ライフサイエンスコーパス: wide-ranging

1 health effects of chronic coffee intake are wide ranging.

2 ounds of LIP neurons are spatially tuned and wide ranging.

3 ows the matrix and alkali concentrations are wide-ranging.

4 , the TAp63 and DeltaNp63 variants possess a wide ranging ability to up-regulate p53 target genes.

5 icts that the diffuse risk cues generated by wide-ranging, active predators should induce prey behavi

6 They harbor wide-ranging adaptive traits that include high levels of

7 Wide-ranging adverse clinical events can seriously confo

8 The mutant-induced structural changes are wide-ranging, affecting ribosome biogenesis, elongation

9 e polymorphism of the KIR and HLA loci, with wide-ranging affinities for individual KIR and HLA allel

10 uring two seasonal month-long campaigns with wide-ranging ambient temperatures (-19 to +30 degrees C)

11 nal Classification confirmed the presence of wide-ranging AMD-like pathologic changes even in those w

12 Here, we report the results of a wide-ranging analysis of the impact of these events on e

13 erse sequelae of adolescent cannabis use are wide ranging and extend into young adulthood.

14 Examples of the uses of these data are wide ranging and include public policy applications, the

15 The wide-ranging and detailed insight informs the design of

16 ysis indicated that individual AMG possessed wide-ranging and elaborate membrane extensions that part

17 These examples illustrate the wide-ranging and fundamental materials physics that can

18 We also predicted that wide-ranging and migratory behaviours could increase inf

19 th consequences of conflict and violence are wide-ranging and pervasive.

20 A wide-ranging and practical synthesis of structurally div

21 immortalization, and this finding could have wide-ranging and profound investigational and medical ap

22 a has declined 29% in total since 1991, with wide-ranging and severe ecological and economic conseque

23 or many species, particularly those that are wide-ranging and sparse.

24 othelium, we believe these data have direct, wide-ranging, and immediate clinical applicability acros

25 yet estimating energetic costs in free- and wide-ranging animals presents a significant challenge.

26 Wide-ranging animals, such as birds, regularly traverse

27 NF-alpha production in monocytes, indicating wide-ranging anti-inflammatory action.

28 hat seaweed-affiliated bacterial flora had a wide-ranging antibacterial activities and potential natu

29 interferon-induced dynamin-like GTPase with wide-ranging antiviral activity, which hinges upon detec

30 ct method (SMCM) is described which promises wide-ranging application in imaging and quantifying elec

31 ng and assembly methods that would allow for wide-ranging application of whole-genome analysis.

32 Stentrodes may have wide ranging applications as a neural interface for trea

33 The DTIA method has wide ranging applications for addressing fundamental pro

34 ineering light-sensitivity into proteins has wide ranging applications in molecular studies and neuro

35 The wide ranging applications of fluorine in drug design are

36 The wide-ranging applications and versatility of these imida

37 erally, PCR-based detection of siRNA carries wide-ranging applications for RNAi reverse genetics.

38 ultiple nuclear species in bulk matter, with wide-ranging applications from basic physics and chemist

39 f CRISPR-Cas biotechnological toolkits, with wide-ranging applications from genome editing to diagnos

40 izing integrated optical meta-circuits, with wide-ranging applications in areas from imaging and sens

41 ose digestion, and microbial symbiosis) with wide-ranging applications in diverse biotechnological ni

42 Such methodology promises to have wide-ranging applications in materials science and in si

43 ate of causal influence; thus, we anticipate wide-ranging applications in neuroscience and beyond.

44 ign blueprint of the sensors we expect their wide-ranging applications in research and medical diagno

45 e band gap on the surface, which may lead to wide-ranging applications in thermoelectrics, infra-red

46 n depth << pair plasma size, which will have wide-ranging applications to astrophysics and fundamenta

47 these hierarchical microshells suitable for wide-ranging applications, including biological ones.

48 operating in low-light-level conditions has wide-ranging applications, spanning biological imaging t

49 This integrated approach will have wide-ranging applications, such as in deep lineage traci

50 f piggyBac transposase that have potentially wide-ranging applications, such as reversible transgenes

51 e-semiconductor compatible silicon chips for wide-ranging applications.

