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1 tial amplitude in peripheral mouse C-fibres (wildtype).
2 afety) in the order Nav 1.8 KO > Nav 1.9KO > wildtype.
3 ical constriction in acellular embryos as in wildtype.
4 be more sensitive to foot-shock compared to wildtype.
5 ell as far more pronephric cells compared to wildtype.
6 reduced selectivity for Ca(2+) compared with wildtype.
7 expression between fiberless mutant and its wildtype.
8 O mice showed a decrease in rod sensitivity (wildtype =-1.97 log units, KO =-1.81 log units; p = .014
10 gnificantly higher activation rates than the wildtype (90-fold versus 20-fold) and interacted with an
15 d high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knoc
17 and glucose tolerance did not differ between wildtype and Cox7a1 knockout mice fed with high fat or c
20 ed CB2R mRNA expression in VTA DA neurons in wildtype and DAT-Cnr2 cKO heterozygous but not in the ho
22 guishing of individual VM and FB tissue from wildtype and FGF-2-deficient embryonic day (E)14.5 embry
23 to potential mechanistic differences between wildtype and FTDP-17 Tau variants, as well as different
25 of isogenic soluble Env trimers, designated wildtype and gV3, which differ only in their potential t
28 h no significant difference observed between wildtype and heterozygous patients in the majority of th
30 cells in the dorsal thalamus was similar in wildtype and knockout mice but there was a notable reduc
33 n human atrial myocardium and in both intact wildtype and M2 or M1/3-receptor knockout mouse Langendo
34 dianion binding to the transition state for wildtype and many mutant TIM-catalyzed reactions of subs
36 istribution and brain PET imaging studies in wildtype and mGluR2 knockout rats in a primate and in hu
41 r understanding RTT pathophysiology, wherein wildtype and mutant neurons are intermixed throughout th
43 comparison of rNTP incorporation kinetics by wildtype and mutant Pol mu indicates that rNTP accommoda
46 is in concert with physiological data of G20 wildtype and mutants demonstrated that pyruvate fermenta
47 eases force at submaximal activation in both wildtype and NEB KO fiber bundles and, importantly, that
50 distribution of Panx1 in the mouse retina of wildtype and Panx1-null mice by reverse-transcription po
52 lacking T, B, and NK cells) when compared to wildtype and Rag1-null mice (lacking T and B cells but r
54 orted that elucidate differences between the wildtype and this mutant form of human GALE, little is k
55 nce APAP evoked hypothermia was identical in wildtype and Trpv1(-/-) mice, and not reduced by adminis
56 ation of APAP evoked a marked hypothermia in wildtype and Trpv1(-/-) mice, but only restored normal b
59 of SIfTER-computed energy landscapes for the wildtype and two oncogenic variants, G12V and Q61L, sugg
60 formed molecular dynamics simulations on the wildtype and V94M enzyme in different states of substrat
61 aging experimentally-available structures of wildtype and variant sequences of a protein to define a
62 of SBMA, a myogenic model that overexpresses wildtype androgen receptor (AR) exclusively in muscle fi
63 x from PE to PC of Gnmt(-/-) mice to that of wildtype animals and normalized DG and TG content preven
64 lagl1 and Sox9 did not induce gliogenesis in wildtype animals, but nonetheless activated expression o
65 CD electroporation, inhibited gliogenesis in wildtype animals, but rescued MG development in Lhx2-def
66 s evolved the binucleation rate decreased in wildtype animals, whereas it remained high in p38alpha-d
68 rus were inoculated into Rad54-deficient and wildtype Arabidopsis thaliana plant lines to compare the
70 spine density to an even greater extent than wildtype Arf4, whereas the inactive Arf4-T31N mutant doe
71 ed with sorafenib (25 mg/kg)-treated C57BL/6 wildtype as well as hepatitis B virus (HBV) and lymphoto
73 when RAD52 was depleted in a BRCA1- or PALB2-wildtype background, a negligible decrease in colony sur
78 ding of the mutant was nearly similar to the wildtype; binding of Mg2+ occurred with higher affinity.
80 trongly associated with tumors that are KRAS wildtype, BRAF wildtype, have no or a low CpG island met
89 w that the modified Prox-1-GFP mice carrying wildtype C57BL/6 background provide a valuable tool for
93 moderate inhibition of PI3K-AKT signaling in wildtype cells was sufficient to cause AJ alterations.
95 cells were longer and more flagellated than wildtype cells, which may explain their predominance on
97 increases the steady-state levels of mature wildtype CFTR in a CFTR-associated ligand (CAL)- and TC1
100 ly increased mDA fiber outgrowth compared to wildtype cocultures, proving a regulatory role of FGF-2
103 had a less activated phenotype, unlike their wildtype counterparts that expressed IFN-gamma and espec
105 3H/HeJ mice were sensitized with recombinant wildtype Cyp c 1 or carp extract by intragastric gavage.
