ライフサイエンスコーパス: whole blood

1 ts had expression quantitative trait loci in whole blood.

2 rformed Tn-seq on GBS strain A909 with human whole blood.

3 The largest number of PFASs were detected in whole blood.

4 ability and predictive potential via qPCR in whole blood.

5 dditive effects in promoting GAS survival in whole blood.

6 nsitive method for detecting ZIKV antigen in whole blood.

7 an endogenous human metabolite in men and in whole blood.

8 o comparisons with neutrophils maintained in whole blood.

9 s the separation of cellular components from whole blood.

10 plasmablast cells were measured in serum and whole blood.

11 IL-8 and of stimulated production of IL-8 by whole blood.

12 egate human platelets, either isolated or in whole blood.

13 ecome easily activated after separation from whole blood.

14 HUVEC were incubated with human whole blood.

15 blood and 113 to receive standard untreated whole blood.

16 in newborn cord, infant, adult, and elderly whole blood.

17 and 99.99% depletion of white blood cells in whole blood.

18 tion of S. aureus cells as low as 682 CFU in whole blood.

19 well below clinical relevancy for undiluted whole blood.

20 or molecular detection of bacterial DNA from whole blood.

21 tems and by thromboelastometry in plasma and whole blood.

22 a triglycerides, or clock gene expression in whole blood.

23 etween groups receiving untreated or treated whole blood.

24 eously detect EBOV and SUDV in 200 microL of whole blood.

25 traversed 5- to 10-mum constrictions even in whole blood.

26 was 4.7 ng/test in serum and 9.4 ng/test in whole blood.

27 piked in 100-fold diluted serum, plasma, and whole blood.

28 arable to standard laboratory-based ELISA in whole blood.

29 showed little evidence for IFN signature in whole blood.

30 nditions such as in platelet-rich plasma and whole blood.

31 s for HFV should be validated with serum and whole blood.

32 the highest concentrations were observed in whole blood.

33 of three species of Borrelia spirochetes in whole blood.

34 new strategy for the isolation of CTCs from whole blood.

35 ive oxygen species formation caused by CC in whole blood.

36 A sample of the whole blood ( 10microL or less) is first collected into

37 0.57), urine (6.36; 95% CI, 2.48-16.32), and whole blood (11.88; 95% CI, 4.12-34.20).

38 Plasma and whole blood (125)I-PrP(Sc) reached maximal levels by 30

39 ractive alphavbeta3 receptors that influence whole-blood 5-HT levels and may influence the risk for a

40 ; mean age across cohorts 42-76 years) using whole blood (9643 European and 2423 African ancestries)

41 architecture of gene expression measured in whole blood across n=1048 males and n=1005 females by tr

42 ent of enzymatic amperometric biosensors for whole blood analysis, to enhance the enzymes stability a

43 essential pH sensors property when aimed for whole-blood analysis.

44 The development of real-time whole blood analytic and diagnostic tools to detect abno

45 ients, 113 were allocated to receive treated whole blood and 113 to receive standard untreated whole

46 tip protein Cpa promoted Alab49 survival in whole blood and appears to fully account for the antipha

47 Using DNAm assayed in whole blood and colorectal tissue of 132 admixed individ

48 Neutrophils were isolated from whole blood and cultured with the known OSM inducers GM-

49 years; n=14) and specimen type (FFPET versus whole blood and dried blood spot; n=12).

50 ) with the same direction of effect for both whole blood and endometrial tissue.

51 en platelets and leukocytes, we tested human whole blood and found that Efb abolishes the formation o

52 sensing approach for rapid PT/INR testing in whole blood and highlight the potential for use at the p

53 at can recover viable bacteria directly from whole blood and identify them in less than 7 h.

54 nd on DNA methylation of nearby CpG sites in whole blood and in the fetal brain.

55 changes in the size of contracting clots in whole blood and in variously reconstituted samples.

