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1 daunorubicin remain some of the most active wide-spectrum and cost-effective drugs in cancer therapy
2 XAP044 demonstrates good brain exposure and wide spectrum anti-stress and antidepressant- and anxiol
3 atients and encourages the administration of wide spectrum antibiotics, thus resulting in alarming in
5 ritical insight into rational development of wide spectrum antiviral therapeutics to treat infections
6 with orientation-dependent responses over a wide spectrum by focused-ion-beam based patterning and f
10 nal function and proteinuria ranged across a wide spectrum in all groups reflecting the different his
12 olymer networks are readily modulated over a wide spectrum, including white-light emission, simply by
15 lopment of severe CHF in the SHHF model by a wide-spectrum interaction that involves molecular, struc
16 m interactions and Doppler effect, a 7.8-kHz-wide spectrum is observed for the (1)S0-(3)P1(m=0) trans
18 osphamide and total body irradiation develop wide-spectrum manifestations of chronic graft-versus-hos
22 ressed in brain and periphery activated by a wide spectrum of agonists that include, but are not limi
23 ering microscopy paves the way for imaging a wide spectrum of alkyne-labeled small biomolecules with
25 evelopment of medulloblastomas, which bear a wide spectrum of alterations involving the Sonic Hedgeho
26 indicate that Alzheimer's disease exhibits a wide spectrum of amyloid-beta42 structural states and im
27 tional cathelicidin peptide that has shown a wide spectrum of antimicrobial activity by permeabilizin
28 in that 5-HT2B receptor deficiency confers a wide spectrum of antipsychotic-sensitive schizophrenic-l
29 ave revolutionized medicine, but they have a wide spectrum of applications in other fields of science
30 ed biocatalyst could provide the basis for a wide spectrum of applications including detection, ident
31 They have been extensively exploited for a wide spectrum of applications ranging from biomedical de
32 ction of explosive components is vital for a wide spectrum of applications ranging from national secu
41 tionally, the presented peptides exhibited a wide spectrum of binding affinity and HLA-DM susceptibil
42 d in various interactions characterized by a wide spectrum of binding scenarios and an even wider spe
48 oietic system, TGF-beta signaling controls a wide spectrum of biological processes, from homeostasis
51 , is an amphipathic, cationic peptide with a wide spectrum of biological properties that is being con
52 reonine Kinase Receptors (STKR1) transduce a wide spectrum of biological signals mediated by TGF-beta
54 fication, localisation and manipulation of a wide spectrum of biological, physical and chemical agent
57 the critical AKT3 gene are associated with a wide spectrum of brain involvement ranging from focal or
59 series showed potent cytotoxicity against a wide spectrum of cancer cell-lines (IC50 values ranging
60 ere, we report that deoxynyboquinone kills a wide spectrum of cancer cells in an NQO1-dependent manne
66 that the endothelium is responsible for the wide spectrum of cardiac phenotypes displayed in Alagill
68 aregivers of people with dementia describe a wide spectrum of caregiving experiences, from very negat
72 indings support a genetic pathogenesis for a wide spectrum of CHDs and suggest that the disruption of
73 ated Bcl2L13 inhibits apoptosis induced by a wide spectrum of chemo- and targeted therapies upstream
74 e canalicular phospholipid flippase, cause a wide spectrum of cholangiopathy phenotypes in humans.