52 ials are a highly studied field due to their wide-ranging applications; however, only a small group o

53 amount of research has centered on Ref-1, no wide-ranging approach had been performed on the effects

54 The findings enable sEMG from wide ranging areas of the body.

55 est potential utility of e-jet techniques in wide-ranging areas of biotechnology, where its compatibi

56 imprinted genes influence an extraordinarily wide-ranging array of biological processes, the effects

57 nities is achievable, cost effective and has wide-ranging benefits.

58 ions, such that inactivation of MMR can have wide-ranging biological consequences, which can be eithe

59 nonenal (4-HNE) is a signaling mediator with wide-ranging biological effects.

60 Zinc is an essential trace element with wide-ranging biological functions, whereas the Hedgehog

61 d of organic or inorganic materials and have wide-ranging biological roles.

62 We thus demonstrate the wide-ranging biomedical utilities of PLC-derived organoi

63 derstanding this process is essential if the wide-ranging biotechnological applications of methanotro

64 l correlate of Francis's intellectual world: wide-ranging, brilliantly lit, a little overawing, but a

65 ing on adolescent psychosocial problems were wide ranging but diminished by young adulthood for all b

66 Her wide-ranging career began with the study of protein fold

67 posttranslational modification that impacts wide-ranging cellular functions, including transcription

68 in dimerization with hundreds of targets and wide-ranging cellular functions.

69 improvement of functions is associated with wide-ranging changes in functional and structural connec

70 obe epilepsy is associated with large-scale, wide-ranging changes in gene expression in the hippocamp

71 xication, and is associated with persistent, wide-ranging changes in gene expression within the media

72 campus that are associated with large-scale, wide-ranging changes in gene expression.

73 r communist countries in Europe have pursued wide-ranging changes to their health systems.

74 icles on radical SAM enzymes that accomplish wide-ranging chemical transformations.

75 ibility of synthesizing anisotropic dyes and wide ranging choice of liquid crystals nonlinear optical

76 exhibit different cell-cycle lifestyles and wide-ranging chromosome copy numbers, fluctuating from 1

77 Our method is applicable to a wide-ranging class of models and is computationally effi

78 ion by neutrophils likely has a significant, wide ranging clinical impact.

79 are now being reviewed to reflect these new wide-ranging clinical and radiological findings.

80 Monogenic epilepsies with wide-ranging clinical severity have been associated with

81 The frontal lobes control wide-ranging cognitive functions; however, functional su

82 A wide-ranging collection of web-based search forms and to

83 neurogenesis in young-adult mice results in wide-ranging compensatory changes in the structure and d

84 n our thinking when seeking solutions to the wide-ranging complications which face the transplant tea

85 output signal) or the quantification of more wide-ranging concentrations.

86 ons to convert PrP(c) to PrP(Sc) under these wide-ranging conditions remains poorly understood.

87 n of cholinergic neurons that have local and wide-ranging connections.

88 w a single amino acid mutation may have such wide ranging consequences.

89 ies have demonstrated that loss of ABCG1 has wide-ranging consequences and impacts lymphocyte and ste

90 phenology in response to climate change have wide-ranging consequences for ecological systems.

91 Here, wide-ranging consequences of genetic code ambiguity in E

92 tion of resistance to antibiotics has led to wide ranging consultation at National and International

93 t two decades, sentinel testing has revealed wide-ranging contamination rates in mammalian culture.

94 pioneer of surgery in the USA and made many wide-ranging contributions, including the surgical treat

95 ng regulation of PSMs was established before wide-ranging control of virulence was added to the agr r

96 ith the Firegoose and the Gaggle, permitting wide-ranging data exploration and analysis.

97 rotein kinase or phosphatase family can have wide-ranging deleterious effects in both metazoans and p

98 dividual differences in social interest have wide-ranging developmental consequences, impacting infan

99 and protozoa (i.e. microparasites) most for wide-ranging, dietary generalist host species.

100 e?" In a productive 2-day meeting, there was wide-ranging discussion on a broad series of topics, res

101 A wide-ranging discussion on the best approaches to allow

102 asive surgery is being applied to treat more wide-ranging disorders, it is becoming apparent that for

103 to other bacteria, cyanobacteria exist in a wide-ranging diversity of shapes and sizes.

