ライフサイエンスコーパス: wiring

1 an mask condition- or cell-specific 'network wiring'.

2 anism that outweighs the cost of inefficient wiring.

3 s are subject to some degree of localised re-wiring.

4 in dynamics with small modifications in the wiring.

5 should be located in close vicinity to save wiring.

6 ned as a generic emergent property of random wiring.

7 acyclic graph motifs, indicating feedforward wiring.

8 ly able to affect the brain architecture and wiring.

9 ay critical roles in brain morphogenesis and wiring.

10 in regulating axonal branching during brain wiring.

11 of axons and dendrites to establish optimal wiring.

12 eir guided extension to specific targets for wiring.

13 en areas that can accommodate lamps/LEDs and wiring.

14 some, although not all, of their stereotypic wiring.

15 e that there is no need for any percutaneous wiring.

16 that Nrp1 inactivation leads to two distinct wiring alterations, depending on the time at which Nrp1

17 ural differentiation, yet its role in neural wiring and brain organization is not known.

18 vity-dependent mechanisms also contribute to wiring and circuit assembly, but whether and how they re

19 hat moraphology is tightly tuned to minimize wiring and conduction delay of synaptic events.

20 ning of dendritic arbors is critical for the wiring and function of neural circuits.

21 vous system is essential for the appropriate wiring and function of neural networks.

22 or neuron identity directs locomotor circuit wiring and indicate the evolutionary primacy of flexor p

23 experience with measures for both brain-wide wiring and molecular phenotype.

24 rons in the Drosophila central complex whose wiring and physiology provide a means to rotate an angul

25 of human plasma reveals unforeseen metabolic wiring and regulation, suggesting that HPLM should be of

26 form of plasticity underlying developmental wiring and rewiring in the CNS.

27 e multiple sequential functions during brain wiring and supports a general role of tangential migrati

28 on and translation cause defects in neuronal wiring and survival.

29 d contribute to long-term differences in CNS wiring and synaptic function.

30 na, yet recent evidence suggests some common wiring and the existence of a bona fide fitness comparis

31 ations of stents included canalicular cheese-wiring and tube prolapse in approximately 4% each.

32 tates mutually suppress each other, both in "wiring" and in dynamical cooperation.

33 th cyclic graph motifs, indicating recurrent wiring, and acyclic graph motifs, indicating feedforward

34 Here, we examine the morphologies, wiring, and architectures of single synapses of projecti

35 their causal impact on behavior, long-range wiring, and gene expression profiles, with the major dis

36 We propose that this directed wiring approach will be of general utility in functional

37 information represented as the similarity in wiring around non-interacting genes.

38 Using the graphlet degrees to represent the wiring around proteins in PINs and gene ontology (GO) an

39 an cortex with data on macroscale connectome wiring as derived from high-resolution diffusion imaging

40 ide a basis for understanding impaired brain wiring associated with metabolic deficits and prenatal d

41 ect to supervised plasticity, however, dense wiring becomes advantageous, suggesting that the type of

42 The mechanical wiring between cells and their surroundings is fundament

43 Wiring between signaling pathways differs according to c

44 d not reflect fundamental differences in the wiring between the two species.

45 y to be a general mechanism for enabling the wiring between these pathways to switch according to con

46 impact of the processes in a formal printed wiring board (PWB) recycling chain, life cycle assessmen

47 Robo receptors also contribute to wiring brain circuits.

48 t the race-specific aspects of transcriptome wiring by discussing in detail the metastasis-related MA

49 ing of long-range projections, local circuit wiring, cellular relationships, subcellular structures,

50 ural plasticity--of dendritic spines reflect wiring changes within the hippocampal network.

51 unctional map reveals that despite the dense wiring, chemosensory neurons represent the environment u

52 catalytic heme 4 (P460) and of the electron-wiring circuit comprising seven His/His-ligated c-type h

53 ectors to reduce optical losses, latency and wiring complexity associated with off-chip detectors.

