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1  25% free PSA cutoff detected 95% of cancers while avoiding 20% of unnecessary biopsies.
2 ding of the native state at room temperature while avoiding a change to an alkaline state at high tem
3 ance responses to specific antigenic targets while avoiding a general, nonspecific activation of the
4 rafting (CABG), with attendant cost savings, while avoiding a negative impact on coronary events.
5 which C2-KIR interaction evolved from C1-KIR while avoiding a nonfunctional intermediate, that is, ei
6 ility to guard against invasion by pathogens while avoiding a response to the many potential Ags pres
7 ce the permeability of a cell-laden hydrogel while avoiding a significant change in rigidity of the g
8 l fiber increased the rate of CO elimination while avoiding a thoracotomy.
9  and reliable binding with multiple partners while avoiding aberrant interactions.
10 chieve optimal energy and biomass production while avoiding accumulation of toxic metabolites.
11 s that conform to the tumor treatment volume while avoiding adjacent normal tissues.
12  in adoptive immunotherapy to treat melanoma while avoiding adverse autoimmunity-derived effects.
13 I(2) and PGE(2) expression can be suppressed while avoiding adverse cardiovascular events.
14 rocessing conditions which maximize recovery while avoiding aggregation.
15 anscripts that are compatible with each read while avoiding alignment of individual bases.
16 in non-regular secondary structure elements, while avoiding alpha-helices and beta-strands.
17 cating a cellular immune response against DT while avoiding an Abeta-specific T-cell response.
18 or genes identified through previous studies while avoiding an inflation of false positives.
19 n of the biological function(s) for each COG while avoiding annotation errors and overprediction.
20 usly washed, and then digested into peptides while avoiding antibody contamination (on-bead digestion
21 oactive molecules for photo-reconfiguration, while avoiding any damage to the DNA structures.
22 en areas of a nanoparticulate TiO(2) surface while avoiding any deposition of SiO(2) over or under th
23  the sequences to provide suitable reporters while avoiding any impairment of the molecular recogniti
24 t to devise a method that would identify TMs while avoiding arbitrary thresholds on TM sizes and numb
25 ion of any gene or RNA product in the heart, while avoiding artifacts.
26 ontribute to reduction of health disparities while avoiding attribution of causal inference to specif
27 rovide protection against foreign pathogens, while avoiding autoimmunity and immunodeficiency.
28  for maintaining efficient immune responses, while avoiding autoimmunity.
29 R clonotype to have a wide range of agonists while avoiding autorecognition.
30 arge amount of a drug to the tumor site, all while avoiding being eliminated from the body.
31 ure the properties of a given organelle type while avoiding biases caused by ancillary subcellular co
32 ary "nonself" DNA sequences for destruction, while avoiding binding to "self" sequences within the CR
33 ption in a mechanistic and rigorous fashion, while avoiding biological reductionism and artificial ca
34 essive activity associated with cytotoxicity while avoiding blockade of physiologically active NMDARs
35 t body temperatures, seeking relative warmth while avoiding both relative cool and stimuli exceeding
36 led prompt transitions between target levels while avoiding both undershoot and overshoot.
37 d readapt to antigenically variant pathogens while avoiding burnout, which would be the result if all
38 vention, diagnostics, and treatment services while avoiding catastrophic costs incurred by patients.
39 spond to TGFbeta with increased invasiveness while avoiding cell death.
40 acile perylene-to-porphyrin energy transfer, while avoiding charge-transfer quenching of the excited
41 s to ensure optimal cholesterol levels in PM while avoiding cholesterol overaccumulation.
42 get selective, inhibiting projection neurons while avoiding cholinergic interneurons and sparsely con
43 lation is required throughout the synthesis) while avoiding chromatography.
44 ce required for protecting against pathogens while avoiding chronic inflammatory diseases.
45 an der Waals contact between the porphyrins, while avoiding clashes between side chains.