104 factors of interest in scales with multiple, wide-ranging domains.

105 on) and blood pressure were evaluated during wide-ranging doses of intra-arterial (femoral) infusions

106 Overall, this review illustrates the wide-ranging effect of IFN-gamma on the (patho-)physiolo

107 ations in the cellular microenvironment have wide ranging effects on resultant tissue type.

108 hatase nonreceptor type 22 gene, PTPN22, has wide-ranging effects in immune cells including suppressi

109 The model revealed wide-ranging effects of AES on innate and adaptive immun

110 ocorticoid hormone cortisol is known to have wide-ranging effects on a variety of physiological syste

111 iolet radiation is a pervasive stimulus with wide-ranging effects on all living forms.

112 al lymphopoietin (TSLP) is now known to have wide-ranging effects on both hematopoietic and nonhemato

113 nd exposure time, high-temperature water has wide-ranging effects on both the surface roughness and t

114 onstrated that HCV infection has potentially wide-ranging effects on cellular gene and protein expres

115 ode secreted proteins that have profound and wide-ranging effects on cellular metabolism.

116 Ki-67 silencing also had wide-ranging effects on chromatin organisation, disrupti

117 opulation genotypic diversity, may also have wide-ranging effects on community structure and ecosyste

118 iological role of p63 is quite complex, with wide-ranging effects on development, differentiation, an

119 nges in the expression of one miRNA can have wide-ranging effects on diverse cellular processes assoc

120 Changes in resident microbiota may have wide-ranging effects on human health.

121 ular factors regulating mRNA processing have wide-ranging effects on human immunodeficiency virus typ

122 thesized by an organism may have complex and wide-ranging effects on its biology.

123 Lysophosphatidic acid (LPA) has wide-ranging effects on many different cell types, actin

124 tion of chromatin by histone methylation has wide-ranging effects on nuclear function, including tran

125 study shows that biological amphiphiles have wide-ranging effects on plasma membrane heterogeneity an

126 They exert wide-ranging effects on synaptic signaling and plasticit

127 ally on chromatin may be responsible for its wide-ranging effects on the biology of stem and tumor ce

128 The substitutions had wide-ranging effects on the kinetics of l-leucine inhibi

129 vealed that the sigA(G336C) substitution has wide-ranging effects, including elevated expression of t

130 in various organs to drugs with potentially wide-ranging efficacy is needed.

131 Effects of zolpidem were wide ranging (eg, improvement on the JFK Coma Recovery S

132 mophores with diverse electronic spectra and wide-ranging emission intensities.

133 ukaryotic adaptation pathways operate within wide-ranging environmental conditions without stimulus s

134 activated sorting techniques has resulted in wide-ranging estimates, which may be the result of conte

135 he results of different studies have yielded wide-ranging estimates.

136 l conditions associated with this feature is wide-ranging even if never discussed in detail.

137 al intersexual antagonistic coevolution with wide-ranging evolutionary consequences.

138 astomosis visualization among reviewers with wide-ranging experience.

139 hich embody his philosophies of life and his wide-ranging experiences and interests.

140 shown that when medical oncologists claimed wide-ranging expertise over the treatment of all patient

141 domesticated for host needs, reflecting the wide-ranging exploitation of any and all available DNA s

142 Wide-ranging exploration of analogues of an ATP-competit

143 Wide-ranging exploration of potential replacements for a

144 ny different types of ion channels with such wide-ranging expression heterogeneity.

145 evidence suggests that sharks must engage in wide-ranging foraging excursions to meet energy needs [9

146 Therapeutic proteins of wide-ranging function hold great promise for treating di

147 component of the Microprocessor complex with wide-ranging functional consequences.

