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2 ding of the native state at room temperature while avoiding a change to an alkaline state at high tem
3 ance responses to specific antigenic targets while avoiding a general, nonspecific activation of the
5 which C2-KIR interaction evolved from C1-KIR while avoiding a nonfunctional intermediate, that is, ei
6 ility to guard against invasion by pathogens while avoiding a response to the many potential Ags pres
7 ce the permeability of a cell-laden hydrogel while avoiding a significant change in rigidity of the g
19 n of the biological function(s) for each COG while avoiding annotation errors and overprediction.
20 usly washed, and then digested into peptides while avoiding antibody contamination (on-bead digestion
22 en areas of a nanoparticulate TiO(2) surface while avoiding any deposition of SiO(2) over or under th
23 the sequences to provide suitable reporters while avoiding any impairment of the molecular recogniti
24 t to devise a method that would identify TMs while avoiding arbitrary thresholds on TM sizes and numb
26 ontribute to reduction of health disparities while avoiding attribution of causal inference to specif
31 ure the properties of a given organelle type while avoiding biases caused by ancillary subcellular co
32 ary "nonself" DNA sequences for destruction, while avoiding binding to "self" sequences within the CR
33 ption in a mechanistic and rigorous fashion, while avoiding biological reductionism and artificial ca
34 essive activity associated with cytotoxicity while avoiding blockade of physiologically active NMDARs
35 t body temperatures, seeking relative warmth while avoiding both relative cool and stimuli exceeding
37 d readapt to antigenically variant pathogens while avoiding burnout, which would be the result if all
38 vention, diagnostics, and treatment services while avoiding catastrophic costs incurred by patients.
40 acile perylene-to-porphyrin energy transfer, while avoiding charge-transfer quenching of the excited
42 get selective, inhibiting projection neurons while avoiding cholinergic interneurons and sparsely con
46 tions on pathogen adaptation were calculated while avoiding commonly made simplifications that do not
47 s of a PY-null EPO receptor in primary cells while avoiding compensatory mechanisms, a form retaining
48 man immunodeficiency virus (HIV) replication while avoiding concentrations associated with neuronal t
49 bnormalities in rhythm-generating mechanisms while avoiding confounding factors associated with wakin
50 xperimentation within controlled conditions, while avoiding confounding problems encountered in vivo
51 must precisely connect with inner HCs (IHCs) while avoiding connections with nearby outer HCs (OHCs).
52 proach can specify pseudoknotted structures, while avoiding context-sensitive rules, using a single C
53 ifically directed to bind or cut RNA targets while avoiding corresponding DNA sequences, and we demon
57 ielded precise transcription factor profiles while avoiding crosslinking and solubilization issues.
60 otect multiple joints of the same individual while avoiding deleterious side effects often associated
61 trotranslocation and proteasomal degradation while avoiding destruction of productive folding interme
63 he acquisition of DNA from exogenous sources while avoiding detrimental consequences from unregulated
66 ic aspects of treatment by providing support while avoiding discussion of cognitive-behavioral strate
68 py resulted in significant antitumor effects while avoiding dose-limiting toxicity in a head and neck
69 maintain the long-term health of the patient while avoiding drug-related toxicity and preserving viab
70 atterns that fit a given input parameter set while avoiding enumeration of the entire pattern space.
80 lds are necessary to detect weak connections while avoiding false-positive results, but will likely s
86 facile coverage of the substrate with Cu(2)O while avoiding growth of a thicker Cu(2)O layer and incr
89 allenged to maintain acceptable gas exchange while avoiding harmful mechanical ventilation practices.
91 atory cells to: (i) navigate the vasculature while avoiding immune system clearance, (ii) remain rela
92 responses hold these chronic viruses at bay while avoiding immunopathologic damage to persistently i
93 known stoichiometry of the reaction network while avoiding implementation of detailed reaction kinet
94 o adopt a triggering-permissive conformation while avoiding improper contacts with heads of neighbori
96 g how pathogen-specific immunity is elicited while avoiding inappropriate responses to the background
97 allows us to extend the initial assemblies, while avoiding incorrect extensions and early terminatio
98 eestablishing lung elastance and oxygenation while avoiding increased pulmonary vascular resistance.
99 ic strategies that would be highly efficient while avoiding indiscriminate IKK/NF-kappaB inhibition i
105 onarily constrained regions of the protease, while avoiding interactions with residues not essential
107 bound and initially protein-bound fractions, while avoiding interferences from hydrolysis of esterifi
108 he high-affinity uptake of essential metals, while avoiding intracellular contamination by their toxi
109 target biomolecule for covalent attachment, while avoiding irreversible adhesion to the substrate, t
110 menting the number of SERS-active hot-spots, while avoiding irreversible aggregation of the particles
113 times compared with the continuum approach, while avoiding its prediction of divergent conductance a
114 mical strategy for selective FLT3 inhibition while avoiding KIT inhibition with the staurosporine ana
115 EGylation, thereby simplifying the synthesis while avoiding labeling-induced inactivation of AnxA5 an
116 ver parenchyma as possible in the right lobe while avoiding large vessels, on imager-generated parame
117 ovides fast separation in very small samples while avoiding large voltages and heating effects typica
118 s of greater reproducibility and scalability while avoiding limitations associated with strategies th
119 's unique properties in alkyl cross-coupling while avoiding limitations commonly associated with tran
120 omise for achieving potent immune activation while avoiding limiting immune-related adverse events.
