ライフサイエンスコーパス: with overlapping

1 and LEE3 operons are divergently transcribed with overlapping -10 promoter regions, and gene fusion s

2 ellular cytokine staining of PBMC stimulated with overlapping 15/20-mer peptides spanning the protein

3 80 peanut-allergic patients were stimulated with overlapping 20-mer Ara h 2 peptides.

4 e effect on transcript accumulation together with overlapping 24-nucleotide siRNAs.

5 We identified 71 pairs of convergent genes, with overlapping 3' ends longer than 15 nucleotides, tha

6 In ten individuals from six families, with overlapping 6q16.1 deletions, we describe a disorde

7 AJCC and UICC T3 and T4 were indistinct with overlapping 95% CIs for 10-year cumulative incidenc

8 of protein for hazelnut, peanut, and celery with overlapping 95% CIs.

9 o correlation range, 0.81-0.96; P <or= .02), with overlapping 95% confidence intervals (CIs) for sing

10 natural gas production are largely similar, with overlapping 95% uncertainty ranges of 11.0-21.0 g C

11 long-wavelength- (L) sensitive photopigments with overlapping absorbance spectrum maxima (lambda(max)

12 or "enhancer synergy," whereby two enhancers with overlapping activities produce authentic patterns o

13 found a remarkable array of stripe enhancers with overlapping activities surrounding the slp1 transcr

14 t every gap gene contains multiple enhancers with overlapping activities to produce authentic pattern

15 ice with whole recombinant alpha3(IV)NC1 and with overlapping alpha3(IV)NC1 peptides, we defined a HL

16 that among nine synthetic pentacosapeptides with overlapping amino acid sequences spanning the entir

17 Bacteriophage lambda makes two proteins with overlapping amino acid sequences that are essential

18 eins in the septum and that protein networks with overlapping anchoring capacity is a feature of prot

19 of the genetic basis of other complex traits with overlapping and distinct clinical features.

20 s composed of multiple ligands and receptors with overlapping and distinct ligand-receptor binding sp

21 DB levels (CBS and PPA) and were associated with overlapping and distinct neural correlates.

22 py (ART) and pre-exposure prophylaxis (PrEP) with overlapping and nonoverlapping antiretrovirals (ARV

23 e are made of a double layer of co-oligomers with overlapping and strongly pi-stacked PDI units becau

24 as at least five different protein isoforms with overlapping and unique functions.

25 informatics analysis demonstrates that genes with overlapping annotated function are enriched within

26 discriminative sequence features associated with overlapping annotation labels.

27 itude of childhood abuse would be associated with overlapping anterior cingulate cortex (ACC) and ins

28 s overlapped 3' UTRs more than 5' UTRs; UTRs with overlapping antisense tended to be longer; and the

29 Combined ART + PrEP with overlapping ARVs prevents 35% of infections but inc

30 cortical axons in common, and cortical cells with overlapping axons have few striatal target neurons

31 egs reciprocally inhibit late-phase disease, with overlapping B10 cell and Treg functions shaping the

32 yndrome (ASP) are neurobiological conditions with overlapping behavioral symptoms and of unknown etio

33 t malnutrition encompasses numerous regimens with overlapping benefits including longevity and stress

34 ing the competition between distinct ligands with overlapping binding sites and the conformational fl

35 -1)-dependent genes (StAR, Cyp11a1, Cyp17a1) with overlapping binding sites for SF-1 and COUP-TFII in

36 concentrations and that SH2 domain proteins with overlapping binding specificities are unlikely to c

37 ge stages of multipotent, hepatic precursors with overlapping but also distinct phenotypic traits.

38 Screening of four unrelated cases with overlapping but atypical clinical features showed n

39 ned, revealing two distinct SH3b_5 subgroups with overlapping but differentially conserved residues.

40 to the presence of multiple IL-4/13 isoforms with overlapping but distinct activities.

41 clinical variants of frontotemporal dementia with overlapping but distinct anatomical substrates know

42 l exchange for two congeneric mussel species with overlapping but distinct distribution, life history

43 complex revealed a dynamic heme environment with overlapping but distinct heme-binding sites with al

44 1 paralogues within one species may interact with overlapping but distinct sets of proteins in cells.

