ライフサイエンスコーパス: wingless

1 capsule selector genes such as cut, Lim1 and wingless.

2 glycan/HSPG-binding morphogens, Hedgehog and Wingless.

3 s a niche expressing the ligands Serrate and Wingless.

4 ped human medulloblastomas (50 MBSHH, 28 Wnt/Wingless, 44 Group 3 and 94 Group 4) and their conservat

5 Wingless, a Drosophila Wnt homolog, has been reported to

6 Finally, removal of one copy of wingless, a gene required for normal trichome patterning

7 eal an intertissue signaling system in which Wingless acts as an effector of MED13 in heart and muscl

8 kers, and female alates (winged) and queens (wingless), AK cDNA was obtained from the red imported fi

9 Additionally, in response to Wingless, all prospective wing cells produce an unidenti

10 at and Dachsous, organized by the morphogens Wingless and Decapentaplegic, suppress Warts by acting v

11 a dpp intron (dppMX-lacZ) revealed that the Wingless and Dpp pathways are required to activate dpp e

12 of sloppy-paired and paired with respect to wingless and engrailed at the parasegment boundary is co

13 We show that escort cells produce both Wingless and Hedgehog ligands for the FSC lineage, and t

14 mechanism distinct from that induced by Wnt/Wingless and highlight the essential non-metabolic funct

15 tion and development via cross-talk with the wingless and Int (Wnt)/beta-catenin signaling pathway.

16 Wingless and INT-1 (WNT)/beta-catenin signaling is reduc

17 ith cell cycle control and activation of the Wingless and integration site (Wnt)/beta-catenin pathway

18 Wingless and Myc are induced by tissue damage and are im

19 These results indicate that STAT, Wingless and Myc are major parallel regulators of cell c

20 porcupine gene is required for secretion of wingless and other Wnt proteins, and sporadic mutations

21 ess signaling molecules, including Hedgehog, Wingless, and Decapentaplegic, and how these define a pr

22 ate-gene approaches have implicated the JNK, Wingless, and Hippo pathways in regeneration.

23 iquitous: the most basal living insects, the wingless Archaeognatha, possess glomerular antennal lobe

24 ment polarity genes (engrailed, hedgehog and wingless) are not involved in specifying the position of

25 The wingless arthropods evolved a highly textured, hierarchi

26 pective wing cells survive in the absence of Wingless as long as they are not surrounded by Wingless-

27 -binding protein that is secreted along with Wingless at the neuromuscular junction.

28 n and can account for many of the effects of wingless at this synapse.

29 unction of Evenness Interrupted (Evi)/Wls, a Wingless-binding protein that is secreted along with Win

30 are highly modified parasites (including the wingless Braulidae) of bees and other insects.

31 stigated the olfactory system of the primary wingless bristletail Lepismachilis y-signata (Archaeogna

32 In Drosophila, the ligand Wingless causes the C terminus of its Frizzled2 receptor

33 activity of beta-catenin resulting from Wnt/Wingless-dependent or -independent signaling has been de

34 and is required for only a limited number of Wingless-dependent processes.

35 Wingless downregulates the activity of the serine/threon

36 We find that for nearly all Wingless-driven developmental processes, a three- to fou

37 miR-310/13) cluster as a novel antagonist of Wingless (Drosophila Wnt) pathway activity in a function

38 Interestingly, several members of the WNT (Wingless)-DVL signaling cascade, including phospho-GSK3b

39 are required for full function, to maintain wingless expression and parasegment boundaries throughou

40 evolved from simpler schemes by co-option of Wingless expression at new sites.

41 e two groups of vg-dependent tissues in the "wingless" first thoracic segment (T1).

42 Loss of wg (wingless) function alters the number and structure of bo

43 stasis experiments further demonstrated that Wingless functions downstream of MED13 within a muscle-r

44 genome engineering to replace the endogenous wingless gene, which encodes the main Drosophila Wnt, wi

45 c interactions were detected with the Notch, Wingless, Hedgehog or Dpp pathways, nor did Fas2 inhibit

46 d by Pygopus, a protein that is required for Wingless-induced transcription of naked cuticle.

