ライフサイエンスコーパス: wholly

1 Veto-induced B-cell tolerance could be wholly abrogated by treatment with the toll-like recepto

2 er the KCNQ3-Y67F or KCNQ3-Y349F mutants and wholly absent in the KCNQ3-Y67F/Y349F double mutant.

3 years), but this finding could be largely or wholly accounted for by the association of cholesterol w

4 lymorphisms flanking the OPN3 and CHML genes wholly accounted for the original linkage in the Danish

5 lthough increases in IgG(4) levels cannot be wholly accounted for within the allergen-specific fracti

6 It appears that a wholly acellular pertussis vaccine series is significant

7 andeiraea simplicifolia lectin I (BS-I), the wholly alpha-gal-specific BS-I isolectin B4, and elicite

8 he absence of lateralization in partially or wholly androgen-insensitive mice suggests that androgen

9 xtant variation and also provide support for wholly apomictic reproduction within the most common clo

10 al, and behavioral adaptations to suit their wholly aquatic lifestyle.

11 Here, we report a wholly artificial compound that acts on small molecules

12 Here, we report on a wholly artificial small-molecule robotic arm capable of

13 functional tetherin derivatives, including a wholly artificial tetherin molecule.

14 %, suggesting that improvements could not be wholly ascribed to better clinic record keeping.

15 paired LV systolic performance and cannot be wholly ascribed to changes in LV preload or compliance.

16 he observation that endogenous Spi-1 mRNA is wholly associated with polysomes in MEL cells, suggests

17 cted in the first hour after reperfusion was wholly attributable to C5a.

18 ve high mortality that does not appear to be wholly attributable to cryptococcal disease.

19 The difference in older patients was almost wholly attributable to increasing periprocedural stroke

20 impairments in Alzheimer's disease were not wholly attributable to simple auditory perceptual or tas

21 in the H5 HA identified here would render a wholly avian H5N1 virus transmissible.

22 ral RNA segments demonstrated that these are wholly avian influenza viruses of the North American lin

23 icity in mice compared to those containing a wholly avian polymerase complex.

24 uction for TGF-beta signaling to T cells can wholly be explained by its role in induction of Foxp3, a

25 ughput into a single extremely versatile and wholly biocompatible technology.

26 All effects on the CR were wholly blocked by propranolol.

27 o the unchanged inter-subunit bridges formed wholly by RNA, the bridges involving proteins undergo la

28 of the ER and often surrounded, partially or wholly, by a network of ER-bound NS5A protein.

29 ve phaeochromocytoma (PC12) cells, which was wholly Ca2+ dependent, but unaffected by Cd2+ (200 micro

30 nding to DC-SIGN and MDDCs is largely if not wholly carbohydrate dependent.

31 reased, the response to elevated [CO(2)] was wholly caused by increased light-use efficiency.

32 bviating the condition of solution averaging wholly changes expectations of the magnitudes and etiolo

33 ation, although the precise mechanism is not wholly clear.

34 ndons, but the underlying mechanisms are not wholly clear.

35 However, the data are not wholly compatible with a strict multiple system account.

36 dues) and SspB (1462 aa residues) are almost wholly conserved (98% identical) in the C-terminal regio

37 Thus, our metafluid is wholly consistent with equilibrium thermal physics, desp

38 me inhibition assays using TLM analogues are wholly consistent with our structural observations.

39 This result is wholly consistent with previous work showing higher over

40 m the soma at the same level as the branches wholly contained in sublamina b, thereby forming an annu

41 erminal domain such that each active site is wholly contained within a single subunit.

42 ns, the core Cdc13 ssDNA-binding activity is wholly contained within a single tight-binding oligosacc

43 of Ca(2+) with actin, while type 2 sites are wholly contained within gelsolin.

44 e that these organisms might be partially or wholly controlled by augmenting host responses.

45 s that are now occupied by plant communities wholly created by humans, in which diversity may reflect

46 s were established in primary cultures under wholly defined (serum-free) conditions that we developed

47 Using a wholly defined spike-in data set and one from a diabetes

48 We have generated a wholly defined spike-in dataset for Agilent microarrays

49 Our previous wholly defined spike-in datasets, the Golden and Platinu

50 ved or novel substrate specificities are not wholly defined.

51 reconstitution, demonstrates that ILC2s are wholly dependent on Bcl11b for their development.

52 e that induced by A1 receptor stimulation is wholly dependent on KATP channel opening.