56 xpression quantitative trait loci (eQTLs) in whole blood and investigated the messenger RNA expressio

57 ions, performed transcriptional profiling of whole blood and lesional morphea skin, and used double-s

58 sion with a solution containing 10% of fresh whole blood and mechanical ventilation with constant low

59 part explain differences in findings between whole blood and PBMC MGIAs and should be considered when

60 an anti-thrombogenic film in the presence of whole blood and permitted multiple cycles of film regene

61 e we present refractive index data for human whole blood and several aqueous solutions of general int

62 ication requires both plasma generation from whole blood and shipping to specialized laboratories fol

63 niae strongly up-regulated MIF production in whole blood and transcription activity of high-expressio

64 egatively correlates with gene expression in whole-blood and CD8(+) T cells, but not other cell types

65 ved for next-generation sequencing of FFPET, whole blood, and dried blood spot in the evaluation of i

66 ed their inflammatory properties using human whole blood, and the intraperitoneal response after thre

67 , the phenotype was not reproduced in murine whole blood, and those mutants were not attenuated in a

68 We obtained and tested serum, whole blood, and urine samples from 8 patients among the

69 uences from a approximately 1 muL droplet of whole blood, and we amplify plasmid DNA spiked into whol

70 minor allele carriage associated with lower whole-blood arachidonic acid (P </= 0.002), and minor al

71 s often lacking because ideal specimens (ie, whole blood) are not retained routinely at autopsy.

72 t and quantify anti-HPV16 E7 antibodies from whole blood as a non-invasive assisting technology for d

73 icant improvement of cell-count estimates in whole blood as well as in mixtures involving epithelial

74 idate 6 shows good potency in an IDO-1 human whole blood assay and also shows a very favorable ADME p

75 We conclude that the human whole blood assay is an efficient first-phase screening

76 ide inhibitor of C5 cleavage, using in vitro whole-blood assays and an in vivo baboon model of Escher

77 059% red blood cell carryover) by processing whole blood at 3 mL/min, or approximately 300 million ce

78 DNA methylation was measured from whole blood at 421,695 CpG sites distributed throughout

79 rensis in bloodstream infections directly in whole blood at the early stages of infection with a sens

80 lastic properties of the recalcified porcine whole blood, blood added with kaolin as an activator, an

81 several metal salts and human blood samples (whole blood, blood serum, blood plasma, and formed eleme

82 Sixty-three hospitals (70%) could transfuse whole blood but only 7 (7.4%) could separate and bank bl

83 a transcriptomic signature of AMI present in whole blood, but derived from CECs.

84 K cells can be measured in a small volume of whole blood by a commercially available test.

85 Profiling of whole blood by CyTOF demonstrated profound activation of

86 ild Health (PERCH) case-control study tested whole blood by PCR for pneumococcus in children aged 1-5

87 and mtDNAcn (years 15, 25) were measured in whole blood by quantitative PCR.

88 Our findings suggest that a whole blood CEC-derived molecular signature identifies p

89 ion of interferon-gamma (IFN-gamma) in human whole blood cell assay, signifying that anti-inflammator

90 ved the ability of yolkin to stimulate human whole blood cells to release anti-inflammatory cytokines

91 s for dynamic and quantitative assessment of whole blood coagulation using acoustic radiation force o

92 ombined with the caspase inhibitor to form a whole blood cocktail solution, CSWB.

93 transcriptional and cytometric profiling of whole blood collected before vaccination, that heightene

94 re, we performed blinded RNA-seq analysis of whole blood collected from 25 adults diagnosed with CFS

95 ll models, the FRDA mouse model KIKO, and in whole blood collected from patients with FRDA.

96 sfusion of 100 mul, but not 10 mul, of fresh whole blood collected in asymptomatic scrapie-infected d

97 ncer cells (DU145) spiked into a sample with whole blood concentration of the peripheral blood mononu

98 ceptible and 1 resistant), followed by fresh whole blood containing the peak, midpoint, or trough pla

99 Whole-blood cultures stimulated with soluble Leishmania

100 lization and parasite antigen stimulation in whole-blood cultures.