46 tions on pathogen adaptation were calculated while avoiding commonly made simplifications that do not
47 s of a PY-null EPO receptor in primary cells while avoiding compensatory mechanisms, a form retaining
48 man immunodeficiency virus (HIV) replication while avoiding concentrations associated with neuronal t
49 bnormalities in rhythm-generating mechanisms while avoiding confounding factors associated with wakin
50 xperimentation within controlled conditions, while avoiding confounding problems encountered in vivo
51 must precisely connect with inner HCs (IHCs) while avoiding connections with nearby outer HCs (OHCs).
52 proach can specify pseudoknotted structures, while avoiding context-sensitive rules, using a single C
53 ifically directed to bind or cut RNA targets while avoiding corresponding DNA sequences, and we demon
54 ant strains reduce BTZs to inert metabolites while avoiding covalent inactivation.
55 antly shortens the time to recycle NMR tubes while avoiding cross-contamination and tube damage.
56 o self-fuse into separate, single-cell tubes while avoiding crossfusion.
57 ielded precise transcription factor profiles while avoiding crosslinking and solubilization issues.
58 ologists to target tumors more successfully, while avoiding damage to normal tissues.
59 of a specific lysine, retaining it in the ER while avoiding degradation.
60 otect multiple joints of the same individual while avoiding deleterious side effects often associated
61 trotranslocation and proteasomal degradation while avoiding destruction of productive folding interme
62 tively detecting cyanides posing a biohazard while avoiding detection of stable metal cyanides.
63 he acquisition of DNA from exogenous sources while avoiding detrimental consequences from unregulated
64 le to maintain high levels of plasma viremia while avoiding development of immunodeficiency.
65 n optimal size that minimizes metabolic cost while avoiding diffusion limitation.
66 ic aspects of treatment by providing support while avoiding discussion of cognitive-behavioral strate
67 re normal development and tissue homeostasis while avoiding diseases such as cancer.
68 py resulted in significant antitumor effects while avoiding dose-limiting toxicity in a head and neck
69 maintain the long-term health of the patient while avoiding drug-related toxicity and preserving viab
70 atterns that fit a given input parameter set while avoiding enumeration of the entire pattern space.
71 time delay to thereby allow pathogen control while avoiding excess inflammatory damage.
72 or responses sufficiently to clear pathogens while avoiding excessive tissue damage.
73 for replication in the systemic circulation, while avoiding exclusion by host innate immunity.
74 re and softness localized along lines in 3D, while avoiding extended soft Weyl modes.
75 le viral infection to spread within the host while avoiding extracellular immune responses.
76 matal regulation exploits transport capacity while avoiding failure.
77 evidence needed to conclusively document HGT while avoiding false positives.
78 tal compositions of potential conjugates and while avoiding false positives.
79  are highly diagnostic of illicit activities while avoiding false-positive accusations.
80 lds are necessary to detect weak connections while avoiding false-positive results, but will likely s
81 l diversification of the encoded amino acids while avoiding formation of stop codons.
82 dding nucleotides to a growing primer strand while avoiding frameshift and point mutations.
83 cialized inflammatory responses in the brain while avoiding global alterations in CNS function.
84 uch a way as to maximize HIV gene expression while avoiding global T cell activation.
85 y, to potentiate graft-versus-tumor activity while avoiding graft-versus-host disease.
86 facile coverage of the substrate with Cu(2)O while avoiding growth of a thicker Cu(2)O layer and incr
87 a favorable habitat for intracellular growth while avoiding harm to the host.
88  effective therapy to correct tissue hypoxia while avoiding harm to the patient.
89 allenged to maintain acceptable gas exchange while avoiding harmful mechanical ventilation practices.
90 hesis with a treat-to-target insulin therapy while avoiding hypoglycemia and weight gain.
91 atory cells to: (i) navigate the vasculature while avoiding immune system clearance, (ii) remain rela
92  responses hold these chronic viruses at bay while avoiding immunopathologic damage to persistently i
93  known stoichiometry of the reaction network while avoiding implementation of detailed reaction kinet
94 o adopt a triggering-permissive conformation while avoiding improper contacts with heads of neighbori
95  opportunity to minimize the risk of relapse while avoiding in utero medication exposure.
