ライフサイエンスコーパス: wide

1 e enzyme that recognizes a 7-bp motif genome-wide.

2 n dose according to facility continues to be wide.

3 histone H3 lysine 27 methylation chromosome-wide.

4 chromosomal interaction patterns from genome-wide 3C studies are accurately captured in our model at

5 locomotion, here we show that its population-wide activity arises from a low-dimensional spiral attra

6 that of the power sector-has not experienced wide adoption given its high associated costs.

7 Given the wide adoption of polydimethylsiloxane (PDMS) for the rap

8 Despite the wide adoption of TI-seq, there is no computational tool

9 nt surgery in South Carolina utilizing state-wide all-payer discharge claims from 2008 to 2013, linke

10 In schizophrenia, brain-wide alterations have been identified at the molecular a

11 ine a novel concept of functional connectome-wide alterations that are linked to dystonia phenotype a

12 Genome-wide analyses further revealed global DNA hypomethylatio

13 Collectively, our genome-wide analyses implicate condensin in the suppression of

14 Many cost-effective genome-wide analyses of DNA modifications rely on restriction e

15 ylation states are critical to enable genome-wide analyses.

16 tor can be easily used to conduct the genome-wide analysis and the results obtained are quite consist

17 nance in CD8(+) T cells, we performed genome-wide analysis of DNA methylation, histone marking (acety

18 t sequencing of diverse tissues and a genome-wide analysis of Dsx-binding sites.

19 We report genome-wide analysis of gene expression, DNA methylation and sm

20 In the course of a genome-wide analysis of members of a small family of immunoglob

21 This result is consistent with a genome-wide analysis of S. cerevisiae, which reveals that under

22 Here, we present a genome-wide analysis of single-nucleotide polymorphism (SNP) da

23 Genome-wide analysis of the transcribed strand/nontranscribed s

24 Wide and accessible surface of the mesh combined with hi

25 identify aberrant DNA-binding events genome wide and ectopic transcriptional consequences of this bi

26 Here we combine wide-angle X-ray scattering (WAXS) with X-ray photon-cor

27 In situ small/wide-angle X-ray scattering and electron microscopic mea

28 rans (THPs) constitute a core structure of a wide array of bioactive natural products.

29 asis of their diverse and complex roles in a wide array of biological processes.

30 mation and generates behavior by employing a wide array of different cell types.

31 reaction has been successfully tested with a wide array of medicinally important heterocyclic scaffol

32 neurons can function in the integration of a wide array of sensory information and facilitate decisio

33 traits, especially through the use of genome-wide association (GWA) analyses.

34 mmary data from the largest RA and AD Genome Wide Association (GWA) and meta-analysis studies to date

35 ND Two-sample MR was undertaken using genome-wide association (GWA) study data.

36 We performed genome-wide association analyses for twenty serum biomarkers in

37 ord (EHR)-based phenotypes allows for genome-wide association analyses in thousands of traits and has

38 Here, we report the results of genome-wide association analyses of multiple phenotypes and two

39 Genome-wide association analyses were performed in pediatric an

40 Genome-wide association analysis (GWAS) identified genomic regi

41 Using genome-wide association analysis, we identify associations betw

42 Multilocus genome-wide association studies (GWAS) have become the state-of

43 During the past decade, genome-wide association studies (GWAS) have been used to succes

44 Previous genome-wide association studies (GWAS) have identified 18 HbA1c

45 Most genome-wide association studies (GWAS) of QT were performed in

46 In this review, we discuss how genome-wide association studies (GWASs) and recent developments

47 Recent Genome-wide Association Studies (GWASs) for eye diseases/traits

48 Genome-wide association studies (GWASs) have identified sequenc

49 Recent successes in genome-wide association studies (GWASs) make it possible to add

50 Combining data from genome-wide association studies from multiple phenotypes using

51 Genome-wide association studies have implied the association of

52 Genome-wide association studies have revealed an association be

53 Genome-wide association studies identified numerous disease ris

54 Genome-wide association studies of tumor samples have identifie

55 We meta-analyzed 2 genome-wide association studies on self-reported allergy and se

56 Among the participants in the genome-wide association studies, 21 loci jointly influencing sc

57 tely 4200 common variants reported in genome-wide association studies, approximately 1000 de novo mut

58 ssociation results from 7 large-scale genome-wide association studies, we examined the effect of this

59 4184) for triglycerides identified by genome-wide association studies.