47 that encode secreted proteins and found that Wingless inhibition also caused obesity.

48 cell proliferation, survival, and canonical wingless-int (WNT) activity are not mTOR dependent, but

49 Recent studies have begun to highlight Wingless-Int (Wnt) signaling as a key player in synapse

50 hreonine protein kinase AKT-beta-catenin and Wingless-Int (Wnt)-beta-catenin signaling pathways.

51 nic hedgehog, fibroblast growth factors, and wingless-int (Wnt)/beta-catenin.

52 clear beta-catenin zone, which is induced by wingless-int (Wnt)7a protein diffusing in from posterior

53 addition of roof plate-specific spondin 1, a wingless-int agonist, Ring/Dense colony-forming cells ca

54 y Wnt target genes, that remove surface Wnt (wingless-int) receptors.

55 Regional expression of Wingless/Int (Wnt) genes plays a central role in regulat

56 h cells provide a crucial niche by secreting Wingless/Int (Wnt) ligands.

57 In early Caenorhabditis elegans embryos, the Wingless/int (Wnt)- and Src-signaling pathways function

58 ibromin assists in mediating output from the Wingless/Int signaling pathway, and dysfunction of the e

59 phoproteins (DVL1-3), key regulators of Wnt (Wingless/Int) signalling pathways important for axon gui

60 They are bound and activated by the Wingless/Int-1 lipoglycoprotein (WNT) family of secreted

61 Because canonical Wnt (Wingless/Int1) signals critically regulate renewal versu

62 The leukotriene (LT) and wingless/integrase (Wnt) pathways have been implicated i

63 The Wingless/integrase-1 (Wnt) family of protein ligands and

64 Although wingless integrated MMTV (Wnt)/beta-catenin signaling pl

65 We also show that beta-catenin siRNA and the Wingless/integrated (Wnt) inhibitor pyrvinium block the

66 gulation at 5T of immediate-early gene, Wnt (wingless integration site), insulin, and G-protein signa

67 3' UTRs and experimentally verified secreted wingless-interacting molecule (swim) as an authentic tar

68 tterning signals that operate locally (e.g., Wingless/Ints [Wnts], Bone Morphogenetic Proteins [BMPs]

69 We suggest therefore that the spread of Wingless is dispensable for patterning and growth even t

70 Our data also suggested that Wingless is not required during the early stages of disc

71 Sand dwellers show rapid deployment of Wingless, later foxg1 expression and a larger pallium.

72 ow that when making targeted jumps, juvenile wingless mantises first rotated their abdomen about the

73 Interestingly, wingless maternal parasitoids produced more winged proge

74 f MED13 in heart and muscle and suggest that Wingless-mediated cross-talk between striated muscle and

75 We show that wing spots are induced by the Wingless morphogen, which is expressed at many discrete

76 CtBP can both repress and activate Wingless nuclear targets in Drosophila.

77 results from the bidirectional influence of wingless on both presynaptic and postsynaptic structures

78 lost and cannot be restored by activation of Wingless or Myc.

79 basal Axin levels must be controlled for Wnt/Wingless pathway activation, and how Axin stability is r

80 Finally, as observed previously for Wingless pathway components, Tnks activity in absorptive

81 n the adult intestine, where activity of the Wingless pathway is graded and peaks at each compartment

82 erky and Ebd1 interact directly with the Wnt/Wingless pathway transcriptional co-activators beta-cate

83 e downstream transcriptional effector of the Wingless pathway, also evoked an obese phenotype in flie

84 is conferred by a pathway consisting of Wnt (Wingless) pathway components, including posterior pharyn

85 Manipulation of the Hedgehog and Wingless pathways in cichlid and zebrafish embryos is su

86 These include sonic hedgehog, wingless, planar cell polarity and fibroblast growth fac

87 Cells flanking the source of Wingless produce a negative signal (encoded by notum) th

88 Accordingly, in Drosophila, the morphogen Wingless produced in the wing's prospective distal regio

89 cell proliferation and tissue growth through wingless production when apoptosis is inhibited by p35.

