ライフサイエンスコーパス: xanthene

1 hos is 9,9-dimethyl-4,5-bis(diethylphosphino)xanthene).

2 that [(3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3',6'-diyl)bis(iminomethylene-2 ,1-phenylene)]

3 '-dihydroxyspir o[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one} was modified to include a sufficiently

4 The structures of xanthene (4) and fluorene (5) bisphenols have been confi

5 xanthene derivative 9,9-bis(4'-hydroxyphenyl)xanthene (4) elicited a similar biological response but

6 12b-octahydro-4,4,6a,12b-tetramethyl-benzo[a]xanthene (4), after desilylation provided tetracyclic py

7 12b-octahydro-4,4,6a,12b-tetramethyl-benzo[a]xanthene (6), was transformed into (+)-5 and (+)-1.

8 2(or 4)-[10-(dimethylamino)-3-oxo-3H-benzo[c]xanthene-7-yl]-benzenedicarboxylic acid (carboxy SNARF-1

9 vealed efficient hydrogen atom transfer from xanthene, 9,10-dihydroanthracene, and 1,4-cyclohexadiene

10 2b-octahydro-4,4,6a,12b-t etramethyl-benzo[a]xanthene-9,10-diol (3).

11 lacetylcarbamate (Ro 01-6128), and butyl (9H-xanthene-9-carbonyl)carbamate (Ro 67-4853)] displaced th

12 An efficient synthesis of 9H-xanthene-9-carboxaldehyde (3a), 9H-thioxanthene-9-carbox

13 oM with respect to NADPH) 6-hydroxy-3-oxo-3H-xanthene-9-propionic acid (XAN) and human glutathione re

14 The convergent approach is based on a xanthene aldehyde-ester building block that is easily ob

15 by the MacDonald [2 + 2] condensation of the xanthene aldehyde-ester with readily available 5-aryl-su

16 tetraaryl cofacial bisporphyrins anchored by xanthene and dibenzofuran.

17 e undecamer), vinyl and ethanol adducts, and xanthene and xanthylium salt derivatives which were iden

18 The resulting HPX (hanging porphyrin xanthene) and HPD (hanging porphyrin dibenzofuran) syste

19 Dihydroanthracene, xanthene, and fluorene are oxidized by [Mn(2)(O)(2)](3+)

20 oxidations of 9,10-dihydroanthracene (DHA), xanthene, and fluorene by [(bpy)(2)(py)Ru(IV)O](2+) in a

21 oach was employed to identify aminooxazoline xanthenes as potent and selective human beta-secretase i

22 A cobalt(II) hangman porphyrin with a xanthene backbone and a carboxylic acid hanging group ca

23 The presentation of two phenols on a xanthene backbone is akin to the tyrosine dyad (Y730 and

24 Specific fluorophores in this unique xanthene based regioisomeric seminaphthofluorone dye ser

25 We have designed a xanthene-based fluorescent probe 1, in which tightly hel

26 that four halogen atoms are attached to the xanthene benzoate group in ERB, we hypothesized that hal

27 RB, we hypothesized that halogenation of the xanthene benzoate plays a critical role in modulating Ab

28 d reactivity enhancement is observed for the xanthene-bridged platform appended with a pendant carbox

29 This affords unique NIR-absorbing xanthene chromophores.

30 f dicobalt(II) Pacman porphyrins anchored by xanthene [Co2(DPX) (1) and Co2(DPXM) (3)] and dibenzofur

31 ticle, we describe 4-aza substitution on the xanthene core as a means to increase BACE1 potency while

32 Wolff rearrangement to give a ring-expanded xanthene core that is nonemissive.

33 Spirocyclic xanthene-cyclopropene scaffolds were obtained.

34 The bisphenol xanthene derivative 9,9-bis(4'-hydroxyphenyl)xanthene (4

35 Treatment of this xanthene derivative with a variety of aryl aldehydes and

36 n applied successfully to the synthesis of a xanthene derivative.

37 analytes on the basis of charge, most of the xanthene derivatives could be resolved by simple capilla

38 ne), we synthesized eight new 6H-dibenzo[b,h]xanthene derivatives selectively under solvent-free cond

39 a library of theoretically 171 disubstituted xanthene derivatives was analyzed.