76 us, we find mutations in GMPPB can lead to a wide spectrum of clinical features where deficit in neur
77 S5/SPG11/KIAA1840 is the causative gene of a wide spectrum of clinical features, including autosomal
78 e bacterium Burkholderia pseudomallei, has a wide spectrum of clinical manifestations ranging from ac
83 studies 44 HPRT1 mutations associated with a wide spectrum of clinical phenotypes were reconstructed
84 Appropriate management is complicated by the wide spectrum of clinical presentation and disease sever
93 of CNS repair processes, brain aging, and a wide spectrum of CNS disorders, including acute injuries
94 abeling tubulin in HeLa cells and revealed a wide spectrum of colors, ranging from violet-blue to red
97 ed review of low-dose diagnostic images of a wide spectrum of congenital pathologies may serve as an
98 allmark of this disease; however, the genome-wide spectrum of cooperating mutations in this disease s
99 ressive aphasia who collectively displayed a wide spectrum of cortical atrophy sites and language imp
100 , shows significant antitumour activity in a wide spectrum of cultured cancer cells harbouring high T
101 trated greater proneurogenic efficacy than a wide spectrum of currently marketed antidepressant drugs
103 t the various transgenic mouse lines cover a wide spectrum of different human CYP2D6 metabolizer phen
107 ause of human bacterial infection, causing a wide spectrum of disease ranging from skin and soft tiss
113 se aberrant levels of Gli activity lead to a wide spectrum of diseases ranging from neurodevelopmenta
114 They are also strongly associated with a wide spectrum of diseases, including infections, autoimm
124 ronal M-current, have been associated with a wide spectrum of early-onset epileptic disorders ranging
125 n rhythm of the population, and generate the wide spectrum of empirically observed mobility behaviors
126 This long follow-up allowed exploration of a wide spectrum of epilepsies, affecting both subjects who
127 ss talk between the actin cytoskeleton and a wide spectrum of essential cellular functions such as or
129 m monosynaptic excitatory connections onto a wide spectrum of excitatory projection neurons in this a
130 the different values of l corresponding to a wide spectrum of experiments, we find that for a range o
135 ssues confirmed that BambL could recognize a wide spectrum of fucosylated epitopes, albeit with a low
136 The reaction is scalable and tolerates a wide spectrum of functional groups delivering fully subs
137 ic) movement disorders (FMD) are part of the wide spectrum of functional neurological disorders, whic
139 , VO2(A), VO2(B), VO2(M1) and VO2(R), have a wide spectrum of functionalities useful for many potenti
143 d immunoconjugates of ENb and TRAIL target a wide spectrum of GBM cell types with varying degrees of
144 e respective genetic signatures implicates a wide spectrum of Gene Ontology terms and KEGG pathways w
145 ns by integrating tumor genomics data with a wide spectrum of gene-specific properties to search for
146 se whole-genome tiling arrays to show that a wide spectrum of genes and transposable elements are mis
149 ors (KIRs) on NK cells have been linked to a wide spectrum of health conditions such as chronic infec
150 tures make the technique applicable across a wide spectrum of healthcare delivery systems on a truly
151 tionality, presence of comorbid diagnoses, a wide spectrum of HIV risk perception, and feelings of is
152 immunoglobulin heavy chain and neutralize a wide spectrum of HIV-1 strains via targeting the CD4 bin
155 mixture of bioactive molecules that target a wide spectrum of host defense mechanisms to allow ticks
158 ubiquitously in the environment and cause a wide spectrum of human disease, including infections ass
160 Defective primary cilia are causative to a wide spectrum of human genetic disorders, termed ciliopa
161 eroids derived from single PGCCs grew into a wide spectrum of human neoplasms, including germ cell tu
162 in1 at ciliary rootlets and suggest that the wide spectrum of human pathologies linked to truncating
163 in or 5-hydroxytryptamine (5-HT) regulates a wide spectrum of human physiology through the 5-HT recep
164 vating coagulation, is highly expressed in a wide spectrum of human tumor and tumor stromal cells.
166 In susceptible individuals, NSAIDs induce a wide spectrum of hypersensitivity reactions with various
168 domain of immunoglobulin G (IgG) mediates a wide spectrum of immunological functions that influence
171 ignalling pathways have been implicated in a wide spectrum of important biological phenomena, ranging
174 apo) E4 is a major genetic risk factor for a wide spectrum of inflammatory metabolic diseases, includ
175 ent influenza virus strains; (iii) inhibit a wide spectrum of influenza A viruses, which includes the
176 antibodies are able to broadly neutralize a wide spectrum of influenza virus strains and subtypes.
179 is of the GPI anchor are reported to cause a wide spectrum of intellectual disabilities (IDs) with ch
182 opulations in areas of endemicity revealed a wide spectrum of invasion phenotypes and expression prof
185 osis (ALS) is a heterogeneous disease with a wide spectrum of involvement of cognitive functions.
186 or hypoplastic pectoralis major muscle and a wide spectrum of ipsilateral thoracic and upper extremit
188 henotypes should be distinguished within the wide spectrum of irritant-related asthma: (i) definite I
192 es revealed that Gfi-1b directly regulates a wide spectrum of megakaryocytic and erythroid genes, pre
195 f IRF5 disease-associated polymorphisms to a wide spectrum of microbial triggers has broad implicatio
197 tamase (CBL) among other enzymes to resist a wide spectrum of modern antibiotics and pose a major pub
198 us tissue with unique genetic profiles and a wide spectrum of morphologic features, which makes accur
201 evolution of AR and provide the first genome-wide spectrum of mutations associated with the developme
206 protein-43 (TDP-43) has been identified in a wide spectrum of neurodegenerative diseases collectively
207 ude that SPTAN1-related disorders comprise a wide spectrum of neurodevelopmental phenotypes ranging f
213 anding of nanoparticle hazard because of the wide spectrum of NP varying in composition, shape and si
214 n soil alphaproteobacterium that colonizes a wide spectrum of organisms and is being increasingly rec
215 ns and intra-chromosomal translocations in a wide spectrum of organisms from bacteria to humans.