90 Finally, ex has a role in regulating Wingless protein levels in the eye that is not obviously

91 tion is induced by Hedgehog and inhibited by Wingless, providing a sensitive system in which to ident

92 exuals to workers) and the individual level (wingless queens evolve in ants), and other consequences

93 The cortical hem, a source of Wingless-related (WNT) and bone morphogenetic protein (B

94 Gene deletion of intermediates of Wingless-related integration (Wnt) signaling causes hear

95 h homolog protein 1 but higher expression of wingless-related integration site (WNT) family pathway c

96 SIP), follistatin (FST), ecodysplasin (EDA), wingless-related integration site (Wnt), and beta-carote

97 a network of fibroblast growth factor (FGF), wingless-related integration site (WNT), and bone morpho

98 Wingless-related integration site (WNT)/beta-catenin sig

99 on and subsequent increased transcription of Wingless-related integration site target genes.

100 tous polyposis coli), thereby affecting Wnt (Wingless-related integration site) signaling and regulat

101 ranscriptional coactivator in canonical Wnt (wingless-related integration site) signaling.

102 Putative driver mutations affecting WNT (wingless-related integration site), JAK-STAT (Janus kina

103 rious signaling pathways, including the Wnt (wingless-related integration site)/beta-catenin pathway.

104 is work, we show that the timed secretion of Wingless-related MMTV (mouse mammary tumor virus) integr

105 thalamic axons, which secrete the morphogen Wingless-related MMTV (mouse mammary tumor virus) integr

106 Wingless-related MMTV integration site 1 (WNT1)/beta-cat

107 Hypomethylation of wingless-related MMTV integration site 5A (WNT5A), S100

108 (2.5-fold), GABA A receptor (2.9-fold), and wingless-related MMTV integration site 7B (2.8-fold).

109 kkopf 3 (DKK3), a secreted modulator of WNT (Wingless-related MMTV integration site)/beta-catenin sig

110 Dickkopf-1 (DKK1), an antagonist of the wingless-related mouse mammary tumor virus (WNT) signali

111 mpact of CREB on expression of cyclin D1 and wingless-related mouse mammary tumor virus integration s

112 n of a non-canonical signaling member of the wingless-related protein family, Wnt5a.

113 Wingless-related proteins (WNTs) regulate extension of t

114 naling pathways involving hedgehog proteins, wingless-related proteins and fibroblast growth factors

115 velopment, the secretion of Drosophila Wnt1, Wingless, requires the function of Evenness Interrupted

116 ngless as long as they are not surrounded by Wingless-responding cells.

117 Ebd1 is expressed in only a subset of Wingless responsive cell types, and is required for only

118 ere significantly up-regulated in winged and wingless S. avenae small RNA libraries, respectively.

119 es indicated that mutant LRP5 led to reduced wingless signal activation.

120 tors essential for wing development (such as Wingless signal and apterous), and has nubbin enhancer a

121 Wnt/Wingless signal transduction directs fundamental develop

122 The evolutionarily conserved Wnt/Wingless signal transduction pathway directs cell prolif

123 During metazoan development, the Wnt/Wingless signal transduction pathway is activated repeti

124 Wingless signaling acts to balance the proportion of hin

125 Further, in embryos lacking the Wingless signaling component zw3, the same full apical e

126 Wnt/wingless signaling contributes to the development of neu

127 Importantly, cby(1/1) flies did not show Wingless signaling defects.

128 Finally, Gsb has been shown to antagonize Wingless signaling during embryonic fate specification,

129 contrast, perturbation of Decapentaplegic or Wingless signaling failed to affect Rbf niche cell expre

130 identified DIAP1 as a positive regulator of Wingless signaling in a Drosophila S2 cell-based RNAi sc

131 estigated, and found, a role for Dot1 in Wnt/Wingless signaling in an in vivo model system.