60 o the standard univariate analysis in genome-wide association studies.

61 The initial genome-wide association study (GWAS) included 174 Finnish prete

62 elds in terms of gene discovery using genome-wide association study (GWAS) methods.

63 We conducted a genome-wide association study (GWAS) of alcohol consumption in

64 sample (N=108 976), we carried out a genome-wide association study (GWAS) of responses to the questi

65 In contrast to genome-wide association study (GWAS), genomic prediction (GP) i

66 d to human subjects in the form of a phenome-wide association study (PheWAS).

67 This genome-wide association study analyzed criterion counts of como

68 Here, the authors perform a genome-wide association study and identify an association betwe

69 isms for schizophrenia in the largest genome-wide association study conducted to date suggested that

70 We conducted meta-analyses of genome-wide association study data on 2080 cannabis-dependent c

71 We performed the first genome-wide association study for molar shape and used 3D surfa

72 A genome-wide association study identified LMO1, which encodes an

73 We conducted a cross-disorder genome-wide association study meta-analysis to identify whether

74 rlying LBM, we performed a gene-based genome-wide association study of lean mass index (LMI) in 1000

75 se and control sample, we conducted a genome-wide association study of usual daily methadone dose.

76 Here, the authors perform a metagenome-wide association study on stools from individuals with a

77 lso conducted meta-analyses using the genome-wide association study results from the CTD cohorts, the

78 ed to two large Caucasian and Chinese genome-wide association study summary datasets of bone mineral

79 Genotyping, imputation, and genome-wide association study were performed at each study site

80 We therefore performed a genome-wide association study with a dimensional, PD/AG-related

81 that can be used to test for GxE in a genome-wide association study.

82 iber-quality-related traits through a genome-wide association study.

83 Using genome-wide association, we identified Tnni3k as one gene that

84 Efficient wide-bandgap (WBG) perovskite solar cells are needed to

85 In this study, we provide the first genome-wide, base pair-resolution map of 6mA in Tetrahymena by

86 gene expression, we identified transcriptome-wide binding sites for RNA polymerase II and the exosome

87 r the entire applied frequency range and the wide bipolar bias regions using Debye-Frohlich model (co

88 tudy examined longitudinal changes of genome-wide blood DNA methylation profiles in relation to the d

89 ditol acetate derivatives were analysed on a wide bore capillary column with detection by flame ioniz

90 ease of wildlife, livestock and humans world-wide, but long-term empirical datasets describing this c

91 The ICHOM will endeavor to achieve wide buy-in of this set and facilitate its implementatio

92 We investigated the impact of genome-wide cardiac DNA methylation on global gene expression i

93 nd that the overall drug collection covers a wide CCS range for the same mass, suggesting a large str

94 ting drug resistance mechanisms using genome-wide chemical mutagenesis allied to next-generation sequ

95 me point demonstrated that changes in genome-wide chromatin accessibility were similar across hiPSC a

96 Genome-wide chromatin immunoprecipitation-sequencing analysis r

97 Here, we perform a continent-wide climate change vulnerability assessment whereby we

98 ed eight gene association methods for genome-wide coexpression analysis between each TF and all other

99 To date, however, no genome-wide comparisons have been performed to provide an unbia

100 Genome-wide correlation studies have revealed that histone acti

101 ed hand-held device successfully exhibited a wide cortisol-detection range from 3 pg/mL to 10 mug/mL,

102 and service groups to analyze typical genome-wide datasets being generated by H3Africa research group

103 web-based computational tool for the genome-wide detection of AARS coding sequences.

