ライフサイエンスコーパス: xanthine oxidase

1 oxidase), or a superoxide-producing oxidase (xanthine oxidase).

2 tochondrial stressors (antimycin-A, xanthine/xanthine oxidase).

3 howed that RH1 was an in vitro substrate for xanthine oxidase.

4 activities of the enzymes AMP deaminase and xanthine oxidase.

5 and superoxide radical produced by xanthine/xanthine oxidase.

6 on of reactive oxygen species generated from xanthine oxidase.

7 p90 did not affect the O(2)(-.) generated by xanthine oxidase.

8 urinol (10 mg kg(-1), I.V.), an inhibitor of xanthine oxidase.

9 enzymes alpha-amylase, alpha-glucosidase and xanthine oxidase.

10 , perhaps by reducing production of O(2-) by xanthine oxidase.

11 oduced from the oxidation of hypoxanthine by xanthine oxidase.

12 ly suppressed ROS generated by xanthine with xanthine oxidase.

13 eutrophils was not affected by inhibition of xanthine oxidase.

14 by superoxide generation with xanthine plus xanthine oxidase.

15 vity and 5 displayed an inhibitory effect on xanthine oxidase.

16 nsition pore (PTP), but not by inhibition of xanthine oxidase.

17 ine is effectively converted to uric acid by xanthine oxidase.

18 L to 200 micromol/L diphenyleneiodonium) and xanthine oxidase (1 mmol/L allopurinol) caused reduction

19 )(-)), from spermine/NO (2.7 microM/min) and xanthine oxidase (1-28 microM O(2)(-)/min), respectively

20 of the reactive oxygen species generated by xanthine oxidase (10 milliunits/ml, plus 500 microM xant

21 Addition of xanthine/xanthine oxidase (100 micromol/L per 0.038 U/mL), an O(2

22 duced by xanthine (0.1%; drinking water) and xanthine oxidase (5 U/kg; i.p.).

23 In addition to neutrophils, xanthine oxidase, a constituent of endothelial cells, is

24 down also leads to a decrease in activity of xanthine oxidase, a distinct cytosolic Fe-S protein.

25 Inhibiting xanthine oxidase, a major reactive oxygen species (ROS)

26 Finally, xanthine oxidase, a potent superoxide generator, is decr

27 With xanthine oxidase, a rationale is presented as to why it

28 Increased NAD(P)H oxidase and xanthine oxidase activities contributed to the observed

29 ion of superoxide anion radicals by reducing xanthine oxidase activity by 38%, 97% and 47%, respectiv

30 e, the present study suggests that increased xanthine oxidase activity contributes to endothelial dys

31 rease reactive oxygen species production and xanthine oxidase activity in NOS3TG hearts to the levels

32 Moreover, xanthine oxidase activity was approximately 4-fold incre

33 Endothelium-bound xanthine oxidase activity was increased by >200% in pati

34 sion and activity of cytochrome P450 2E1 and xanthine oxidase activity were down-regulated in fa/fa c

35 NOS3TG hearts, in part, because of increased xanthine oxidase activity.

36 ric acid production through its influence on xanthine oxidase activity.

37 consumption (ebselen) but not inhibition of xanthine oxidase (allopurinol), attenuated the effects o

38 oxide radicals generated by hypoxanthine and xanthine oxidase also induced the activation of N-SMase,

39 O2*- generation by xanthine/xanthine oxidase also reduced HIF-1alpha levels, confirm

40 f cells with the superoxide-producing enzyme xanthine oxidase also resulted in isoprostane release, w

41 Uric acid is a product of the activity of xanthine oxidase, an enzyme linked to oxidative stress,

42 rat studies and assay systems were used with xanthine oxidase and activated canine granulocytes to te

43 , and studies with inhibitors suggested that xanthine oxidase and aldehyde oxidase are involved in th

44 re the products resulting from metabolism by xanthine oxidase and aldehyde oxidase differ in many ins

45 nalin levels as well as through reduction in xanthine oxidase and dehydrogenase activities.