121 ety of diseases and traits in a single study while avoiding major weaknesses of the case-control desi
122 tion (CR), the consumption of fewer calories while avoiding malnutrition, decelerates the rate of agi
123 n size, shape, self-association, and binding while avoiding many limitations associated with size exc
124 neage suppresses atherosclerosis progression while avoiding many of the undesirable side effects caus
127 than 8 mmol/L (moderate glycaemic control), while avoiding mild hypoglycaemia (<3.9 mmol/L), is a re
128 lts resolve a persistent issue of selective (while avoiding multiwalled nanotubes and other carbon na
133 ures in the crowded environment of the cell, while avoiding non-native conformations that can lead to
136 eating this heterogeneous group of patients, while avoiding nonspecific immunosuppression and its adv
137 otoxic lymphocytes must destroy target cells while avoiding nonspecific killing of surrounding health
138 est variation between supine and prone scans while avoiding observer variability and may be best for
140 mal gradients over nanometre-scale distances while avoiding other heat transfer mechanisms, namely co
141 recting clinicians to a particular treatment while avoiding other potentially deleterious therapies.
143 h to capture biases of arbitrary complexity, while avoiding overfitting that would invalidate downstr
146 ging by encapsidating only their genomic RNA while avoiding packaging of the more abundant viral subg
147 n their interaction with the gut epithelium, while avoiding phagocytosis by professional phagocytes.
148 5-year incidence of depression was examined, while avoiding possible confounding effects of clinical
149 detect formation of the liquid-ordered phase while avoiding possible detergent artifacts, we have now
150 overexpression of sense or antisense miRNAs, while avoiding potential in vitro selection effects.
152 romising way to treat patients with diabetes while avoiding potential side effects associated with th
153 uld provide a means to control cell behavior while avoiding potentially harmful genomic integration i
154 s designed to coordinately prevent infection while avoiding potentially harmful inflammation and auto
155 bond by approximately 12 orders of magnitude while avoiding potentially harmful side reactions remain
158 eve high coverage of the region of interest, while avoiding primer dimers and satisfying the physico-
161 recognize a conserved substrate (eIF2alpha) while avoiding rapidly evolving substrate mimics such as
162 respond to a wide array of foreign antigens while avoiding reactivity to self is largely determined
164 tire network in response to a brief stimulus while avoiding runaway excitation; (2) exhibit spatially
165 ated thin-film photovoltaic (PV) technology, while avoiding scarce and/or toxic metals; however, cati
166 sinophils deliver their supporting functions while avoiding self-inflicted injury is poorly understoo
168 This model minimizes waste due to expiration while avoiding shortages; the number of remaining platel
169 ubstrate (11)C-N-desmethyl-loperamide (dLop) while avoiding side effects associated with high doses o
170 h in a manner similar to that of doxorubicin while avoiding side effects induced by the free drug.
172 on binding experiments with high sensitivity while avoiding signal overlap that tends to hamper the i
174 ly regarded as a way to administer pyruvate, while avoiding some of the problems associated with the
175 roviding sample molecular weight information while avoiding spot staining and chemical extraction pro
179 ent event-free survival and overall survival while avoiding surgical intervention in a large majority
181 decrease microvascular thrombotic sequelae, while avoiding systemic anticoagulation and its associat
182 decrease microvascular thrombotic sequelae, while avoiding systemic anticoagulation and its associat
183 ategy to protect hESCs from immune rejection while avoiding systemic immunosuppression, potentially f
186 ting the therapeutic, anti-lipolytic pathway while avoiding the activation of the parallel flush-indu
187 iinflammatory efficacy by depressing PGE(2), while avoiding the adverse cardiovascular consequences a
188 pertrophy seen with broad TGF-beta blockers, while avoiding the adverse effects due to inhibition of
189 c potential for treating various pathologies while avoiding the adverse psychotropic effects that can
190 use of group-wise averages to reduce biases while avoiding the arbitrary selection of a single indiv
191 ify influence and susceptibility in networks while avoiding the biases inherent in traditional estima
192 of the metabolic potential of the microbiota while avoiding the challenges of cultivating fastidious
194 signaling, and Ca2+-dependent cell adhesion, while avoiding the complexities of the global conformati
195 nous adenosine would enhance neuroprotection while avoiding the confounding effects of exogenous liga
196 eta in the progression of established tumors while avoiding the confounding inhibitory effects of TGF
197 ntrolled to ensure it is optimal for defense while avoiding the consequences of excessive inflammatio
198 ost complete hydrolysis of the targeted mRNA while avoiding the degradation of untargeted genes (off-
199 st continuously repair inevitable DNA damage while avoiding the deleterious consequences of imprecise
200 lving power beyond that previously feasible, while avoiding the electrical breakdown inevitable in He
202 he leading haplogroup classifier, HaploGrep, while avoiding the errors that may occur when preparing
203 llows for the analysis of Ag-specific events while avoiding the extreme skewing frequently seen in pu
204 red compounds to be synthesized in the bulk, while avoiding the formation of many binary intermediate
