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1 risk, 1.79; 95% CI, 1.53 to 2.10 for overall worsening).
2 es of this phenomenon, should it persist and worsen.
3 nced improved LGE, in a small percentage LGE worsened.
4 mmon receptor CD74 may contribute to disease worsening.
5 ecline in volume correlated with symptomatic worsening.
6 ts diabetic retinopathy (DR) improvement and worsening.
7 atments were associated with low rates of DR worsening.
8 ost important risk factor for attaining EDSS worsening.
9 (>/=3 months) and sometimes induced seizure worsening.
10 patients who had no DRSS change or any DRSS worsening.
11 .0% had no change, and 3.2% experienced DRSS worsening.
12 th +5.0 letters in patients who had any DRSS worsening.
13 ll death, contributing to periodontal lesion worsening.
16 terval [CI] = 1.21-3.10, p = 0.006) and EDSS worsening (97.5th percentile: OR = 2.41, 95% CI = 1.07-5
17 a single bolus at postnatal day 1, markedly worsened AAA outcomes in XY in comparison with XX adult
18 fatty acids by insulin) showed a continuous worsening across the spectrum of IHTG accumulation in NA
19 ican American women were also more likely to worsen after initial diagnosis (30 [35.3%] vs 14 [18.4%]
22 was associated with greater eGFR decline or worsening albuminuria (increase >/=10%/year with change
23 o more likely to experience eGFR decline and worsening albuminuria compared with HIV-uninfected indiv
28 ; for this z score, negative values indicate worsening and positive values indicate improvement) sign
29 death rises exponentially as kidney function worsens and is largely attributable to death from cardio
31 rices; health disparities are persistent and worsening; and the health and financial burdens of chron
32 content as the individual's health condition worsens; and, using trained non-physician facilitators t
39 n the EORTC QLQ-H&N35, clinically meaningful worsening at week 15 was seen in no domains in the nivol
47 defined as an initial ASPECTS of 6 or higher worsening between RH and TCSC CTs to a score of less tha
48 rachytherapy (20.5 [95% CI, 15.1-25.9]); and worsened bowel symptoms with external beam radiotherapy
49 % CI -2.6 to 0.7) in the exenatide group and worsened by 2.1 points (-0.6 to 4.8) in the placebo grou
50 surveillance, mean sexual dysfunction scores worsened by 3 months for patients who received radical p
51 k 120, performance on the timed 25-foot walk worsened by 38.9% with ocrelizumab versus 55.1% with pla
52 titutes of Health Stroke Scale (NIHSS) score worsened by a mean (SD) 2.5 (1.9) points, and deficits w
53 versed by alleviation of pCO2 stress, or are worsened by departures from prior high pCO2 conditions t
59 between de novo or recently diagnosed HF and worsening chronic HF should be considered in the design
61 significantly increased amyloid plaques and worsened cognitive performance compared to mice on norma
62 f 120 mm Hg or lower was not associated with worsening cognitive outcome and may be superior to the J
64 GF1R signaling initiated by RT-activated CAF worsens colorectal cancer progression, establishing a pr
65 s with PDR, ranibizumab resulted in less PDR worsening compared with PRP, especially in eyes not requ
67 e (18 [15%]) in the tight control group, and worsening Crohn's disease (35 [29%] of 122 patients), ar
68 T has been associated with the potential for worsening CVD risk factors (such as blood pressure eleva
70 over, the EFT was the strongest predictor of worsening disability at 1 year (adjusted OR: 2.13; 95% C
71 volumes (<1.99 mm3) had a 6.4-fold risk for worsening disability during follow-up compared with pati
72 d constitutes an independent risk factor for worsening disability, whereas high INL volumes are assoc
76 p eGFR>/=10% higher than baseline pre-TAVR), worsened eGFR (>/=10% lower), or no change in renal func
79 or participants with improved, unchanged, or worsening eGFR was 84.90 (6.91) years, 84.37 (7.13) year
80 proved eGFR did not improve 1-year outcomes, worsening eGFR was associated with increased mortality.