106 proliferation experiments using recombinant wildtype Cyp c 1, and overlapping peptides spanning the
107 hat crypts (one or two) are a normal part of wildtype development but they almost all resolve by birt
109 echanism in the presumptive retina region in wildtype embryos, thus accounting for the apparent up-re
112 cific response compared with that induced by wildtype Env and could be explained by a loss of V3-dire
114 bsequently, we showed that C. jejuni 81-176 (wildtype) exhibited enhanced chemoattraction to and resp
115 could follow the double pulsed stimulus with wildtype fibres blocking first and Nav 1.8 KO fibres end
116 lockade on the wheel-running performances of wildtype (gamma-aminobutyric acid [GABA]-CB(1)(+)/(+)) a
117 obal gene expression patterns in livers from wildtype, Gcn2 (-/-), and Atf4 (-/-) mice treated with a
119 edict whether an unknown mouse has a CF or a wildtype genotype with 1.0, 0.84, and 0.9 accuracy for e
120 rkB receptors mimics the MeCP2 deficiency in wildtype glutamatergic neurons, while re-expression of B
123 ted with tumors that are KRAS wildtype, BRAF wildtype, have no or a low CpG island methylator phenoty
124 exhibit light responses very similar to the wildtype HBC(R/MC)s, suggesting that the mixed rod-cone
125 hagy was inhibited chemically in ER-stressed wildtype hepatocytes, which resulted in cytoplasmic vacu
126 eles was compared as well as those that were wildtype, heterozygous, or homozygous for the TSLPrs1898
127 GS(double dagger))GA+HPi = 3.3 kcal/mol, for wildtype hlGPDH-catalyzed reaction of GA + HPi, and for
128 lues of kcat/KGAKX for dianion activation of wildtype hlGPDH-catalyzed reduction of GA and kcat/KGAKX
129 ted for the interactions between the 180 kDa wildtype homotrimeric tailspike protein of the bacteriop
131 sociated virus pseudotype 2/5 to overexpress wildtype human alpha-synuclein (rAAV2/5 alpha-syn).
132 ng fibres in knockout animals as compared to wildtypes, in combination with reduced per-pulse sodium
133 oliferation led us to explore the biology of wildtype KLF6 (KLF6(WT) ) and its antagonistic, alternat
136 e, we find that inducing the DosR regulon to wildtype levels in aerobic, replicating M. tuberculosis
139 -)) mice gained less body weight compared to wildtype littermate control (M-JAK2(+/+)) mice and were
141 ogy (3 months of age) in comparison to their wildtype littermates and assessed changes in cognition,
150 umor suppressor gene in TUSC2 deficient EGFR wildtype lung cancer cells increased sensitivity to erlo
151 idently identified 22 gene products from the wildtype M. marinum secretome in a single CZE-tandem mas
153 l mice developed 50% fewer colon tumors than wildtype mice after exposure to azoxymethane and dextran
154 Forced overexpression of UCP2 protected wildtype mice against APAP-induced hepatotoxicity in the
155 d the effects of environmental enrichment in wildtype mice and in a mouse model of Abeta neuropatholo
156 ed by the scavenging of extracellular ATP in wildtype mice and in Rag2/common gamma-null mice after a
157 travenously inoculated in IL-15 knockout and wildtype mice and in wildtype mice treated with anti-IL-
159 4))-induced liver fibrosis in Cxcr3(-/-) and wildtype mice by histological, molecular, and functional
162 increased Ptp4a3 expression in the colon of wildtype mice immediately following treatment with the c
163 significantly when the study was repeated in wildtype mice made deficient in eosinophils with a deple
167 his study we used FMR1 knockout and isogenic wildtype mice to systematically map the distribution of
168 d in IL-15 knockout and wildtype mice and in wildtype mice treated with anti-IL-15 antibodies (aIL-15
172 e cranial base of newborn Pax7-deficient and wildtype mice using a computational shape modeling techn
173 the study of D1-MSN dendrite development in wildtype mice, and its degeneration in a mouse model of
175 in p55(Deltans/Deltans) mice, but absent in wildtype mice, confirming that the p55(Deltans/Deltans)
180 duction in M-wave root mean square (RMS) for wildtype mice, which was in stark contrast to mdx mice t
193 two significant alterations when compared to wildtype mice: They die at birth due to a malformed diap
194 ated by these mutations, is expressed at the wildtype Michaelis complex, and ca. 50% is only expresse
197 nized transgenic UGT1A-SNP and corresponding wildtype mouse model were established carrying the GS-as
199 y cages, APPSWE /PS1dE9 (n = 27) and healthy wildtype (n = 21) mice were randomly assigned to either
200 BDNF acts cell autonomous and autocrine, as wildtype neurons are not capable of rescuing growth defi
202 ations in KRAS [KRAS wildtype] or BRAF [BRAF wildtype], no or a low CpG island methylator phenotype,
206 lopment of metabolic and skeletal changes in wildtype offspring, with a greater effect of maternal di
209 ith reconstituted troponin containing either wildtype or a 65% mix of K206I/wildtype and measured for
210 xpression profiles of planulae with either a wildtype or an experimentally expanded apical organ, we
211 fects of the novel variant, we expressed the wildtype or mutant hEAAT1 in mammalian cells and perform
212 using green fluorescent protein-tagged PKD (wildtype or mutant S427E) and targeted fluorescence reso
214 ne residue, is severely impaired compared to wildtype or the mutant viruses encoding K77R or K113R.