205 approach to generating cytotoxic DNA damage while avoiding the formation of promutagenic lesions tha
207 controlled and adjusted in plants and algae, while avoiding the formation of the inappropriate epsilo
208 alent bonds in a precise and concise fashion while avoiding the formation of unwanted kinetic by-prod
210 improvements in nighttime activity measures while avoiding the general motor-decreasing effects of t
211 ging graft survival in transplant recipients while avoiding the hazardous sequelae of nonspecific imm
212 37 degrees C even when extensively modified, while avoiding the high temperatures that promote RNA de
213 launch effective immunity against pathogens while avoiding the horror autotoxicus of autoimmunity is
215 benchmarking different methods and projects while avoiding the inefficiencies and time delays associ
216 al to allow for rapid noninvasive genotyping while avoiding the inherent shortcomings of tissue genot
217 IZ1 interaction might combat leukemic growth while avoiding the intolerable toxicities of NOTCH inhib
218 erization of N-alkylimidoylketenes, e.g.,1d, while avoiding the intramolecular rearrangements observe
219 ts T. brucei a helical propagation mechanism while avoiding the large viscous drag associated with a
220 red a majority of established primary tumors while avoiding the lethal inflammatory toxicities caused
221 evaluate the inhibition of primase activity while avoiding the limitations of existing assays that r
222 el can explain many geochemical observations while avoiding the major pitfalls of invoking isolated m
223 assical nonsteroidal antiinflammatory agents while avoiding the major side effects associated with in
224 iently targets terminally misfolded proteins while avoiding the misidentification of nascent polypept
225 -T3, clinically node-negative breast cancers while avoiding the morbidity of axillary lymph node diss
226 erties of native auricular elastic cartilage while avoiding the morbidity of traditional autologous r
227 rol of reprogramming factor (RF) expression, while avoiding the mutagenic potential of gene transfer.
228 lude that reframing can promote self-control while avoiding the need for additional willpower expendi
231 This step allows the assay to be competitive while avoiding the need to establish precise hybridizati
232 peed limitation of confocal Raman microscopy while avoiding the nonresonant background problem of coh
234 ontrol provided by pulsed laser irradiation, while avoiding the phototoxicity problems encountered wi
235 mally and robustly exploits useful knowledge while avoiding the pitfalls of misleading information.
237 the role of these multifunctional molecules while avoiding the potential drawbacks of ectopic expres
238 herapeutic intervention for thrombocytopenia while avoiding the potential generation of neutralizing
239 IL-2 to boost tissue-resident Foxp3(+)Tregs while avoiding the potential toxic effects of systemic I
240 y significant doses of the drug to the tumor while avoiding the previously observed solubility limita
241 pyruvate to scavenge reactive oxygen species while avoiding the problems associated with the instabil
242 and dexmedetomidine is comparably effective while avoiding the respiratory depression association wi
243 boost the protective type 2 T cell response while avoiding the risk of Ab-mediated allergic side eff
244 ld allow for hematologic response assessment while avoiding the risk of deleterious organ progression
245 s the immense regenerative power of ES cells while avoiding the risks associated with direct ES or ES
246 but also to disseminated metastatic disease, while avoiding the risks associated with systemic admini
247 delivery and other biomedical applications, while avoiding the safety risks and engineering challeng
248 n incentive to engage in costly cooperation, while avoiding the second-order free rider problem becau
249 icient but vulnerable water transport system while avoiding the severe effects that water stress pose
250 gs to treat retinal and macular degeneration while avoiding the substantial side effects of the retin
251 may allow widespread protective immunization while avoiding the suppression of lasting immunity that
252 reagent properties and candidates in vitro, while avoiding the synthesis of many putative candidates
253 e method of administering aspirin to the eye while avoiding the systemic side effects associated with
254 coordinated synthesis of heme and hemoglobin while avoiding the toxic effects of chemically reactive
255 inhibit the evolution of de novo resistance while avoiding the toxicity associated with more traditi
257 hat achieves a sufficient affinity for metal while avoiding the unfavorable electrostatics that would
267 proton-transfer and electron-transfer events while avoiding traditional metal-hydride intermediates.
268 heir genomes rapidly and efficiently in vivo while avoiding triggering their hosts' antiviral defense
271 dignity and well-being of research subjects while avoiding undue impediments to valuable scientific
274 efficiently control mammal pest populations while avoiding unnecessary suffering, applied and theore
275 ers that have reached clinical significance, while avoiding unnecessary tests and surgery in patients
277 loss but also exert anabolic effects on bone while avoiding unwanted effects on reproductive organs.
278 improve cognitive function in these patients while avoiding unwanted peripheral responses associated
280 l vaccine would elicit protective antibodies while avoiding virus-specific T-cell responses, which ha
282 rs high sensitivity, speed, and convenience, while avoiding waste and error associated with tradition
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