101 SNP rs3820282 is a significant eQTL in whole blood decreasing expression of LINC00339 (also kno

102 of transcriptome-wide gene expression using whole blood-derived RNA from 10,233 participants of Euro

103 profiling of 283 microRNAs was conducted on whole blood-derived RNA from 5023 Framingham Heart Study

104 r over 400,000 CpGs assayed by microarray in whole-blood-derived DNA from 3,743 participants in the F

105 itivity against a panel of gametocyte-spiked whole blood, detecting 10 gametocytes/mL; in comparison,

106 djustment for parental educational level and whole-blood DHA.This study showed associations between r

107 ralized Anxiety Disorder (GAD-7) instrument, whole blood DNA methylation was measured (Illumina 450K

108 Next, using whole-blood DNA from the same twins, we found a signific

109 de association studies of eGFR and CKD using whole-blood DNA methylation of 2264 ARIC Study and 2595

110 methylation levels at 14 CHI3L1 CpG sites in whole-blood DNA, and circulating YKL-40 levels at 4 year

111 Limits on the frequency of whole blood donation exist primarily to safeguard donor

112 45 263 whole blood donors (22 466 men, 22 797 women) were recru

113 p, pragmatic, randomised trial, we recruited whole blood donors aged 18 years or older from 25 centre

114 Plasma was prepared from whole blood drawn on ICU admission in patients with infl

115 lood, and we amplify plasmid DNA spiked into whole blood droplets to represent circulating viral DNA

116 enome-wide transcriptomic profiling of mouse whole blood during blood-stage infections of two strains

117 require transfusion with up to two units of whole blood during the 3 days following study entry.

118 re baseline drift when deployed in undiluted whole blood either in vitro or in vivo.

119 ctive inhibitor of some CAs, also inhibiting whole blood enzymes from several mammalian species, whic

120 re accurately than in standard unconditional whole blood eQTL databases.

121 d high conservation and enrichments for GTEx whole-blood eQTLs located within transcription-factor-bi

122 at IFN-alpha therapy enhanced GAS killing in whole blood ex vivo despite the decreased neutrophil and

123 The deterioration of whole blood ex vivo represents a logistical hurdle in cl

124 eus from these 2 groups were introduced into whole blood ex vivo to determine IL-10 production with v

125 325-4 attenuated bacterial survival in human whole blood ex vivo, which was associated with increased

126 Optimization of whole blood extraction conditions on DBS filter paper cu

127 s174448, and rs174468) and ELOVL5 rs2397142, whole-blood fatty acid composition, and performance in t

128 he absolute number of circulating basophils; whole-blood FCER1A, carboxypeptidase A3 (CPA3), and L-hi

129 e first study of an off-label protocol using whole blood finger-prick samples tested with and without

130 culated platelets were assessed by automated whole blood flow cytometry: absolute immature platelet c

131 in the viscoelastic properties of a drop of whole blood following activation of coagulation with thr

132 ucted an epigenome-wide association study in whole blood for liver enzyme levels, including gamma-glu

133 blood spot samples that are comparable with whole blood for several species of lipids including phos

134 at cytosine-guanine dinucleotides (CpGs) in whole blood from 2306 individuals from 2 population-base

135 Whole blood from 43 persistent carriers and 49 noncarrie

136 To explore this, serum, plasma, and whole blood from 61 adults in Oslo, Norway were collecte

137 We used gene expression data collected from whole blood from 862 individuals and endometrial tissue

138 Macrophages and whole blood from Cmah(-/-) mice also killed bacteria mor

139 blind panel of 98 field-collected samples of whole blood from codon 96 glycine/glycine, captive white

140 rs were determined in SDS-treated plasma and whole blood from EBOV-infected nonhuman primates (NHPs).

141 ar haemoglobin and in vitro growth of BCG in whole blood from healthy UK human volunteers.

142 ofiles and CVD risk was therefore studied in whole blood from individuals from the NBS cohort and RA

143 ginosa strain UCBPP_PA14 (PA14) was grown in whole blood from severely burned patients.

144 The measured values of whole blood from the micro-channel (4.17cP) and the vacu

145 ted an RNA-Seq transcriptomic analysis using whole blood from two HD cohorts, and performed gene set

146 We used microarray data on whole blood from two independent case-control studies of

147 ated positively with mycobacterial growth in whole blood from UK/Asian adults and, to a lesser extent

148 of three (1) REBOA plus 4 units of IV fresh whole blood (FWB), (2) SAAP with oxygenated lactated Rin

149 We examined variations in whole blood gene expression and conducted Mendelian rand

150 We performed an integrative analysis of whole blood gene expression and plasma analytes, compari

151 s) associated with 1,960 traits, we explored whole blood gene expression associations of trait-associ