46 Inspection of melting curves of bovine xanthine oxidase and Entamoeba histolytica cysteine prot

47 ROS generated by addition of xanthine oxidase and hypoxanthine induced RANTES and ICA

48 superoxide was generated by the reaction of xanthine oxidase and hypoxanthine with rates of 0.1-6.0

49 n species were generated enzymatically using xanthine oxidase and hypoxanthine.

50 ore characterized the vascular activities of xanthine oxidase and NAD(P)H oxidase, 2 major O2*--produ

51 We report that the combination of xanthine oxidase and NADH is toxic to cultures of cerebe

52 r agent tirapazamine by the enzymes xanthine/xanthine oxidase and NADPH:cytochrome P450 oxidoreductas

53 lls (ECs) sequentially induces activation of xanthine oxidase and p38 MAPK.

54 The active sites of the xanthine oxidase and sulfite oxidase enzyme families con

55 cattle sera was due to their low content of xanthine oxidase and sustained catalase activity.

56 ity, P<0.05; n=19 older/n=18 young), whereas xanthine oxidase and the antioxidant enzymes cytosolic a

57 ctron transfer in two complex flavoproteins, xanthine oxidase and trimethylamine dehydrogenase, has b

58 ofactors and has two interconvertible forms, xanthine oxidase and xanthine dehydrogenase, which trans

59 It appears that xanthine oxidase (and by inference, the closely related

60 Both allopurinol, an inhibitor of xanthine oxidase, and aminobenzotriazole, a cytochrome P

61 luding nitric oxide synthase, NADPH oxidase, xanthine oxidase, and complex IV of the mitochondrial el

62 This contrasts to the behavior seen with xanthine oxidase, and the basis for this difference is d

63 eas expressions of COX-2, Cu/Zn-SOD, Mn-SOD, xanthine oxidase, and the NAD(P)H oxidase subunits p47(p

64 e, and sources of vascular NAD(P)H oxidases, xanthine oxidase, and uncoupled endothelial nitric oxide

65 NAD(P)H oxidase and xanthine oxidase are sources of.O(2)(-) production in th

66 r and small interfering RNA studies identify xanthine oxidase as a major source of superoxide radical

67 eroxide radical anions generated by xanthine/xanthine oxidase as a measure of excretory/secretory pro

68 In experiments using xanthine oxidase as a source of superoxide, tyrosine nit

69 Using hypoxanthine-xanthine oxidase as the oxidizing method, XRCC1 deficien

70 (*)(-) by NQO1 were estimated using xanthine/xanthine oxidase as the source of O(2)(*)(-) and after N

71 anions were produced by using a hypoxanthine/xanthine-oxidase assay.

72 Reactive oxygen metabolites generated by xanthine oxidase at reperfusion have been found to trigg

73 suggest that reactive oxidants generated by xanthine oxidase at reperfusion, stimulated by PAF, medi

74 ol reduced LAA O2*-, implying that NADPH and xanthine oxidases both contributed to increased O2*- pro

75 effect on the cytosolic Fe-S cluster enzyme xanthine oxidase but led to loss of cytosolic aconitase

76 elting of milk fat and the Tdenaturation for xanthine oxidase by 2-3 degrees C.

77 enzyme systems NADPH oxidase by apocynin and xanthine oxidase by allopurinol individually reduced STA

78 buxostat, a non-purine-analogue inhibitor of xanthine oxidase, by the European Medicines Agency and t

79 Thermodynamics of milk components (milk fat, xanthine oxidase, caseins and whey proteins) in pulsed e

80 resent study tested the hypothesis that both xanthine oxidase-catalysed oxidation of purines and neut

81 Another potential source of these species is xanthine oxidase-catalysed oxidation of purines.

82 inute rates by spermine/NO decomposition and xanthine oxidase-catalyzed oxidation of hypoxanthine, re

83 Xanthine oxidase-cell binding was not inhibited by serum

84 These data suggest that xanthine oxidase contributes importantly to endothelial

85 We tested the hypothesis that xanthine oxidase contributes to endothelial dysfunction

86 O(2)(.-) generation (xanthine+xanthine oxidase) decreased K(+) current density, with n

87 al temperatures of fat melting (Tmelting) or xanthine oxidase denaturation (Tdenaturation), whereas t

88 Xanthine oxidase denaturation was approximately 13% less

89 coelenterazine had no significant effect on xanthine oxidase-dependent oxygen consumption, endotheli

90 We also found that NADPH- and xanthine oxidase-dependent reactive oxygen species (ROS)

91 Expression of the xanthine oxidase-dependent trypanocidal activity in Cape

92 eak, hyponitrosylation of RyR2, and enhanced xanthine oxidase derived superoxide.

