ライフサイエンスコーパス: worsening of

1 mately 24% improvement from baseline) with a worsening of 0.3% in the placebo group (P < 0.001).

2 owing: (1) worsening from no PDR to PDR, (2) worsening of 2 or more severity levels on reading center

3 s with de novo PD is associated with reduced worsening of a range of NMSs in preliminary analyses.

4 mprovement in accrual to adjuvant trials but worsening of accrual for neoadjuvant/metastatic trials.

5 fering ribonucleic acid also resulted in the worsening of actively induced and adoptively transferred

6 njury on admission and any development of or worsening of acute kidney injury during the pediatric in

7 posure to grass pollen induced a significant worsening of AD.

8 variables associated with an improvement or worsening of adherence of >/=25%.

9 ria, diuretic resistance, and in many cases, worsening of ADHF symptoms.

10 tissues, but this was not associated with a worsening of age-associated insulin resistance and, conv

11 culating IgE, Th2 cytokine production, and a worsening of AHR.

12 ducing iNKT cell subset, thus explaining the worsening of airway inflammation by some viral infection

13 er ischemia-reperfusion injury mitigated the worsening of AKI.

14 abstinence from cocaine was associated with worsening of all measured polysomnographic sleep outcome

15 on and weather changes may contribute to the worsening of allergic conjunctivitis.

16 Persistence or worsening of AMR in a subsequent biopsy occurred in 38.2

17 presented with leukemic conversion and with worsening of an erythematous generalized papular rash, h

18 Acute worsening of anemia with infections requiring urgent blo

19 GF-beta target gene output, which paralleled worsening of aneurysm pathology and coincided with upreg

20 experienced paradoxical QT prolongation and worsening of arrhythmias after mexiletine treatment.

21 platelet count and albumin as well as severe worsening of AST/ALT ratio and albumin was the best pred

22 0, 95% confidence interval: 0.7, 1.7) and no worsening of asthma from before September 11 to the 4 we

23 he definition of "asthma exacerbation" be "a worsening of asthma requiring the use of systemic cortic

24 Acute worsening of asthma symptoms (exacerbation) is predomina

25 ticipants who exhibited no evidence of acute worsening of asthma symptoms, reversible airflow obstruc

26 ically significant exacerbations (defined as worsening of asthma that required the use of systemic co

27 agia progression-free survival (defined as a worsening of at least 1 point on the Mellow scale from b

28 The 60mg/kg/day dose was discontinued due to worsening of ataxia in 2 patients.

29 The retinal vessel movements correlated to worsening of BCVA and increased CMT, and were more prono

30 They experienced slightly worsening of beta cell function and insulin sensitivity

31 Regression analysis revealed a significant worsening of BiS with strabismus for 2.5% (P = .009) and

32 gion of the hippocampus in RRMS with further worsening of CA1 loss and extension into other CA region

33 ardial metabolism, often contributing to the worsening of cardiac function and health outcomes.

34 ed chemotherapy does not result in long-term worsening of cardiac function, cardiac symptoms, or heal

35 ty to diabetes mellitus is likely related to worsening of cardiac mitochondrial function because impa

36 -79% decrease, P < 0.05) during progressive worsening of cerebrovascular autoregulation in one patie

37 llow-up is needed to ascertain resolution or worsening of chronic kidney disease and hypertension.

38 d bone marrow chimeras demonstrated that the worsening of cisplatin nephrotoxicity in DC-depleted mic

39 infection or antigen that causes paradoxical worsening of clinical disease.

40 ival inflammation and may play a role in the worsening of clinical parameters of periodontitis, such

41 induces asthma exacerbations, which leads to worsening of clinical symptoms and may result in a susta

42 tients was found although not accompanied by worsening of clinical symptoms.

43 ry end points of increased plaque burden and worsening of clinically relevant luminal obstructions tr

44 muL; rates of new-onset CMV retinitis and of worsening of CMV retinitis (either increasing border act

45 Worsening of cognition (-1.05 points; 95% CI, -1.97 to -

46 0, whereas spread to neocortical regions and worsening of cognition is associated with beta-amyloid (

47 Factor scores were sensitive to worsening of cognitive functioning in prHD, typically mo

48 Furthermore, it implies that gradual worsening of conditions across a species' habitat may le

49 Respiratory disorders, particularly worsening of COPD, were the most common adverse events (

50 The respiratory disorders, in particular worsening of COPD, were the most common serious adverse

51 Mild adverse events, such as worsening of cough, occurred more frequently among child

52 extrinsic IgE-mediated form of AD induced a worsening of cutaneous symptoms.