45 cIAP1 and cIAP2 associate with overlapping but distinct subsets of E2 (ubiquitin c

46 EF2A, MEF2B, MEF2C, and MEF2D, are expressed with overlapping but distinct temporospatial patterns.

47 s cover a wide range of childhood conditions with overlapping but heterogeneous phenotypes and underl

48 tory directors come from diverse backgrounds with overlapping but not identical training experiences.

49 ts were extensively expressed in adult brain with overlapping but subunit-specific distributions.

50 15 inputs, many of them from cortical areas with overlapping, but not identical, functional properti

51 of the TCR, we vaccinated seven MS patients with overlapping BV5S2 peptides spanning amino acids 1-9

52 controlled by multiple Ca2+ channel subtypes with overlapping Ca2+ microdomains and that autoinhibiti

53 These gap junction proteins are expressed with overlapping cellular and tissue specificity, and co

54 -OM differ clinically and epidemiologically, with overlapping characteristics.

55 are a set of chronic hematopoietic neoplasms with overlapping clinical and molecular features.

56 hies are genetically heterogeneous disorders with overlapping clinical and neuroimaging features refl

57 s group of clonal disorders of hematopoiesis with overlapping clinical features and inconsistent nome

58 diseases typically have an insidious onset, with overlapping clinical features early in the disease

59 doxanthoma elasticum, and related conditions with overlapping clinical features include generalized a

60 asia punctata (RCDP) is a group of disorders with overlapping clinical features including rhizomelia,

61 orders (AVCD) represent a group of syndromes with overlapping clinical features, manifesting as senso

62 group of interrelated inflammatory disorders with overlapping clinical features.

63 th active tuberculosis from that of controls with overlapping clinical features.

64 s origin can have a variety of presentations with overlapping clinical features.

65 of 13 individuals from 10 unrelated families with overlapping clinical manifestations identified loss

66 ancers, infections, or inflammations present with overlapping clinical manifestations.

67 s led to the identification of nine families with overlapping clinical presentations and affected by

68 rs of the TRAPP complex have been associated with overlapping clinical presentations, indicating shar

69 bial community/IL-1beta structures, although with overlapping clinical presentations.

70 gy searches were used to reduce redundancies with overlapping clones and to eliminate those that show

71 lone fingerprint analysis and was integrated with overlapping clones from the telomeric end of a sepa

72 pecifically investigated for predicted genes with overlapping coding sequences.

73 mportance of understanding multiple pathways with overlapping, complementary, or opposing effects and

74 Rats given extensive training with overlapping complex odorant mixtures showed improve

75 d through fusion partners AF9, AF4, and ELL) with overlapping components, different elongation activi

76 of the linear slope ranging from 4.5 to 5.1, with overlapping confidence intervals.

77 branches of the MAP kinase signaling pathway with overlapping consequences are involved in the pathog

78 At least two mechanisms, with overlapping consequences, account for the eukaryoti

79 d electrified frames in three stream reaches with overlapping consumer assemblages in Trinidad, West

80 . bronchiseptica expresses multiple adhesins with overlapping contributions to ciliary adhesion and t

81 gene in place of parental meq was generated with overlapping cosmid clones of Md5, a very virulent M

82 We identified 2 patients with overlapping deletions at 7q21 and 2 patients with i

83 Mutants with overlapping deletions comprising N-terminal amino a

84 plication, we constructed a panel of mutants with overlapping deletions in the N-terminal, central, a

85 al and molecular analysis of six individuals with overlapping deletions involving 2q37.3 that refine

86 Danish cohort, we identified eight patients with overlapping deletions of AADAC.

87 We identified five patients with overlapping deletions on chromosome 16p11.2 that we

88 elationship between starburst amacrine cells with overlapping dendrites.

89 of the same Dscam isoforms in two da neurons with overlapping dendritic fields forced a spatial segre

90 he mechanisms by which transcription factors with overlapping direct-target genes integrate and selec

91 s were tested in nearly identical procedures with overlapping display sizes.

92 inferring accurately the history of species with overlapping distributions.

93 rtainty in how eukaryotic genetic regulators with overlapping DNA sequence preferences achieve target

94 on experiments are performed on fluorophores with overlapping emission spectra.

95 dent primary Abs against a small flexible Ag with overlapping epitopes was analyzed to address the de

96 ed tonsil PNAd, all MAbs were found to react with overlapping epitopes.