93 potential source of oxidative stress in ALI; xanthine oxidase-derived oxidants enhance NE toxicity in

94 m, with no effect on Nox2-, Nox4-, Nox5-, or xanthine oxidase-derived reactive oxygen species product

95 hypoxic fetus, associated with increases in xanthine oxidase-derived reactive oxygen species.

96 Inhibition of NADPH oxidase and xanthine oxidase did not affect the inhibitory actions o

97 uperoxide and hydrogen peroxide generated by xanthine oxidase did not significantly decrease complex

98 roxide generated by lumazine or xanthine and xanthine oxidase, did not show an inhibitory effect on E

99 lae-enriched membranes to ROS (xanthine plus xanthine oxidase) dissociated caveolin more readily than

100 of the "very rapid" EPR signal generated by xanthine oxidase during reaction with 13C8-HMP.

101 With xanthine oxidase, electron transfer from the molybdenum

102 Xanthine oxidase enzymatic activity was reproducible and

103 s) are homodimeric proteins belonging to the xanthine oxidase family of molybdenum-containing enzymes

104 Xdh) genes encode two complex members of the xanthine oxidase family of molybdo-flavoenzymes that car

105 of aldehyde oxidoreductase, a member of the xanthine oxidase family.

106 SNPs at another 2 loci at the xanthine oxidase gene were also associated with NCPH: rs

107 ate that activation of p38 MAPK, mediated by xanthine oxidase-generated oxidant production, is requir

108 SNPs at the 5'-nucleotidase and xanthine oxidase genes influence the risk of NCPH in HIV

109 Xanthine oxidase has been implicated in postischemic-rep

110 The kinetics of xanthine oxidase has been investigated with the aim of a

111 reversal of this phenotype by inhibition of xanthine oxidase has important pathophysiologic and ther

112 The expression of xanthine dehydrogenase/xanthine oxidase holoenzyme and the activity of xanthine

113 A xanthine oxidase hydroxyl radical (.OH)-generating syste

114 tion by superoxide dismutase, stimulation by xanthine oxidase/hypoxanthine, and the lack of an effect

115 e.g., 3-morpholinosydnonimine; NONOates plus xanthine oxidase/hypoxanthine, menadione, or mitomycin C

116 The formaldehyde-inhibited Mo(V) state of xanthine oxidase (I) has been studied for four decades,

117 [Symbol: see text] generated by the xanthine/xanthine oxidase, implying that it exhibits antioxidant

118 The role of xanthine oxidase in activation of these afferents was de

119 t superoxide produced from hypoxanthine plus xanthine oxidase in combination with nitric oxide produc

120 Inhibiting xanthine oxidase in hyperuricemic HF patients may improv

121 ng and immunoblotting demonstrated increased xanthine oxidase in MR versus normal subjects (p < 0.05)

122 ediated by H2O2 and required the presence of xanthine oxidase in serum but not the addition of purine

123 rystal structures of as-isolated, functional xanthine oxidase in the course of reaction with the pter

124 an intermediate in the reduction of iron by xanthine oxidase in vitro but not in vivo.

125 Furthermore, activity of endothelium-bound xanthine oxidase in vivo and FDD of the radial artery we

126 ere improved by allopurinol (an inhibitor of xanthine oxidase) in vessels from diabetic IL-10(- /-) m

127 ed, structurally assigned Mo(V) species from xanthine oxidase, in conjunction with complementary comp

128 buxostat, a nonpurine selective inhibitor of xanthine oxidase, in establishing normal serum urate (sU

129 ction of oxidative stress with xanthine plus xanthine oxidase increased placental production of isopr

130 Allopurinol, an inhibitor of xanthine oxidase, increases myofilament calcium responsi

131 tor of NF-kappab ligand (RANKL) and Xanthine/Xanthine Oxidase induced TRAP mRNA expression in mouse m

132 allopurinol could be related to its reducing xanthine oxidase-induced OS, and our second aim was to s

133 hemorrhage, but not endotoxemia, in mice fed xanthine oxidase-inhibiting diets.