216 lecular subtypes (no mutations in KRAS [KRAS wildtype] or BRAF [BRAF wildtype], no or a low CpG islan
218 nents can occasionally reverse the cell near wildtype periodicity, but frz- cells are otherwise in a
219 s showed that repeated rounds of swarming by wildtype Pf-5 drives the accumulation of gacS/gacA spont
220 inate on the edge and that initial DeltagacA:wildtype Pf-5 ratios of at least 2:1 lead to a collapse
223 w reduced growth and seed yields relative to wildtype plants in fluctuating light and/or temperature.
225 g [Ca(2+)] at normal resting levels while in wildtype PNs mGluR1 EPSCs are enhanced by elevated [Ca(2
226 hibition of histone deacetylases, mutant and wildtype promoters were induced to the same level, indic
227 , importantly, all appear to destabilise the wildtype protein in co-transfection experiments in a hum
229 through a mutant that closely resembles the wildtype protein, but not through a mutant engineered fo
233 enotype was restored by expression of either wildtype PSI1 or PSI1 G2A with a mutated myristate attac
235 ed in recently available mGluR2 knockout and wildtype rats and in a monkey using a structurally disti
236 riments in Wistar and in mGluR2 knockout and wildtype rats as well as in vivo biodistribution and bra
241 Sf9 cell lines stably expressing either the wildtype RyR or the G4946E variant, in order to test the
246 al G12/13 coupling, thrombin-stimulated PAR1 wildtype strongly induced RhoA-mediated stress fiber for
247 th Dnmt3a-null bone marrow in the absence of wildtype support cells succumbed to bone marrow failure
251 f substrate pieces shows that ca. 50% of the wildtype TIM dianion binding energy, eliminated by these
255 tributions of RMP were not different between wildtype uninjured and injured muscle cells (median: -73
256 th two-photon laser scanning for analysis of wildtype, Val/Met, and Met/Met mice both at baseline and
259 1,000 Da) for differential expression in XOR wildtype vs. mice with inactivated XOR, arising from gen
260 high-resolution structures, so comparison of wildtype-vs.-mutant crystal structure pairs is not suffi
261 eared in the order NaV 1.8 KO > NaV 1.9 KO > wildtype, which is most likely explained by the relative
262 e cyanobacterium Synechocystis sp. PCC 6803 (wildtype) with alanine, present in higher plants, or wit
263 set specific (NS)-Pten heterozygous (HT) and wildtype (WT) adult mice received either intraperitoneal
265 bution of ASS to the pathophysiology of ALD, wildtype (WT) and Ass(+/-) mice (Ass(-/-) are lethal due
268 roteins did not significantly differ between wildtype (WT) and KO mice at each time point, the timing
269 ee genomic transgenic mouse lines expressing wildtype (WT) and L151F mutant mouse GCAP1 with or witho
270 tely high fat plus cholesterol diet (HFC)-on wildtype (WT) and liver-specific Foxo1/3/4 triple knocko
274 ing the whole dataset (399 transgenic HD and wildtype (WT) brains, from mice aged 9-80 weeks) publicl
276 erozygous knockout (Foxp2+/-) mice and their wildtype (WT) littermates from juvenile to adult ages, a
277 and accumulation of free fatty acid (FFA) in wildtype (WT) livers, which were significantly reduced i
278 was isolated from p58(IPK) knockout (KO) and wildtype (WT) mice and treated with lipopolysaccharide (
280 of HPbetaCD resulted in OHC death in prestin wildtype (WT) mice whereas OHCs were largely spared in p
281 was significantly lower in Flt3L KO than in wildtype (WT) mice with lower alanine aminotransferase (
282 A), and IL-17A mRNA in IRF3-deficient versus wildtype (WT) mice, whereas IL-27p28 mRNA expression was
286 cles display the same number of myofibers as wildtype (WT) muscles, but by E18.5 dyW-/- muscles are s
287 s of db mutant, which overexpress leptin, to wildtype (WT) or genetically obese (ob) mice has been re
288 , mediated prominent 2-APB-induced Ip on the wildtype (WT) Orai1 channels of narrow pore sizes, while
290 88(L265P)CXCR4(WHIM/FS) or MYD88(L265P)CXCR4(WILDTYPE (WT)) had intermediate BM and serum immunoglobu
291 vity was monitored in cells transfected with wildtype (WT), Cys42Ser or Cys117/195Ser PKGIalpha that
292 ter the induction of ConA-acute hepatitis in wildtype (WT), perforin(-/-) , tumor necrosis factor rel
293 Cs had lower mitochondrial calcium than Ucp2 wildtype (WT)-PASMCs at baseline and during histamine-st
295 ided into those carrying >/=3 major alleles (wildtype [WT]+: G-C/G-C, G-C/T-C, G-C/G-A, N = 100) and
298 tegrin, we compared the sterol dependence of wildtype Y. pseudotuberculosis internalization with that
299 MS), we analysed the retina of adult longfin wildtype zebrafish at 0, 3 and 18 days after Ouabain inj
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