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1 rimers were designed to allow loop formation while retaining 3'-single-strand extensions to facilitat

2 (YL2) that fails to stimulate HCMV infection while retaining 30 to 80% of the activity of the wt prot

3 L43A mutation reduces temperature stability while retaining a ground-state structure similar to WT.

4 ance of a previous lower-throughput platform while retaining a high degree of flexibility, potentiall

5 TCRs had improved T cell activation potency while retaining a high degree of specificity.

6 time by 100-fold and 10-fold, respectively, while retaining a level of analytical performance requir

7 identifying electrolytes with larger windows while retaining a Li(+) conductivity sigma(Li) > 10(-3)

8 differentiate into basophils and mast cells while retaining a limited capacity to differentiate into

9 ses, ricolinostat selectively inhibits HDAC6 while retaining a low and tolerable level of class I HDA

10 ovide a dramatic jump in localized activity, while retaining a low dark-state background remains a si

11 the availability of curative therapy in CLL while retaining a low treatment-related toxicity.

12 Participants performed an ongoing task while retaining a PM instruction to respond to specific

13 vely lose their toxicity against human cells while retaining a potent antiparasitic activity both in

14 lar IC50 for NF-kappaB inhibition of 0.3 muM while retaining a potent EGFR kinase inhibition (IC50 =

15 osteric site affinity as compared with BQCA, while retaining a similar level of positive cooperativit

16 EN2) or more (CEN5) alternate CEN haplotypes while retaining a single haplotype at domestication loci

17 dom access to hundreds of gigabytes of data, while retaining a small disk space footprint.

18 with conductivities a thousand times higher while retaining a strain of 100 per cent.

19 uplicate their chromatin, DNA, and histones, while retaining a subset of epigenetic marks, in a highl

20 AS01 improved the immunogenicity of gE while retaining acceptable safety and reactogenicity pro

21 ther proteins were washed off with 3 M NaCl, while retaining AChE bound to Hupresin.

22 ication of compounds with enhanced stability while retaining activity.

23 the costs associated with larger genome size while retaining adaptive substitutions.

24 ize a flexible loop between helices 3 and 4, while retaining affinity for the hGH receptor, we have e

25 tether, and pendant substituted amido group while retaining an N-methyl group as a site for labeling

26 r phosphate metabolites needed for outgrowth while retaining an outer membrane.

27 icient mice, proliferated for at least 6 mo, while retaining an SSC phenotype in the testes of recipi

28 y and acquire an immunosuppressive phenotype while retaining anti-bacterial and wound-healing propert

29 m doxorubicin-induced neutropenia and anemia while retaining antitumor efficacy.

30 orted across the intestinal epithelial layer while retaining at least partial bioactivity.

31 hogenic GR-dependent processes in the brain, while retaining beneficial aspects of GR signaling.

32 P2 and to block its function in cancer, even while retaining binding capacity to WBP2.

33 uctive IgG antibody blocking antigen binding while retaining binding to FcRn.

34 red binding to heat-shock protein 90 (Hsp90) while retaining binding to RhoGEFs.

35 inflammation and recruitment of innate cells while retaining bioactive TNF to foster neutrophil circu

36 minimum detection levels, i.e., <1% to 4-6%, while retaining biochemical potency.

37 the fraction unbound to human plasma protein while retaining biochemical potency.

38 in extracts enriched in selected polyphenols while retaining biological activity.

39 ovariates to correct for technical artifacts while retaining biological heterogeneity in genomic data

40 ster and undergo spontaneous immortalization while retaining both Arf and p53.

41 hrough synthetic control of the composition, while retaining both structural and functional propertie

42 are deleted, K4CP loses polymerase activity while retaining both transfer activities.

43 s that accommodate 25-residue loop insertion while retaining catalytic activity.

44 Fab fragments of PG102, while retaining CD40 binding, did not induce TRAF degrad

45 ons via a non-proliferative two-step process while retaining cellular plasticity.

46 While retaining certain B-cell signatures, iPCs are pois

47 of the total albumin in human plasma samples while retaining close to 100% for two of three therapeut

48 emplated spatially by A-tracts of B-form DNA while retaining coherent energy transfer.