96 g how pathogen-specific immunity is elicited while avoiding inappropriate responses to the background
97  allows us to extend the initial assemblies, while avoiding incorrect extensions and early terminatio
98 eestablishing lung elastance and oxygenation while avoiding increased pulmonary vascular resistance.
99 ic strategies that would be highly efficient while avoiding indiscriminate IKK/NF-kappaB inhibition i
100                  To maximize CDC engraftment while avoiding infarction, we optimized the infusion pro
101 lantation is to balance preventing rejection while avoiding infectious complications.
102 ial to ensure host defense against infection while avoiding inflammatory disease.
103 tability to the episome in replicating cells while avoiding insertional mutagenesis.
104 A molecule between conformational substates, while avoiding inter-atomic clashes.
105 onarily constrained regions of the protease, while avoiding interactions with residues not essential
106                    This allows local effects while avoiding interference with other systems.
107 bound and initially protein-bound fractions, while avoiding interferences from hydrolysis of esterifi
108 he high-affinity uptake of essential metals, while avoiding intracellular contamination by their toxi
109  target biomolecule for covalent attachment, while avoiding irreversible adhesion to the substrate, t
110 menting the number of SERS-active hot-spots, while avoiding irreversible aggregation of the particles
111 ans of delivering IGF-I's potential benefits while avoiding its deleterious side effects.
112 oy the creative side of sexual recombination while avoiding its destructive side.
113  times compared with the continuum approach, while avoiding its prediction of divergent conductance a
114 mical strategy for selective FLT3 inhibition while avoiding KIT inhibition with the staurosporine ana
115 EGylation, thereby simplifying the synthesis while avoiding labeling-induced inactivation of AnxA5 an
116 ver parenchyma as possible in the right lobe while avoiding large vessels, on imager-generated parame
117 ovides fast separation in very small samples while avoiding large voltages and heating effects typica
118 s of greater reproducibility and scalability while avoiding limitations associated with strategies th
119 's unique properties in alkyl cross-coupling while avoiding limitations commonly associated with tran
120 omise for achieving potent immune activation while avoiding limiting immune-related adverse events.
121 ety of diseases and traits in a single study while avoiding major weaknesses of the case-control desi
122 tion (CR), the consumption of fewer calories while avoiding malnutrition, decelerates the rate of agi
123 n size, shape, self-association, and binding while avoiding many limitations associated with size exc
124 neage suppresses atherosclerosis progression while avoiding many of the undesirable side effects caus
125 , as this may provide reasonable ventilation while avoiding massive stomach inflation.
126  transplantation potentially improves growth while avoiding metabolic and other adverse events.
127  than 8 mmol/L (moderate glycaemic control), while avoiding mild hypoglycaemia (<3.9 mmol/L), is a re
128 lts resolve a persistent issue of selective (while avoiding multiwalled nanotubes and other carbon na
129 ovides optimum graft perfusion and recovery, while avoiding myocardial ischemia.
130  is to selectively engage the desired kinase while avoiding myriad off-target kinases.
131 tage of reduced NO(x) and particle emissions while avoiding NH(3) and HNCO slip.
132  of charges in an organic photovoltaic cell, while avoiding non-geminate recombination losses.
133 ures in the crowded environment of the cell, while avoiding non-native conformations that can lead to
134 ecular cooperation of two thiourea sub-units while avoiding nonproductive aggregation.
135 candidates to elicit a neutralizing response while avoiding nonprotective specificities.
136 eating this heterogeneous group of patients, while avoiding nonspecific immunosuppression and its adv
137 otoxic lymphocytes must destroy target cells while avoiding nonspecific killing of surrounding health
138 est variation between supine and prone scans while avoiding observer variability and may be best for
139  be used to obtain new biological activities while avoiding or limiting bacterial resistance.
140 mal gradients over nanometre-scale distances while avoiding other heat transfer mechanisms, namely co
141 recting clinicians to a particular treatment while avoiding other potentially deleterious therapies.
142 arning models, using multiple hidden layers, while avoiding overfitting on the training data.