54 Thus, VMHdm/c neurons employ a one-to-many wiring configuration to orchestrate multiple aspects of

55 ce may be partially attributable to cortical wiring constraints.

56 ortant role, but the nature of the molecular wiring controlling InR transcription has not been elucid

57 ng an optimal trade-off model between neural wiring cost and the representative functional requiremen

58 imal spanning neurite trees constrained by a wiring cost equation and find that STG neurons do not ad

59 amined the relationship between topology and wiring cost in the mouse connectome by using data from 4

60 We conclude that the high wiring cost of the globally integrative rich club of neu

61 Differences in global and local wiring cost were predominantly observed in fronto-tempor

62 Anatomical conservation of "wiring cost" explains many but not all aspects of these

63 e between connected nodes, a proxy marker of wiring cost).

64 between the efficiency of a network and its wiring cost.

65 We show that empirical wiring-cost constraints inadequately explain connectome

66 rticipation hubs, which are not explained by wiring-cost minimization but instead reflect competitive

67 The strategies for reducing wiring costs are shared across phyla and point to the po

68 the locations of neurons based on minimizing wiring costs for any given connectivity.

69 estimated brain-wide weights, distances, and wiring costs of axonal projections and performed a multi

70 we observed significantly reduced intrinsic wiring costs of cortex in ASD, both globally and locally

71 s" to assess the global and local intrinsic "wiring costs" of the cortex (i.e., estimated length of h

72 cally localized modules, had especially high wiring costs, and closely corresponded to regions of the

73 modular structure, and greater-than-minimal wiring costs.

74 of connections combined with nearly minimal wiring costs.

75 endosomal compartments, leading to aberrant wiring defects.

76 ex with information on macroscale anatomical wiring derived from tract tracing studies, this study fo

77 Due to its nearly complete wiring diagram and large behavioral repertoire, the nema

78 of Drosophila larvae by mapping the synaptic wiring diagram and neurotransmitters.

79 s multiple redundant interactions, a complex wiring diagram can be constructed with extraordinary fid

80 Moreover, as complete descriptions of the wiring diagram in cortical tissues are becoming availabl

81 nsus of the constituent cell types and their wiring diagram in mature neocortex remains elusive.

82 Comprehensive knowledge of the brain's wiring diagram is fundamental for understanding how the

83 naptic targets, thereby creating the precise wiring diagram necessary for adult function.

84 nt is essential for survival, but a complete wiring diagram of a higher-order circuit supporting asso

85 n the present study we extend the functional wiring diagram of the ACx with an investigation of the c

86 These results reveal the long-range wiring diagram of the BF circuit with highly convergent

87 The complete wiring diagram of the C. elegans nervous system has been

88 , providing new insights into the functional wiring diagram of the cell.

89 plex and pathway modules to map a functional wiring diagram of the cell.

90 mapped with electron microscopy the complete wiring diagram of the Drosophila larval antennal lobe, a

91 The complete synaptic wiring diagram of the LON paves the way to understanding

92 The complete wiring diagram of the nervous system, the complete cell

93 first is a graph theoretic reduction of the wiring diagram of the network, while preserving all info

94 The wiring diagram of the uncovered asthma module suggests a

95 recent issue of Nature, Oh et al. present a wiring diagram of the whole mouse brain, where standardi

96 The wiring diagram revealed a complex multilevel multimodal

97 This complete wiring diagram will support experimental and theoretical

98 ly available method for determining a neural wiring diagram with single synapse precision-a 'connecto

99 oday's neuroscience is to study the brain's 'wiring diagram'.

100 tributed circuit orthogonal to the classical wiring diagram, with several essential neurons that expr

101 ues of parameters, and are based only on the wiring diagram.

102 on Language) format, electronic circuits and wiring diagrams as well as software code.

103 s allow direct access to the outlines of the wiring diagrams of adapting systems.