82 irst Expanded Disability Status Scale (EDSS)-worsening event (HR, 95% CI = 0.59, 0.42-0.83; 0.75, 0.7
83 gnificantly higher incidence of a first EDSS-worsening event in patients with multifocal or isolated
84 econd clinical attack and a first disability-worsening event in pediatric clinically isolated syndrom
85 e as the most protective factor against EDSS-worsening events and relapses as the most important risk
86 ew-onset cytomegalovirus (CMV) retinitis and worsening existing CMV retinitis in patients with AIDS a
87 , global Mif deletion or MIF inhibition also worsened fibrosis and inflammation and associated with w
91 itial to final follow-up visit, mean VA also worsened for decade 1 eyes (P = 0.03), but remained stab
94 Secondary outcome: In the AG, the mean BCVA worsened from logMAR 0.57 +/- 0.33 at baseline to 0.63 +
96 FS was vasomotor symptoms, with the greatest worsening from baseline at 6 months (on the order of 30
97 in itself cannot be ruled out as a source of worsened functional status among patients receiving long
99 deaminase-deficient cells, and its depletion worsens genome instability, compromising cell survival.
100 eloped ventricular diastolic dysfunction and worsening global cardiac function evidenced by elevated
103 ividuals with type 1 diabetes increased with worsening glycaemic control and renal complications.
104 no evidence that increased foreclosure rates worsened glycemic control in this continuously insured p
105 ents in some PROs, QILD, and QLF, while FVC% worsening >/=MCID was associated with statistically sign
110 ed to avoid overlooking the possibility that worsening heart failure is a consequence of mechanical i
112 ts of Tolvaptan in Patients Hospitalized for Worsening Heart Failure With Challenging Volume Manageme
113 oints included myocardial infarction, new or worsening heart failure, atrial fibrillation, stroke, de
114 It is important to note that NAC did not worsen hemorrhagic stroke outcome, suggesting that it ex
115 ed a reduction in the composite end point of worsening HF hospitalization or death during the 3-year
118 Although PD-L1 deficiency in donor tissue worsened histopathological outcome, and increased system
119 igh-fat diet, deletion of PKD1 in beta-cells worsened hyperglycemia, hyperinsulinemia, and glucose in
120 tients (13%) at 6 months: hypotension (n=2), worsening hypertension (n=1), intermittent claudication
121 ons, access to neurologist care is likely to worsen in many regions if there are no changes to models
122 coverage of health-care needs significantly worsened in 2013 compared with in 2005 (227 [69%] percei
125 receiving exemestane or not, experiencing a worsening in any MENQOL domain or, especially, overall m
128 nt characteristics and clinically meaningful worsening in menopause-specific quality of life (QOL) wi
129 ined total exacerbations as subject-reported worsening in respiratory health requiring therapy with c
130 of women experienced a clinically meaningful worsening in the vasomotor, sexual, physical, and psycho
134 all, 9 patients improved spontaneously and 7 worsened (liver transplantation [LT] (n=5), deceased (n=
135 as a decrement of 12.6 wpm on MNRead per 0.1 worsening logMAR (95% CI: -18.7, -6.6, P < .001), but VA
136 87; P = 0.012), while viremia per se did not worsen LT outcomes, such as the incidence of acute rejec
138 with 1-year waitlist death or delisting for worsening medical condition was assessed within the deri
139 We investigated the association between worsening menopause-specific quality of life, baseline p
140 tiffening; left ventricular hypertrophy; and worsened metrics of diabetes, hypertension, and hyperlip
142 ing equations suggested that PERG amplitudes worsened more in treated eyes than in fellow eyes by app
143 itigating motor symptoms, selective deletion worsened motor function and accelerated the onset of par
145 yptotic erythrocytes and hematoma clearance, worsened neurological recovery, exacerbated iron deposit
146 KO mice presented larger brain infarct size, worsened neurological scores, and reduced sensorimotor f
147 s observed in CLIPPERS (23/23), and clinical worsening occurred in all 12 CLIPPERS cases when cortico
148 mprovement in accrual to adjuvant trials but worsening of accrual for neoadjuvant/metastatic trials.