132 tive signal (encoded by notum) that inhibits Wingless signaling in nearby cells.

133 dgehog ligands for the FSC lineage, and that Wingless signaling is specific for the FSC niche whereas

134 Therefore, relative differences in Wingless signaling lead to competitive cell interactions

135 Examining Wnt/wingless signaling mechanisms, we find that a distinct p

136 The Wingless signaling pathway controls various developmenta

137 The wingless signaling pathway establishes a midline anterio

138 anscriptional activity downstream of the Wnt/Wingless signaling pathway has been observed in many hum

139 y Dot1 and its associated factors to the Wnt/Wingless signaling pathway.

140 ogy of PCLD to deregulation of the canonical wingless signaling pathway.

141 Finally, we show that Wingless signaling reduces ACF1 binding to WG targets, a

142 mplex and mediate the same context-dependent Wingless signaling responses.

143 ivity, promotes contextual regulation of Wnt/Wingless signaling responses.

144 , postsynaptic response, and anterograde Wnt/Wingless signaling, all of which modulate NMJ growth thr

145 ndent on hid but independent of Myc, Yorkie, Wingless signaling, and of ribosome biogenesis.

146 atenin degradation and prevent inappropriate Wingless signaling, but its effects on the Hedgehog path

147 ompensation rescues both Decapentaplegic and Wingless signaling, suggesting a universal role of this

148 ment boundaries during GBE is independent of Wingless signaling, suggesting pair-rule gene control.

149 Instead, due to regulation by Wingless signaling, the Nub and Tsh expression boundarie

150 hat Notum could amplify local differences in Wingless signaling, thus serving as an early trigger of

151 NRF1), in promoting contextual regulation of Wingless signaling.

152 ating role in both physiological and ectopic Wingless signaling.

153 umor suppressor, a negative regulator of Wnt/Wingless signaling.

154 -regulation of Axin, a negative regulator of Wingless signaling.

155 Because WNT (wingless) signaling-induced activation of the transcript

156 -related protein 1 levels and increased WNT (wingless) signaling.

157 Wingless signalling plays only a permissive role by trig

158 l co-activators facilitate cell-specific Wnt/Wingless signalling responses by modulating beta-catenin

159 nts that cannot dimerize are able to promote Wingless signalling, but are defective in repressing Win

160 engaged in a positive feedback loop with Wnt/Wingless signalling, modulated by Src and Fak kinases.

161 and Pygopus, a nuclear protein required for Wingless signalling, support a model where monomeric CtB

162 a genetic screen for components that promote Wingless signalling, we identified Earthbound 1 (Ebd1),

163 l where CtBP is a gene-specific regulator of Wingless signalling, with some targets requiring CtBP di

164 strength and timing of opposing Hedgehog and Wingless signals establish evolutionary divergence in do

165 t that competing ventral Hedgehog and dorsal Wingless signals mediate evolutionary diversification of

166 sulting in expression of foxg1 before dorsal Wingless signals, and a larger subpallium.

167 ile ISWI is localized to the same regions of Wingless target gene chromatin as TCF, we find that ACF1

168 cumulate beta-Catenin and ectopically induce Wingless target genes.

169 sults in decreased expression of a subset of Wingless target genes.

170 kuld, are essential for the transcription of Wingless target genes.

171 dependent role of ISWI-ACF1 in repression of Wingless targets is also observed.

172 ro-dimerization and consequent repression of Wingless targets.

173 signalling, but are defective in repressing Wingless targets.

174 cts downstream of Pygopus in activating some Wingless targets.

175 s a similar reduction in expression of these Wingless targets.

176 levels and a reduction in expression of many Wingless targets.

177 key cell-fate determinants, such as the Wnt (Wingless), TGF-beta/BMP, Hh and RTK/Ras pathways.

178 and increased and disorganized expression of wingless, the central component of the Wnt signaling pat

179 teins and vertebrate orthologs of Drosophila wingless, the Wnts.

