ライフサイエンスコーパス: white adipocyte

1 ered energy storage capacity and browning of white adipocytes.

2 mption required the presence of beta3-ARs in white adipocytes.

3 liver kinase b1 and histone deacetylase 4 in white adipocytes.

4 (LD) growth and triglyceride (TG) storage in white adipocytes.

5 thetic nerve fibers that directly "envelope" white adipocytes.

6 o increase the brown-like characteristics in white adipocytes.

7 nesis pathway, in mature brown as well as in white adipocytes.

8 he differentiation and function of brown and white adipocytes.

9 glucose uptake in skeletal muscle but not in white adipocytes.

10 nduces, Ppargc1a and Prdm16 transcription in white adipocytes.

11 metabolic rate and attenuated hypertrophy of white adipocytes.

12 chymal cells and inhibits differentiation of white adipocytes.

13 e ability for efficient differentiation into white adipocytes.

14 ochondrial depolarization in human and mouse white adipocytes.

15 s with mitochondrial fatty acid oxidation in white adipocytes.

16 eous (SC) or intra-abdominal epididymal (EP) white adipocytes.

17 cted to a subset of preadipocytes and mature white adipocytes.

18 in determining the switch between brown and white adipocytes.

19 wn adipocytes stimulates their conversion to white adipocytes.

20 f a latent leptin-stimulated caloric sump in white adipocytes.

21 ion in mammals; that is, fat mobilization in white adipocytes.

22 by up-regulating fatty acid oxidation within white adipocytes.

23 apular brown adipose tissue and subcutaneous white adipocytes, a cell autonomous effect.

24 other maneuvers that increase cAMP levels in white adipocytes acutely induces mitochondrial uncouplin

25 roplets in brown adipose tissue, and smaller white adipocytes after a high fat diet feeding or in age

26 t fat tissues in vivo, i.e. inguinal fat for white adipocytes and brite cells, interscapular brown ad

27 s, beige adipocytes sporadically reside with white adipocytes and emerge in response to certain envir

28 circulating hormone released primarily from white adipocytes and is crucial for regulating satiety a

29 ycolytic metabolism within subpopulations of white adipocytes and preadipocytes.

30 Adiponectin is a hormone secreted from white adipocytes and takes part in the regulation of sev

31 he significance of fat-storing properties of white adipocytes and the role of local FSP27 in whole-bo

32 pressed in skeletal muscle, heart, brown and white adipocytes, and testes.

33 It is generally assumed that white adipocytes arise from resident adipose tissue mese

34 with induction of brown fat-like features in white adipocytes, as demonstrated by increases in brown

35 rose non-fermenting-related kinase (SNRK) in white adipocyte biology was investigated.

36 f Egr1 identifies the molecular signature of white adipocyte browning downstream of Egr1 deletion and

37 ented uncoupled respiration predominantly in white adipocytes (browning), whereas streptomycin antago

38 protein-1 (Ucp1) mRNA and protein levels in white adipocytes by selectively activating the retinoic

39 nt mice not producing brown fat suggest that white adipocytes convert into fat-oxidizing cells when b

40 tivator-3 (SRC-3) is a critical regulator of white adipocyte development.

41 has been described as an essential player in white adipocyte differentiation in mice.

42 Furthermore, both brown and white adipocyte differentiation is markedly impaired in

43 f bone morphogenetic proteins (BMPs) support white adipocyte differentiation, BMP7 singularly promote

44 mic reticulum membrane protein essential for white adipocyte differentiation.

45 ipocytes, and ear mesenchymal stem cells for white adipocytes from adult mice.

46 Fragmentation of lipid droplets in white adipocytes from FSP27-KO mice caused both increase

47 levance of these effects in vivo, we studied white adipocytes from ob/ob mice during the development

48 Inhibition of the white adipocyte genes also depends on the expression of

49 unilocular lipid droplets and expression of white adipocyte genes suggest conversion of brown adipos

50 Leptin, secreted by white adipocytes, has profound feeding, metabolic, and n

51 White adipocytes have a unique structure in which nearly

52 both the de novo development of a subset of white adipocytes in adults and a previously uncharacteri

53 White adipocytes in adults are typically derived from ti

54 ce, our results reveal an unexpected role of white adipocytes in maintaining properties of preexistin

55 ia-inducible factor 1alpha (HIF-1alpha) than white adipocytes in response to low O(2) but induced hig

56 ing precursor fibroblasts differentiate into white adipocytes in the embryo.

