented in its membrane-bound form
286 an increase in luciferase activity under HG, which was reduced after mutation of the Sp-1-binding sit
287 s revealed three clusters (subtypes), one of which was strongly associated with genital inflammation.
288 n, respectively, in the extracellular space, which we attributed to a residual calyx attached to the
289 iple features arising from the same analyte, which we call "degenerate features", using a context-dri
290 d novel glycylation-specific antibodies with which we detected glycylation in many primary cilia.
292 or suppressed oligomerization respectively, which we use to tune the levels of Raf/MEK/ERK signaling
293 e midzonal hepatocyte death in control mice, which were strongly minimized in HSC-depleted mice.
294 g of arylenethynylene macrocycles with ODNs, which were used to mediate the assembly of gold nanopart
295 retrospective measurements of peripouch fat, which will foster future investigation of the role of me
296 el community assemblages in future climates, which will require a mechanistic understanding of the tr
299 leukin-1alpha possibly fulfills the criteria which would be expected from a substance to be released
300 ad of MJNV RNA in various tissues of shrews, which would reflect the dynamic infectious status and ci
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