180 us, cells influence each other's response to Wingless through at least two modes of lateral inhibitio

181 t the microRNA, miR-965, acts via string and wingless to control histoblast proliferation and migrati

182 otein Evi is a versatile carrier that guides Wingless to presynaptic terminals of motor neurons and t

183 the developmental fate of their embryos from wingless to winged morphs.

184 how that, in the prospective wing, prolonged wingless transcription followed by memory of earlier sig

185 Apc likely promotes Wingless transduction through down-regulation of Axin, a

186 Here, we show that, in parallel, Wingless triggers two nonautonomous inhibitory programs

187 omeobox (Hox)-Fibroblast growth factor (Fgf)-Wingless type MMTV integration site family (Wnt) genetic

188 Elements of the sonic hedgehog pathway and Wingless type MMTV integration site family were validate

189 eted Frizzled-related protein 1 (SFRP1) is a Wingless-type (Wnt) antagonist that has been associated

190 s of the CCN family and a target gene of the Wingless-type (WNT) signaling pathway.

191 1/2) activation in conjunction with elevated wingless-type (Wnt) signaling.

192 demonstrate a critical paracrine role of the wingless-type (WNT)/beta-catenin pathway in estrogen/pro

193 Aberrant activation of Wingless-type (Wnt)/beta-catenin signaling is widespread

194 eak, including fibroblast growth factors and wingless-type family members (Wnt).

195 nd wnt/beta-catenin (where wnt refers to the wingless-type mammary tumor virus integration site famil

196 Whereas the roles of the canonical wingless-type MMTV (mouse mammary tumor virus) integrati

197 We identified 3 main clusters of HCCs: the wingless-type MMTV integration site (32 of 89; 36%), int

198 e site was rescued by local treatment with a Wingless-type MMTV integration site (Wnt) antagonist, Di

199 croenvironment converging to dysregulate the Wingless-type MMTV integration site (Wnt)/beta-catenin s

200 The vital role of Wingless-type MMTV integration site (Wnt)/beta-catenin s

201 Aberrant activation of canonical Wingless-type MMTV integration site family (Wnt) signali

202 The wingless-type MMTV integration site family (WNT)/beta-ca

203 Wingless-type MMTV integration site family (WNT)16 is a

204 n which we identified causative mutations in wingless-type MMTV integration site family 1 (WNT1).

205 hogens of the bone morphogenetic protein and wingless-type MMTV integration site family member (Wnt)

206 , while defects in SP7 transcription factor, wingless-type MMTV integration site family member 1 (WNT

207 ironment that includes the Wnt family member wingless-type MMTV integration site family member 16B (W

208 on of a truncated protein, which retains the Wingless-type MMTV integration site family member-ligand

209 bone morphogenetic proteins (BMPs) and Wnt (wingless-type MMTV integration site family) expression b

210 KD1), which is a repressor of canonical WNT (wingless-type MMTV integration site) signaling.

211 ) compartment where they become inducible by wingless-type mouse mammary tumor virus integration site

212 y modulating the balance between mesenchymal Wingless-type Mouse Mammary Tumor Virus integration site

213 astoma as four molecular subtypes, including wingless-type murine mammary tumor virus integration sit

214 ated protein 4) as a facilitator of the WNT (Wingless-type) antagonist sclerostin and found mutations

215 ion, emphasizing that workers are not simply wingless versions of queens.

216 For example, the Wnt ligand Wingless (Wg) activates the naked cuticle (nkd) gene in

217 Epidermal growth factor receptor (EGFR) and wingless (wg) alleles also modify the ago apoptotic phen

218 cy of many ligands, including Hedgehog (Hh), Wingless (Wg) and Bone morphogenetic proteins (BMPs).

219 mbined gradients of two secreted morphogens, Wingless (Wg) and Decapentaplegic (Dpp).