134 There was no statistical difference between xanthine oxidase inhibition by rutin before and after hy

135 Xanthine oxidase inhibition did prevent hemorrhage- but

136 Xanthine oxidase inhibition restored global and RyR2 nit

137 However, xanthine oxidase inhibition with allopurinol failed to a

138 tion fraction and elevated uric acid levels, xanthine oxidase inhibition with allopurinol failed to i

139 attenuated by PAF inhibition with WEB 2170, xanthine oxidase inhibition with allopurinol, antioxidan

140 Xanthine oxidase inhibition, achieved by feeding allopur

141 own about the effects on fetal physiology of xanthine oxidase inhibition.

142 intervention or following treatment with an xanthine oxidase inhibitor (allopurinol), a Na(+)/H(+) e

143 This is despite maternal treatment with the xanthine oxidase inhibitor allopurinol being considered

144 ponses to H/R, whereas pretreatment with the xanthine oxidase inhibitor allopurinol had no effect.

145 (Exploring the therapeutic potential of xanthine oxidase inhibitor allopurinol in angina; ISRCTN

146 Introducing the xanthine oxidase inhibitor allopurinol led to rapid norm

147 Treatment of mothers with the xanthine oxidase inhibitor allopurinol reduced placental

148 enhanced in p47phox-/- mice treated with the xanthine oxidase inhibitor allopurinol, but the duration

149 itor N(omega)-L-arginine methyl ester or the xanthine oxidase inhibitor allopurinol.

150 itor L-NAME (N-monomethyl-L-arginine) or the xanthine oxidase inhibitor allopurinol.

151 te plea basis to patients of any age in whom xanthine oxidase inhibitor therapy was indicated as an a

152 e phosphate oxidase inhibitor), allopurinol (xanthine oxidase inhibitor), and ACE8/8 crossed with P67

153 his increase was inhibited by allopurinol (a xanthine oxidase inhibitor), Me2SO (a hydroxyl radical s

154 hydroxyl radical scavenger), allopurinol (a xanthine oxidase inhibitor), or deferoxamine (an iron ch

155 nant kidney (RK) surgery with or without the xanthine oxidase inhibitor, allopurinol, or the uricosur

156 enylene iodonium (DPI), but not the xanthine/xanthine oxidase inhibitor, allopurinol.

157 ent include febuxostat, a nonpurine analogue xanthine oxidase inhibitor, and pegloticase, a pegylated

158 Allopurinol, a xanthine oxidase inhibitor, attenuated endotoxin-induced

159 Allopurinol, a xanthine oxidase inhibitor, blocks purine degradation an

160 Allopurinol, a xanthine oxidase inhibitor, can reverse the hypertension

161 A new xanthine oxidase inhibitor, febuxostat, and pegylated ur

162 Allopurinol, a xanthine oxidase inhibitor, has been shown to reduce LV

163 Allopurinol, a xanthine oxidase inhibitor, prolongs the time to chest p

164 Febuxostat, a novel xanthine oxidase inhibitor, represents a potential alter

165 ion in PMECs was inhibited by allopurinol, a xanthine oxidase inhibitor.

166 Experimental evidence suggests that xanthine oxidase inhibitors can reduce myocardial oxygen

167 Data on the impact of xanthine oxidase inhibitors or uricosurics on clinical h

168 t not by the cytosolic phospholipase A(2) or xanthine oxidase inhibitors.

169 e armamentarium has been eclipsed by that of xanthine oxidase inhibitors.

