ライフサイエンスコーパス: with the goal of *ing

1 y be willing to reduce cigarette consumption with the goal of quitting.

2 e to be profiled and evaluated preclinically with the goal of having 2 antivirals available for use i

3 With the goal of achieving a better understanding of the

4 ameterized rotor-speed schedule is optimized with the goal of achieving a minimal time to equilibrium

5 ation profile, with or without chemotherapy, with the goal of achieving a second chronic phase and pr

6 d strategy (n = 446) had HF therapy titrated with the goal of achieving a target NT-proBNP of less th

7 opolymerized on carbon-fiber microelectrodes with the goal of creating a mechanically stable, robust,

8 to facilitate extensibility at every level, with the goal of creating a more powerful tool that cont

9 ld-type or codon-optimized HeV glycoprotein, with the goal of developing a candidate vaccine against

10 Thus, with the goal of developing a compound with enhanced met

11 d methodology that can be adopted by others, with the goal of developing a finely grained portrait of

12 With the goal of developing a general approach for ident

13 With the goal of developing a second generation of HDAC

14 stics using a specific cluster-DNA conjugate with the goal of developing a sensitive and selective bi

15 With the goal of developing a virus-like particle-based

16 s synthesized in this research were designed with the goal of establishing a new paradigm for mixed-b

17 s multiple immune cell subsets and subjects, with the goal of establishing a reference framework agai

18 ors containing a boronic acid pharmacophore, with the goal of finding a potent inhibitor of serine ca

19 iors are being reconstructed in the pipeline with the goal of generating a complete Drosophila connec

20 an TDP-43 protein in Caenorhabditis elegans, with the goal of generating a convenient in vivo model o

21 With the goal of identifying a lead conjugate with optim

22 lus subtilis PBP-null mutants were evaluated with the goal of identifying a potential primary PBP res

23 Various polymer materials are investigated with the goal of identifying a set of coatings suitable

24 atial patterns is an active area of research with the goal of obtaining a better understanding of the

25 ons were searched through the PubMed library with the goal of providing a concise review.

26 tion of pancreata from diabetic organ donors with the goal of providing a foundation for the informed

27 With the goal of providing a human genomic reference mat

28 With the goal of realizing a one-dimensional topological

29 entilation with load-adjustable gain factors with the goal of targeting a predefined range of respira

30 easured in epidemiological/clinical settings with the goal of testing a host of hypotheses related to

31 rovided and skills are taught and practiced, with the goal of being able to assess risk from acquaint

32 synthetic platform to prepare G-CSF aglycone with the goal of enabling access to native and designed

33 With the goal of improving access to kidney transplant,

34 ernative to conventional laboratory testing, with the goal of improving accessibility to medical diag

35 e provided to assist patients and clinicians with the goal of improving adherence to effective screen

36 tionalized ILs were designed and synthesized with the goal of obtaining adjustable wettability.

37 ine-interface training was done for 13 weeks with the goal of controlling an anthropomorphic prosthet

38 from regulatory bodies and key stakeholders, with the goal of developing an algorithmic approach to d

39 MR methods tailored to investigate allostery with the goal of offering an overview of which NMR appro

40 This review summarizes the progress made, with the goal of providing an integrated view of the fun

41 This report details the elaboration of hit 8 with the goal of achieving and maintaining maximum GCS i

42 ype 2 diabetes, immunology, and microbiology with the goal of discussing and defining potential patho

43 clinical research initiatives be implemented with the goal of elucidating and more effectively genera

44 reduction in experimental design complexity with the goal of facilitating and improving portability

45 ment of a CLL patient starting on ibrutinib, with the goal of minimizing and managing toxicity to mai

46 offer our opinions on this emerging material with the goal of motivating and inspiring fellow researc

47 Accordingly, improved national surveillance with the goal of optimizing and monitoring SCD preventio

48 eat for Future Academicians was held in 2001 with the goal of recruiting and encouraging talented res

49 sceptible tuberculosis and MDR-tuberculosis, with the goal of shortening and simplifying treatment.

50 and clinical networks were recently created with the goal of optimizing animal studies and human tri

51 e and conserved sites on the HIV-1 envelope, with the goal of eliciting antiviral antibodies.