49 source to avoid X ray-induced sample damage, while retaining comparable acquisition time to the synch

50 omatic compounds with low H/C and O/C ratios while retaining compounds with high H/C and O/C ratios.

51 optimized protocol efficiently removes cells while retaining crucial ECM and biochemical components.

52 n the pyrazole ring (ester, acid, and amide) while retaining DeltaF508-CFTR corrector activity (EC(50

53 lls clonally expanded as spheres in culture, while retaining ductal characteristics.

54 thereby minimizing potential adverse effects while retaining efficacy.

55 nable both antigen and adjuvant dose sparing while retaining efficacy.

56 cyl and beta-syringyl ether-linked compounds while retaining either beta(R)- or beta(S)-stereospecifi

57 preserve the spatial cues in the speech ENVs while retaining/eliminating them from the TFS.

58 genome-wide using less than 1 million cells while retaining endogenous DNA methylation information f

59 permit virus to be propagated in fibroblasts while retaining epithelial cell tropism.

60 g from intrinsic immuno-stimulatory features while retaining excellent safety profile through the use

61 the active site, permitting novel functions while retaining existing function.

62 ating induction of proinflammatory cytokines while retaining expression of anti-inflammatory and anti

63 ifically ablated Tcf1 long isoforms in mice, while retaining expression of Tcf1 short isoforms.

64 ility in comparison to the parent compound 5 while retaining favorable pharmacological parameters tog

65 FcRn-expressing cellular monolayers in vitro while retaining FcgammaRIIIa binding and function, inclu

66 While retaining fidelity, H69 ribosomes exhibit much slo

67 ogation with light and macromolecular labels while retaining fine structure and native biological mol

68 tically modifying the target to be detected, while retaining flexibility in the choice of the reporte

69 components of a functional community portal while retaining flexibility to rapidly extend the resour

70 C must thus be specialized to specific tasks while retaining flexibility.

71 The ribozyme was truncated to 96 nt, while retaining full activity.

72 imultaneously select for protease resistance while retaining function-first by degrading the starting

73 ral fusion peptide may be greatly simplified while retaining fusogenic function and minimizing membra

74 f snakes has lost hindlimb enhancer function while retaining genital activity.

75 ated mouse model that is susceptible to DENV while retaining global immune competence.

76 the high level of resistance to oseltamivir while retaining good fitness of viruses carrying I221L v

77 howed significant improvements in solubility while retaining good functional activity but displayed n

78 affold was optimized to subnanomolar potency while retaining good physical druglike properties.

79 tte of FPs can be localized in plant tissues while retaining good structural cell preservation, and t

80 improved survival in a mouse model of aGVHD while retaining graft-versus-leukemia effects, unveiling

81 aling has recently been shown to reduce GVHD while retaining graft-versus-leukemia/lymphoma (GVL) res

82 ydroxymethylation prior to hypermethylation, while retaining H3K27me3.

83 up to 10 x faster than existing algorithms, while retaining high accuracy and the ability to align r

84 can endure multiple rounds of lyophilization while retaining high biological activity.

85 gh breakage of bonds when strain is applied, while retaining high charge transport abilities.

86 is globally hypomethylated in the CG context while retaining high non-CG methylation.

87 we are able to suppress dark current density while retaining high responsivity in an ultrasensitive n

88 false-positive rates (FPRs) for good outcome while retaining high sensitivity for poor outcome.

89 egime is characterized by large fluctuations while retaining high sensitivity to external varying sti

90 system is dominated by internal fluctuation while retaining high sensitivity to externally varying s

91 logy can reach centimeters penetration depth while retaining high spatial resolution in biological ti

92 ic sensitivity than current 2-tier serology, while retaining high specificity.

93 n sensitivity on novel substrates of kinases while retaining high specificity.

94 This ion swap led to enzyme inactivation while retaining high-affinity substrate interactions.

95 h medicinal chemistry to improve its potency while retaining histone reader selectivity.

96 ide can improve its antimicrobial properties while retaining host biocompatibility.

97 liferative capacity upon secondary challenge while retaining immediate in vivo effector capabilities:

98 goal of making pigs refractory to infection while retaining important CD163 functions.

99 ion where the model is reduced to two states while retaining important characteristics of the origina

100 h resolution by removing projection artifact while retaining in-situ flow signal from real blood vess

101 expands the range of the assigned molecules, while retaining information already observed with the ge

102 cell travel time and relative cell diameter while retaining information on the cell level.