152 at nine (16%) CpG sites was associated with whole blood gene expression in cis (P < 8.47 x 10(-5)),

153 ene expression levels and clinical data of a whole blood gene expression microarray study, including

154 Here, we show, using longitudinal whole-blood gene expression data from a twin cohort, tha

155 or comprehensively assessing the validity of whole blood glucose measurement in critically ill patien

156 Infants with hypoglycemia (whole-blood glucose concentration <47 mg/dL) were treate

157 Consistently, in human whole blood, GPVI stimulation of platelets increased pla

158 Whole-blood GUCY1A3 mRNA levels were significantly lower

159 the transfusion of 200 mul of prion-infected whole blood has an apparent 100% efficacy for disease tr

160 al epigenome-wide methylation analyses using whole blood highlighted 36 differentially methylated sit

161 formed rapidly and require a small volume of whole blood highlighting their potential utility in clin

162 le potency (IC50 = 12 nM in an ex vivo human whole blood (HWB) assay) and absorption, distribution, m

163 The ancestry-stratified meta-analysis in whole blood identified 328 (9643 European ancestry sampl

164 s that are highly heritable and expressed in whole blood in 1748 unrelated individuals of European an

165 ray-based gene and exon expression levels in whole blood in a cohort of 5257 individuals, exceeding t

166 Here we describe a method to preserve whole blood in its minimally altered state by combining

167 ISA device was used to fractionate 400 mL of whole blood in less than 3 hours, and produce an ultrapu

168 richment method to concentrate bacteria from whole blood in less than 3h.

169 sion of complement receptors on monocytes in whole blood in response to CC exposure.

170 und 2 exerted excellent potency in 50% human whole blood in vitro and blocked AP activity ex vivo aft

171 a few percent after several hours in flowing whole blood in vitro.

172 alidated a four-gene expression signature in whole blood, indicative of a general host systemic respo

173 That the human whole blood inflammatory reactions paralleled the host r

174 enriches viable microorganisms from 10 mL of whole blood into a 200 muL aliquot.

175 cells in response to BCG were measured using whole blood intracellular cytokine staining and flow cyt

176 The qPCR threshold cycle for direct PCR from whole blood is comparable to that of direct PCR with pur

177 Whole blood is frequently utilized in genome-wide associ

178 demonstrate that total ZC3HC1 expression in whole blood is similar across genotypes, despite express

179 Activation of human MAIT cells in whole blood leads to MR1- and cytokine-dependent NK cell

180 on (CE-MS) to assess hemoglobin glycation in whole blood lysate.

181 locus are associated with the regulation of whole-blood manganese (Mn) and multiple physiological tr

182 is the detection of sepsis, where 6-10mL of whole blood may contain as little as one bacterial colon

183 DNA extracted from cancer patients' whole blood may contain somatic mutations from circulati

184 nesis of TBM-IRIS, we performed longitudinal whole-blood microarray analysis of HIV-infected patients

185 [AAV-ZIP8]) resulted in increased tissue and whole blood Mn levels.

186 ic basis for the association of SLC39A8 with whole-blood Mn, potentially linking SLC39A8 variants wit

187 in a C3-dependent manner in an ex vivo human whole-blood model.

188 naling pathways, and with gene expression in whole blood, monocytes, and myocardial tissue.

189 We developed and validated a multivariate whole-blood mRNA-based predictor of melatonin phase whic

190 ons of L-phenylalanine (L-Phe) in plasma and whole-blood newborns samples diagnosed with Phenylketonu

191 MCs by flow cytometry, and examined cells in whole blood obtained before and after challenge by CyTOF

192 study entry with a point-of-care assay using whole blood obtained by fingerprick (concentration >/=10

193 Herein, we typed over 450,000 CpG sites in whole blood of 573 individuals of diverse Hispanic origi

194 ed acid metabolite was found in the serum or whole blood of all eight patients, with concentrations r

195 y decreased Mn levels in multiple organs and whole blood of both mouse models.

196 Here, whole blood of healthy seropositive individuals (n = 75)

197 in FRDA cells, the KIKO mouse model, and in whole blood of patients with FRDA, and this deficiency c

198 Biliary tissue, bile, and whole blood of PSC patients and healthy controls were sc

199 tected the expression of ASFV genes from the whole blood of the GRG, but not the OURT pigs, consisten

200 hage still heavily depends on transfusion of whole blood or blood's hemostatic components (platelets,

201 ETHODS AND Nineteen FFPET (heart) and blood (whole blood or dried blood spot) specimens underwent tar

202 metabolites measured in participants' serum, whole blood, or urine.