53 creasing fat attenuation are associated with worsening of CVD risk factors beyond the associations wi

54 een associated with no improvement or even a worsening of CVD risk, at least in part through effects

55 uate which factors influence the progression/worsening of dental and periodontal tissue conditions of

56 suicidal ideation or behavior and no overall worsening of depression or anxiety in either group.

57 ; or discontinuation for lack of efficacy or worsening of depression or suicidality.

58 The phenomenon of temporary paradoxical worsening of diabetic macular edema after insulin treatm

59 , 1.08 [95% CI, 0.44-2.61], P = .87), or the worsening of diabetic retinopathy (HR, 0.94 [95% CI, 0.8

60 in and the incidence of macular edema or the worsening of diabetic retinopathy in persons with type 1

61 s suggest that use of these drugs to prevent worsening of diabetic retinopathy may be feasible.

62 Worsening of diabetic retinopathy, incidence of prolifer

63 baseline left ventricular ejection fraction, worsening of diastolic function is an independent predic

64 There are limited data, however, on whether worsening of diastolic function is associated with worse

65 entricular ejection fraction to <55% and any worsening of diastolic function were independently assoc

66 -RSV) vaccine in 1966-1967 caused disastrous worsening of disease and death in infants during subsequ

67 ith severe and mild EAMG were protected from worsening of disease and had limited weight loss.

68 th intrathecal variables are associated with worsening of disease in patients with relapsing-remittin

69 of reports linking aeroallergens to seasonal worsening of disease.

70 iral uptake, leading to enhanced viremia and worsening of disease.

71 xposure to a causative agent and progressive worsening of disease; conversely, diagnosing OA when it

72 d pressure reduction was not associated with worsening of diuresis or decongestion.

73 mprovement of hypokinesia contrasting with a worsening of DOPA-unresponsive gait and balance disorder

74 s was independently associated with two-fold worsening of DSS, DFS, and OS after surgery for EAC, aft

75 n), involuntary movements (ie, dyskinesia or worsening of dystonia; five vs one), and depression (one

76 The main outcome was a worsening of either torsion or pattern strabismus.

77 ncreased rate of new-onset CMV retinitis nor worsening of existing CMV retinitis in the first 6 month

78 leading to an increase in effector cells and worsening of experimental autoimmune encephalomyelitis.

79 However, despite weight gain, KCl prevented worsening of fasting glucose.

80 activity score by at least 2 points without worsening of fibrosis from baseline to the end of treatm

81 with contribution from >1 parameter, without worsening of fibrosis, 1 year after the last dose of EPA

82 ity score in 2 histologic categories without worsening of fibrosis.

83 oint was NAFLD activity score </= 3, without worsening of fibrosis; or a decrease in NAFLD activity s

84 those with injury alone, inactivation caused worsening of forelimb function; the initial deficit was

85 ts receiving the higher dose had significant worsening of functional ability.

86 iation of MCID estimates for improvement and worsening of FVC% with patient reported outcomes (PROs)

87 s for disease progression defined by 48-week worsening of FVC, dyspnea (University of California, San

88 Rates of improvement or worsening of GERD symptoms, development of new-onset GER

89 at 6 weeks of age resulted in time-dependent worsening of glucose tolerance, impairment of insulin se

90 ever, CTs cured 53% of animals and prevented worsening of glycemic control in nonprotected individual

91 Dose-related worsening of glycemic control was noted in 14.5% of pati

92 Recurrence or worsening of HAE symptoms (22 of 97) was the most common

93 sis of RCTs did not show significant risk in worsening of hard exudates and severity of DME in the li

94 Many episodes of worsening of heart failure (HF) are treated by increasin

95 ome was a composite of death from any cause, worsening of heart failure during the initial hospitaliz

96 ality and cardiac hospitalization because of worsening of heart failure; the secondary end point was

97 Worsening of hemodynamics coincided with reappearance of

98 A significant worsening of hemodynamics was observed immediately when

99 induced hepatotoxic effects, and monitor for worsening of hepatic fibrosis scores during MTX therapy.