103 rived cfDNA and short nuclear genomic cfDNA, while retaining information provided by standard dsDNA l

104 ut also enhances its ability to restrict HIV while retaining inhibition of retrotransposition.

105 r walls to nucleate and anchor nanocrystals, while retaining intact inner walls for highly conducting

106 recise size with near-neutral surface charge while retaining interior charged groups.

107 ld from deceased and pancreatitis pancreases while retaining islet quality and function.

108 uld stabilize the Ig superfamily domain fold while retaining its ability to bind to LFA-1 and rhinovi

109 ully link the LDH molecule to those surfaces while retaining its activity.

110 physical properties of an engineered protein while retaining its advantages.

111 as recoded with underrepresented codon pairs while retaining its amino acid sequence and determined t

112 t state, tantalum flows like a viscous fluid while retaining its crystal lattice and remaining a stro

113 and showed high factor H-capturing activity while retaining its functional integrity.

114 etwork becomes malleable at room temperature while retaining its insolubility.

115 es to roll on, budding off more disciplines, while retaining its own identity.

116 dditional attribute such as biodegradability while retaining its pharmacological potency.

117 ) that utilized rhesus CD4 more efficiently, while retaining its resistance to antibodies and sera fr

118 idopsis and maize (Zea mays) cellular assays while retaining its specificity.

119 misuse and diversion of daily buprenorphine while retaining its therapeutic benefits.

120 t information in our environment or our mind while retaining limited important relevant contents.

121 to increase bond stability by >40 degrees C, while retaining long-range order and crystal habit.

122 es monomers by thermophoresis and convection while retaining longer polymers exponentially better.

123 like) batteries show outstanding performance while retaining low cost, multifunctionality, versatilit

124 greatly improve discharged energy densities while retaining low loss and high charge-discharge effic

125 unds showed improved activity against MDR-TB while retaining low toxicity with higher microsomal, met

126 based on only 0.3% of the original data set, while retaining low-intensity isotope peaks, was accompl

127 chment of other functional units or payloads while retaining low-micromolar or better affinity for th

128 salt and 47% other dissolved solids removed while retaining majority of the pigment ( approximately

129 in principle, they are infinitely deformable while retaining metallic conductivity.

130 rtantly, FunFrame reduced spurious diversity while retaining more sequences than a commonly used de-n

131 sulted in an increased cellulose hydrolysis, while retaining more than 70% functional stability.

132 ell can cycle over 6,000 times in half cells while retaining more than 85% of their initial capacity.

133 mbly is a reduced representation of raw data while retaining most of the original information.

134 at cerebellum developing into mature neurons while retaining mouse-specific morphometric traits.

135 lic stability and membrane permeability of 2 while retaining mu-opioid receptor binding affinity and

136 cally incorporating long-term climate change while retaining much of the predictive power of a stable

137 nces allow electronic properties to be tuned while retaining nanofibrillar morphologies similar to th

138 tively removes cellular and nuclear material while retaining native dimensionality and stiffness of l

139 sitions of the H168/H318 twin-histidine site while retaining near wild-type activity.

140 in silica-core-gold-shell nanoparticle size, while retaining near-infrared plasmon resonance, and kee

141 deficient in its ability to bind Gbetagamma while retaining normal calcium-dependent Syt1 binding to

142 eered to reduce APC-associated bleeding risk while retaining normal cell-signaling activity, have sho

143 transition (MET) and led to multinucleation, while retaining nuclear AR.

144 ormance because they learn new skills faster while retaining old skills more and because they have a

145 voided and superior miscibility is provided, while retaining optimal pi-pi stacking to warrant effici

146 mproves the rank of near native predictions, while retaining or even improving the numerical efficien

147 molecules can improve membrane permeability while retaining or improving other favorable drug-like p

148 hat selectively disrupts OAZ-O/E interaction while retaining other activities, exhibits apparently no

149 ple mutations significantly reduce synergism while retaining other wild-type kinetic properties.

150 focally bent and shaped into a neural tube, while retaining overall epithelial integrity.

151 us RdRPs can result in functional innovation while retaining overall protein fold and quaternary stru

152 ptimal workflow for removing intact protein, while retaining peptides for MS-based analyses.