97 poptotic members of the Bcl-2 protein family with overlapping, essential roles in the intrinsic apopt

98 ancer suggested two breast cancer phenotypes with overlapping etiologies and distinct clinical featur

99 existing open-field optical imaging devices with overlapping excitation and emission spectra to be u

100 ng to identify cancer-specific bioconjugates with overlapping excitation and emission wavelengths.

101 Genes with overlapping expression and function may gradually d

102 ed posttranslationally, so that bHLH factors with overlapping expression can function independently.

103 differentiation-related transcription factor with overlapping expression in hard and soft connective

104 forkhead/winged helix transcription factors with overlapping expression in the forming somites and h

105 There are four neuronal MAGUKs with overlapping expression patterns in the mammalian br

106 ons support the idea that adjacent Hox genes with overlapping expression patterns may interact functi

107 d Pcdh19, in structures of the limbic system with overlapping expression patterns particularly within

108 Mecp2e2 transcripts were widely distributed, with overlapping expression patterns throughout the brai

109 high level of similarity (greater than 61%), with overlapping expression patterns.

110 de (nt) 5'-untranslated region (UTR) AS mRNA with overlapping extended 5'-UTRs of 66 and 92 nt.

111 ers constitute a diverse group of phenotypes with overlapping features and a tendency toward familial

112 ise a wide spectrum of inflammatory diseases with overlapping features characterized histologically b

113 ded protein aggregates represent a continuum with overlapping features in neurodegenerative diseases,

114 M2 mutations can be associated with LQTS and with overlapping features of LQTS and CPVT.

115 hildren typically developed unique disorders with overlapping features of MDS and MPS.

116 However, these methods cannot deal well with overlapping features, especially when they are merg

117 EOPARD syndromes are developmental disorders with overlapping features, including cardiac abnormaliti

118 en LEGOs(R) were used to create object pairs with overlapping features, the aged monkeys took signifi

119 ization occurs between unconditioned stimuli with overlapping features.

120 urately differentiating multiple experiences with overlapping features.

121 nly a small number of the strongest patterns with overlapping features.

122 We uncovered gene networks with overlapping feedback loops that are modulated by nu

123 stnatal field size and shape when the nerves with overlapping fields are cut, and this anatomical pla

124 , is difficult when cells express constructs with overlapping fluorescent emissions.

125 osome 7 have properties different from those with overlapping focalEGFR amplification: the broad even

126 , which reduces sample complexity associated with overlapping fragmentation patterns and provides str

127 With overlapping function retained on an evolutionary ti

128 CatM, a paralog with overlapping function, responds only to muconate.

129 l a gene's function can be obscured by genes with overlapping function.

130 germline mutation that arises in characters with overlapping function.

131 obin degradation uses dual protease families with overlapping function; and (v) hemoglobin-degrading

132 nary advantage in having multiple components with overlapping functionality (i.e degeneracy) in organ

133 elix-loop-helix (bHLH) transcription factors with overlapping functionality.

134 hat concomitant loss of three E2F activators with overlapping functions (E2F1, E2F2, and E2F3) trigge

135 ha and theta contribute to T-cell activation with overlapping functions essential for GVHD induction

136 erestingly, AKT activity inhibits mGluR-LTD, with overlapping functions for AKT1 and AKT3.

137 uplications, it is much less clear why genes with overlapping functions have been retained, in some c

138 observed increased expression of nine genes with overlapping functions in bacterial invasion of its

139 pA, -B, and -C (biofilm maturation protein), with overlapping functions in biofilm maturation.

140 members, are microtubule-associated proteins with overlapping functions in both neuronal migration an

141 Thus, Wag1p and CnjBp are two novel players with overlapping functions in RNA interference-mediated

142 ossibly due to the presence of other systems with overlapping functions in this pathogen.

143 A network of adhesion molecules with overlapping functions mediate the capture, rolling

144 Closely related molecules with overlapping functions, such as the Syk kinases, SYK

145 occurs mainly between nonessential reactions with overlapping functions, whereas positive epistasis u

146 ed in the identification of homologous genes with overlapping functions.

147 receptor might couple to multiple effectors with overlapping functions.

148 ought and include numerous analogous enzymes with overlapping functions.

149 y observed among duplicated genes (paralogs) with overlapping functions.

