ライフサイエンスコーパス: wobble base pair

1 n interacts with N7 of the cleavage site G.U wobble base pair.

2 d duplex at an A-U base pair adjacent to the wobble base pair.

3 NMR data and modeling indicated a T(a).T(d) wobble base pair.

4 5'-U-U-3'/3'-G-G-5' non-symmetric tandem GxU wobble base pairs.

5 n both sides by cis Watson-Crick G/C and G/U wobble base pairs.

6 rmediate that involves DNA-base flipping and wobble base-pairs.

7 oaching that of its natural analogue, a G-T (wobble) base pair.

8 tion of miRNA base pairing or by creation of wobble base pairing.

9 ribozymes suggest that a pair of tandem G:U wobble base pairs adjacent to the reactive center consti

10 containing a bulged nucleotide adjacent to a wobble base pair also was primarily affected by non-near

11 The control duplex contained a G-U wobble base pair and also a G-A mismatched base pair.

12 Urd was substituted in one duplex at the G-U wobble base pair and in the second duplex at an A-U base

13 other hand, recognizes the TG mismatch as a wobble base pair and penetrates the DNA with three aroma

14 These sites contain a G-U wobble base-pair and a downstream uridine which is cleav

15 bove the average value and those between the wobble base-pairs and the flanking Watson-Crick base-pai

16 one containing a central G-T mismatched or "wobble" base pair, and one in which the thymine in this

17 er, interactions between adjacent codons and wobble base pairing are key.

18 ues for five terminal mismatches adjacent to wobble base pairs are also reported.

19 Adjacent GxU wobble base pairs are frequently found in rRNA.

20 crystallographic studies showing that tandem wobble base pairs are good binding sites for metal hexaa

21 ly occurring RNA hairpin sequences closed by wobble base pairs are reported.

22 G.U wobble base pairs are the most common and highly conserv

23 Guanine-uracil (G.U) wobble base-pairs are a detrimental lesion in DNA.

24 Previous investigations have shown that such wobble base-pairs are more prone to base-opening than th

25 he templating base, Poliota accommodates the wobble base pair better than the Watson-Crick base pair.

26 The former is most likely due to wobble base pairing between ClU and G, which may be more

27 side chain plays a pivotal role in excluding wobble base pairs between template pyrimidines and purin

28 n an accurate but inefficient manner with a "wobble" base pairing between C and O(6)-MeG.

29 cted that the free G-N2 amino group in a T:G wobble base pair can form two individual hydrogen bonds

30 The wobble base pairs contribute to the catalytic rate enhan

31 he ribozyme and the data here show that this wobble base pair destabilizes neighboring base pairs on

32 ostatic potential at the major groove of G.U wobble base pairs embedded in RNA helices, suitable for

33 The G.U wobble base pair formed between a (15)N-labeled strand a

34 nces of the type GGXANmAYCC, where XY is the wobble base pair, GU or UG, and the underlined loop sequ

35 e modified base pair in the structure adopts wobble base pairing (hydrogen bonds between [POB]dG(N1)

36 econciled by possible tautomerization of the wobble base pair in mRNA-tRNA.

37 laRS) has depended predominantly on a single wobble base pair in the acceptor stem, G3*U70, mainly on

38 reases the stability of duplexes closed with wobble base pairs in an idiosyncratic manner.

39 ructure and the importance of two tandem G:U wobble base pairs in the template domain were studied by

40 The G.U wobble base-pair in the acceptor helix of Escherichia co

41 The G.U wobble base-pair in the acceptor helix of Escherichia co

42 a G.C replacement were reversed by a distal wobble base-pair in the anticodon helix.

43 However, G:U wobble base-pairing in this region interferes with activ

44 d, to a lesser extent, guanine residues from wobble base-pairs in hairpin stems.

45 ed 5ns molecular dynamics simulations on G.U wobble base-pairs in two different sequence contexts, TG

46 The helical distortions and wobble base pairing induced by the covalent binding of P

47 Importantly, the mcm(5)s(2)U(34).G(3) wobble base pair is in the Watson-Crick geometry, requir

48 G.U wobble base pairing is tolerated as a match for both RNA

49 at the negativity at the major groove of G.U wobble base pairs is determined by the combined effect o

50 n is bound in the major groove of the tandem wobble base pairs, is precisely positioned by the ribozy

51 spite of the presence of two adjacent G x U wobble base-pairs located at the center of the helix.

52 nt for elongation and that it is the U50.G64 wobble base pair, located at the same position in the TP

53 mately 1.5 kcal/mol and the d(G x T) reverse wobble base-pair more stable by approximately 0.5 kcal/m

54 air (on the guanine containing strand) and a wobble base pair (on the strand containing the difluorot

55 polymerase active site and the asymmetry of wobble base pairs, provides a plausible explanation for

56 ent upon the position and orientation of the wobble base pair relative the bulged nucleotide.

57 xes containing symmetrical tandem GxU or GxT wobble base pairs show that nearest-neighbor sequence de

58 om A-form helix occur where the guanine of a wobble base pair stacks over a purine from the opposite

59 -thymine mispairs may be associated with its wobble base pair structure.

60 Proton NMR suggests that wobble base pairing takes place between the 3'-T of the

61 Incorporation of 6MI yields wobble base-pairs that open more readily than their guan

62 ure, including a protonated adenine-cytosine wobble base-pair, that positions the cytosine base 5' to

63 or both of the bulge nearest neighbors was a wobble base pair, the free energy increment for insertio

64 In this wobble base pair, the G forms two hydrogen bonds with U

65 Mutation of the U50.G64 wobble base pair to C50:G64 or U50:A64 base pairs increa

66 ingly, when combinations of Watson-Crick (or wobble) base pairs were introduced in these positions, c

67 However, the wobble base pairing, where T pairs with G instead of A,

68 However, the wobble base pairs, where U in RNA (or T in DNA) pairs wi

69 d melting temperature for duplexes closed by wobble base pairs with 3' single or double-nucleotide ov