153 fectiveness of removing interfering proteins while retaining peptides of interest.

154 , which undergoes plus-end-directed movement while retaining physiological cargo interactions in the

155 al magnetic moment into an electrical signal while retaining picosecond temporal resolution.

156 embled with high accuracy during development while retaining plasticity for local and dynamic regulat

157 so that ESCs can undergo rapid self-renewal while retaining pluripotency is poorly understood.

158 e biased towards mesoderm and endoderm fates while retaining pluripotency.

159 the polar surface area of the P3 substituent while retaining polarity in the P2' side chain.

160 activity of HIV-1 RT in the micromolar range while retaining potency against RT variants carrying one

161 crease solubility and enable dose escalation while retaining potency.

162 ity and plasma-protein binding were improved while retaining potent anti-pseudomonal activity in vitr

163 hat focused on improving compound stability, while retaining potent antiproliferative and splicing ac

164 49e displayed lower hERG K(+) channel block while retaining potent in vitro antibacterial activity a

165 r previously reported pyrazoloketone series, while retaining potent inhibition of ACC1 and ACC2.

166 that is devoid of its natural neurotoxicity while retaining potent oncolytic activity.

167 users through the steps of data integration, while retaining powerful features for more experienced u

168 ty in order to reduce unwanted side effects, while retaining procognitive effects.

169 f gamma oscillations at the stimulation site while retaining propagating waves of gamma oscillations

170 eoside and its ability to replace G residues while retaining proper folding.

171 r promise to selectively abrogate acute GVHD while retaining protection from primary disease relapse

172 r exciton functionalities by at least 10(4), while retaining quantum efficiencies above 50%, and demo

173 de polymorphism-based IBD detection methods, while retaining reasonable accuracy for IBD tracts as sm

174 folding simulations would be more economical while retaining reasonable accuracy, and provide feedbac

175 ocation of somatic reserves to reproduction, while retaining reserves as insurance for survival in un

176 liferation, and anchorage-independent growth while retaining responsiveness to both insulin and IGF-I

177 T2:ERG and PCA3 can avert unnecessary biopsy while retaining robust sensitivity for detecting aggress

178 eased d of the base alloy from 729 to 740 nm while retaining Rq from 1 nm to 3 nm.

179 ) Y37P exhibited enhanced antagonism of AMY1 while retaining selectivity.

180 duce differentiated bronchioalveolar tissue, while retaining self-renewal, as they can undergo serial

181 R-based case-detection algorithms by 20-70%, while retaining sensitivities of 58-75%.

182 imized contribution from white matter signal while retaining sensitivity in detecting gray matter sig

183 s for (99m)Tc-labeled MPS is highly feasible while retaining short imaging protocols.

184 ion and facilitates extracellular secretion, while retaining signaling capacity.

185 rate compared to other denoising algorithms, while retaining significantly more sequence information.

186 tests, exhibiting improved statistical power while retaining similar, and reliable type I errors.

187 t to the Paneth or enteroendocrine lineages, while retaining some stem cell activity.

188 ites (TfbD) are identified with sensitivity, while retaining specificity in the identification the sm

189 enhances the sensitivity of TCR recognition while retaining specificity.

190 errogate increasingly specific subphenotypes while retaining statistical power to detect genetic asso

191 ability to bind an unknown cellular receptor while retaining substantial sialidase activity.

192 assembly to allow access to the obstruction, while retaining subunits that maintain fork licensing an

193 membrane integration via the Sec translocon, while retaining sufficient chemical and structural detai

194 tures and how these structures remain stable while retaining sufficient dynamics for functionality is

195 from a sample solution in approximately 1 s while retaining sufficiently high concentration of a rel

196 permits further speedup in approximate mode while retaining support for selection.

197 gement that restored the minus-strand origin while retaining tetracycline resistance.

198 f the 5'-phosphate from the phosphate pocket while retaining the 3' overhang in the 3' pocket.

199 jections from the mPFC to drive BLA activity while retaining the ability of intercalated neurons to i

200 d for more than 3 days and in a cost savings while retaining the ability of the clinician to obtain t

201 duplex substrates relative to the wild-type, while retaining the ability to bind X junctions.