151 ticipants who exhibited no evidence of acute worsening of asthma symptoms, reversible airflow obstruc
152 agia progression-free survival (defined as a worsening of at least 1 point on the Mellow scale from b
153 ed chemotherapy does not result in long-term worsening of cardiac function, cardiac symptoms, or heal
154 induces asthma exacerbations, which leads to worsening of clinical symptoms and may result in a susta
155 muL; rates of new-onset CMV retinitis and of worsening of CMV retinitis (either increasing border act
156 0, whereas spread to neocortical regions and worsening of cognition is associated with beta-amyloid (
158 th intrathecal variables are associated with worsening of disease in patients with relapsing-remittin
159 xposure to a causative agent and progressive worsening of disease; conversely, diagnosing OA when it
160 ncreased rate of new-onset CMV retinitis nor worsening of existing CMV retinitis in the first 6 month
162 iation of MCID estimates for improvement and worsening of FVC% with patient reported outcomes (PROs)
163 at 6 weeks of age resulted in time-dependent worsening of glucose tolerance, impairment of insulin se
165 induced hepatotoxic effects, and monitor for worsening of hepatic fibrosis scores during MTX therapy.
168 ough, upper respiratory tract infection, and worsening of IPF; and the most common grade 3 or 4 adver
169 parameter was indicative for the subsequent worsening of left ventricular ejection fraction in perma
170 he study, mice in the control group showed a worsening of memory and learning abilities, whereas mice
171 onance images (MRIs) within 1 month of acute worsening of myelopathy; and (4) follow-up duration >/=
172 t failure are closely intertwined, such that worsening of one condition is frequently accompanied by
176 predictive factors for events that represent worsening of proliferative diabetic retinopathy (PDR) in
178 hs), and progressive disease (progression or worsening of proven or suspected lesion due to ECD).
179 taking capecitabine had clinically relevant worsening of quality of life at end of treatment (255 [5
181 inary diagnostic criteria for PSR: transient worsening of residual poststroke focal neurologic defici
183 ng the GHRH antagonist, MIA-602, resulted in worsening of retinal morphology and a significant altera
184 ent adverse events (eg, insomnia, akathisia, worsening of schizophrenia, headache, anxiety) were repo
188 e ALOX5 is responsible for the Hcy-dependent worsening of the AD phenotype in a relevant mouse model
189 tion of axonal lysosomes was revealed by the worsening of the amyloid plaque pathology arising from J
190 mia and hypoxia play a major role in further worsening of the damage, a process referred to as 'secon
193 late-born neurons are likely yielding to the worsening of the microcephaly phenotype postnatally.
194 f one condition is frequently accompanied by worsening of the other; the degree of clinical accelerat
195 ienced a significant and clinically relevant worsening of the rhinitis, with increase in emergency as
196 ther accumulation of IHTG is associated with worsening of these parameters has not been properly asse
198 statectomy (33.6 [95% CI, 27.8-39.2]); acute worsening of urinary obstruction and irritation with ext
199 comes included intraocular pressure control, worsening of visual acuity, cystoid macular edema, retro
202 Over the entire trial, we noted significant worsening on tests of verbal memory (T score decline of
203 increases over 1 and 2 years were related to worsening on the Hoehn and Yahr scale over 4 years; and
207 Time from randomization to a composite PDR-worsening outcome defined as the first occurrence of vit
208 fected children might accelerate recovery or worsen outcomes associated with immune reconstitution.
212 y risk was even greater if the MSIS-29 score worsened over 1 year (HR 2.3, 95% CI 1.2-4.4, p = 0.02).
213 lower onset skin disease initially, but then worsened over time, suggesting that a lack of IL-6 led t
214 ally, insufficient or poor-quality sleep may worsen pain and this enhanced pain may be reduced not by
215 suggesting that sleep disturbances alone may worsen pain, and experimental sleep deprivation in human
216 hanisms by which opioids might paradoxically worsen pain, and implementation of an opioid detoxificat
218 as not accompanied by increased rejection or worsening patient/allograft survival in the short term.
221 rough 2 years, the cumulative probability of worsening PDR was 42% (PRP) versus 34% (ranibizumab; haz
222 cale) were associated with increased risk of worsening PDR, regardless of treatment group (64% [high-
223 URB597 and JZL184 increased the enhanced (worsened) permeability caused by inflammation and hypoxi
224 ice, we discovered a series of progressively worsening phenotypes that could not be easily explained.