143 h to capture biases of arbitrary complexity, while avoiding overfitting that would invalidate downstr
144 nce producers aim to promote informativeness while avoiding overstatement.
145 ilicity to achieve robust aqueous solubility while avoiding P-gp mediated efflux.
146 ging by encapsidating only their genomic RNA while avoiding packaging of the more abundant viral subg
147 n their interaction with the gut epithelium, while avoiding phagocytosis by professional phagocytes.
148 5-year incidence of depression was examined, while avoiding possible confounding effects of clinical
149 detect formation of the liquid-ordered phase while avoiding possible detergent artifacts, we have now
150 overexpression of sense or antisense miRNAs, while avoiding potential in vitro selection effects.
151 to maximize the value of such collaborations while avoiding potential pitfalls.
152 romising way to treat patients with diabetes while avoiding potential side effects associated with th
153 uld provide a means to control cell behavior while avoiding potentially harmful genomic integration i
154 s designed to coordinately prevent infection while avoiding potentially harmful inflammation and auto
155 bond by approximately 12 orders of magnitude while avoiding potentially harmful side reactions remain
156 e problem of foraging and maintaining growth while avoiding predators.
157 ism allows rapid completion of DNA synthesis while avoiding premature replisome disassembly.
158 eve high coverage of the region of interest, while avoiding primer dimers and satisfying the physico-
159                To amplify vaccine transgenes while avoiding production of infectious progeny viruses,
160 on of patients with congenital heart disease while avoiding radiation exposure.
161  recognize a conserved substrate (eIF2alpha) while avoiding rapidly evolving substrate mimics such as
162  respond to a wide array of foreign antigens while avoiding reactivity to self is largely determined
163 r the benefits of minimally invasive surgery while avoiding risks of vaginal mesh.
164 tire network in response to a brief stimulus while avoiding runaway excitation; (2) exhibit spatially
165 ated thin-film photovoltaic (PV) technology, while avoiding scarce and/or toxic metals; however, cati
166 sinophils deliver their supporting functions while avoiding self-inflicted injury is poorly understoo
167 lowing rapidly dividing cells to proliferate while avoiding senescence and apoptosis.
168 This model minimizes waste due to expiration while avoiding shortages; the number of remaining platel
169 ubstrate (11)C-N-desmethyl-loperamide (dLop) while avoiding side effects associated with high doses o
170 h in a manner similar to that of doxorubicin while avoiding side effects induced by the free drug.
171 rm has as its goal to effectively treat pain while avoiding side effects.
172 on binding experiments with high sensitivity while avoiding signal overlap that tends to hamper the i
173  doses that stimulate hematopoietic recovery while avoiding significant mast cell activation.
174 ly regarded as a way to administer pyruvate, while avoiding some of the problems associated with the
175 roviding sample molecular weight information while avoiding spot staining and chemical extraction pro
176  enables functional and regulatory diversity while avoiding structural complications.
177 f information technology and redundancy, all while avoiding suboptimization.
178  Kenyan agricultural systems for high yields while avoiding substantial impacts on air quality.
179 ent event-free survival and overall survival while avoiding surgical intervention in a large majority
180 riate sublocalization for an adequate period while avoiding switching on opposing RAS signals.
181  decrease microvascular thrombotic sequelae, while avoiding systemic anticoagulation and its associat
182  decrease microvascular thrombotic sequelae, while avoiding systemic anticoagulation and its associat
183 ategy to protect hESCs from immune rejection while avoiding systemic immunosuppression, potentially f
184  of the metabolic syndrome and dyslipidemia, while avoiding systemic toxicity.
185  efficacious in both major subtypes of DLBCL while avoiding systemic toxicity.
186 ting the therapeutic, anti-lipolytic pathway while avoiding the activation of the parallel flush-indu
187 iinflammatory efficacy by depressing PGE(2), while avoiding the adverse cardiovascular consequences a
188 pertrophy seen with broad TGF-beta blockers, while avoiding the adverse effects due to inhibition of
189 c potential for treating various pathologies while avoiding the adverse psychotropic effects that can
190  use of group-wise averages to reduce biases while avoiding the arbitrary selection of a single indiv
191 ify influence and susceptibility in networks while avoiding the biases inherent in traditional estima
192 of the metabolic potential of the microbiota while avoiding the challenges of cultivating fastidious
193 tile means of evaluating defect interactions while avoiding the complexities of doping.