202 tive means for exposing rare events in SDEs, while retaining the ability to compute bounds on the pro

203 onvenient for forming microcontacts to SAMs) while retaining the ability to deform and flow upon cont

204 rmation of an insulating polydopamine layer, while retaining the ability to detect DA.

205 expanded in vitro for at least five passages while retaining the ability to differentiate into multip

206 To decrease such variability while retaining the ability to distinguish and enumerate

207 mouse T cells, B cells and dendritic cells, while retaining the ability to enhance naive T-cell diff

208 To decrease variability between animals while retaining the ability to enumerate transmitted/fou

209 m each of several popular processing methods while retaining the ability to incrementally renormalize

210 runcated analogs lose all cytotoxic activity while retaining the ability to inhibit protein translati

211 ormation transmission in a given environment while retaining the ability to quickly adapt to a new en

212 f its unconstrained parental peptide 22-fold while retaining the absence of endogenous biological act

213 , which increases the efficiency of sampling while retaining the accuracy of docking results.

214 able to overcome some of these disadvantages while retaining the advantages of both the systems.

215 -squares (MCR-ALS), to circumvent this issue while retaining the advantages of multivariate analysis.

216 er than that of the ten competing statistics while retaining the appropriate type 1 errors.

217 depolymerization and deoxygenation of lignin while retaining the aromatic functionality are attractiv

218 ever, simulating realistically sized systems while retaining the atomistic description remains comput

219 those of silicon-based waveguide modulators while retaining the benefit of further device miniaturiz

220 , low dissociation rate and reduced toxicity while retaining the capability of conjugating Ts1 with m

221 karyocyte maturation or platelet activation, while retaining the capacity for cross-correction in pat

222 ied and maintained for >25 passages (>100 d) while retaining the capacity to differentiate into perip

223 and decreasing the catalyst loading density while retaining the comparably high yield.

224 n in nuclear and multi-generational families while retaining the computational efficiency.

225 the complete (i.e. per-fragment) likelihood, while retaining the computational efficiently of the com

226 urements based on the above X-ray techniques while retaining the coordinate system.

227 nocrystals with negligible Ostwald ripening, while retaining the crystallographic phase (wurtzite or

228 ajor histocompatibility complex restriction, while retaining the desirable antitumor properties of a

229 technique to selectively remove free PARP-1 while retaining the DNA-bound PARP-1, we demonstrate a d

230 ese engineered dimers do not expose the FLE, while retaining the EDE exposure.

231 ndogenous GSNO in several cancer cell lines, while retaining the elements of the SNO functional group

232 While retaining the elevated DNL (indicated by the upreg

233 tantly evolves to escape the immune response while retaining the essential elements needed to mediate

234 integrate multiple advanced unit operations while retaining the fibrous morphology necessary to gene

235 losed-loop control in biological experiments while retaining the flexibility needed for experimental

236 p classical mechanisms throughout the brain, while retaining the flexibility to investigate new mecha

237 or hetero-bivalent binding to the Env trimer while retaining the functional properties of the IgG1-Fc

238 enhancer that allows for skipping of exon 2, while retaining the functional RPGR-interacting domain (

239 s that ablate the arginine's positive charge while retaining the hydrophobic contacts of its methylen

240 ntly in protein solubility and functionality while retaining the identical original amino acid sequen

241 g residues 623-641 of the C-terminal region, while retaining the IEEVD motif, caused a significant de

242 tors to evade immune recognition by the host while retaining the immunomodulatory potential of their

243 o IgG4 equivalent to those of standard IgG1, while retaining the inability to trigger ADCC and CDC.

244 lume samples with reduced reagents and time, while retaining the information content of a typical Wes

245 T), bimatoprost 0.01 % improved tolerability while retaining the intraocular pressure (IOP)-lowering

246 ystals and surface decorating of Na species, while retaining the kesterite CZTS phase.

247 at of Barreto Lemos et al.'s quantum system, while retaining the latter's ability to image with undet

248 l ROS suppression should minimize the former while retaining the latter, which we achieved by express

249 duce the amount of protein present in plasma while retaining the less abundant peptides present in pl

250 lso, BLESS 2 showed at least 11% higher gain while retaining the memory efficiency of the previous ve

251 aterial (black and white photographic film), while retaining the necessary precision to identify sulf

252 To produce strong SERS intensity while retaining the nonaggregated state and biocompatibi

253 te replacement of its anionic organic linker while retaining the original extended inorganic layer.