52 stigations of conventional outflow function, with the goal of identifying areas for future inquiry an

53 ral responses to food and to drugs of abuse, with the goal of identifying areas of research that woul

54 iated with a drifting probability of reward, with the goal of earning as much money as possible.

55 tolerated by RNase H or RISC-dependent ASOs, with the goal of improving ASO drug properties.

56 ables that may improve phenotype designation with the goal of improving asthma prevention and treatme

57 NCICAS) and Inner-City Asthma (ICAS) Studies with the goal of reducing asthma symptoms in New Orleans

58 Men should be counseled on physical activity with the goal of achieving at least a moderate level of

59 that centralizes EV biology and methodology with the goal of stimulating authors, reviewers, editors

60 the potential for directed lineage switching with the goal of generating autologous cell populations

61 amidine and guanidine cores were synthesized with the goal of finding BACE-1 inhibitors as a treatmen

62 okinesis in theCaenorhabditis eleganszygote, with the goal of uncovering basic principles of ring clo

63 verrepresentation of known and novel motifs, with the goal of identifying binding sites for direct re

64 started to engineer simplified model systems with the goal of mimicking biological responses of intra

65 Genetic analyses of GV span six decades, with the goal of understanding biological mechanisms and

66 With the goal of identifying biomarkers of sensitivity t

67 d cells into hematopoietic stem cells (HSCs) with the goal of generating blood lineages de novo.

68 al clodronate, a macrophage depleting agent, with the goal of vacating BM niches for preferential reo

69 sented in the IAI "Instructions to Authors," with the goal of helping both readers and authors better

70 gene silencing efficacy in vitro and in vivo with the goal of overcoming both cell-level and systemic

71 d for future HIV-1 vaccine trials in humans, with the goal of eliciting broadly active neutralizing a

72 mpressing deuterium-tritium-filled capsules, with the goal of achieving burning fusion plasmas and en

73 first approach based on their tumor genetics with the goal of utilizing cancer genomics in the clinic

74 ryonic stem cell-derived definitive endoderm with the goal of identifying cell surface markers that c

75 cies, homeless shelters, and school systems) with the goal of fostering changes in policy and practic

76 A375 melanoma cells resistant to vemurafenib with the goal of investigating changes in miRNA expressi

77 led multi- and interdisciplinary innovations with the goal of driving clinical noninvasive imaging st

78 recision medicine research and clinical care with the goal of accelerating clinically-actionable disc

79 ng social workers and psychology technicians with the goal of improving cognitive and functional outc

80 n patients with confirmed and persistent LGD with the goal of achieving complete eradication of intes

81 ies aim for deep and long-lasting remission, with the goal of preventing complications, such as surge

82 t altered muscle cell surface glycosylation, with the goal of finding compounds that increase abundan

83 sembl Genomes has undergone rapid expansion, with the goal of providing coverage of all major experim

84 prior to and during neuromuscular blockade, with the goal of achieving deep sedation.

85 he human and mouse genomes in space and time with the goal of gaining deeper mechanistic insights int

86 define mechanisms underlying drug resistance with the goal of guiding development of therapeutic stra

87 screening of feet to detect sensation loss, with the goal of improving diabetic management and preve

88 terations associated with liposarcomagenesis with the goal of exploiting differentially expressed miR

89 rofiles under different biological contexts, with the goal of identifying differentially methylated r

90 oups (e.g. a control and drug-treated group) with the goal of identifying discriminatory metabolites

91 With the goal of finding drugs that reduce the expressio

92 ts to understand their underlying mechanisms with the goal of uncovering effective therapeutic target

93 late biological functionality more directly, with the goal of improving efficiency and scale.