194 signaling, and Ca2+-dependent cell adhesion, while avoiding the complexities of the global conformati
195 nous adenosine would enhance neuroprotection while avoiding the confounding effects of exogenous liga
196 eta in the progression of established tumors while avoiding the confounding inhibitory effects of TGF
197 ntrolled to ensure it is optimal for defense while avoiding the consequences of excessive inflammatio
198 ost complete hydrolysis of the targeted mRNA while avoiding the degradation of untargeted genes (off-
199 st continuously repair inevitable DNA damage while avoiding the deleterious consequences of imprecise
200 lving power beyond that previously feasible, while avoiding the electrical breakdown inevitable in He
201             To disrupt both CKIdelta/epsilon while avoiding the embryonic lethality of CKIdelta disru
202 he leading haplogroup classifier, HaploGrep, while avoiding the errors that may occur when preparing
203 llows for the analysis of Ag-specific events while avoiding the extreme skewing frequently seen in pu
204 red compounds to be synthesized in the bulk, while avoiding the formation of many binary intermediate
205  approach to generating cytotoxic DNA damage while avoiding the formation of promutagenic lesions tha
206 of other donors as the fourth chelating arm, while avoiding the formation of stereoisomers.
207 controlled and adjusted in plants and algae, while avoiding the formation of the inappropriate epsilo
208 alent bonds in a precise and concise fashion while avoiding the formation of unwanted kinetic by-prod
209 n effectively control local-regional disease while avoiding the functional morbidity of APR.
210  improvements in nighttime activity measures while avoiding the general motor-decreasing effects of t
211 ging graft survival in transplant recipients while avoiding the hazardous sequelae of nonspecific imm
212 37 degrees C even when extensively modified, while avoiding the high temperatures that promote RNA de
213  launch effective immunity against pathogens while avoiding the horror autotoxicus of autoimmunity is
214 cellular conduits, secures virus propagation while avoiding the host's immune surveillance.
215  benchmarking different methods and projects while avoiding the inefficiencies and time delays associ
216 al to allow for rapid noninvasive genotyping while avoiding the inherent shortcomings of tissue genot
217 IZ1 interaction might combat leukemic growth while avoiding the intolerable toxicities of NOTCH inhib
218 erization of N-alkylimidoylketenes, e.g.,1d, while avoiding the intramolecular rearrangements observe
219 ts T. brucei a helical propagation mechanism while avoiding the large viscous drag associated with a
220 red a majority of established primary tumors while avoiding the lethal inflammatory toxicities caused
221  evaluate the inhibition of primase activity while avoiding the limitations of existing assays that r
222 el can explain many geochemical observations while avoiding the major pitfalls of invoking isolated m
223 assical nonsteroidal antiinflammatory agents while avoiding the major side effects associated with in
224 iently targets terminally misfolded proteins while avoiding the misidentification of nascent polypept
225 -T3, clinically node-negative breast cancers while avoiding the morbidity of axillary lymph node diss
226 erties of native auricular elastic cartilage while avoiding the morbidity of traditional autologous r
227 rol of reprogramming factor (RF) expression, while avoiding the mutagenic potential of gene transfer.
228 lude that reframing can promote self-control while avoiding the need for additional willpower expendi
229 s in moderate to good yields in a single pot while avoiding the need for protecting groups.
230 ing which tumors may use this escape pathway while avoiding the need for repeated biopsies.
231 This step allows the assay to be competitive while avoiding the need to establish precise hybridizati
232 peed limitation of confocal Raman microscopy while avoiding the nonresonant background problem of coh
233 e "pinning" of FCD centers near pillar edges while avoiding the opposing effect of confinement.
234 ontrol provided by pulsed laser irradiation, while avoiding the phototoxicity problems encountered wi
235 mally and robustly exploits useful knowledge while avoiding the pitfalls of misleading information.