104 oteins are fundamental to life and exhibit a wide diversity of activities, some of which are toxic.

105 of cells is central to understanding how the wide diversity of cell types develops.

106 thylation in MS patients, by assaying genome-wide DNA methylation and comparing smokers, former smoke

107 renatal maternal lead exposure and epigenome-wide DNA methylation in umbilical cord blood nucleated c

108 We tested for association between genome-wide DNA methylation in WBCs and total IgE levels in 2 s

109 retrospective review of de-identified region-wide donor data January 1, 2010 through December 31, 201

110 detecting cTnT and cTnI in human serum with wide dynamic range.

111 s (PRSs) have successfully summarized genome-wide effects of genetic variants in schizophrenia with s

112 opening the possibility to assess population-wide exposure to PFRs.

113 of clinical phenotypes using baseline genome-wide expression data that makes use of prior biological

114 Wide-field amacrine cells span large segments of the ret

115 ially available devices able to obtain ultra-wide-field OCT or OCTA images in neonates.

116 -cone-driven surround inhibition mediated by wide-field spiking GABAergic amacrine cells.

117 Furthermore, a genome-wide forward screen with Haplobank identified PLA2G16 as

118 The resulting edge modes cover a very wide frequency range.

119 Here we developed a genome-wide functional screen to interrogate the transcription

120 f bivalent degraders are anticipated to have wide future applicability.

121 Transcriptome and genome-wide GABP-binding site analyses identify GABP direct tar

122 We used genome-wide gene expression analysis in clinical samples to ide

123 Early perturbations in tissue-wide gene expression, as observed here, may underpin a p

124 Here, we use an unbiased genome-wide genetic screen in near-haploid human cells to uncov

125 established psychiatric diagnoses and genome-wide genotype data.

126 We capitalized on wide geographic span of our sampling to address intrigui

127 human and animal Enterobacteriaceae, with a wide geographical distribution and many producer strains

128 3/5-PRC1 complex, which catalyzes chromosome-wide H2A lysine 119 ubiquitylation, signaling recruitmen

129 engagement until 30 June 2015 using province-wide health databases and the National Death Registry.

130 Proteome-wide identification of both, transcription factors and c

131 f X-ray radiation have great potential for a wide impact on science, and are a critical element for u

132 P conduction velocity, which potentially has wide implications for the temporal transfer of informati

133 However, the genome-wide intensity of this selection is not exceptional comp

134 We performed genome-wide interaction analyses between genetic variants and a

135 The genome-wide investigation of DNA methylation levels has been li

136 rojects as FANTOM and ENCODE, forming genome-wide landscapes in a series of human cell lines.

137 The results showed that this biosensor has wide liner detection ranges (0.05-100ng/mL for VEGF and

138 We conducted a genome-wide linkage and association study in three European pop

139 Candidate gene and genome-wide linkage studies have not significantly contributed

140 a BRCA mutation or high percentage of genome-wide loss of heterozygosity.

141 present the first quantitative human genome-wide map of DNA lesions induced by ultraviolet (UV) radi

142 an cells thus provides an extensive proteome-wide map of protein ligandability and facilitates the co

143 of 5hmU, we develop a method for the genome-wide mapping of 5hmU-modified loci based on a chemical t

144 and hepatocyte-like cells (HLCs) for genome-wide mapping of expression quantitative trait loci (eQTL

145 At both time points the genome-wide mapping reveals that there is significant co-occupa

146 omponents are highly correlated to continent-wide masting in European beech and Norway spruce.

147 n fuel consumption improvements from a fleet-wide mean of 5.6 L/100 km in 2014 to 3.0 L/100 km by 203

148 -specific readmission measures to a hospital-wide measure would have on average penalties for safety-

149 Changing to the hospital-wide measure would result in 76 more hospitals being eli

150 Combining genome-wide measures of DNA hydroxymethylation with comprehensi

151 ne regulation and function requires a genome-wide method capable of capturing both gene expression le

152 d a systems approach of integrating a genome-wide miRNA screen with patient-derived phospho-proteomic

153 ities with downstream targets, transcriptome-wide mRNA 3' UTR interaction sites were experimentally d

154 these channels perform important roles in a wide number of physiological systems.