104 establishing precise layer-by-layer synaptic wiring diagrams of excitatory neurons in the visual cort

105 Laminar-specific synaptic wiring diagrams of excitatory neurons were constructed o

106 Interareal connectomes are whole-brain wiring diagrams of white-matter pathways.

107 by their synaptic connectivity, yet synaptic wiring diagrams often provide limited insight into netwo

108 After overlaying the functional wiring diagrams onto the imaged field of view, we found

109 Revised wiring diagrams that take into account this updated arch

110 ons between neurons, we generated functional wiring diagrams to evaluate the topological features of

111 ity between neurons, we generated functional wiring diagrams to gain insight into the underlying neoc

112 properties consistent with Rentian scaling: wiring diagrams were topologically efficient because the

113 rich clubs as structural hallmarks of these wiring diagrams.

114 ct circuits and create anatomically enriched wiring diagrams.

115 To examine if regional wiring differences represent functional adaptations, we

116 t is delivered by the mechanisms of OSN axon wiring, differentially for the various OSN populations e

117 gated the role of Slit and Robo receptors in wiring Drosophila higher-order brain circuits and identi

118 We conclude that proper axonal wiring during brain development depends on the precise m

119 he intricate coordination between growth and wiring during brain development.

120 molecular mechanisms that establish optimal wiring during development are unknown.

121 Proper brain wiring during development is pivotal for adult brain fun

122 Neuronal wiring during development requires that the growth cones

123 ynchronous dynamics and forming microcircuit wiring during development, however, is not yet fully und

124 imal combination of the two basic factors of wiring economy and processing efficiency, clearly higher

125 ining, studies suggest that it improves both wiring economy and the V1 population code read downstrea

126 As the developmental mechanisms underpinning wiring economy are only now being elucidated, whether th

127 ganization, and neural networks reveals that wiring economy is a significant determinant of nervous s

128 The wiring economy principle proposes that animals have evol

129 d arrangements may simply be a reflection of wiring economy, a general principle that tends to reduce

130 tely explained by evolutionary pressures for wiring economy, but that the other hallmarks are not exp

131 has identified an OS mechanism in selective wiring from lateral geniculate nucleus (LGN) to primary

132 trategies are being explored for efficiently wiring glucose dehydrogenase (GDh) enzymes capable of gl

133 into the limited space of the skull and its wiring has associated developmental and metabolic costs.

134 putational model explains robust and precise wiring in a crowded brain region despite extensive growt

135 e of these substances can alter normal brain wiring in different ways depending on the consumed cockt

136 e responses, similar to those underlying the wiring in electronics.

137 ne receptor, to prevent aberrant VD synaptic wiring in later larval and adult stages.

138 has the ability to function without external wiring in nano or molecular circuitry since it is powere

139 single-cell phosphoproteomics and network re-wiring in predicting cancer treatment responses.

140 ing and suggest an important role of initial wiring in the brain for predispositions to different tas

141 pan the molecular determinants of firing and wiring in the developing brain.

142 ostatic plasticity shapes cell-type-specific wiring in the developing retina to stabilize visual info

143 om the device; and 3- industrial Cu used for wiring in the device.

144 lecular mechanism regulates neuronal circuit wiring in the Drosophila brain, partly in response to si

145 Proteins with similar wiring in the PIN (topology around them) have been shown

146 e intellectual disability via abnormal brain wiring induced by the defective differentiation of corti

147 m, with new olfactory sensory neurons (OSNs) wiring into highly organized olfactory bulb (OB) circuit

148 DC patterns (including Shift, Cross, and Re-wiring) into one uniform Bayes factor.

149 This de novo wiring is both condition specific and region specific be

150 Correct wiring is crucial for the proper functioning of the nerv

151 t is often assumed that this "topography" of wiring is essential for decoding sensory stimuli.

152 A very common feature of brain wiring is that neighboring points on a sensory surface (

153 to the C-terminal PDZ-binding motif of PTHR, wiring it to retromer for endosomal sorting.

154 orted in other muscles, including suboptimal wiring length and distribution of motor unit size.