150 ciparum has maintained four plasmepsin genes with overlapping functions.

151 t from expression of a related gene (AtSMC2) with overlapping functions.

152 athogens vs. parasitoid wasps) and symbionts with overlapping functions.

153 two murine membrane C3 complement regulators with overlapping functions.

154 Furthermore, respondents with overlapping gastrointestinal (GI) symptom complexes

155 hallenging, especially for small populations with overlapping generations and substantial environment

156 y applicable to simulations of whole genomes with overlapping generations in a finite population, alt

157 ect" theory based on recruitment variability with overlapping generations, (ii) climate variables are

158 nd Ne/N is revisited for iteroparous species with overlapping generations, with a focus on the annual

159 rete, but it is routinely applied to species with overlapping generations.

160 emporal method can be applied to any species with overlapping generations.

161 cal clustering was used to identify pathways with overlapping genes, and clusters with an excess of a

162 Cortical regions with overlapping genetic architecture showed correlated

163 Biobank imaging data comprised participants with overlapping genetic data and subcortical volumes (N

164 ickerstaff's brainstem encephalitis or those with overlapping Guillain-Barre syndrome.

165 NA, representing an AT-rich response element with overlapping half-sites, maintains superhelical traj

166 inoma (BCC) and Merkel cell carcinoma (MCC), with overlapping histologic features but distinct cellul

167 man disease are different clinical disorders with overlapping histologic features.

168 ing sebaceous carcinoma from other neoplasms with overlapping histology.

169 interferon-secreting PBMC after stimulation with overlapping HIV-1 peptides spanning the Gag, Pol, E

170 ition to IL-21 ex vivo following stimulation with overlapping HIV-1 peptides.

171 se H1 provide insight into why these enzymes with overlapping hybrid-removal activities have been con

172 ypically discard data from crowded molecules with overlapping images, wasting valuable image informat

173 ic output and PAM dopaminergic input neurons with overlapping innervation in the MB-beta'2 lobe regio

174 brain in a spatially organized manner, often with overlapping inputs to multiple target neurons.

175 showing all items from the first track along with overlapping items from the other tracks.

176 s-LT receptor [CysLT1R], CysLT2R, and GPR99) with overlapping ligand preferences.

177 , a member of the same gene family as LRP-1, with overlapping ligand-binding specificity.

178 single G3T molecules unfold and fold rapidly with overlapping melting and refolding curves, G3T multi

179 tified by testing randomly generated subsets with overlapping membership in individually housed germ-

180 on of all known cardiomyopathy-causing genes with overlapping morphology.

181 lly form extensive double-stranded molecules with overlapping mRNAs.

182 tation to its transmissible allograft niche, with overlapping mutations at every step of immunosurvei

183 We introduce clustering with overlapping neighborhood expansion (ClusterONE), a

184 ong links preferentially occur between nodes with overlapping neighbourhoods; we relate this to globa

185 ere is at least 2 different kinds of obesity with overlapping network activity, but different in ante

186 For example, diseases with overlapping network modules show significant coexpr

187 in conducting clinical trials with patients with overlapping neurologic and psychiatric disorders.

188 ncies sired by males expressing alloantigens with overlapping NIMA specificity, thereby averting feta

189 OCA encompasses a range of subtypes with overlapping, often hypomorphic phenotypes.

190 nfected rhesus macaques consistently reacted with overlapping oligopeptides corresponding to a region

191 For two cell types with overlapping On and Off responses, which recalled ei

192 ous studies have focused on pairs of neurons with overlapping or collinear receptive fields.

193 while restricting coalescence to node pairs with overlapping or near-overlapping genetic material.

194 Sheltered from deleterious mutations, genes with overlapping or partially redundant functions may be

195 udy, a peptide from the Ebola virus L domain with overlapping P(T/S)APP and PPXY motifs showed except

196 n second-generation females carrying embryos with overlapping paternally inherited antigens.

197 disease (COPD) are heterogeneous conditions with overlapping pathophysiological and clinical feature

198 Conventional methods (spa typing combined with overlapping patient stay) falsely identified 3 pati

199 ta ERD over bilateral sensorimotor cortices, with overlapping patterns for different body parts.

200 n Drosophila, vertebrates have three or more with overlapping patterns of embryonic expression.