57 Furthermore, we also confirmed that white adipocytes in visceral fat of metabolically unheal

58 e essential for the browning of subcutaneous white adipocytes in vitro and in vivo.

59 thetic agonists induces a brown phenotype in white adipocytes in vivo and in vitro.

60 ge-related transition of beige adipocytes to white adipocytes in vivo, whereas loss of Lsd1 precipita

61 n profiles on SDS gels of CPT I in brown and white adipocytes, indicate that the muscle form of the e

62 The white adipocyte is at the center of dysfunctional regula

63 ed that alternative lineage specification of white adipocytes is also present in human adipose tissue

64 r in cultured brown preadipocytes promoted a white adipocyte-like phenotype and reduced expression of

65 either brown (e.g. uncoupling protein 1) nor white adipocyte markers.

66 oxidative stress by limitingNrf2function in white adipocytes may be a novel means to modulate energy

67 ary human subcutaneous adipocytes as a human white adipocyte model, guiding the selection of appropri

68 petent beige adipocytes progressively gain a white adipocyte morphology.

69 geneous cell population consisting of mature white adipocytes, multipotent mesenchymal stem cells, co

70 OCS-3), was compared in the hypothalamus and white adipocytes of young and old rats before and after

71 filed the transcriptome of primary brown and white adipocytes, preadipocytes, and cultured adipocytes

72 A-2 and GATA-3 are specifically expressed in white adipocyte precursors and that their down-regulatio

73 ning can be engineered by directing visceral white adipocyte precursors to a thermogenic adipocyte fa

74 Knockdown of PPARgamma in mature white adipocytes prevented the usual robust induction of

75 sms by which beta3-AR agonist stimulation of white adipocytes produces these responses are unknown bu

76 homeostasis, at least partly by controlling white adipocyte profile and adiponectin secretion.

77 asculature, but the identity and location of white adipocyte progenitor cells in vivo are unknown.

78 or, is selectively expressed in subcutaneous white adipocytes relative to other white fat depots in m

79 ge-related transition of beige adipocytes to white adipocytes remain unclear.

80 However, it is not clear why differentiated white adipocytes require enhanced respiratory chain acti

81 These data demonstrate that the response of white adipocytes requires HIF-1alpha but also depends on

82 ilocular lipid droplet structure within each white adipocyte (see the related article beginning on pa

83 ore muscular than controls, have 62% smaller white adipocytes, show elevated basal lipolysis that is

84 d-coating protein highly expressed in mature white adipocytes that contributes to unilocular lipid dr

85 hich is typically expressed in brown but not white adipocytes, that RIP140 is essential for both DNA

86 In contrast to the white adipocyte, the brown adipocyte is characterized by

87 sulin regulates metabolism in both brown and white adipocytes, the role of these tissues in energy st

88 ipogenesis and the metabolic state of mature white adipocytes through a common mechanism that is link

89 Exposure of white adipocytes to a peroxisome proliferator-activated

90 contrast, Adrb3 activation stimulates mature white adipocytes to convert into beige adipocytes.

91 The response of white adipocytes to hypoxia required HIF-1alpha, but its

92 sults suggest that NPs promote "browning" of white adipocytes to increase energy expenditure, definin

93 chanism controlling the age-related beige-to-white adipocyte transition and identify Lsd1 as a regula

94 Mobilization of fatty acids from white adipocytes upon fasting is compromised in Sirt1+/-

95 The presence of NPC2 in mature white adipocytes was also necessary for their maintenanc

96 terestingly, approximately 50% of the mutant white adipocytes were multilocular.

97 The mutant white adipocytes were smaller with a larger volume of cy

98 pargamma mutant induces a brown phenotype in white adipocytes, whereas an acetylated mimetic fails to

99 eceptors, noradrenaline induces lipolysis in white adipocytes, whereas it stimulates the expression o

100 Here we demonstrate that the white adipocytes, which share a common precursor with th

101 ssion of thermogenic genes in both brown and white adipocytes, which was largely abolished by inhibit

102 induced pre-adipocyte differentiation toward white adipocytes while directly elevating uncoupling pro

103 strategies to enhance the brown phenotype in white adipocytes while reducing secretion of stress-rela

104 irected pre-adipocyte differentiation toward white adipocytes while suppressing differentiation into

105 ss beta3-AR mRNA abundantly in brown but not white adipocytes, while rodents express beta3-AR mRNA ab

106 g beige (brite) adipocytes to energy-storing white adipocytes, with a reduction in mitochondrial ther

107 nment of a brown adipocyte cell phenotype in white adipocytes, with their abundant mitochondria and i