148 ctures with desired chiroptical response for wide-ranging functionalities and applications by bottom-

149 constituents of basement membranes and have wide ranging functions during development and in the adu

150 erparts, are highly divergent proteins whose wide-ranging functions are thought to correlate with the

151 y regulate 7346 downstream target genes with wide-ranging functions in DNA repair, cell cycle regulat

152 In this report, we reveal wide-ranging functions of STAT3 in T-cells and provide e

153 amine neurons is regulated and underlies the wide-ranging functions that have been attributed to dopa

154 strate this adaptive response and secure the wide-ranging gains of a regimented exercise program are

155 the standard BLAST output for investigating wide-ranging genomic problems, including single query an

156 hilic and nonthermophilic environments, with wide-ranging growth temperatures (4-108 degrees C).

157 ilability of their prey, a foraging shift in wide-ranging Hawaiian petrel populations suggests a rela

158 physical activity levels are associated with wide-ranging health benefits, disease prevention, and lo

159 to complex heteroarylated phenol moieties by wide-ranging heterocyclic scaffolds.

160 We find this pattern to be wide ranging, holding for large and small synapses in th

161 sting that rel(Spn) and (p)ppGpp amount play wide-ranging homeostatic roles in pneumococcal physiolog

162 importance of these regulatory molecules is wide-ranging, however, few loss-of-function mutants have

163 endence on ion chemistry and charge, despite wide-ranging hydration energies and the membrane's dipol

164 ate immune system that initiate and regulate wide-ranging immunological responses.

165 rvation and their relevance to assessing the wide-ranging impact of fisheries and climate change on m

166 Our results highlight the wide-ranging impact of sSNPs, which invert the programme

167 ximal oxygen uptake, VO2 max ), a trait with wide-ranging impact on health and performance indicators

168 both humans and crops-can have immediate and wide-ranging impacts on diversity that conflict with exp

169 elopmental verbal dyspraxia), accompanied by wide-ranging impairments in expressive and receptive lan

170 ate-linked bottom-up mechanisms and may have wide ranging implications for alpine ecosystems.

171 cells and we believe that our findings have wide ranging implications for the entire cannabinoid fie

172 in humans have presented findings that have wide ranging implications.

173 ify cells and organisms almost at will, with wide-ranging implications across biology and medicine.

174 These findings have wide-ranging implications because this study was designe

175 Despite its wide-ranging implications for biology and conservation,

176 of both STIM1 and PMCA, these findings have wide-ranging implications for Ca(2+) signalling in multi

177 regulated by caspase-mediated cleavage, with wide-ranging implications for cell death and differentia

178 ithin drug design and the finding might have wide-ranging implications for drug design.

179 Our findings have wide-ranging implications for health services and for ex

180 Transgenerational effects have wide-ranging implications for human health, biological a

181 ith loss of ATP13A2 function that could have wide-ranging implications for it as a therapeutic target

182 This has wide-ranging implications for our ability to quantitativ

183 This condition has wide-ranging implications for physical and psychological

184 This new reality has wide-ranging implications for the care of surgical patie

185 er otherwise constant conditions, could have wide-ranging implications for the future development of

186 This result has wide-ranging implications for the geological history of

187 These findings have wide-ranging implications for the many pathophysiologica

188 ceptors on basolateral nucleus efferents has wide-ranging implications for the numerous deleterious s

189 and galactic cosmic rays at tens of TeV has wide-ranging implications for the structure of our helio

190 These results have wide-ranging implications for understanding reactive tra

191 arasite community diversity and turnover has wide-ranging implications for understanding the selectiv

192 rrogate endpoint for cardiorenal disease has wide-ranging implications from the monitoring and treatm

193 This study has wide-ranging implications in the engineering and use of

194 molecules for treatment of SMA, our work has wide-ranging implications in understanding how small mol

195 The wide-ranging implications of the work are discussed, and

196 of 'Making Sense of Stress', this review has wide-ranging implications that are not limited to one di

197 h high resolution and in real time will have wide-ranging implications to understand the role of nucl

198 titrophic level interactions and discuss its wide-ranging implications.

199 to approximate the effects of policies with wide-ranging implications.