100 One month later, she developed progressive worsening of her choroidal detachments and angle closure

101 ristics that predict crossover to surgery or worsening of hernia symptoms.

102 ovascular mortality and hospitalization from worsening of HF (n=465), was investigated in 1245 patien

103 aturase activity significantly predicted the worsening of hyperglycemia (glucose area under the curve

104 These abnormalities contributed to worsening of hyperglycemia and glucose-intolerance in th

105 We investigated EMFAs as predictors of the worsening of hyperglycemia and incident type 2 diabetes

106 ion, high levels of KBs predicted subsequent worsening of hyperglycemia, and a common variant of GCKR

107 side increased adiposity and the progressive worsening of hyperphagia-associated hyperinsulinaemia.

108 ls; increase in VAT, IHL, and lipolysis; 45% worsening of IMGU; and decreased expression of lipid met

109 ing to a characteristic dyslipidemia and the worsening of impaired insulin action and obesity.

110 -DTR transgenic mice resulted in substantial worsening of infection, as indicated by increased bacter

111 insulin suppression of lipolysis and only 8% worsening of insulin-mediated glucose uptake (IMGU).

112 nt system implementation was associated with worsening of intraoperative nursing documentation time e

113 Worsening of intrinsic myocardial contraction in the tra

114 most common grade 3 or 4 adverse events were worsening of IPF, dyspnoea, and pneumonia.

115 ough, upper respiratory tract infection, and worsening of IPF; and the most common grade 3 or 4 adver

116 n contributes to progression of RNP and thus worsening of ischemia.

117 New onset or worsening of isolated cerebellar ataxia in patients bein

118 with other baseline K/L grades to experience worsening of knee OA.

119 rend of increasing outcomes with more marked worsening of laboratory values over 2 years, particularl

120 parameter was indicative for the subsequent worsening of left ventricular ejection fraction in perma

121 should always increase in degree along with worsening of lesion severity (which happens for all know

122 A worsening of letter verbal fluency was seen in STN.

123 of COPD, and this decline is paralleled by a worsening of lung function and health status.

124 apex-paced animals, which was accompanied by worsening of LV function (maximum LV mechanical delay/LV

125 al MT1-MMP levels resulted in poor survival, worsening of LV function, and significant fibrosis.

126 systolic blood pressure over time predicted worsening of LVDF (P</=0.014).

127 sociated with a 184% increase in the odds of worsening of LVDF (P<0.0001).

128 Baseline age was a strong predictor of worsening of LVDF from normal/mild grade to more advance

129 The incidence of development or worsening of macular edema (ME) is variable in eyes with

130 plant was shown to prevent the recurrence or worsening of macular edema in uveitic patients with a hi

131 taract surgery may prevent the postoperative worsening of macular edema.

132 he study, mice in the control group showed a worsening of memory and learning abilities, whereas mice

133 vation in Abeta levels and deposition, and a worsening of memory deficits in AD transgenic mice.

134 efit from high-folate status and could see a worsening of memory.

135 o CD8-deficient mice (CD8(null)) resulted in worsening of metabolic parameters compared with wild-typ

136 Improvements or worsening of METAVIR necroinflammatory activity and fibr

137 Conversely, transient worsening of mismatch by episodic hypoxemia or hypotensi

138 ether older subjects with IGT have a further worsening of mitochondrial function (lower ATP productio

139 ed with the degrees of cognitive decline and worsening of mood though the associations were relativel

140 east three of the six core criteria for JIA, worsening of more than 30% in no more than one of the cr

141 rated with no significant safety concerns or worsening of motor function.

142 nt mice had no shortening of lifespan and no worsening of motor or memory deficits.

143 alpha -syn, in particular, showed a gradual worsening of motor performance, with increased motor coo

144 administration in PD patients may result in worsening of motor symptoms, at least in part, by exacer

145 onance images (MRIs) within 1 month of acute worsening of myelopathy; and (4) follow-up duration >/=

146 clopidogrel to aspirin correlates with less worsening of native coronary artery disease 1 year after

147 ular RNFL thickness loss was associated with worsening of NEI VFQ-25 scores over time.