201 We found microRNAs and mRNAs with overlapping patterns of expression that correlated

202 Briefly, human PBMCs are first stimulated with overlapping peptides encoding a given antigen for 4

203 al-treated individuals (n = 9) were cultured with overlapping peptides for 12 days.

204 plenocytes from norovirus VRP-immunized mice with overlapping peptides from complete libraries of the

205 The data obtained with overlapping peptides in interleukin-2 (IL-2) enzyme

206 DR2, DR3, or DR4 HLA alleles were immunized with overlapping peptides of the WNV proteome, and pepti

207 Spleen cells were stimulated in culture with overlapping peptides representing the entire IRBP m

208 d CD8+ T cells was studied after stimulation with overlapping peptides spanning all proteins encoded

209 onal cell death by monitoring iNOS induction with overlapping peptides spanning gp41.

210 ic individuals were tested in ELISPOT assays with overlapping peptides spanning known Phl p allergens

211 iduals were tested in ex vivo ELISPOT assays with overlapping peptides spanning the entirety of these

212 cing capacities were analyzed by stimulation with overlapping peptides spanning the large HDV antigen

213 ma release was used to screen CD8(+) T cells with overlapping peptides spanning the mycobacterial maj

214 ve T cell hybridomas then were characterized with overlapping peptides synthesized to span the entire

215 s (SARS-CoV) were mapped by Pepscan analysis with overlapping peptides that span the N protein sequen

216 sis (NPHP), and related ciliopathies present with overlapping phenotypes and display considerable all

217 With overlapping phenotypes and modest interobserver agr

218 associated with several clinical syndromes, with overlapping phenotypes, for example, velocardiofaci

219 enes for HHT and possibly vascular disorders with overlapping phenotypes.

220 independent homozygous mutations in patients with overlapping phenotypes.

221 amage and DNA repair in two genetic diseases with overlapping phenotypes.

222 n pairs of simultaneously active CA1 neurons with overlapping place fields distinguished the start an

223 s was accomplished by replacement of cosmids with overlapping plasmid subclones.

224 Other regions with overlapping populations of labeled cells included a

225 Both ligands induce myocyte hypertrophy with overlapping potencies.

226 y compressing the networks into power graphs with overlapping power nodes.

227 ich we termed Sequential insertion of Target with ovErlapping Primers (STEP) to seamlessly fuse the g

228 ealed the presence of reciprocal connections with overlapping projections to and from discrete region

229 subtypes of dendritic cells and macrophages with overlapping properties complicates resolution of th

230 emonstrated high intrasession repeatability, with overlapping ranges for CR(W), CV(W), and ICC.

231 Eukaryotic genes with overlapping reading frames exemplify some of the mo

232 lutionary framework for the analysis of loci with overlapping reading frames, which can be used for i

233 ing several genes in the same genomic region with overlapping reading frames.

234 are spe-cified by a single bicistronic mRNA with overlapping reading frames.

235 cortical simple cells in the striate cortex with overlapping receptive fields and evaluated disynapt

236 we show that pairs of leech sensory neurons with overlapping receptive fields encode touch location

237 equency bands, we found that pyramidal cells with overlapping receptive fields exhibit strong stimulu

238 lls receive input from multiple simple cells with overlapping receptive fields.

239 ng neurons in the lateral geniculate nucleus with overlapping receptive fields.

240 rs, consisting of only 10 cells of two types with overlapping receptive fields.

241 uccessfully applied to differentiate species with overlapping redox potentials, such as dopamine/Fe(C

242 o light and shade confirms that the PIFs act with overlapping redundancy on seedling morphogenesis an

243 anization in both cervical segments studied, with overlapping regions between the areas dedicated for

244 spatial pattern of rabies in northeast Texas with overlapping reservoir species (skunks and bats).

245 unk and bat model demonstrate that the model with overlapping reservoir species more accurately repro

246 rd mixture of three known molecules in D(2)O with overlapping resonances and is further demonstrated

247 reduced f-HupS presents complex EPR spectra with overlapping resonances centered on g = 1.94, g = 1.

248 riment, we identified a cluster of LIP cells with overlapping response fields (RFs) and sustained act

249 top significant loci in a subset of samples with overlapping ROHs.

250 xed heterodimers between different isotypes, with overlapping roles in ligand binding.