203 ) and DNA methylation at probe cg16596957 in whole blood (p = 5.3 x 10(-6) ).

204 In human whole blood, PAV coating at high dose (100 microg/ml) in

205 Activity was determined in whole blood, plasma, and urine.

206 In silico, direct numerical simulations of whole blood predicted elevated hematocrit increases the

207 Using this method, whole blood preserved for up to 72 h can be readily proc

208 Modular analyses of RNA transcripts in whole blood previously identified an upregulation of man

209 Whole blood production for hBD-2 was negatively associat

210 We evaluated whole blood profiling using RNASeq to discriminate infec

211 ent amplification of plasmid DNA spiked into whole blood proves that the large mass of human genomic

212 ta from adipose tissue, skeletal muscle, and whole blood provide evidence that rs75493593 is associat

213 th the Mirasol pathogen reduction system for whole blood reduced the incidence of transfusion-transmi

214 rved for these sensors in flowing, undiluted whole blood, reducing drift of up to 50% to less than 2%

215 However, the whole-blood response to the TLR2/6 agonist staphylococca

216 Both TLN- and HLL-treated rhesus or human whole blood result in significantly prolonged r-time com

217 Combining whole-blood RNA-seq with extensive environmental annotat

218 T. gondii in an approximately 1-mul serum or whole-blood sample.

219 Clinical tests of micronutrient levels from whole blood samples (n=95) show comparable sensitivity a

220 or the analysis of lipid extracts from human whole blood samples and dried blood spots collected on c

221 imit of detection (LoD) for Borrelia spp. in whole blood samples and is able to detect B. burgdorferi

222 and Laminate (PCL) method that accepts eight whole blood samples and provides the capabilities to not

223 on profiles in nasopharyngeal (NP) swabs and whole blood samples during natural RSV and rhinovirus (h

224 nanogram per milliliter levels were found in whole blood samples for all studied compounds with a hig

225 We assessed global RNA expression levels in whole blood samples from 150 participants, representing

226 a human validation by collecting fingerprick whole blood samples from 20 participants to assess iron

227 e Philippines, and DNAm was characterized in whole blood samples from 494 participants (age 20-22 y).

228 l CD63 expression was transiently reduced in whole blood samples from both omalizumab- and placebo-tr

229 le types, including synthetic constructs and whole blood samples from healthy volunteers spiked with

230 parasites, blood glucose, and urea levels in whole blood samples from thick blood films on glass slid

231 nce standard, a test for NK cell activity in whole blood samples identified patients with CRC with 87

232 the laboratory standard IMMULITE analyzer in whole blood samples, a correlation of 0.92 (P<0.0001) wa

233 characteristics to glucose determination in whole blood samples, discriminating among healthy and hy

234 ogy of sample preparation and SERS to spiked whole blood samples, we were able to correctly identify

235 assay for the rapid detection of AIV H5N1 in whole blood samples.

236 ation in which we compared measurements from whole-blood samples obtained by venapuncture with measur

237 rmed meta-analysis and variable selection in whole-blood samples of people of European ancestry (n=69

238 Plasma and finger-stick capillary whole-blood samples were collected from participants in

239 Whole-blood samples were obtained at the acute and early

240 Whole-blood samples were obtained from 96 people with sc

241 Serum and whole-blood samples were treated with 0.1% or 1% sodium

242 General Population Cohort and obtained their whole-blood samples.

243 with venepuncture and finger-stick capillary whole-blood samples.

244 spergillus PCR Initiative for the testing of whole blood, serum, and plasma.

245 Serum specimens and whole-blood specimens collected using the DBS technique

246 ique can be used to collect, store, and ship whole-blood specimens.

247 in a defined leukocyte subset from patients' whole-blood specimens.

248 95% for donor serum panels and 97% for donor whole-blood specimens.