155 using a data set comprising > 216 000 world-wide observations of Fabaceae, spanning three orders of

156 Here, we use genotypic data to study range-wide patterns of genetic admixture between the serpentin

157 pigenetic reprogramming, by comparing genome-wide patterns of methylation and variation at the DNA le

158 ders all had high solubility (>80%) across a wide pH range in water and their solubility improved fur

159 Many common diseases show wide phenotypic variation.

160 veloping specific and sensitive devices with wide potential applications.

161 and conservation scores: including 13 genome-wide prediction algorithms and conservation scores, 12 n

162 Secretome-wide predictions and confocal microscopy reveal that rus

163 s for T2D, we analyzed and replicated genome-wide protein coding variation in a total of 8,227 indivi

164 Estimated fluxes span a wide range due to the range of diffusivity measured.

165 ing Fe-doped ZIF nanocrystal precursors in a wide range from 20 to 1000 nm followed by one-step therm

166 inhibition for the effective treatment of a wide range of AD-like pathophysiological and cognitive i

167 A wide range of alpha-silylesters and alpha-thioesters was

168 ill partition into the condensed state for a wide range of ambient conditions if absorptive partition

169 However, the extension of DGT to a wide range of analytes and its use under varied conditio

170 le for robotic design, that generalizes to a wide range of animal behaviours in moving fluids.

171 a standardized AP parameter analysis over a wide range of AP waveforms and firing rates, owing in pa

172 ses and chemicals offers the potential for a wide range of applications in therapeutic development, a

173 luster was observed to react directly with a wide range of arenes in a step-wise and controlled manne

174 d purification under magnetic actuation of a wide range of biotinylated molecules, and their downstre

175 ic agent commonly used in the treatment of a wide range of cancers.

176 Over the wide range of cardiac output produced by hemorrhage and

177 ponse of the skin to hypoxia feeds back on a wide range of cardiovascular parameters, including heart

178 ing, affinity studies were carried out for a wide range of CB2R reference ligands, spanning the range

179 O-GlcNAc transferase (OGT) regulates a wide range of cellular processes through the addition of

180 d by mixing these complexes, coatings with a wide range of colors can be achieved.

181 sed caffeine-induced Ca(2+) release across a wide range of concentrations in the absence of altered c

182 onates and adults were exposed for 48 h to a wide range of concentrations, and immobilization and mor

183 on the ability to identify an odor across a wide range of concentrations.

184 ntial control of fR and VT that applies in a wide range of conditions.

185 e very promising, and this was robust over a wide range of costs and assumptions.

186 C09), which has been applied to describing a wide range of dispersion-bound systems, we explore the p

187 All the simulations display wide range of distribution on a two-dimensional(2D) plot

188 ate the performance of this extraction for a wide range of elements by mechanistic geochemical modeli

189 ificantly broadening their versatility for a wide range of energy and environmental applications.

190 its sensory systems being able to adapt to a wide range of environmental conditions, by maximizing th

191 h renders this approach applicable to a very wide range of existing constructs.

192 sed to adjust for potential confounding by a wide range of factors.

193 This system has potential applications in a wide range of fields, including point-of-care diagnostic

194 tro experimental data and can be used over a wide range of flow shear rates ([Formula: see text]).

195 s been developed for the identification of a wide range of gangliosides in biological samples.

196 reaction is high yielding and amenable to a wide range of glycal donors and OH nucleophiles.

197 licability has been successfully tested in a wide range of infant foods.

198 volvement of complement-driven networks in a wide range of inflammatory and neurodegenerative disorde

199 Coarse-grained simulations of a wide range of junction topologies indicate that differen

200 acoustic vortex fields and stably levitate a wide range of liquid and solid objects.

201 of neurons in visual cortex increases over a wide range of mammalian species.