53 benthic communities in the ocean are almost wholly dependent on near-surface pelagic ecosystems for

54 Moreover, we suggest that odor perception is wholly dependent on the integrity of this memory system

55 e believed to be obligate biotrophs that are wholly dependent on the plant partner for their carbon s

56 response upon re-encounter with antigen) is wholly dependent on the presence of T(H) cells during, b

57 aling upstream of LET-60 RAS in a manner not wholly dependent on the ubiquitin-ligase domain.

58 protein (MAP) kinases ERK1 and ERK2 and was wholly dependent upon extracellular calcium ions.

59 ethanesulfonate-induced alkylation damage is wholly dependent upon glycosylase-mediated initiation of

60 s for words and show that visual recognition wholly depends on attention even for highly familiar and

61 uggests that temperature compensation is not wholly determined by the intrinsic properties of the cen

62 er space", with sensory and cognitive worlds wholly different from our own.

63 d 36 CVD-related proteins, respectively, are wholly disordered.

64 c infection with large doses of virus, it is wholly disposable in both control of virus replication a

65 he biosyntheses of their bicyclic nuclei are wholly dissimilar.

66 he subtypes of dyslexia might have partly or wholly distinct genetic causes.

67 nd reading ability appeared to be largely or wholly distinct, suggesting that the correlation between

68 sequences, design and biochemical testing of wholly DNA sensor constructs, and translation to a funct

69 PCR products are prepared in wholly double-stranded homoduplex form for a baseline me

70 At -60 mV, EPSCs were wholly due to CNQX-sensitive, non-NMDA glutamate recepto

71 fited from surveillance, the program was not wholly effective in cancer prevention.

72 also indicated, but these approaches are not wholly effective.

73 ading module gave polyketide products almost wholly either acetate derived or propionate derived, res

74 he results we describe are consistent with a wholly empirical explanation of color contrast effects.

75 tures of different shapes is determined by a wholly empirical strategy of visual processing.

76 as substrates for secretion seems not to be wholly encoded within the Yop peptide sequence.

77 , this evidence questions existing models of wholly endogenous demographic boom-bust.

78 s, confers transforming activity while it is wholly endoplasmic reticulum-retained in U87 cells.

79 hich the developing spore (the forespore) is wholly engulfed by the adjacent mother cell.

80 irds, H5N2, H5N8, and H5N1, representing the wholly Eurasian lineage H5N8 and two novel reassortant v

81 finding suggests that when animal foods are wholly excluded from the diet, the endogenous production

82 Competition for FABPs may in part or wholly explain the increased circulating levels of endoc

83 isk of death from CHD and stroke that is not wholly explained by antipsychotic medication, smoking, o

84 core excluded volume theory, nor can they be wholly explained by interactions between the head groups

85 ent evidence that the threshold model is not wholly explained by sensory (feedforward) information bu

86 p in survival from prostate cancer cannot be wholly explained by socio-economic differentials in earl

87 the effect of the glycation index on risk is wholly explained by the associated level of A1C.

88 ther influences, i.e. their activity was not wholly explicable in terms of saccade parameters.

89 species, life-history strategies range from wholly freshwater-resident populations, to migratory and

90 ail and confirmed that the projection arises wholly from pyramidal cells.

91 behavior measured by all informants, that is wholly genetic in origin.

92 en recovered from Canadian pigs, including a wholly human H1N2 virus and human-swine reassortants.

93 In contrast, a wholly human H3N2 virus was isolated from a single baby

94 rt, we identified a novel influenza virus of wholly human origin that has been circulating undetected

95 hogenicities and replication kinetics of the wholly human virus and a triple-reassortant virus in 7-w

96 Genetic differences between this wholly human virus and the triple-reassortant viruses ma

97 pulmonary lesions, while infection with the wholly human virus induced only mild pulmonary changes.

98 Our results demonstrate that the wholly human virus replicated to significantly lower tit

99 ine virus into the genetic background of the wholly human virus resulted in a significant increase in

100 2-associated responses, which are largely or wholly IL-4 dependent, such as the production of IgG1 or

101 ila and human, including Parkin S65, did not wholly impair Parkin translocation to mitochondria.

102 icit water were significantly different than wholly implicit solvent calculations with the calculated

103 by a set of DNA cassettes that are prepared wholly in vitro.

104 that the common use of sand or dust proxy is wholly inadequate for the prediction of the behaviour of

105 t of bitter phytonutrients for health may be wholly incompatible with consumer acceptance.

106 rimental vicinal proton couplings, which are wholly inconsistent with the trans conformation.

107 A fourth option, a 'do-nothing' approach, is wholly inconsistent with the well-established scientific

108 ch suggest that the present findings are not wholly inconsistent with those of the earlier study.