94 ted in the vicinity of the S2 cleavage site, with the goal of examining elastase-mediated cleavage wi

95 s for tissue regeneration or onto substrates with the goal of accessing encapsulated stem cells of in

96 non-overlapping primary ependymoma cohorts, with the goal of identifying essential super-enhancer-as

97 of markers to describe macrophage activation-with the goal of unifying experimental standards for div

98 egies to antagonize or block these receptors with the goal of reducing extracellular ATP production o

99 mechanisms underlying brain self-protection, with the goal of identifying features that could provide

100 ructures, RAG (RNA-As-Graphs), is presented, with the goal of understanding features of RNA-like and

101 ith skin cancers requires sustained research with the goal of obtaining fresh insights into disease o

102 isms of generalization of emotional learning with the goal of encouraging further research on general

103 s an overview of these areas of DDR research with the goal of fostering further investigation of thes

104 more comprehensive model of vmPFC function, with the goal of fostering further progress in understan

105 and source code for the microBAR instrument with the goal of spurring further innovation toward low-

106 ergent neuroimaging effects across disorders with the goal of informing future research examining the

107 l of AIV transmission in animals and humans, with the goal of preventing future epidemics and pandemi

108 ntifying transcription factor binding sites, with the goal of predicting gene expression from DNA seq

109 to motivate new experiments for each field, with the goal of finding general principles for how the

110 tition open to the whole research community, with the goal of understanding general strategies for mo

111 cly available literature on RNA interference with the goal of identifying genes essential for cell su

112 With the goal of identifying genes that regulate dendrit

113 draft genome sequence of R. gelatinosus CBS with the goal of providing genetic insight into the meta

114 We developed a DRI for AA with HCV with the goal of enhancing graft loss predictions.

115 s, which we sought to examine quantitatively with the goal of developing "heuristics" to define struc

116 interest in combining both modes of therapy with the goal of achieving high response rates with prol

117 Solution processing procedures developed with the goal of depositing highly ordered and oriented

118 ment types on deer ranges are not compatible with the goal of maintaining highly productive deer popu

119 arginine to lysine (R57K), are characterized with the goal of understanding how altered salt bridge i

120 two distinct colonial marine invertebrates - with the goal of understanding how immune adaptation and

121 ported on organized monolayers of dipeptides with the goal of understanding how peptide-based interfa

122 te the origins of stereoretentive metathesis with the goal of understanding how to design a new class

123 ning, engagement, and commitment) variables, with the goal of understanding how well-being might be p

124 es, linking innovations in the data sciences with the goal of advancing human well-being and sustaina

125 With the goal of modeling human disease of the large int

126 ansmembrane domains in AT1R homomer assembly with the goal of identifying hydrophobic interfaces that

127 d the therapeutic strategies being developed with the goal of restoring immune tolerance.

128 viral innate immune responses in early life, with the goal of identifying immunological factors under

129 With the goal of visualizing, in real-time, the spatiote

130 Windows-based application has been developed with the goal of providing individual investigators with

131 ological sample types from the same subjects with the goal of leveraging information across biospecim

132 ggest that participants select eye movements with the goal of maximizing information about abstract c

133 ed by an alpha-helical segment of a protein, with the goal of creating inhibitors of helix-mediated p

134 entification and propose potential solutions with the goal of spurring innovative research in this ar

135 ing two reproductive genes, dvvgr and dvbol, with the goal of reducing insect fecundity as a new tool

136 rgo recognition in selective macroautophagy, with the goal of providing insights into some of the key

137 characterize these regions cost effectively with the goal of providing investigators a clear directi

138 an adhesive microparticulate delivery system with the goal of improving its effect by prolonging its

139 ic deceleration in INS1 (832/13) beta-cells, with the goal of identifying key pathways and metabolite

140 ses to resolve these limitations, consistent with the goal of predicting large-scale biosphere respon

141 variance was aligned to kinematic deviations with the goal of maintaining leg orientation trajectory.

142 ecades, cancer treatments have been modified with the goal of reducing life-threatening late effects.

143 cate remaining tumor cells following surgery with the goal of maximizing local control and increasing

144 With the goal of circumventing marrow toxicity, marrow w

145 nd testing of cognitive training approaches, with the goal of creating maximally efficient and effect

146 for 2030, 2040, and 2050 that are compatible with the goal of limiting mean global temperature rise t

147 s a requisite PDGF-gradient-sensing pathway, with the goal of identifying mechanisms that can amplify

148 nc-responsive transcriptional repressor Loz1 with the goal of identifying metabolic pathways that wer

149 With the goal of profiling metabolite content in differe

150 nds have been the focus of adjuvant research with the goal of generating modern vaccine combinations