170 l pregnant women to test the hypothesis that xanthine oxidase is a mediator of oxidative stress in pl

171 Xanthine oxidase is a molybdenum-containing enzyme catal

172 Xanthine oxidase is a molybdenum-containing enzyme that

173 at, a novel nonpurine selective inhibitor of xanthine oxidase, is a potential alternative to allopuri

174 Inhibition of xanthine oxidase led to further increase in the activati

175 exerted a pronounced inhibitory effect upon xanthine oxidase-mediated reduction of iron in ferritin,

176 f the free enzyme determined by the xanthine-xanthine oxidase method is -0.132 V at pH 7.0, slightly

177 Our results indicate that xanthine oxidase modulates cAMP response element binding

178 of NAD(P)H:quinone oxidoreductase (NQO1) and xanthine oxidase, most of the reductive activation of 3-

179 n=4) but were not prevented by inhibitors of xanthine oxidase (n=5), cyclooxygenase (n=4), nitric oxi

180 nhibits a variety of flavoenzymes, including xanthine oxidase, NADH dehydrogenase, and NADPH oxidase.

181 c systems that are capable of producing ROS, xanthine oxidase, NADH/NADPH oxidase, and uncoupled endo

182 Exposure of the cerebral cortex to a xanthine oxidase O(-)(2) generating system (OX) reversed

183 Exposure of the cerebral cortex to a xanthine oxidase O(-)(2) generating system blunted masto

184 o monitor the enzyme-catalyzed conversion by xanthine oxidase of hypoxanthine to xanthine to uric aci

185 llular superoxide generated by the action of xanthine oxidase on xanthine.

186 teine-labeled rat brain slices with xanthine/xanthine oxidase or a combination of xanthine/xanthine o

187 fect on either the O(2)(-)-generating enzyme xanthine oxidase or potassium superoxide-generated O(2)(

188 cation of the O2--generating system xanthine/xanthine oxidase or the potent NO scavenger oxyhemoglobi

189 mide adenine dinucleotide phosphate oxidase, xanthine oxidase, or mitochondria, are among the most ha

190 This was accompanied by increases in xanthine oxidase (P<0.001) and NADPH oxidase (P<0.05), m

191 ncreases in LAA NAD(P)H oxidase (P=0.04) and xanthine oxidase (P=0.01) activities.

192 Thus, ROI generated via the xanthine oxidase pathway contribute to the control of as

193 the latter mediated through activation of a xanthine oxidase pathway leading to ROS generation and p

194 The first two findings indicate that xanthine oxidase pathways contribute to free radical for

195 supplementations on adrenalin, noradrenalin, xanthine oxidase plus dehydrogenase (XO + XD) activities

196 ddition of lucigenin to reaction mixtures of xanthine oxidase plus NADH resulted in increased oxygen

197 er pKa assigned to an active-site residue of xanthine oxidase (possibly Glu-1261, by analogy to Glu-8

198 The enzyme xanthine oxidase produces oxidative free radicals.

199 Xanthine oxidase produces oxidative stress and therefore

200 Xanthine oxidase purified from bovine cream bound specif

201 nous to tissue fractions were reduced by the xanthine oxidase reaction and this caused a decrease in

202 O(2)(-). generated in situ from the xanthine/xanthine oxidase reaction caused a slowly developing dec

203 l as O2*- generated either from the xanthine-xanthine oxidase reaction or by the addition of nicotina

204 g by O(2)(-) generated by pyrogallol and the xanthine oxidase reaction than the parental 2308 strain

205 eroxide and hydrogen peroxide imposed by the xanthine oxidase reaction.

206 When treated with xanthine oxidase reduced levels of initial mtDNA damage

207 superoxide radical (O(2)(*-)) using xanthine/xanthine oxidase resulted in an increase in cell invasio

208 on of NO formation profiles between mARC and xanthine oxidase reveals similar Kcat and Vmax values bu

209 In contrast, the ROS generator Xanthine-Xanthine oxidase significantly increased neuronal firing

210 an be rationalized by comparing the AOX3 and xanthine oxidase structures.

211 fects (eg, interleukin-1beta/decoy receptor, xanthine oxidase/superoxide dismutase, Ca2+-dependent PL

212 of superoxide anion generated in a xanthine-xanthine oxidase system in solution.

213 exogenous O(2)(-.) generated by the xanthine/xanthine oxidase system mimicked the effect of hypertoni

214 on protein kinase C (PKC) using the xanthine/xanthine oxidase system of generating superoxide.