251 t further delay tumor appearance, consistent with overlapping roles of TF and PAR2 in promoting the a

252 ropositive (HIV(+)) subjects were stimulated with overlapping RT peptide pools.

253 After propensity matching those with overlapping scores, blood transfusion was associate

254 termediate" type II restriction endonuclease with overlapping sequence specificities to BamHI and Bgl

255 r DNA binding domains and appear to bind DNA with overlapping sequence specificities.

256 The two peptides, a decamer and nonamer with overlapping sequences (ELAGIGILTV and ALGIGILTV), a

257 ameshift controls production of two proteins with overlapping sequences, gpG and gpGT, that are requi

258 usly identified naturally processed peptides with overlapping sequences, LSPFPFDL (p2Ca) and VAITRIEQ

259 ifferent projection neurons, including those with overlapping sets of cotransmitters.

260 gh these two proteins acetylate and interact with overlapping sets of proteins, we found that p300 an

261 etylases and auxiliary factors, can interact with overlapping sets of transcription factor partners,

262 this region contains two divergent promoters with overlapping sigma70 type -35 and -10 promoter recog

263 These data suggest that multiple pathways with overlapping specificities are involved in the remov

264 Using a series of caspase inhibitors with overlapping specificities, enzyme-specific chromoge

265 e how the induction of transcription factors with overlapping specificity can lead to cross-coupling

266 pite the presence of more proximal enhancers with overlapping specificity, strongly suggesting intera

267 and two oligopeptide permeases (Opp and App) with overlapping specificity.

268 In contrast they are depleted in genes with overlapping stable ncRNAs (SUTs), presumably to avo

269 ormation is encountered in coronary arteries with overlapping stents.

270 ng by resolving ambiguity in discriminations with overlapping stimulus elements.

271 studies to include simulations of procedures with overlapping subsets such as subtractive pooling, bo

272 esis", highly regulated transporter networks with overlapping substrate preferences are involved in s

273 ells possess multiple DNA glycosylases (DGs) with overlapping substrate ranges for repairing oxidativ

274 rane transporters and metal binding proteins with overlapping substrate specificities and complex reg

275 contains a large number of reductase enzymes with overlapping substrate specificities but differing s

276 Thus, HSV-1 encodes an Akt surrogate with overlapping substrate specificity to activate mTORC

277 yeast reductases in hosts that lack enzymes with overlapping substrate specificity.

278 road array of specific membrane transporters with overlapping substrate specificity.

279 ue to the numerous kinases in the cell, many with overlapping substrates, it is difficult to find nov

280 ) are highly heritable psychiatric disorders with overlapping susceptibility loci and symptomatology.

281 skull frequently had a collapsed appearance with overlapping sutures and redundant skin folds and, o

282 phrenia (SZ) and bipolar disorder, illnesses with overlapping symptoms and genetic risk.

283 Previously, an A1632E mutation of a patient with overlapping symptoms of IEM and PEPD was reported,

284 used to rule out other vestibular disorders with overlapping symptoms.

285 se affected by related psychiatric illnesses with overlapping symptoms.

286 cing of PIK3CA in ten additional individuals with overlapping syndromes identified either the p.His10

287 al d 1-specific T-cell lines were stimulated with overlapping synthetic 12-mer peptides.

288 Using Elispot with overlapping synthetic peptides across Gag, Tat, Rev

289 grin COOH deletion constructs and ultimately with overlapping synthetic peptides.

290 further mapped within amino acids 168 to 178 with overlapping synthetic peptides.

291 Regimens should avoid drugs with overlapping toxicity or linked mechanisms of resist

292 the use of multiple chemotherapeutic agents with overlapping toxicity profiles.

293 e N-tail TNT1 domain that directly interacts with overlapping tropomyosin (Tm).

294 ing sites occur at high frequencies in genes with overlapping unstable ncRNAs (CUTs), so limiting the

295 biguity of approximately 300 000 nucleotides with overlapping V1 and S1 cleavage sites.

296 is needed in external first-episode samples with overlapping variables, which are not available in t

297 However, high-dose re-irradiation with overlapping volumes of previously irradiated tissue

298 expressed in a temporally regulated pattern with overlapping waves of expression, and they display f

299 mains so that the cell can target regulators with overlapping, yet distinct functions to specific car

300 ples was observed on the basis of origin but with overlapping zones; consequently, two supervised dis