ライフサイエンスコーパス: xenoantibody

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1 re not then rejected despite the presence of xenoantibody.

2 lerance and an absence of induced anti-donor xenoantibodies.

3 y to produce species-specific, T-independent xenoantibodies.

4 al cell antibodies, similar to human natural xenoantibodies and reactive with epitopes of thyroglobul

5 mmunodeficient (NOD/scid) mouse, which lacks xenoantibodies and therefore allows infused human platel

6 VH genes encoding rat anti-pig xenoantibodies are expressed in germline configuration a

7 e primate renal capsule and assessed natural xenoantibody binding, complement activation and cell lys

8 In vitro, these natural xenoantibodies can be blocked by alphaGal-containing oli

9 Rat anti-hamster IgG xenoantibodies continue to express the V(H)HAR family of

10 Further investigation on allo- and xenoantibody cross-reactivity is required.

11 Xenoantibodies directed at the gal carbohydrate or porci

12 s are characterized by the production of IgM xenoantibodies encoded by a restricted group of Ig germl

13 showed either low or high levels of anti-pig xenoantibodies of the IgM, IgG1, and IgG2a isotypes.

14 0% CD4+ cells all had low levels of anti-pig xenoantibodies of these isotypes and displayed mixed lym

15 ibody response and inhibited IgG but not IgM xenoantibody production (which led to xenograft rejectio

16 ocytotoxic antibody response and IgG and IgM xenoantibody production induced by cardiac xenotransplan

17 t survival, as well as completely inhibiting xenoantibody production.

18 Our results demonstrate that the xenoantibody response in humans is encoded by IgVH genes

19 ft tolerance and avoidance of the anti-donor xenoantibody responses observed in mice with poor CD4 re

20 Xenoantibody sequestration in this model was evaluated i

21 t serum ELISAs, no significant difference in xenoantibody sequestration was detected between the xeno

22 demonstrated a dramatic increase in anti-pig xenoantibody titers and correlated with histological stu

23 oglobulin genes responsible for encoding rat xenoantibodies to hamster heart grafts.

24 serum normally contains guinea pig reactive xenoantibodies), we wished to determine the extent to wh

25 Nucleic and amino acid sequences of these xenoantibodies were compared with immunoglobulin genes e

26 and CD4 reconstitution and mouse anti-donor xenoantibodies were followed by flow cytometry.

27 Anti-gal xenoantibodies were not produced in gal chimeras, but no

28 Anti-alphaGal xenoantibodies were not produced in mice reconstituted w

29 Recently, xenoantibodies with limited abilities to activate the cl

30 In this study, we have examined the xenoantibody (XAb) response in eight patients with acute

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