109 ual cell's decision to die or survive is not wholly independent but depends, at least in part, on fee

110 at the replicative capacity of Ad5 dl1520 is wholly independent of host cell p53 status, as is the re

111 bability distributions suggests they are not wholly independent processes.

112 where agriculture is thought to have arisen wholly independently.

113 We also show that other colors are less or wholly ineffective.

114 properties of the mirror system are neither wholly innate [14] nor fixed once acquired; instead they

115 summarize variability in the population are wholly insufficient for modeling intraindividual persona

116 They have been construed as wholly intolerant of oxygen, a feature that was original

117 angiogenin, only six residues appeared to be wholly intolerant to substitution: two histidine residue

118 ecessary kinetic studies, catalysis being a "wholly kinetic phenomenon" as J.

119 etastatic D2.A1 organoids were spherical and wholly lacked E-cad expression.

120 um levels; this effect was partially but not wholly mediated through relapse prevention.

121 One mutation, L376W, leads to a wholly monomeric variant that shows full activity.

122 the initial stages of motor learning are not wholly motor but rather involve plasticity in somatic an

123 rom macrophages, in which case the effect is wholly MyD88 dependent but only partially TLR9 dependent

124 offers a preclinical proof-of-concept for a wholly new approach to chemoprevention in carriers of BR

125 f thermodynamic conditions, toward realizing wholly new electronic properties.

126 Overall, our results identify a wholly new facet to the multifunctionality of MDSC in dr

127 ecently, in the 1990s, the introduction of a wholly new form of noninvasive cross-sectional imaging,

128 his MRI approach may provide the basis for a wholly new strategy to evaluate Alzheimer's disease susc

129 both homo and heterosequence nucleopeptides wholly on solid support with high yield and purity.

130 target genes by Bck2 depends partly, but not wholly, on SBF and MBF.

131 these observations is that Rab27a functions wholly or in part as the melanosome receptor for myosin

132 f secondary metabolites that are synthesized wholly or in part by nonribosomal peptide synthetases.

133 thetic ganglion neuronal cell number are due wholly or in part to the division of neuronal cells with

134 y neurological diseases are being associated wholly or in part with functional changes within specifi

135 ins from some B. thuringiensis serovars were wholly or largely assigned to a single ST, for example,

136 t this reduced paternal inheritance might be wholly or partially due to postfertilization events.

137 ented legislation prohibiting smoking in all wholly or partially enclosed public spaces.

138 ITY CRITERIA: Published 1950-2009; conducted wholly or partially in England; original data on inciden

139 A subset of these are located wholly or partially in looped regions in the Y3 and Y4 R

140 ibility that zeta-globin production might be wholly or partially redundant in embryos in which the ad

141 ining hepatitis C virus (HCV)-like IRESs, is wholly or partially resistant to inhibition by eIF2 phos

142 ested in combination with D371A and found to wholly or partially revert these phenotypes.

143 nce evolution, while those whose history was wholly or partially within the dinoflagellate plastid ge

144 sceptibility to diacetyl chloramphenicol was wholly or partly the consequence of intrinsic carboxyles

145 istent with its roles in RNA replication, is wholly or predominantly on the cytoplasmic face of the E

146 on in the absence of detergent and, thus, is wholly or predominantly on the cytoplasmic face of the v

147 monium fluoride quantitatively generates the wholly organic 81-atom-loop trefoil knot.

148 s represents one of the hardest and stiffest wholly organic materials known.

149 dium ethylenediaminetetraacetate affords the wholly organic molecular link.

150 gy, and subsequent demetalation afforded the wholly organic Solomon link.

151 Lilly and Company and ImClone Systems LLC, a wholly owned subsidiary of Eli Lilly and Company.

152 Oncoethix GmbH (a wholly owned subsidiary of Merck Sharp & Dohme Corp).

153 Oncoethix GmbH, a wholly owned subsidiary of Merck Sharp & Dohme Corp.

154 Millennium Pharmaceuticals, Inc, a wholly owned subsidiary of Takeda Pharmaceutical Company

155 Millennium Pharmaceuticals, a wholly owned subsidiary of Takeda Pharmaceutical Interna

156 f strategies used by individual women is not wholly predictable from prepregnant indexes.

157 Although not wholly predictive of clinical success, in vitro and in v

158 ects of team strategy, with no single metric wholly predictive of success.

159 torage, so they can no longer be regarded as wholly pristine.