202 ors of transmitter-gated ion channels have a wide range of maximal effects as well as Hill slopes, su

203 ng the Chloroflexi, a phylum common across a wide range of modern environments.

204 se Khib-modified proteins were involved in a wide range of molecular functions and cellular processes

205 A wide range of molecular probing technologies involving r

206 ain was more abundant in the secretomes of a wide range of necrotising fungi relative to biotrophs.

207 Spasticity occurs in a wide range of neurological diseases, including neurodege

208 dic constriction sorter device to separate a wide range of nucleic acid analytes into distinct microc

209 idene as a phosphorus transfer reagent for a wide range of organic and inorganic substrates has been

210 the developed methodology is applicable to a wide range of phenomena across many energy technologies,

211 H2S regulates a wide range of physiological processes, namely cardiovasc

212 ophisticated and subtle distinctions among a wide range of positive emotions and reason about the pro

213 This tool opens up a wide range of possible studies to quantitatively assess

214 7.1 [0.39]; P = .001) after adjustment for a wide range of potential confounders.

215 sistance, with candidate genes involved in a wide range of processes including cell wall structure, h

216 rate the utility of CLAM, we applied it to a wide range of public CLIP-seq/RIP-seq datasets involving

217 The wide range of RNA-seq applications and their high-comput

218 ing on simulated tumour phylogenies across a wide range of sample purities (15-95%) and sequencing de

219 c window in a series of compounds spanning a wide range of signaling bias.

220 Although a wide range of SIRT5 targets have been identified, the ov

221 nspire the study of barocaloric effects in a wide range of solid electrolytes, as well as the paralle

222 nd can help achieve band-like transport on a wide range of substrate platforms.

223 ducted over short time periods, and employ a wide range of survey protocols.

224 talline forms of cellulose and chitin over a wide range of temperatures, pH levels, and ionic strengt

225 l threats for marine ecosystems, affecting a wide range of top predators.

226 uncertainty in both cost and effect using a wide range of willingness to pay thresholds, we found le

227 We find this pattern to be wide ranging, holding for large and small synapses in th

228 The model revealed wide-ranging effects of AES on innate and adaptive immun

229 health nutrition strategies because of their wide reach and frequent use by children.

230 ysical distances was examined and the genome-wide recombination rate was found to be much smaller tha

231 neration sequencing (NGS) to generate genome-wide repair maps.

232 Overall, our in vitro results propose a wide repertoire of potential bacterial RNA capping molec

233 terized drugs and genes, COSMIC v78 contains wide resistance mutation profiles across 20 drugs, detai

234 Recent genome-wide ribosome profiling studies suggest that thousands o

235 ve cell lines was subjected to transcriptome-wide RNA sequencing analysis.

236 Here we have carried out the first genome-wide RNA-Sequencing study in human conjunctival fibrosis

237 At a genome-wide scale estimation of correlation matrices can also b

238 It is oftentimes unknown, at a genome-wide scale, how much transdifferentiated cells differ qu

239 At the genome-wide scale, our data indicate that ATRX modifies gene ex

240 Additionally, we performed a genome-wide scan and identified one SNP with significantly diff

241 The epigenome-wide scan suggested differences in methylation between s

242 We performed 2 high-density, genome-wide scans comprising 2345 cases of African Americans wi

243 Here we used a system-wide screen to address the frequency of susceptibility t

244 therefore enable simultaneous transcriptome-wide screening and mechanistic investigation at large sc

245 Kinome-wide screening would have the advantage of providing str

246 RISPRi and CRISPRa) in the context of genome-wide screens to identify components that influence resis

247 We performed genome-wide sequencing and analyzed mRNA and miRNA expression,

248 ed in v78 (September 2016), combining genome-wide sequencing results from 28 366 tumours with complet

249 No associations reached genome-wide significance (p>5 x 10(-8)).

250 noteworthy (FPRP <0.2) and approaches genome-wide significance in multivariable analysis (P multivari

251 h DNA methylation in cord blood at epigenome-wide significance level [false discovery rate (FDR)<0.05

252 near integrin alpha6 (ITGA6) reached genome-wide significance with PA (P=1.80x10(-8)), whereas SNPs

253 is approach identified 13 new loci at genome-wide significance, 12 of which were on our previous list

254 , we identified 22 loci associated at genome-wide significance, including 13 new associations with CO

255 ciated with emphysema distribution at genome-wide significance.