148 CAM-1 provides a potential therapy to combat worsening of neovascular diseases by oxidative stress.

149 efficacy (measured by number of attacks [new worsening of neurological function lasting for more than

150 a-CNS disease progression, no tumour-related worsening of neurological signs or symptoms, and no incr

151 both patients and healthy volunteers; (ii) a worsening of neuropsychiatric performance (wake EEG slow

152 Worsening of NIH skin score at 6 months was associated w

153 nsive genes caused in part by VCAM-1-induced worsening of nonperfusion and, hence, ischemia, because

154 lation, pupil constriction, dyschromatopsia, worsening of ocular myasthenia gravis, posterior reversi

155 t failure are closely intertwined, such that worsening of one condition is frequently accompanied by

156 smoke (SHS) exposure has been linked to the worsening of ongoing lung diseases.

157 atins may protect against the development or worsening of open-angle glaucoma (OAG).

158 A total 79.4% of patients reported worsening of orthostatic tremor symptoms.

159 xcessive consumption results in proportional worsening of outcomes.

160 matory cytokine production and autophagy and worsening of oxidative stress.

161 loss of appetite, and significantly delayed worsening of pain and haemoptysis.

162 Denosumab may delay worsening of pain compared with bisphosphonates.

163 fth had an increase, and the improvement and worsening of pain varied by baseline pain score.

164 He denied neurologic symptoms or worsening of pain while lying down.

165 lity could contribute to the maintenance and worsening of panic disorder symptoms by increasing antic

166 a decrease in aortic-valve gradient, with no worsening of paravalvular aortic regurgitation.

167 mbined preladenant group versus placebo were worsening of Parkinson's disease (22 [11%] vs 4 [9%]), s

168 She experienced worsening of parkinsonism with severe dyskinesias, and u

169 n of disease control, but is associated with worsening of patient-reported HRQoL and no detectable OS

170 reactivation can occur resulting in further worsening of patients.

171 for diabetic macular edema on development or worsening of PDR might lead to new therapies for PDR.

172 Outcomes were mortality and worsening of pediatric cerebral performance category fro

173 r metabolic syndrome predicts tooth loss and worsening of periodontal disease in a cohort of 760 men

174 factors for development of periodontitis or worsening of periodontal measures.

175 ndrome may play a role in the development or worsening of periodontitis.

176 Significant worsening of PFT results occurred in 25.6% of patients r

177 Some studies showed no improvement or worsening of PIH after laser treatment.

178 count, AST/ALT ratio, bilirubin, and severe worsening of platelet count, bilirubin, and albumin was

179 , whereas 40% experience new-onset or severe worsening of preexisting abnormalities of liver tests, i

180 predictive factors for events that represent worsening of proliferative diabetic retinopathy (PDR) in

181 with statistically significant or numerical worsening of PROs, QILD, and QLF.

182 hs), and progressive disease (progression or worsening of proven or suspected lesion due to ECD).

183 Numerous reports of the induction or worsening of psoriasis in patients treated with tumor ne

184 Worsening of pulmonary arterial hypertension was the mos

185 intravenous or subcutaneous prostanoids, or worsening of pulmonary arterial hypertension.

186 This worsening of pulmonary inflammation, in response to pers

187 tients with PXE worldwide may be at risk for worsening of PXE as a result of warfarin therapy.

188 g given exemestane with clinically important worsening of QOL at one time or another; specifically, 8

189 taking capecitabine had clinically relevant worsening of quality of life at end of treatment (255 [5

190 Progressive worsening of RA reservoir and conduit functions is relat

191 ia (MSIMI) was defined as the development or worsening of regional wall motion abnormality, reduction

192 diography, was defined as: 1) development or worsening of regional wall motion abnormality; 2) left v

193 currence of MSIMI, defined as development or worsening of regional wall motion abnormality; left vent

194 elated adverse events (myasthenia gravis and worsening of renal failure), and one patient who receive

195 were associated with age, diabetes mellitus, worsening of renal function (reduction in estimated glom

196 s with systolic heart failure but may induce worsening of renal function (WRF) and hyperkalemia (HK).

197 le disease course, but dose reduction led to worsening of renal function and symptoms.