151 With the goal of defining molecular requirements for Psd

152 particular a list of potential FMRP targets, with the goal of facilitating molecular characterization

153 sing gene expression microarrays or RNA-seq, with the goal of understanding molecular effects arising

154 onal Measurement Institute, Australia (NMIA) with the goal of determining more polyphenolic compounds

155 policy makers, communities, and researchers with the goal of promoting more effective action to bala

156 ited Neuropathy Consortium (INC) was created with the goal of obtaining much needed natural history d

157 sport network and trained healthcare workers with the goal of improving multidrug-resistant tuberculo

158 s (or panomics) approaches are often adopted with the goal of combining multiple types of omics data

159 rolytes (COEs), WMG1 and WMG2, were designed with the goal of achieving near infrared absorption and

160 ealing with errors after they have occurred, with the goal of minimizing negative and maximizing posi

161 protein-based therapeutics is being pursued with the goal of preventing nerve agent toxicity and pro

162 With the goal of discovering new vaccine antigens, we sy

163 d models, and outlines outstanding questions with the goal of stimulating new research in this area.

164 e, our data are the basis for future studies with the goal of identifying non-MHC EBA susceptibility

165 e planarian flatworm Schmidtea mediterranea, with the goal of identifying novel developmental paradig

166 Consequently, fungi are challenged with the goal of obtaining nutrients while simultaneousl

167 vel NOTA-PEG7-Tz radioligand was synthesized with the goal of improving on a previously reported anal

168 major sources and pathways were identified, with the goal of informing opportunities for loading red

169 zation of high KDPI grafts in older patients with the goal of avoiding or limiting time on dialysis.

170 are culled from a diverse patient population with the goal of evaluating other primary outcome parame

171 ful Herrenhausen Palace in Hannover, Germany with the goal of broadening our understanding of the agi

172 f the soil and roots compartment properties, with the goal of improving our understanding of water ac

173 ing used to develop cooperative group trials with the goal of improving outcomes for this subset of p

174 ization with antibiotic-resistant pathogens, with the goal of reducing pathogen transmission and syst

175 tematically characterized the transcriptomes with the goal of identifying pathways and genes critical

176 al standards, guidelines and protocols - all with the goal of improving patient outcomes.

177 bitors that target Rv1894c and its homologs, with the goal of killing persistent bacteria, thereby sh

178 lop refinements in the modification of CD163 with the goal of making pigs refractory to infection whi

179 reat outcomes with novel nonthreat outcomes, with the goal of reducing postextinction return of defen

180 are typically spared from surgical resection with the goal of preserving postoperative language.

181 forts to optimize the aromatic functionality with the goal of improving potency and in vivo propertie

182 ations into the mechanisms of this pathology with the goal of identifying potential therapeutic targe

183 nciples underpinning phylogenetic inference, with the goal of providing practical guidance on the des

184 reening for and managing these late effects, with the goal of reducing preventable morbidity and mort

185 With the goal of improving previously reported Mn bipyri

186 e review and integrate these different plans with the goal of identifying priority conservation areas

187 activation energies of these rearrangements with the goal of explaining product selectivities.

188 and strategies that are currently available with the goal of improving progression-free and overall

189 , bone tissue engineering, and drug delivery with the goal of identifying promising approaches and ar

190 With the goal of exploiting prostate cancer cell procliv

191 for more research in sexuality and intimacy with the goal of improving quality of life for this larg

192 oggled against four pairs of aminoglycosides with the goal of isolating reagents that recognize conse

193 te (COE), PTTP, was designed and synthesized with the goal of providing red-shifted absorption spectr

194 phase 1 clinical trial without toxic effects with the goal of promoting remyelination in multiple scl

195 report highlights the workshop deliberations with the goal of stimulating research and providing a fr

196 of a great deal of research in recent years with the goal of improving restoration performance by ch

197 facile screening of bacterial transformants with the goal of selecting, retrieving, and using recomb

198 the rituximab era, we built an enhanced IPI with the goal of improving risk stratification.

199 d success when focusing on effector immunity with the goal of eliciting robust tumor-specific T-cell

200 of drug-eluting stent to high-risk patients, with the goal of improving safety and reducing costs.