215 an lung fibroblasts and identified NADPH and xanthine oxidase systems as sources of H(2)O(2) that dri

216 anion, generated as a flux from xanthine and xanthine oxidase, the cells die by a non-apoptotic mecha

217 thine oxidase holoenzyme and the activity of xanthine oxidase, the isoform known to generate reactive

218 ide adenine dinucleotide phosphate) oxidase, xanthine oxidase, the mitochondrial electron transport c

219 sine deaminase, nucleoside phosphorylase and xanthine oxidase, the sensor responded linearly to exoge

220 nitric oxide synthase, the NAD(P)H oxidases, xanthine oxidases, the mitochondrial permeability transi

221 by enzymatic studies using purified NPR and xanthine oxidase to activate KS119.

222 NO donors, or a combination of xanthine and xanthine oxidase to generate superoxide did not show an

223 n the addition of superoxide, generated from xanthine oxidase, to several peptide-derived tyrosyl rad

224 We report here the crystal structure of xanthine oxidase, trapped at the stage of a critical int

225 consumption impairs placental function via a xanthine oxidase/uric acid-dependent mechanism, and simi

226 ) compound related to the very rapid form of xanthine oxidase (VR-XnO) is reported.

227 Inhibition of xanthine oxidase was achieved by a single oral dose of 6

228 ite host matrix for enzyme immobilization of xanthine oxidase was developed by incorporating MWCNT in

229 Xanthine oxidase was used as an in vitro model of locali

230 rredoxin: NADP+ oxidoreductase, and xanthine/xanthine oxidase was used to provide a calibrated flux o

231 olic-II, purine nucleoside phosphorylase and xanthine oxidase) was performed using SNPlex microarray

232 which would scavenge superoxide produced by xanthine oxidase, was reduced in the same cells.

233 nds examined, while the observed products of xanthine oxidase were not well predicted.

234 nts during neutrophil adherence may activate xanthine oxidase, which in turn mediates the ROS product

235 nNOS increases O2- through the activation of xanthine oxidase, which is mediated by the activation of

236 neration, which was attenuated by inhibiting xanthine oxidase with allopurinol.

237 o block cyclooxygenase with indomethacin and xanthine oxidase with oxypurinol) on superoxide release

238 anthine oxidase or a combination of xanthine/xanthine oxidase with sodium nitroprusside resulted in a

239 ONOate, and an enzymatic source of O(-*)(2), xanthine oxidase, with either hypoxanthine or lumazine a

240 First, we used the xanthine-xanthine oxidase (X-XO) system to generate reactive oxyg

241 oxygen species (ROS) generated via xanthine/xanthine oxidase (X/Xo) but failed to inhibit X/Xo-induc

242 The oxidizing agent xanthine/xanthine oxidase (X/XO) decreased the NMDAR-mediated syn

243 ation with oxygen radical-producing xanthine/xanthine oxidase (X/XO) induces apoptosis in primary cul

244 A xanthine/xanthine oxidase (X/XO) model system provided sustained

245 th the superoxide-generating system xanthine/xanthine oxidase (X/XO) produces a long-lasting potentia

246 The xanthine/xanthine oxidase (X/XO) system was used for the steady s

247 eactive oxygen species generated by xanthine/xanthine oxidase (X/XO).

248 Oxidative stress (xanthine oxidase + xanthine) induced an activation and m

249 iboside:quinone oxidoreductase 2 (NQO2), and xanthine oxidase/xanthine dehydrogenase (XO/XDH) also co

250 at oxidative stress resulting from increased xanthine oxidase (XO) activity contributes to this imbal

251 Superoxide (O(2)(-)) generated by enhanced xanthine oxidase (XO) activity may contribute to the inc

252 Plasma xanthine oxidase (XO) activity was defined as a source o

253 sociated with oxidative stress and increased xanthine oxidase (XO) activity, an important source of r

254 Xanthine oxidase (XO) and dipeptidyl peptidase IV (DPP-I

255 n be prepared in two interconvertible forms, xanthine oxidase (XO) and xanthine dehydrogenase (XDH),

256 In previous work, we identified xanthine oxidase (XO) as an important enzyme in the inte

257 ed during anoxia from nitrite reduction, and xanthine oxidase (XO) catalyzes this process.