220 velopment is that secreted molecules such as Wingless (Wg) and Hedgehog (Hh) generate pattern by indu

221 intestinal stem cells (ISCs) by stimulating Wingless (Wg) and JAK/STAT pathway activities, whereas c

222 ine and Raspberry increase the activities of Wingless (Wg) and the EGF-ligand Spitz (Spi), respective

223 n of multiple genes, including the WNT genes wingless (wg) and Wnt6.

224 signaling proteins such as Hedgehog (Hh) and Wingless (Wg) depend on heparan sulfate proteoglycans (H

225 nkd) gene limits signaling by the Wnt ligand Wingless (Wg) during embryo segmentation.

226 gene attenuates signaling by the Wnt ligand Wingless (Wg) during segmentation.

227 sophila wing disc, wherein apically secreted Wingless (Wg) encounters its receptor, DFrizzled2 (DFz2)

228 d (Fz)-containing myoblast cytonemes take up Wingless (Wg) from the disc, and Delta (Dl)-containing m

229 s discovered the link between the Drosophila wingless (Wg) gene and the vertebrate oncogene int-1, th

230 Dlp), cognate receptor Frizzled-2 (Frz2) and Wingless (Wg) ligand.

231 gaster follicle stem cells are controlled by Wingless (Wg) ligands secreted 50 microm away, raising t

232 The mechanisms by which the Wingless (Wg) morphogen modulates the activity of the tr

233 cific and segment-specific regulation of the Wingless (Wg) morphogen underlies the development of sex

234 Hth expression is the result of Wingless (Wg) pathway activity at the eye margins and re

235 e report a screen for miRNAs that affect the Wingless (Wg) pathway, a conserved pathway that regulate

236 To identify regulators of the Wnt/Wingless (Wg) pathway, we performed a genetic screen in

237 al margins is blocked by the activity of the Wingless (Wg) pathway.

238 Spatial and temporal control of Notch and Wingless (Wg) pathways during development is regulated a

239 In the Drosophila melanogaster ovary, Wingless (Wg) promotes proliferation of follicle stem ce

240 Lipid-modified Wnt/Wingless (Wg) proteins can signal to their target cells

241 F progression is due to ectopic induction of Wingless (Wg) signaling and Homothorax (Hth), the negati

242 iR-8 controls the activity of the long-range Wingless (Wg) signaling by regulating Swim expression in

243 We show that reduced Wingless (Wg) signaling dominantly inhibits Stat92E acti

244 In Wingless (Wg) signaling in Drosophila, target gene regul

245 we describe genetic interactions between the Wingless (Wg) signaling pathway and a nonmuscle myosin h

246 Here we show that components of the Wingless (Wg) signaling pathway are expressed in prohemo

247 ophila wing discs, Dlp represses short-range Wingless (Wg) signaling, but activates long-range Wg sig

248 Based on my studies on Wingless (Wg) signaling, I report that the neuronal migr

249 ologue of Sulfs, Sulf1, negatively regulates Wingless (Wg) signaling.

250 egulation of cell fate through modulation of Wingless (Wg) signaling.

251 ative cell proliferation in cooperation with Wingless (Wg) signaling.

252 he segment polarity genes engrailed (en) and wingless (wg) via regulation of secondary pair-rule gene

253 Unexpectedly, we identified wingless (wg), a secreted morphogen that regulates synap

254 onizes the signaling of the prototypical Wnt Wingless (Wg), by releasing glypicans from the cell surf

255 L3E)] fed on sucrose alone showed suppressed Wingless (WG), Cut (CT) and Senseless (SENS) expression.

256 on/acylation in regulating the activities of Wingless (Wg), the main Drosophila Wnt member.

257 secreted signals, Decapentaplegic (Dpp) and Wingless (Wg), to form the proximodistal (PD) axis.

258 leg requires both Decapentaplegic (Dpp) and Wingless (Wg), two signals that establish the proximo-di

259 me cells to secrete the long-range morphogen Wingless (Wg), which drives vg expression in surrounding

260 vi is required for the secretion of the Wnt, Wingless (Wg).