249 by the water content of each sample and the whole blood spectra exhibit additional strong features d

250 chanisms that enhance PGA formation in human whole blood stimulated with thrombin receptor-activating

251 id dendritic cells (pDCs) were isolated from whole blood, stimulated with Toll-like receptor 7 agonis

252 Lipopolysaccharide whole-blood stimulation resulted in a significant change

253 t of age of the individuals, smoking habits, whole-blood storage time, and various inflammatory condi

254 We selected clinical, time-matched, whole blood studies of sepsis and acute infections as co

255 ype 9, type 17, and type 22 cytokines in the whole-blood supernatants.

256 Deletion of nonA did not change GBS-whole blood survival or brain microvascular cell invasio

257 of increased staphyloxanthin production in a whole-blood survival assay.

258 In contrast, TBR normalized to whole blood (TBR-WB) appeared to be a useful outcome mea

259 multiple linear regression model integrating whole blood TCR gamma constant region gene expression le

260 istate-13-acetate (PMA) were added back into whole blood, the extent and rate of clot contraction wer

261 ing effects and hence hindered propulsion in whole blood, the platelet-membrane-cloaked nanomotors di

262 ased approach in combination with individual whole-blood time-activity curves in the other 8 subjects

263 We performed RNA sequencing of lupus patient whole blood to determine common pathways in murine and h

264 In vitro exposure of human whole blood to PhNHOH and NOB demonstrated that only sul

265 METHODS AND We performed whole blood transcriptome and flow cytometry analyses on

266 Whole-blood transcriptome findings complement protein me

267 We thus assessed the whole-blood transcriptome of patients with Chagas diseas

268 By analyzing whole blood transcriptomes of 922 individuals, we have c

269 Whole-blood transcriptomic analyses were conducted to in

270 This comparative whole-blood transcriptomics profiling of virulent and av

271 The whole blood tuberculosis risk signature prospectively id

272 cyte viability and erythrocyte morphology in whole blood under ambient storage.

273 In whole blood under flow, the MARCKS peptides colocalize w

274 with blood group O+, who required up to two whole blood unit transfusions within 3 days of randomisa

275 exed determination of microbial species from whole blood using the paper-folding technique of origami

276 ng between 2-100 + cells were recovered from whole blood using this integrated two-stage device with

277 solation devices by increasing the processed whole blood volume.

278 bronchoalveolar lavage (BAL), and peripheral whole blood was collected into PAXgene tubes for all sub

279 Increased TLR4 and TLR5 gene expression in whole blood was demonstrated in a separate validation co

280 ity for mephedrone on DBS compared to liquid whole blood was observed.

281 When human whole blood was perfused over collagen at arterial shear

282 Whole blood was stimulated with Escherichia coli derived

283 WBC separated from whole blood was trapped by the paper with microelectrode

284 (GAS) better than before initiating therapy, whole blood was used to perform ex vivo GAS killing assa

285 neXpert Ebola assay on clinical venipuncture whole blood (WB) and buccal swab (BS) specimens submitte

286 differentially expressed genes (DEGs) within whole blood (WB) and peripheral blood mononuclear cells

287 vided recommendations for the PCR testing of whole blood (WB) and serum/plasma.

288 ith gene expression data derived from either whole blood (WB) or unstimulated CD4(+) T lymphocytes (C

289 Cs) (current clinical standard for OCS); (2) whole blood (WB); and (3) acellular buffered dextran-alb

290 atelet concentrates prepared from F-LR + MPR whole blood were also nonimmunogenic; that is, 10 of 10

291 m normal and irradiated Wistar rat lungs and whole blood were analyzed by next-generation sequencing

292 erol efflux and anti-inflammatory effects in whole blood were carried by the 2 small species with lit

293 Peripheral blood mononuclear cells or whole blood were collected at baseline from 425 particip

294 ine conditional cis eQTL mapping catalog for whole blood, which can be used to lookup eQTLs more accu

295 The test involves stimulation of whole blood with cytokine that induces NK cells to secre

296 these surfaces can capture tumor cells from whole blood with enrichment factors (specifically vs non

297 Treatment of whole blood with the Mirasol pathogen reduction system f

298 tes and quantify nCD64 levels from 10 mul of whole blood without any manual processing.

299 enables in-transit separation of plasma from whole blood without the need of a centrifuge.

300 obin A1c (HbA1c) and total hemoglobin in the whole blood (without pretreatment) in a single step for