217 HIV-1 infection, B57 heterozygotes display a wide spectrum of outcomes, including rapid progression,
220 silencing and are proposed to function in a wide spectrum of pathologies, including cancers and vira
222 ting GLI transcription factors may benefit a wide spectrum of patients with mutations at different no
224 hension of self-organization processes and a wide spectrum of physical, chemical, and biological phen
226 sing alkaptonuria cartilage specimens with a wide spectrum of pigmentation, we have characterized the
232 erative for a radiologist to be aware of its wide spectrum of presentation on ultrasound in first tri
233 studies at low temperature, which revealed a wide spectrum of pressure-related functionalities includ
234 broblasts, the binding of MYXV and VACV to a wide spectrum of primary human leukocytes could not be c
235 of definitive treatment for children with a wide spectrum of primary immunodeficiencies (PIDs), but
237 on onto solid surfaces is of importance in a wide spectrum of problems, including environmental micro
239 nd can be applied to the identification of a wide spectrum of protein features that lack sequence con
240 d in vivo by MHC II molecules derives from a wide spectrum of proteins produced by different cell typ
241 logy promises flexibility in the design of a wide spectrum of ratiometric biosensors and expanded in
242 t patterns for moving collectively involve a wide spectrum of reasons, such as evading predators or o
243 tors allows the sensors to function across a wide spectrum of refractive indices, such as that encoun
244 -dependent regulation was conserved across a wide spectrum of representative S. aureus isolates.
248 absorber unit, a process known to produce a wide spectrum of secondary amine products that are more
249 Pathogen-controlled processes, involving a wide spectrum of secreted factors, are responsible for t
250 signature of reading proficiency across the wide spectrum of selected languages, whether their writi
254 D repeat domain 62 (WDR62) as the cause of a wide spectrum of severe cerebral cortical malformations
255 otrusion type requires the coordination of a wide spectrum of signaling molecules and regulators of c
257 protein-coupled receptors (GPCRs) exhibit a wide spectrum of spatial and temporal response propertie
260 orelay (MSP) cascades mediate responses to a wide spectrum of stimuli, including plant hormonal signa
265 ein misfolding process and is effective on a wide spectrum of substrate proteins, including alphaSyn
266 al-independent manner, which may explain the wide spectrum of substrate specificities of EcEndoV.
270 s of heteromeric assembly via a surprisingly wide spectrum of subunit-specific association affinities
272 d has demonstrated superior performance on a wide spectrum of synthetic and real world networks espec
273 We now report cGVHD manifestations in a wide spectrum of target organs, including those with muc
274 wn that highly stable binding proteins for a wide spectrum of targets can be generated through mutage
275 ssenger via differential interactions with a wide spectrum of targets to modulate their diverse bioch
276 f computational pipelines that can address a wide spectrum of tasks ranging from pre-processing and q
279 nt chemotherapeutic agent for treatment of a wide spectrum of therapeutically challenging solid tumor
281 onferred the superior inhibition against the wide spectrum of TLRs and prevented the constitutive act
282 ions in most or all cell types to regulate a wide spectrum of transcripts, Drosophila PTB encodes an
284 al. and Klein et al. characterize the genome-wide spectrum of translocations that form from a single
285 very zeolite must experience prior to use, a wide spectrum of treatments exists to alter individual o
286 he cytotoxic potential of NK cells against a wide spectrum of tumor subtypes could be markedly enhanc
288 a relatively rare congenital anomaly with a wide spectrum of ultrasound features depending on the sp
290 Patients with LCA and CEP290 mutations had a wide spectrum of VA that was not related to age or lengt
291 venular PAMM with en face OCT demonstrates a wide spectrum of variation with narrow fern-like periven
293 he same genetic material also morphed into a wide spectrum of viruses and other parasitic genetic ele
294 uch antibodies can act antivirally against a wide spectrum of viruses by targeting relatively conserv
295 intelligently incorporate predictions from a wide-spectrum of strategies in order to form aggregate p
296 des (MDPs) and their analogs have emerged as wide-spectrum, stress response factors protective in amy
298 he mean proliferation index with cytokeratin wide-spectrum was 2.55 vs 1.13 (P = .06), and the mean p
299 avelength narrow-band green or red light, or wide-spectrum white light, and thereby provide extra vis
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