200 targeted cohesin loading, a phenomenon with wide-ranging importance in chromosome segregation and, i

201 The wide-ranging improvements reflect the convergence of P2R

202 Although these diseases are wide ranging in their clinical manifestations, each can

203 e potential applications of such efforts are wide ranging, including the generation of fuels, chemica

204 Urinary control of SCN activity exhibits wide ranging individual differences.

205 ubiquitinases (DUBs) are responsible for the wide-ranging influence of this pathway as well as its se

206 Their potentially wide-ranging influence on disease phenotype also suggest

207 e excitatory RF of A1 neurons is cocooned by wide-ranging inhibition that contributes to the high sel

208 ting movements in one direction, whereas the wide-ranging inhibitory projections attenuate the activi

209 he research and bioethics communities lead a wide-ranging inquiry aimed at mapping out solutions to t

210 committed to supporting oncologists in their wide-ranging involvement in cancer prevention.

211 structural genes provide evidence for EOBI's wide-ranging involvement in the production of floral vol

212 urified, recombinant GSTs were shown to have wide-ranging kinetic properties, suggesting that the sui

213 ble collection of achievements that covers a wide ranging landscape of molecular complexity and diver

214 s to be recognized in conservation plans for wide-ranging, large-bodied species, minimal ecological r

215 Our findings indicate wide ranging LC50 24 h postfertilization values (0.487 p

216 d distinct symptom profiles characterized by wide-ranging levels of severity.

217 A wide-ranging literature review using targeted medical su

218 Despite a wide-ranging literature, questions remain as to whether

219 rience of HSCT for a malignant disease has a wide-ranging, longstanding, and profound impact on adult

220 g season from 2013 to 2063, which results in wide-ranging magnitudes of effects across guilds and fun

221 photolysis in the NMR probe, resulting in a wide-ranging map of kinetic selectivities.

222 hat the population dynamics of a long-lived, wide-ranging marine predator are associated with changes

223 These findings suggest a wide-ranging mechanism by which direct interaction of Gb

224 We provide evidence that the wide-ranging melting temperatures of zeolitic MOFs are r

225 litary and sedentary to mass aggregation and wide ranging migration.

226 This suggests either wide-ranging migration and intense natural selection or

227 cate that Cdc14 targets proteins involved in wide-ranging mitotic events.

228 Tie2 expression declined rapidly in wide-ranging models of leak-associated infections, inclu

229 Computational models routinely invoke wide-ranging mutually suppressive interactions in spatia

230 e therapies are emerging, but because of the wide-ranging nature of phenotypic expression and overlap

231 ed by local and global conformations, with a wide ranging net nucleosome core screening charge (56-10

232 o suggest mechanisms and implications of the wide-ranging observations that have been made and conclu

233 The Center for Disease Control (CDC) Wide-ranging Online Data for Epidemiologic Research (WON

234 e Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research data

235 S Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research onli

236 ngton State residents were obtained from the Wide-ranging OnLine Data for Epidemiologic Research syst

237 ers for Disease Control and Prevention (CDC) Wide-Ranging Online Data for Epidemiological Research (W

238 spherical particles and hence disregards the wide-ranging particle shapes occurring in nature, such a

239 ng exploration of toxicity to organisms from wide-ranging parts of the ecosystem food webs.

240 oup A Streptococcus, GAS) is responsible for wide-ranging pathologies at numerous sites in the body b

241 Finally, the wide-ranging phenotypes that result from loss of functio

242 er in diverse species of bacteria to trigger wide-ranging physiological changes, including cell diffe

243 organize the signaling complexes involved in wide-ranging physiological processes including neural de

244 ytoplasmic mRNAs, but how m(6)A achieves its wide-ranging physiological role needs further exploratio

245 /suburban, agricultural and/or forested) and wide ranging population densities.

246 pattern in calixarene chemistry showing the wide-ranging possibility of thiacalixarene skeleton modi

247 redictive map of population density revealed wide-ranging potential for an invasive large mammal to e

248 poietic chimerism, these cells demonstrate a wide-ranging potential for the development of multifacet

249 of two-dimensional (2D) semiconductors with wide-ranging practical applications.

250 machines is matched to their roles in these wide-ranging processes.

251 on or triplication of Xq28 causes an equally wide-ranging progressive neurological disorder, MECP2 du

252 The wide-ranging properties of KIR allotypes arise from subs

253 concepts in high-energy physics, leading to wide-ranging protected properties in transport and spect

254 ced professionals who have worked to achieve wide-ranging reforms dedicated to preserving life, prote

255 mble to keep up with the frequent release of wide-ranging regulations.