256 A genome-wide significant association was found between ACQ and s

257 n lung tissue, respectively; and were genome-wide significant in a meta-analysis including both ident

258 Near genome-wide significant interaction effect was observed for rs7

259 fied analysis identified 2 additional genome-wide significant loci in females.

260 The authors identified one genome-wide significant locus on chromosome 12 (rs4622308) in a

261 ssion in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1.12 x 10(-10)) on chromosome

262 We report 106 genome-wide significant signals that have not been previously i

263 equency <0.01, (rs3025380 at DBH) was genome-wide significant.

264 inally, we show that there are transcriptome-wide similarities between the opossum attachment reactio

265 Our high-throughput genome-wide siRNA screen identified host factors that prevent r

266 Our data suggest that the wide spectrum of clinical outcomes, ranging from mental

267 t domain 62 (WDR62) cause microcephaly and a wide spectrum of severe brain malformations.

268 Their development and wide-spread investigation has, however, been severely li

269 roven SUSCC without bone invasion treated by wide surgical excision of the nail unit followed by full

270 An Australia-wide survey (2012-2014) was undertaken through the Austr

271 gorillas, we conducted the first population-wide survey of oral samples for an EBV-like virus in a n

272 Recent transcriptome-wide surveys have uncovered evidence for promiscuous tra

273 A genome-wide survival analysis of 14,406 Alzheimer's disease (AD

274 ich makes optical temperature measurement in wide temperature range possible.

275 Analyzing genome-wide transcription and repair by next-generation sequenc

276 xpression substantially recapitulates genome-wide transcriptional profiles and alternative splicing i

277 Genome-wide transcriptome analysis reveals that lipid biosynthe

278 of corneoscleral limbal dissection owing to wide tumor excision (8 vs 7; P = .12), were comparable.

279 Thus, CaMPARI enables network-wide, tunable, all-optical functional circuit mapping th

280 d with MR/Optical gene markers may also find wide use in cell lineage MRI studies.

281 ntiepileptic drug of interest because of its wide use, publications indicating problems with generic

282 By monitoring recombination genome-wide using cytological assays and at hotspots using mole

283 is regulated at multiple levels, leading to wide variability in terpene content and chemistry.

284 There was a wide variation in the number of opioid pills prescribed

285 ted with AF, but the contributions of genome-wide variation to AF susceptibility have not been quanti

286 ces and wild species, we characterize genome-wide variation.

287 entally important for mediating anxiety in a wide variety of animal species.

288 ly utilized in the visible and infrared in a wide variety of applications.

289 tendable to other metal combinations) with a wide variety of compositions and sizes based on high-tem

290 t the Miami Veterans Affairs Hospital with a wide variety of dry eye symptoms and signs (ranging from

291 cause it can maintain stable yields across a wide variety of environmental conditions, including drou

292 lowing adaptation of domesticated wheat to a wide variety of environments across the globe.

293 layer approaches and their stabilities for a wide variety of experimental photoelectrodes for water r

294 ic bistable dynamics, with applications to a wide variety of fields.

295 By investigating a wide variety of functional materials, general criteria f

296 different sensors and analysis devices in a wide variety of in-vitro applications.

297 nment of terminal or spiroepoxides bearing a wide variety of molecular complexity and conformational

298 id has enabled the asymmetric synthesis of a wide variety of polyketides.

299 A wide variety of synthetic metalloporphyrinoid complexes

300 L(-1)), and L2 (76 g L(-1))-to gain a genome-wide view of the mechanism of citrate accumulation.