155 and mammals are organized so as to minimize wiring length for a functional number of synaptic connec

156 I wish to put forth a 'power-of-two'-based wiring logic that provides the basic computational princ

157 evidence that developmental deficits in ENS wiring may contribute to the pathogenesis of idiopathic

158 rcalated mass (IM) inhibitory neurons, whose wiring may help modulate autonomic function.

159 tential functional roles in brain evolution, wiring minimization, and the emergence of functional spe

160 We generalize and examine the stochastic wiring model proposed by Ringach and coworkers, in which

161 t be explained by generic random feedforward-wiring models.

162 The axonal wiring molecule Slit and its Round-About (Robo) receptor

163 ks features an overrepresentation of certain wiring motifs compared to simple random-network models.

164 ersible modifications of specific inhibitory wiring motifs thus contribute to the adaptive remodeling

165 emarkably stereotyped, the abundance of some wiring motifs varies greatly between cortical areas.

166 ides a draft reference of the basic physical wiring network of this evolutionarily important model mi

167 nectivity by regulating the interhemispheric wiring of a subpopulation of neurons within the mouse an

168 key axonal molecule that participates in the wiring of amygdala circuits and helps bring about fear e

169 ae is ultimately dispensable for the correct wiring of direction-selective tectal circuits, but it is

170 Our results indicate that the wiring of DPP signaling buffers against environmental ch

171 drifting gratings.SIGNIFICANCE STATEMENT The wiring of excitatory and inhibitory neurons in cortical

172 waves are believed to be instructive for the wiring of functional connections throughout the visual s

173 hus, we demonstrate a dramatically different wiring of Hpo signaling in neighboring cell populations

174 ve criteria spanning biophysical properties, wiring of inputs, wiring of outputs, and activity during

175 cteristic of regulatory networks is that the wiring of interactions can change over time.

176 me course of cellular development and axonal wiring of interneurons expressing GFP under control of t

177 refines and stabilizes before directing the wiring of its downstream target.

178 naptic structures known to guide the de novo wiring of nascent cortical circuits.

179 ng growth, which in turn ensures the correct wiring of neocortical circuitry.

180 cal activity has the potential to sculpt the wiring of neural circuits and to modulate their function

181 indows of opportunity that ensure the proper wiring of neural circuits, as well as windows of vulnera

182 are important for information processing and wiring of neural circuits.

183 communications remain opaque, unraveling the wiring of organelle networks is critical to understand h

184 ng biophysical properties, wiring of inputs, wiring of outputs, and activity during behavior, linking

185 s underlay the functioning of a cell and the wiring of proteins in protein-protein interaction networ

186 hat glutamatergic waves may also support the wiring of retinal receptive fields.

187 It also opens the door for the direct wiring of robust brain-machine interfaces as well as for

188 de that ELFN1 is necessary for the selective wiring of rods into the primary rod pathway and is requi

189 Cell, Wei et al. (2016) identify adaptive re-wiring of signaling nodes in glioma as major mechanisms

190 d provide insight into tissue origin and the wiring of signaling proteins at membranes to predict ons

191 ity arising from abnormal neurodevelopmental wiring of structural connections linking putative hub re

192 Within TNBC, the wiring of the affected pathways with isomiRs and tRFs di

193 Improved understanding of the molecular wiring of the AKT signaling network continues to make an

194 ating the functional properties and neuronal wiring of the AL are conducted in vivo, although so far

195 How EVs help to orchestrate the wiring of the brain while allowing for plasticity associ

196 is key to an understanding of the functional wiring of the brain.

197 Although the wiring of the cerebellar cortex appears to be uniform, t

198 s-specific identity can actively control the wiring of the cortical microcircuit.

199 that the spatiotemporal control of synaptic wiring of the D-type neurons is controlled by an interse

200 phagocytic cells control the patterning and wiring of the developing central nervous system (CNS) by

201 diverse tissues and organs, which may enable wiring of the developing parasympathetic nervous system.