236 nly through the anterior half of each somite while avoiding the posterior half.
237  the role of these multifunctional molecules while avoiding the potential drawbacks of ectopic expres
238 herapeutic intervention for thrombocytopenia while avoiding the potential generation of neutralizing
239  IL-2 to boost tissue-resident Foxp3(+)Tregs while avoiding the potential toxic effects of systemic I
240 y significant doses of the drug to the tumor while avoiding the previously observed solubility limita
241 pyruvate to scavenge reactive oxygen species while avoiding the problems associated with the instabil
242  and dexmedetomidine is comparably effective while avoiding the respiratory depression association wi
243  boost the protective type 2 T cell response while avoiding the risk of Ab-mediated allergic side eff
244 ld allow for hematologic response assessment while avoiding the risk of deleterious organ progression
245 s the immense regenerative power of ES cells while avoiding the risks associated with direct ES or ES
246 but also to disseminated metastatic disease, while avoiding the risks associated with systemic admini
247  delivery and other biomedical applications, while avoiding the safety risks and engineering challeng
248 n incentive to engage in costly cooperation, while avoiding the second-order free rider problem becau
249 icient but vulnerable water transport system while avoiding the severe effects that water stress pose
250 gs to treat retinal and macular degeneration while avoiding the substantial side effects of the retin
251 may allow widespread protective immunization while avoiding the suppression of lasting immunity that
252  reagent properties and candidates in vitro, while avoiding the synthesis of many putative candidates
253 e method of administering aspirin to the eye while avoiding the systemic side effects associated with
254 coordinated synthesis of heme and hemoglobin while avoiding the toxic effects of chemically reactive
255  inhibit the evolution of de novo resistance while avoiding the toxicity associated with more traditi
256 basic needs (food, water, shelter, and mate) while avoiding the ultimate cost of predation.
257 hat achieves a sufficient affinity for metal while avoiding the unfavorable electrostatics that would
258  decoys, receptor mimics may lessen symptoms while avoiding the use of antibiotics.
259 er of samples in a very short period of time while avoiding the use of toxic organic chemicals.
260 iers and cell-mediated drug delivery systems while avoiding their limitations.
261 f the lambda bacteriophage and RecA systems, while avoiding their major weaknesses.
262 to PCMHs that build on the strengths of HMOs while avoiding their mistakes.
263 enefits of sparse residue interaction graphs while avoiding their potential inaccuracies.
264  is required to allow effective host defense while avoiding tissue damage and autoimmunity.
265 lated to ensure efficient pathogen clearance while avoiding tissue damage.
266 le harms caused by restoration of normoxemia while avoiding tissue hypoxia.
267 proton-transfer and electron-transfer events while avoiding traditional metal-hydride intermediates.
268 heir genomes rapidly and efficiently in vivo while avoiding triggering their hosts' antiviral defense
269  the central incisor with a single injection while avoiding undesirable side effects.
270 led coils that mediate specific interactions while avoiding undesired crosstalk.
271  dignity and well-being of research subjects while avoiding undue impediments to valuable scientific
272  newer induction chemotherapeutic approaches while avoiding unnecessary laparotomy.
273 D-OCT gives both sensitivity and specificity while avoiding unnecessary stoppage of the drug.
274  efficiently control mammal pest populations while avoiding unnecessary suffering, applied and theore
275 ers that have reached clinical significance, while avoiding unnecessary tests and surgery in patients
276 ate immune sensor RIG-I recognizes viral RNA while avoiding unwanted activation by self RNA.
277 loss but also exert anabolic effects on bone while avoiding unwanted effects on reproductive organs.
278 improve cognitive function in these patients while avoiding unwanted peripheral responses associated
279 enefit from this novel transfection strategy while avoiding unwanted side effect.
280 l vaccine would elicit protective antibodies while avoiding virus-specific T-cell responses, which ha
281  remove the thyroid gland from a remote site while avoiding visible neck scars.
282 rs high sensitivity, speed, and convenience, while avoiding waste and error associated with tradition

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