160 mmense number of sequence combinations makes wholly random sampling unfeasible, two key simplificatio

161 scription elongation and termination using a wholly recombinant archaeal RNAP and synthetic nucleic a

162 information of RNAPs at high-resolution and wholly recombinant archaeal transcription systems, we ar

163 and interaction with the archaeal RNAP in a wholly recombinant in vitro transcription system.

164 information captured by each measure was not wholly redundant.

165 onal properties of developing tendon are not wholly reflected by protein expression and tissue morpho

166 ling is the generation of a basal epithelium wholly replacing the epidermis of the wound.

167 , by making versions of Chordin partially or wholly resistant to Tld cleavage and introducing them in

168 from an anarchic, cycling piwi-1+ population wholly responsible for production of all temporary and d

169 revealed that PKR contributes to but is not wholly responsible for reovirus-induced host shutoff.

170 the notion that a Th2 response is partly or wholly responsible for the inability of Th1-mediated imm

171 ardiovascular risk factors do not seem to be wholly responsible for the increased cardiovascular risk

172 ing that the IL-2 production failure was not wholly responsible for the proliferation defect.

173 onkeys by this time, with ocean barriers not wholly restricting their northward movements, requiring

174 Kraepelin's pivotal distinction was neither wholly right nor wholly wrong: the 2 major psychoses sho

175 from the wild-type crystal structure was not wholly satisfactory, as errors accumulated with successi

176 withdrawal-induced cell death, again by two wholly separate signaling mechanisms, PKA-dependent for

177 ' and stated categorically that 'no organism wholly soft can be preserved'.

178 st time that synthetic alpha-Syn fibrils are wholly sufficient to initiate PD-like LBs/LNs and to tra

179 provide the only experimental approach that wholly supports all the critical aspects of LCR activity

180 omic force microscopy (AFM) show that ADH-41 wholly suppresses the aggregation of Abeta at a substoic

181 A wholly synthetic 20-mer peptide containing cysteine 106

182 The operation of this wholly synthetic and stripped-down system compares to th

183 But efforts to produce wholly synthetic catalytic peptides have typically resul

184 A wholly synthetic interferon, interferon alfacon-1 or con

185 edersen half a century ago, the chemistry of wholly synthetic macrocycles for structure-specific, hig

186 The realization of the Borromean link in a wholly synthetic molecular form is reported.

187 Here we describe a wholly synthetic molecular system that converts an exter

188 Wholly synthetic molecules involving both mechanical bon

189 can be unraveled through the application of wholly synthetic networks with well-defined chemistries

190 Herein, we describe a wholly synthetic small-molecule system that, under the i

191 Developing 'wholly synthetic' macromolecular analogues that can mimi

192 Here, we report on wholly synthetic, water-soluble, and chiral tubules that

193 o the offspring before gestation or if it is wholly the gestational exposure that affects offspring b

194 progression of cells from G1 into S phase is wholly to activate an E2F-1-like activity through phosph

195 s living in darkness, I attribute their loss wholly to disuse"[1].

196 privilege in the CNS is often mis-attributed wholly to the blood-brain barrier.

197 nesis and that this effect can be attributed wholly to the high-dose insulin in SEB-1 cells.

198 ss are those that accrue unexpectedly or are wholly unanticipated.

199 Coarctation stenting was performed wholly under rtMRI guidance in 13 swine.

200 specific aspects of social phenotype remain wholly undescribed.

201 d in the first symmetry-breaking step remain wholly unknown in the most obviously chiral animals, the

202 rences for groups of a given size are almost wholly unknown.

203 ars of work, many thousands of patients, and wholly unreasonable delay in approval of a treatment who

204 luconeogenesis and, outside the cell, exerts wholly unrelated cytokine properties.

205 MOG-specific T cells were not wholly unresponsive though, as they did secrete IL-10 af

206 The patient was wholly unresponsive to sulfonylurea therapy (up to 1.14

207 therapy based on differences in biology are wholly untapped.

208 This region includes c-myc and is wholly within 8q24.

209 ly some monoclonal antibodies, with epitopes wholly within domain 1 of ICAM-3, were able to block bin

210 ) antiport in the transporters-are contained wholly within each subunit of the homodimer.

211 eletion interval spans 600-1,100 kb and lies wholly within the 1.3-Mb region identified by recombinat

212 cts of the E. coli 16S gene were then placed wholly within the IVS sequence, and the 16S gene was del

213 oteoglycan gene family, exists and functions wholly within the tumor microenvironment to suppress tum

214 eneration, because they evolved from a state wholly without sex chromosomes (rather than after a larg

215 tal distinction was neither wholly right nor wholly wrong: the 2 major psychoses show both distinctiv