225 Stage Liver Disease (MELD) score transiently worsened postantibiotics, but reverted to baseline post-
226 were reported, including one fatality due to worsening pre-existing peripheral arterial occlusive dis
227 associated with many chronic diseases, which worsens prognosis of primary illness leading to enhanced
230 s in the open lung approach strategy did not worsen pulmonary vascular mechanics, improved lung mecha
231 ngitudinal feature alterations occurred with worsening pulmonary function independent of an increase
233 Secondary, gated outcomes included new and worsened radiographic vertebral fractures, clinical frac
234 Two-year cumulative rates for retinopathy worsening ranged from 7.1% to 10.2% and 17.2% to 26.4% a
237 al status in acute HF and are prognostic for worsening renal function and in-hospital mortality as we
238 renal events in the IASD group and 1 event (worsening renal function) in the control group (P=1.0).
240 (>/=change of 1.5 units for improvement and worsening, respectively) and the SF-36 Health Transition
241 ) is associated with increased mortality and worsened respiratory outcomes, including bronchopulmonar
242 each increasing hemoglobin unit, the odds of worsened respiratory Sequential Organ Failure Assessment
243 was associated with a higher probability of worsening respiratory dysfunction scores the following d
245 nt our study by assessing the association of worsening retinopathy with objectively measured function
246 progressive multiple sclerosis that prevent worsening, reverse damage, and restore function are a ma
247 ease in 28-day mortality was associated with worsening severity of acute kidney injury (P<0.001 by lo
248 to the emergency department in December with worsening shortness of breath and chest heaviness for 1
249 but autoluminescence of the paper substrate worsens signal-to-noise ratios of fluorescence-based ass
252 s associated with 2-fold increase in odds of worsening SMR over time (OR 2.14; 95% CI 1.07-4.26, P =
253 in HFpEF exacerbates diastolic dysfunction, worsens sympatho-vagal imbalance and markedly increases
255 lasting for at least 3 consecutive days, or worsening symptoms after a typical viral illness that la
257 resulting in an increased use of medication, worsening symptoms, and, frequently, hospital admission.
260 hile chronic inhibition of synaptic activity worsened Tau pathology and caused detrimental effects on
261 environmental factors that may alleviate or worsen the condition of hyperbilirubinemia are discussed
262 enicity secondary to ferroptosis may further worsen the damage, although necroptosis-related proteins
263 ium channel blocking antiepileptic drugs may worsen the disease, we predicted the phenotype of Scn1a
264 growth factor-amniotic fluid stem cells can worsen the ischemia-reperfusion injury when delivered in
265 ms were to test whether ApN deficiency could worsen the mdx phenotype and whether ApN supplementation
269 with higher than 500 cells per muL does not worsen the short-term clinical and immunological outcome
270 ighest interaction frequency, a dynamic that worsened the interaction deficit among plant species wit
274 cenocepacia independently contributes to and worsens the overall oxidative burst deficits in CF MDMs
276 isease-specific symptoms and quality of life worsened, the probability of having visited an HCP incre
277 hereas treatment with an aerosolized agonist worsens these phenotypes, suggesting that beta2AR signal
278 The increasing prevalence of IBD will only worsen this problem globally-population health managemen
279 and cumulative probabilities for retinopathy worsening through 2-year without adjustment for multiple
280 ts leading to discontinuation increased with worsening UACR status at baseline, but were similar betw
283 mpared with active surveillance at 3 months, worsened urinary incontinence was associated with radica
285 -forward process, which potentially leads to worsening vascular amyloid-beta accumulation, activation
290 both eyes (p = 0.01 for both eyes) while no worsening was noted in either the lens or punctal plugs
295 n the contrary, sponge cakes were noticeable worsened with the use of banana flours (lower specific v
296 was evident in schizophrenia, progressively worsening with age to a maximal loss of 8% in the sevent
297 l corticosteroid treatment visual acuity was worsening with similar optical coherence tomography exam
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