201 enges for the next phase of stigma research, with the goal of continuing scientific activity that enh

202 spectrometry (CW-CRDS) device was developed with the goal of measuring seasonal changes in the isoto

203 roving CBF and brain oxygen tension (PbrO2), with the goal of decreasing secondary injury.

204 n deciphering the mechanism of MBT assembly, with the goal of targeting select biosynthetic steps for

205 es of pyrazolopyrimidine inhibitors of CDPK1 with the goal of increasing selectivity over host enzyme

206 spectrometer (GC-IRMS) system was developed with the goal of increasing sensitivity, reducing dead-v

207 With the goal of identifying signaling mechanisms that u

208 With the goal of decreasing size and thereby facilitatin

209 l-defined molecular catalysts were initiated with the goal of finding solutions to solar energy conve

210 n attractive yet elusive therapeutic option, with the goal of increasing specificity and effectivenes

211 sment for severe neonatal hyperbilirubinemia with the goal of minimizing subsequent risk of chronic b

212 t clinical strains of Staphylococcus aureus, with the goal of using such strains in mouse models.

213 The SCIP was established in 2006 with the goal of reducing surgical complications by 25%

214 possible, or conventional therapy (n = 730) with the goal of avoiding symptomatic hypoglycemia and h

215 n the context of the tumor microenvironment, with the goal of identifying targets to heighten prolife

216 With the goal of using TdT as an on-chip labeling method

217 s are discussed in light of these principles with the goal of generating testable hypotheses.

218 ces that facilitated uptake and presentation with the goal of improving Th cell activation in vitro a

219 as a community-based mental health programme with the goal of addressing the mental health risk facto

220 Thus, with the goal of advancing the molecular understanding o

221 ixed paraffin-embedded breast cancer tissue, with the goal of assessing the prognostic value of the p

222 ly controlling the degree of their charging, with the goal of clarifying the role of charging in blin

223 emergence and re-emergence of viral diseases with the goal of containing the spread of viral agents r

224 based multivariate reporter algorithm (MIRA) with the goal of eliminating the following problems in d

225 sets from chemical perturbation experiments, with the goal of elucidating the modes of actions of the

226 ll spread, to its parental genome, J6/JFH-1, with the goal of elucidating the molecular mechanisms of

227 sociations can prioritize future experiments with the goal of elucidating the regulatory mechanisms b

228 lasmid resources continue to enable research with the goal of elucidating the role of proteins in bot

229 tic targeting of plaque-associated microglia with the goal of enhancing the microglia barrier and pot

230 ferent glass-forming compounds were prepared with the goal of enhancing the stability of the amorphou

231 ombretastatin A-4 analogues, was synthesized with the goal of evaluating the effects of various patte

232 tion times in (18)F-fluoromisonidazole dPET, with the goal of expediting the clinical implementation

233 the photophysics of this class of compounds with the goal of explaining the concepts, ground- and ex

234 mprove pediatric asthma control is addressed with the goal of exploring the potential and pitfalls of

235 With the goal of harnessing the immunomodulatory capacit

236 ty throughout the brains of larval zebrafish with the goal of identifying the cellular responses, bra

237 and crystallization properties were analyzed with the goal of identifying the key parameters that may

238 ancer genome sequencing efforts are underway with the goal of identifying the somatic mutations that

239 developed clickable GSM photoaffinity probes with the goal of identifying the target of various class

240 With the goal of improving the physico-chemical performa

241 ell-established drug development principles, with the goal of improving the success of clinical drug

242 ehabilitation strategies have been developed with the goal of increasing the probability and speed of

243 s of immunopathogenesis of arterial disease, with the goal of integrating the players and the layers

244 ge sensor toxin (VSTx1) and lipid membranes, with the goal of localizing the toxin in the membrane an

245 ble on early Earth from prebiotic reactions, with the goal of making the model less discontinuous.