202 The direct wiring of the FDH in a highly original osmium-polymer hy

203 e the seemingly complex neural superposition wiring of the fly visual map without an elaborate molecu

204 uggest a model for the integrated neurohemal wiring of the hypothalamo-neurohypophyseal axis.

205 our method adapts the hierarchy based on the wiring of the interactions only for the nodes which have

206 These results reveal a unique wiring of the lysosomal pathway that melanomas exploit t

207 g during development is essential for proper wiring of the mature nervous system, but its regulation

208 ateral horn contrasts with the probabilistic wiring of the mushroom body, reflecting the distinct rol

209 nt for neuronal outgrowth during the initial wiring of the nervous system and after trauma, yet subce

210 The wiring of the nervous system requires that axons navigat

211 fields for neurons and are essential for the wiring of the nervous system.

212 ecise emergence of anatomy, particularly the wiring of the nervous system.

213 his flexibility is essential for the correct wiring of the nervous system.

214 he developing axon is crucial for the proper wiring of the nervous system.

215 ored cell adhesion molecules involved in the wiring of the nervous system.

216 Achiasma in humans causes gross mis-wiring of the retinal-fugal projection, resulting in ove

217 biochemistry have defined the components and wiring of the signaling pathways that pattern the embryo

218 these results uncover the basic logic of the wiring of the taste system at the periphery, and illustr

219 found that glucose deprivation stimulated re-wiring of the tricarboxylic acid (TCA) cycle and early s

220 es (PR) present, organization of the eye and wiring of the underlying neural circuit.

221 ward in our understanding of the coordinated wiring of the vascular and nervous systems in various ti

222 spatio-temporal control that governs axonal wiring of the zebrafish spinal cord.

223 Neural circuits rely upon a precise wiring of their component neurons to perform meaningful

224 circuits, but the mechanisms controlling the wiring of these cells remain largely unknown.

225 The molecular wiring of this enzymatic pathway defines the ability of

226 c/catabolic state of the liver cell, but the wiring of this process is still largely unknown.

227 into both the general and context-dependent wiring of transcription factor networks in stem cells by

228 This polymer facilitates the "wiring" of in situ enzymatically generated CdS QDs, whic

229 n the enzyme surface promoted the effective "wiring" of the GOX active site to an external electrode.

230 we review the recently discovered rapid 're-wiring' of in vivo transcription factor binding between

231 hapes and configurations consistent with the wiring optimization principle.

232 ot adhere to prevailing hypotheses regarding wiring optimization principles.

233 of synaptic connections, a phenomenon called wiring optimization.

234 nary intervention, especially when antegrade wiring or retrograde approaches are not feasible.

235 merging evidence suggests disruptions in the wiring organization of the brain's network in schizophre

236 s differing in biophysical properties, input wiring, output wiring to dorsomedial striatum (DMS) vers

237 from the major input that shape the H3 HC's wiring pattern during development persist to restrict mi

238 each type generate a unique and stereotypic wiring pattern with cone photoreceptors by gaining synap

239 r mechanisms that together shape stereotypic wiring patterns along the visual pathway, from within th

240 Mature wiring patterns are often attained upon the refinement o

241 les uncovering the relationships between the wiring patterns around nodes in a directed network and t

242 n-mediated processes can produce stereotypic wiring patterns by promoting selective synapse formation

243 ology and light microscopy to illustrate the wiring patterns in mouse retina.

244 transcription factors (TFs) instruct precise wiring patterns in the developing nervous system; howeve

245 such as its gross domestic product, from its wiring patterns in the WTN for up-to ten years in the fu

246 similarity scores by fusing information from wiring patterns of all aligned PPI networks and sequence

247 e is to properly quantify similarity between wiring patterns of two networks in an alignment-free fas

248 ervation of enzyme function from the network wiring patterns rather than from sequence data.

249 sequences) and functioning similarity (from wiring patterns) are supported by all networks.