256 Therefore, M. universalis displays wide-ranging responses to adapt between growth on methan

257 ip between a predator and its prey can cause wide-ranging ripple effects through ecosystems, includin

258 Prefrontal cortex (PFC) is thought to have a wide-ranging role in cognition, often described as execu

259 We found that MRFs play an unexpectedly wide-ranging role in directing the assembly and usage of

260 m for GIGANTEA activity that can explain its wide-ranging role in plant biology.The plant-specific GI

261 This study reveals the wide-ranging roles for this protein modifier in nuclear

262 The 14-3-3 protein hub, which plays wide-ranging roles in cellular processes, has been linke

263 ray of putative protein interactions and the wide-ranging roles played by CBP within a single tissue

264 he known interaction between fisheries and a wide-ranging seabird, the Northern gannet Morus bassanus

265 Wide ranging, seemingly unrelated Escherichia coli physi

266 ve correction for potential confounding, and wide-ranging sensitivity analyses.

267 Herein, using a unique polymer family with a wide-ranging set of cationic and hydrophobic features, w

268 ers intrinsic resistance to TKI therapy in a wide-ranging set of leukemias, and might represent a uni

269 An understanding of these processes may have wide-ranging significance in health care applications an

270 ariation proves significant to a generalist, wide-ranging species, at the slow end of the slow-fast c

271 mong locally adapted populations of a single wide-ranging species, or among closely related species t

272 of migratory connectivity for highly-mobile, wide-ranging species, such as sea turtles, is challengin

273 llow high-risk hotspots to be identified for wide-ranging species.

274 ot only of pulmonary fibrosis, but also of a wide-ranging spectrum of chronic disorders.

275 permatozoal RNA from infertile patients with wide-ranging sperm concentrations varied between 91 and

276 hing iron nitrosyls and S-nitrosothiols with wide-ranging stabilities and reactivities.

277 nes macrophages (Mphi) as plastic cells with wide-ranging states of activation and expression of diff

278 n-pairing catalysis was demonstrated to be a wide-ranging strategy that can utilize a variety of cati

279 neurons is strongly influenced by spatially wide-ranging surround suppression in a manner that effec

280 duction of a diverse array of compounds with wide-ranging synthesis requirements, alongside synthesis

281 n oxidation catalysts hold great promise for wide-ranging synthetic applications.

282 uence, this work shows that AP2 domains have wide-ranging target specificities and provides a missing

283 , Tamas Freund and Gyorgy Buzsaki 'for their wide-ranging, technically and conceptually brilliant res

284 ilms and polymer-nanocrystal composites with wide-ranging technological applications.

285 ed for suspected preeclampsia (n = 1888) had wide-ranging test accuracy (sensitivity, 22%-100%; speci

286 exchange properties of the mutants were also wide-ranging: the MBR mutant apoproteins exhibited H/D e

287 e deepest unsolved problems in science, with wide-ranging theoretical, clinical, and ethical implicat

288 sely allied with host evolution, even across wide-ranging timescales and diverse animal systems reare

289 s they will have to physiologically straddle wide-ranging timescales in the alteration of ocean condi

290 cardiac M2-like macrophages highly expressed wide-ranging tissue repair-related genes.

291 ata provides a roadmap for interrogating the wide-ranging toxicity data in the literature and suggest

292 utes to metastatic dissemination by inducing wide-ranging transcriptional and functional changes.

293 that PKA has been coopted into effecting the wide-ranging transformation from solitarious to gregario

294 ly Next-Generation Sequencing has identified wide-ranging usage with highly diverse and unique repert

295 -38.3 degrees ) demonstrates a potential for wide-ranging use.

296 Synthetic gene networks have wide-ranging uses in reprogramming and rewiring organism

297 a revolutionary gene editing technology with wide-ranging utility.

298 ogens are notorious for their aggressive and wide-ranging virulence strategies that promote host cell

299 dual exploration-exploitation strategy using wide ranging wandering albatrosses (Diomedea exulans) as

300 Here, we used the wide-ranging wandering albatross Diomedea exulans to inv