261 on of the mitogens Decapentaplegic (Dpp) and Wingless (Wg).

262 wingless (wg)/Wnt family are essential to development in

263 Previously, the Wingless (Wg)/Wnt pathway was shown to underlie the stru

264 Wingless (Wg)/Wnt signaling directs a variety of cellula

265 In the fly epidermis, Wingless (Wg)/Wnt signaling directs cells to produce eit

266 Wingless (Wg)/Wnt signaling is essential for patterning

267 Wingless (Wg)/Wnt signaling is fundamental in metazoan d

268 Dpp antagonizes activity of wingless (Wg)/Wnt signaling, which positively regulates

269 Here, we study the role and regulation of Wingless (Wg)/Wnt signalling during intestinal regenerat

270 endants, are controlled by locally emanating Wingless (Wg, a Drosophila Wnt homologue) and Hh signals

271 These cells reside in domains of high Wingless (Wg, Drosophila Wnt-1) and STAT92E (sole Drosop

272 lture or in situ by ubiquitous expression of wingless (wg/wnt1).

273 mporally with that of ac-sc in the notum, is Wingless (Wg; also known as Wnt).

274 Wnt signaling ligand discovered, Drosophila Wingless (Wg; Wnt1 in mammals), plays crucial roles in s

275 to asymmetric division additionally requires Wingless, which regulates Numb expression in the AMP lin

276 appaB ligand (RANKL), osteoprotegerin (OPG), wingless (WNT) 10b, dickkopf-related protein 1 (DKK-1),

277 sfrp5 and bmper, notable for roles in Wingless (Wnt) and bone morphogenetic protein (BMP) sign

278 nce of joint shape, including members of the Wingless (Wnt) and the bone morphogenetic protein (BMP)

279 Positive signaling by the canonical wingless (Wnt) pathway is critical for the differentiati

280 entional DCs via activation of the canonical Wingless (Wnt) pathway.

281 supports normal PAEC function by recruiting Wingless (Wnt) signaling pathways to promote proliferati

282 n Akt/glycogen synthase kinase-3 (GSK-3) and wingless (Wnt) signaling pathways, which have been assoc

283 rise frequently as a consequence of aberrant wingless (Wnt) signalling.

284 n kinase Akt (Akt) signaling cooperates with Wingless (Wnt) to activate beta-catenin in intestinal st

285 naling pathways, including Hedgehog (Hh) and Wingless (Wnt), and oriented cell divisions, all of whic

286 ry pathways, including Sonic hedgehog (Shh), Wingless (Wnt), retinoic acid receptor (RAR), and bone m

287 four molecular subgroups of medulloblastoma-wingless (WNT), sonic hedgehog (SHH), group 3, and group

288 cally distinct subgroups of medulloblastoma: wingless (WNT), sonic hedgehog (SHH), Group 3, and Group

289 In this review, we summarize how the wingless (Wnt), transforming growth factor-beta, and bon

290 ecutively and interdependently activates the wingless (Wnt)-beta-catenin (betaC) and Wnt-planar cell

291 for glycogen synthase kinase 3 and upstream wingless (Wnt)-frizzled (Fz) signaling pathways in mood

292 TP53 mutations are enriched in wingless (WNT; 16%) and sonic hedgehog (SHH; 21%) medull

293 5-year EFS and OS differed between low-risk (wingless [WNT], n = 4; both 100%), high-risk ( MYCC/ MYC

294 The secreted Wingless/Wnt molecule is a potent regulator of synaptic

295 High dietary sugar increased canonical Wingless/Wnt pathway activity, which upregulated insulin

296 ntify a presynaptic effector molecule of the Wingless/Wnt signal, Cortactin.

297 The highly conserved Wingless/Wnt signaling pathway controls many development

298 Proper regulation of the Wingless/Wnt signaling pathway is essential for normal d

299 zing centers correspond precisely with WntA, wingless, Wnt6, and Wnt10 expression patterns, thus sugg

300 marked divergence between winged queens and wingless workers, but morphological specializations for