198 These results suggest that transient worsening of renal function may be an expected consequen

199 Worsening of renal function was defined as an annual dec

200 ockade was associated with more hypotension, worsening of renal function, and hyperkalemia than was a

201 It was not associated with a worsening of renal function, but it was associated with

202 ed heart failure will experience significant worsening of renal function, which is associated with wo

203 in-hospital loop diuretic administered, and worsening of renal function.

204 e secondary measures but also with transient worsening of renal function.

205 OHT and was listed for HKT due to subsequent worsening of renal function.

206 inary diagnostic criteria for PSR: transient worsening of residual poststroke focal neurologic defici

207 was not clinically effective and resulted in worsening of respiratory allergic symptoms.

208 Patients recorded daily worsening of respiratory symptoms and peak expiratory fl

209 inography parameters indicative of stable or worsening of retinal functions, and optical coherence to

210 ng the GHRH antagonist, MIA-602, resulted in worsening of retinal morphology and a significant altera

211 that contributed to oxidative stress-induced worsening of retinal NV that were abrogated by blockade

212 ver, our data also suggest that VEGF-induced worsening of retinal perfusion in DME is superimposed on

213 IRR) and 20 experienced paradoxical clinical worsening of retinitis (paradoxical CMV-IRR).

214 reatment of Diabetic Retinopathy Study scale worsening of retinopathy (P </= 0.002), independent of e

215 Exploratory analysis was performed on worsening of retinopathy, defined as 1 or more of the fo

216 e of these treatments to reduce the rates of worsening of retinopathy, with or without PDR, does not

217 After 5 years of follow-up, a worsening of rhinitis was detected in 26.2%, with an inc

218 was not observed in patients who presented a worsening of right ventricular function (right ventricul

219 ly, aggressive blockade of VEGF prevents the worsening of RNP, promotes reperfusion, and eliminates a

220 tripetal photopic threshold elevation led by worsening of rod photoreceptor function.

221 analyses showed significant estimated annual worsening of SARA (regression coefficient 0.86 points [S

222 ent adverse events (eg, insomnia, akathisia, worsening of schizophrenia, headache, anxiety) were repo

223 There was worsening of sCr, eGFR, and uPr/uCr within the groups ov

224 Worsening of serous RD was associated with appearance of

225 25% corresponded to a clinically meaningful worsening of SF-36 PCS scores.

226 r 2 years, but only by 5.4% in those without worsening of SF-36 PCS scores.

227 eaction (JHR) is a well-recognized transient worsening of signs and symptoms occurring soon after the

228 Within 3 days of acute worsening of sinonasal symptoms, subjects underwent a st

229 t may also participate to the development or worsening of some traits of the disease.

230 mprove OH slightly but significantly without worsening of supine hypertension.

231 injury do not confirm either improvement or worsening of survival.

232 Worsening of symptom scores in surviving patients was co

233 QoL, but patients receiving placebo reported worsening of symptoms and other PROs.

234 attributed to ECD), and progressive disease (worsening of symptoms attributed to ECD).

235 M was significantly greater in patients with worsening of symptoms compared with ERM eyes with unchan

236 Worsening of symptoms in concussive blast TBI was also o

237 nt depressive symptoms and with shorter-term worsening of symptoms in women.

238 For some patients there was a worsening of symptoms on changing from pyridoxine to pyr

239 than one-third (37%) reported persistence or worsening of symptoms over 5 years.

240 failure, baseline symptoms of depression and worsening of symptoms over time are associated with incr

241 Worsening of symptoms was defined as an increase of 15 m

242 r these quality-of-life analyses was time to worsening of symptoms, analysed for all randomised patie

243 of anesthesia, skin injury, nonresolution or worsening of symptoms, and possible need for further or

244 ive pulmonary disease (COPD) are episodes of worsening of symptoms, leading to substantial morbidity

245 uded needle-related discomfort and temporary worsening of symptoms, pressure to continue treatment an

246 cal events such as infections often provoked worsening of symptoms, suggesting that careful monitorin

247 erbations occur, which result in a permanent worsening of symptoms.