246 We introduce a novel SNP selection method with the goal of maximizing the number of associated SNP

247 Methods We define the rolling-arms design with the goal of minimizing the complexity of random ass

248 rbon-containing catalyst have been developed with the goal of minimizing the cost of regeneration of

249 n tailoring the treatment to the individual, with the goal of optimizing the balance of risks and ben

250 ession analysis, a marker panel was selected with the goal of optimizing the negative predictive valu

251 r on-site expansion and differentiation, all with the goal of protecting the host with minimal bystan

252 Here we review phosphoryl-transfer reactions with the goal of providing the reader with the conceptua

253 chemistries (e.g., fresh, brine, and acidic) with the goal of quantifying the extent of natural REE v

254 attering and analytical ultracentrifugation, with the goal of reconstructing the overall structure of

255 In 2005, with the goal of reducing the numbers of maternal and ne

256 gm shifting for the influenza vaccine field, with the goal of replacing the current standard of care

257 ropoxyisoindoline-1,3-dione ((18)F-MNI-659), with the goal of selecting the best one for use in futur

258 A Quality Improvement bundle was implemented with the goal of standardizing the multidisciplinary app

259 was to independently validate these results with the goal of testing the efficacy of our CD22 immuno

260 molecular characterization of CidA and LrgA with the goal of testing the holin model.

261 knockout alleles for mouse Lmnb1 and Lmnb2, with the goal of testing the hypothesis that B-type lami

262 With the goal of testing the potential of the three form

263 mputationally designed retroaldolase enzymes with the goal of understanding the extent and the origin

264 movements or from language about action, and with the goal of understanding the implementation ("how"

265 e collective behavior of the whole community with the goal of understanding the origin of clustering

266 mune response and encourage further research with the goal of understanding the pathways involved.

267 eous Zr-sulfate chemistry as a model system, with the goal of understanding the structures of oligome

268 opposed to the Tam-sensitive MCF7 cell line, with the goal of understanding the underlying mechanisms

269 uence most of the named viruses in the genus with the goal of clarifying their phylogenetic relations

270 rst venture out of the laboratory or library with the goal of linking their knowledge with action, th

271 ation of phenylenevinylene oligoelectrolytes with the goal of tailoring their optical and electronic

272 sical-chemical foundation for future studies with the goal of understanding their roles in systems of

273 With the goal of finding therapeutic routes to treat dia

274 hanisms governing chromatin binding of AR-Vs with the goal of identifying therapeutic vulnerabilities

275 this review we outline the salient features, with the goal of adding these techniques to the urology

276 science was rooted in fundamental discovery with the goal of translating these findings into clinica

277 With the goal of alleviating this bottleneck, we describ

278 echanisms of this physiological heart growth with the goal of applying this knowledge to the mammalia

279 ecent laboratory studies have been performed with the goal of characterizing this process, but questi

280 With the goal of streamlining this process, transient tr

281 ht be considered in highly selected patients with the goal of providing time off of systemic chemothe

282 the connections between individual myocytes with the goal of restoring tissue CV, specifically throu

283 hronic obstructive pulmonary disease (COPD), with the goal of contributing to a personalized approach

284 L, and to eliminate minimal residual disease with the goal of achieving total elimination of the dise

285 imal models for psychiatric disease research with the goal of attaining translational utility to ulti

286 lts are obtained by a multidisciplinary team with the goal of individualizing treatment for patients.

287 imating distributions of phylogenetic trees, with the goal of identifying trees that are significantl

288 ed a more comprehensive mutagenesis approach with the goal of identifying trimer variants with improv

289 ous oncolytic viruses and chemotherapeutics, with the goal of inducing tumor-specific immunity while

290 se xenograft models of human uveal melanoma, with the goal of modeling tumor growth to evaluate treat

291 With the goal of downstaging underlying disease before a

292 opentadithiophene and difluorophenylene unit with the goal of favoring unipolar organic field effect

293 ymal stromal cell (MSC) therapy are emerging with the goal of speeding up biology, thereby reducing t

294 e findings do not support the use of statins with the goal of improving VAP outcomes.

295 volition is reviewed in the agency section, with the goal of delineating variables that promote or c

296 sign variants of the PG9 antibody HCDR3 loop with the goal of identifying variants with increased pot

297 xes is an active and ongoing research topic, with the goal of finding ways to improve biomass convers

298 y of atovaquone-proguanil to prevent malaria with the goal of simulating weekly dosing in a human Pla

299 task and high-density electroencephalography with the goal of determining whether compensatory proces

300 ina and the lateral geniculate nucleus (LGN) with the goal of determining whether the most informativ