258 re, we investigated whether ROS derived from xanthine oxidase (XO) contribute to the fetal peripheral

259 er optic xanthine sensor using entrapment of xanthine oxidase (XO) enzyme in several nanostructures o

260 Islet xanthine oxidase (XO) expression was increased in 15-mo

261 as a chronic state of inflammation in which xanthine oxidase (XO) from ischemic tissues increases va

262 The enzyme xanthine oxidase (XO) has been implicated in the pathoge

263 Recently, xanthine oxidase (XO) has been reported to catalyze orga

264 Inhibition of xanthine oxidase (XO) in failing hearts improves cardiac

265 h inducible nitric oxide synthase (iNOS) and xanthine oxidase (XO) in free radical formation.

266 he release of mast-cell-derived heparin, and xanthine oxidase (XO) inhibition stabilizes mast cells.

267 ence of NO synthase (NOS) inhibitors and the xanthine oxidase (XO) inhibitor allopurinol and in NOS-3

268 hypothesis that acute administration of the xanthine oxidase (XO) inhibitor allopurinol improves car

269 nt with the macrophage toxicant GdCl(3), the xanthine oxidase (XO) inhibitor allopurinol, and the Fe(

270 Administration of the xanthine oxidase (XO) inhibitor oxypurinol or aldehyde o

271 at followed after a delay was blocked by the xanthine oxidase (XO) inhibitor oxypurinol.

272 This study evaluated whether a xanthine oxidase (XO) inhibitor, oxypurinol, produces cl

273 was to estimate the phenolic composition and xanthine oxidase (XO) inhibitory activity of green coffe

274 Xanthine oxidase (XO) is a central mechanism of oxidativ

275 Xanthine oxidase (XO) is another enzyme known to produce

276 The oxidation of xanthine by xanthine oxidase (XO) or xanthine dehydrogenase represen

277 Although the binding of xanthine oxidase (XO) to glycosaminoglycans (GAGs) resul

278 We tested the hypothesis that xanthine oxidase (XO), a major vascular source of reacti

279 This question was addressed by blocking xanthine oxidase (XO), a superoxide-generating enzyme th

280 ed this question by blocking the activity of xanthine oxidase (XO), a superoxide-generating enzyme th

281 Xanthine oxidase (XO), also known as xanthine oxidoreduc

282 Xanthine oxidase (XO), an enzyme that converts hypoxanth

283 lations evoked by a O2 donor, xanthine (X) + xanthine oxidase (XO), dose-dependently.

284 iated by a rapid increase in the activity of xanthine oxidase (XO), the oxidized form of xanthine deh

285 Under anaerobic conditions, xanthine oxidase (XO)-catalyzed nitrite reduction can be

286 Xanthine oxidase (XO)-catalyzed nitrite reduction with n

287 causal link of this association is increased xanthine oxidase (XO)-derived oxygen free radical produc

288 We showed that CoCl2 increased xanthine oxidase (XO)-derived reactive oxygen species (R

289 o the 2'-amino inhibitors (3, X = Cl, Br) by xanthine oxidase (XO).

290 to sodium nitroprusside (SNP)+xanthine (XA)+xanthine oxidase (XO).

291 The ROS donor hypoxanthine-xanthine oxidase (XO/HX) and the JNK activator ANISO ant

292 The sensor was developed by entrapment of xanthine oxidase (XOD) and ferrocene carboxylic acid (Fc

293 Free radical generation by xanthine/xanthine oxidase (XOD) can directly damage protein synth

294 Xanthine oxidase (XOD) is an enzyme which plays a centra

295 Purine nucleoside phosphorylase (PNP) and xanthine oxidase (XOD) were co-immobilized via entrapmen

296 oxidase (GOx), glutamate oxidase (GluOx), or xanthine oxidase (XOD).

297 roenvironment for direct electrochemistry of xanthine oxidase (XOD).

298 th nano-interface for sensing xanthine using xanthine oxidase (XOx) has been developed.

299 ydrogenase, ADH; lactate dehydrogenase, LDH; xanthine oxidase, XOx; glucose oxidase, GOx).

300 mixtures containing m-aconitase and xanthine/xanthine oxidase yielded methyl radical, which was detec