254 by L2R containing an N-terminal epitope tag while retaining the original promoter.

255 of these gene loci lose repressive H3K27me3 while retaining the permissive H3K4me3 modification.

256 y, ghost cell production and membrane damage while retaining the pole localization.

257 emical properties of the designed inhibitors while retaining the potency for neural nitric oxide synt

258 most effective combination to remove albumin while retaining the protein of interest.

259 es the electron-density of the labeled cells while retaining the quality of the ultrastructure.

260 odel is proposed to reduce the resource cost while retaining the relevant ionic dynamics.

261 2 to evoke pneumonic plague in a mouse model while retaining the required immunogenicity needed for s

262 flexibility of the main His-beta-Ala chain, while retaining the rigidity conferred by the Zn-imidazo

263 nctionally demethylate expressed gene bodies while retaining the role of MeCP2 in chromatin organizat

264 thenticated, authorized and encrypted manner while retaining the same characteristics of standard Bit

265 a) with respect to the host cations (La, Sm) while retaining the same charge state.

266 sign avenue to increase open-circuit voltage while retaining the short-circuit current.

267 e polarization of the particles takes place, while retaining the size-quantized nature of the materia

268 d analogues ('human receptor') than avian H7 while retaining the strong binding to alpha-2,3-linked s

269 the K(+) ion sites partially by Li(+) ions, while retaining the structural integrity and accessible

270 ely protect the magnetic core from corrosion while retaining the superior contrast effect for MRI in

271 llular ligand-binding domain of the receptor while retaining the transmembrane and tyrosine kinase do

272 geometry) leads to switching to an off state while retaining the ultrahigh electron mobility in the o

273 ior to elephant ivory and selected plastics, while retaining the visual appeal of a naturally occurri

274 sses that augment the structures' capability while retaining their essential features.

275 Those neurons adapt to frequent sounds while retaining their excitability to rare sounds.

276 reduced ability to cross-present protein Ags while retaining their exogenous peptide presentation cap

277 ngs or neutral molecules larger than 3.4 nm, while retaining their high permeances to organic solvent

278 nvolved--qubits--communicate to other qubits while retaining their identity.

279 While retaining their mechanical properties and remainin

280 favor the expansion of human muscle SP cells while retaining their myogenic potential have yet to be

281 capturing membrane proteins on chip surfaces while retaining their native conformation.

282 at reduce their negative psychological costs while retaining their positive societal benefits.

283 lpha) and immunomodulatory (IL-10) cytokines while retaining their suppressive capacity.

284 nize into organoids that self-renew in vitro while retaining their tissue-of-origin commitment, genet

285 out of the tropics (OTT) to higher latitudes while retaining their tropical presence.

286 als that reduce their environmental toxicity while retaining their useful antibacterial properties ca

287 hydrogen bond donor and acceptor groups, all while retaining their Watson-Crick geometries.

288 rum, giving access to metabolite information while retaining tissue integrity and hence allowing dire

289 t of molecules associated with axonal damage while retaining transcription factors modulating neuropr

290 r IIx) yielded negligible rRNA reads (<3.5%) while retaining transcriptome sequencing fidelity.

291 ulation of constitutive proteasome subunits, while retaining unaltered immunoproteasome subunit expre

292 aches to the rational attenuation of VSIV NV while retaining vector immunogenicity and have led to id

293 ty compared to the gold-standard (N-MePhe)4, while retaining very high transport values.

294 is defined by their ability to secrete IL-1 while retaining viability, yet it is unclear how IL-1 ca

295 rinsic ability of emm1 S. pyogenes to spread while retaining virulence.

296 rtially recreate a complex antibody epitope, while retaining virus viability.

297 identities at the cleavage site (e.g. T^G), while retaining Watson-Crick sequence generality beyond

298 lacks the phylogenetically conserved stem P1 while retaining wild-type activity.

299 s subtilis that allows tRNA(Ile) mischarging while retaining wild-type Ile-tRNA(Ile) synthesis activi

300 te the p53 pathway by mutating p19(ARF)/MDM2 while retaining wild-type p53 allele.

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