40 led to selective ea coordination, while the xanthene derived system L3c gave predominant ee coordina

41 med into biologically important benzofurans, xanthenes, diaryl indoles, and unsymmetrical benzophenon

42 s affords a series of regioisomerically pure xanthene dye derivatives.

43 The synthesis of new benzo[a]- and [b]xanthene dye frameworks is described.

44 f protease substrates was synthesized with a xanthene dye on each side of the cleavage site.

45 Xanthene dyes are known to form dimers with spectral cha

46 gen bonding to modulate the HOMO-LUMO gap in xanthene dyes.

47 In contrast, a single phenol appended to a xanthene exhibits a two-electron process, consistent wit

48 oxidanyl (TEMPO), 1,2-diphenylhydrazine, and xanthene experimentally bracketed this value between 67.

49 lding preparation of widely used oxazine and xanthene fluorophores from a common diaryl ether interme

50 ide family with a previously uncharacterized xanthene framework resulting from sequential oxidative c

51 Xanthene hydroxylation by 1 occurred with a very large s

52 Hetero-PAHs such as acridine, xanthene, indole, 2-methylbenzofuran, 2,3-dimethylbenzof

53 e optimization of a series of aminooxazoline xanthene inhibitors of beta-site amyloid precursor prote

54 first chelating bis(N-heterocyclic silylene)xanthene ligand [Si(II)(Xant)Si(II)] as well as its Ni c

55 for the attachment of porphyrins to a rigid xanthene or dibenzofuran pillar bearing the H-bond penda

56 However, halogenation of either the xanthenes or benzoate ring of fluorescein substantially

57 e major product (approximately 90% yield) of xanthene oxidation by 1.

58 The intermediates are in the requisite xanthene oxidation state, thus avoiding the need for rel

59 ng N-substitution patterns and replacing the xanthene oxygen with a dimethylsilicon moiety can shift

60 tectures bearing hydrogen-bond synthons on a xanthene platform is presented.

61 = 9,9-dimethyl-4,5-bis(diisopropylphosphino)xanthene) reacts with bis(pinacolato)diboron (B2pin2), i

62 zers (PSs) substituting S or Se for O in the xanthene ring give turnover numbers (TONs) as high as 90

63 roduction of a fluorine in position 4 of the xanthene ring improved BACE1 potency (5-10-fold).

64 unctionality at the bridging position of the xanthene ring system are developed as endogenous H2 O2 s

65 bly allows preferential deprotonation of the xanthene rings.

66 by NMR to be a face-to-face stacking of the xanthene rings.

67 ave previously shown that the aminooxazoline xanthene scaffold can generate potent and orally efficac

68 A unique benzo[a]xanthene, seminaphtho[a]fluorone (SNAFR-1), is studied i

69 ion of dipyrromethane with the aldehyde of a xanthene spacer followed by metal insertion using microw

70 p of each PDI to the 4- and 5-positions of a xanthene spacer.

71 d porphyrins bearing a single functionalized xanthene spacer.

72 Porphyrins bearing two trans-functionalized xanthene spacers are prepared by the MacDonald [2 + 2] c

73 on of chiral salen ligands bearing two rigid xanthene spacers functionalized with carboxylic acid and

74 to furnish the appropriately functionalized xanthene spacers to a salicylaldehyde, which is subseque

75 For hydrogen atom transfer from xanthene to (eta(5)-(i)Pr4C5H)(CO)2Os(*), the (E(D) - E(

76 TEMPOH to the stable free radical TEMPO and xanthene to bixanthyl.

77 e observed for the hydrogen abstraction from xanthene to form Cp(CO)2OsH and (eta(5)-(i)Pr4C5H)(CO)2O

78 id dinitrile ligand was synthesized from two xanthene units condensed to a naphthalene-1,4,5,8-diimid

79 action of [(PyPz)Fe(III)(OH) (OH2)](4+) with xanthene was 2.22 x 10(3) M(-1) s(-1), 5-6 orders of mag

80 onfirmed that only the isomer 6H-dibenzo[b,h]xanthene was obtained in all eight cases.

81 phos (9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene), which generates complexes with large P-Pd-P b

82 th cyclohexane, dihydroanthracene (DHA), and xanthene (Xan), we show here that KIE is a selective pro

83 Xanthene/xanthene-d(2) revealed a modest kinetic isotope

84 and the following activation parameters for xanthene (Xn) substrate: DeltaH(++) = 12.7 +/- 0.8 kcal