250 o undamaged cone photoreceptors with correct wiring patterns.

251 ikingly different from the generally assumed wiring principle in vertebrate olfactory systems, axons

252 gnals are modified to fit more complex brain wiring processes is unclear.

253 Each nanorod functions without external wiring, producing 5 x 10(13) H(2) molecules per cm(2) pe

254 dies have suggested that also the macroscale wiring profile of brain areas may have an important cont

255 l tegmental area defined by both genetic and wiring properties.

256 ered neural microstructure, function, and/or wiring rather than gross changes in neuron number or mor

257 y likewise uses cell position as an internal wiring reference.

258 Neural circuit wiring relies on selective synapse formation whereby a p

259 ndent of the circuit's complexity, minimizes wiring requirements and allows component reusability wit

260 We found that a degree-modified Hebbian wiring rule best reproduced the pattern of computation a

261 c circuit using experimental data and simple wiring rules.

262 We show that this wiring scheme confers increased selectivity.

263 This is reflected in an asymmetric wiring scheme where bursting cells and regular firing ce

264 is not cone-type specific, but whether these wiring schemes are maintained closer to the fovea remain

265 eir heterogeneity, they have optimized their wiring schemes to make maximal use of space.

266 The inclusion of the wiring similarity of non-interacting genes contributes 6

267 The wiring specificity and synaptic diversity have a great i

268 ansmission beyond development in maintaining wiring specificity and synaptic organization of neural c

269 derstanding of the mechanisms that establish wiring specificity of complex neural circuits is far fro

270 ne the events that lead to the simple binary wiring specificity of the cochlea.

271 Hence, growth cone dynamics can influence wiring specificity without a direct role in target recog

272 athematical model shows how such 'space-time wiring specificity' could endow SAC dendrites with recep

273 equired for the function of Toll-6/Toll-7 in wiring specificity, nor are their cytoplasmic domains.

274 uggesting a basic framework for establishing wiring specificity.

275 We know considerably less about the wiring strategies of motor networks, where connections c

276 igated so far and represents a new olfactory wiring strategy.

277 fic roles, suggesting distinct steps in axon wiring, such as elongation, pruning, and synaptogenesis.

278 not all, major features of their stereotypic wiring, suggesting that circuit patterns may be unable t

279 e (GlDH-NAD(+)) apoenzyme-coenzyme molecular wiring system on the base gold electrode.

280 oquinoline quinone-based composite molecular wiring system.

281 and kinetic limitations associated with the wiring systems.

282 Antegrade wiring techniques were used more frequently in easy lesi

283 brain developmental mechanisms required for wiring the brain and provide potential avenues for thera

284 Axons act like cables, electrically wiring the nervous system.

285 Axons are cable-like neuronal processes wiring the nervous system.

286 preganglionic fibers, a parsimonious way of wiring the pathway.

287 biophysical properties, input wiring, output wiring to dorsomedial striatum (DMS) versus dorsolateral

288 ction selectivity through precise anatomical wiring to DSGCs.

289 imprinted genes, from neural development and wiring to synaptic function and plasticity, energy balan

290 s, TCF-1 and LEF-1 adopted distinct genetic 'wiring' to promote the CD4(+) T cell fate and establish

291 This suggests that, although wiring topography could provide a starting point for dec

292 he present ECCs, showing great potential for wiring ultrathin circuits for high performance flexible

293 mGluR5 is required for several key steps in wiring up the thalamocortical connections to form the co

294 suggest that Cu employed within the device's wiring was derived from two Cu ore deposits within the U

295 networks; this novel concept of differential wiring was further validated experimentally.

296 sicle creation are bypassed, we term it "hot-wiring." We use hot-wired endocytosis to describe the fu

297 pologically efficient because they minimized wiring with a modular architecture.

298 Considering random wiring with the currently most realistic model of RGC mo

299 ission, of the major BC input also dissuades wiring with the minor input and with synaptically compat

300 Random feedforward wiring within the retino-cortical pathway represents a c