248 Acute-phase reactants were elevated with worsening of symptoms.

249 T, and were more pronounced in patients with worsening of symptoms.

250 Worsening of systemic RV dysfunction or tricuspid regurg

251 ic aberrant Type-I neural activity and [3] a worsening of the activity-dependent central auditory neu

252 e ALOX5 is responsible for the Hcy-dependent worsening of the AD phenotype in a relevant mouse model

253 tion of axonal lysosomes was revealed by the worsening of the amyloid plaque pathology arising from J

254 Qualitative outcome was assessed as worsening of the cartilage score.

255 ange in T2 was significantly associated with worsening of the cartilage WORMS (P = .038).

256 mia and hypoxia play a major role in further worsening of the damage, a process referred to as 'secon

257 n resistance, but may play a key role in the worsening of the disease condition.

258 uce inflammatory pathways thereby leading to worsening of the disease.

259 ghout the observation period, with a general worsening of the drought conditions in recent years.

260 ients [29.4%]; P = .03) were associated with worsening of the EDSS score at 60 months.

261 lobal increase of inflammation, leading to a worsening of the gastritis, measured by an increased epi

262 However, without further worsening of the insulin secretion defect, glucose homeo

263 nt loss of excitatory cortical neurons and a worsening of the interneuron defect.

264 late-born neurons are likely yielding to the worsening of the microcephaly phenotype postnatally.

265 , contrary to expectation, this results in a worsening of the muscle pathology implying that any futu

266 icular mass index and left atrial dimension, worsening of the myocardial performance index, and a dec

267 t in one might be achieved at the expense of worsening of the other.

268 f one condition is frequently accompanied by worsening of the other; the degree of clinical accelerat

269 ienced a significant and clinically relevant worsening of the rhinitis, with increase in emergency as

270 xpression of mito-PstI displayed a selective worsening of the striatum over cortical and hippocampal

271 ng systemic corticosteroids and there was no worsening of the systemic condition, it is reasonable to

272 rrected transposition of the great arteries, worsening of the systemic right ventricle is accompanied

273 s associated with infection and a subsequent worsening of the ulcer.

274 6 month observation period that related to a worsening of the underlying infectious disease, measured

275 However, in the long term, there is worsening of the underlying neurochemical dysregulations

276 t symptom associated with the beginning or a worsening of the visual disturbance (36%), whereas migra

277 betes after transplant displayed significant worsening of their fasting plasma glucose levels during

278 who received only short-term treatment had a worsening of their pattern standard deviation with time

279 y allergic reactions, leading to significant worsening of their quality of life.

280 ther accumulation of IHTG is associated with worsening of these parameters has not been properly asse

281 is, increased bone marrow reticulin, rebound worsening of thrombocytopenia upon discontinuation, and

282 s not required for subsequent development or worsening of thrombocytopenia).

283 also been associated with the development or worsening of thyroid eye disease in approximately 15% to

284 Conceptualizing worsening of TMJ intra-articular disorders as 4 stages a

285 prosthetic gradient of >/= 10 mm Hg and/or a worsening of transprosthetic regurgitation >/= 1/3 class

286 injured tissues, and potential EPO-mediated worsening of tumorigenesis.

287 Worsening of ulcer was seen in 18.2% cases in group A an

288 ea and most common serious adverse event was worsening of underlying Crohn's disease.

289 erious adverse events in period 1 (excluding worsening of underlying disease) occurred in 1.3% of pat

290 as similar outcomes with significant initial worsening of urinary continence and sexual function.

291 statectomy (33.6 [95% CI, 27.8-39.2]); acute worsening of urinary obstruction and irritation with ext

292 g prednisone treatment and 2 patients showed worsening of uveitis despite the systemic corticosteroid

293 ogenesis and is thought to contribute to the worsening of various inflammatory and disease processes.

294 rse of depression and may reflect underlying worsening of vascular disease.

295 y or as a result of medications, may lead to worsening of VF defects.

296 comes included intraocular pressure control, worsening of visual acuity, cystoid macular edema, retro

297 emergency setting to prevent development or worsening of vital organ dysfunction.

298 ovement and does not appear to contribute to worsening of wet AMD.

299 l white adipose tissue was associated with a worsening of whole organism metabolic function, with DKO

300 orst acuity at baseline had slightly greater worsening of WOMAC pain scores (0.47 on a 20-point scale