ライフサイエンスコーパス: xenoantigen

1 s also inhibit GS-1-B(4) from binding to the xenoantigen.

2 ly suppressed an evoked antibody response to xenoantigen.

3 ting peripheral and intrathymic CD4 cells to xenoantigens.

4 onse to in vitro stimulation with guinea pig xenoantigens.

5 on both DTH and IgG antibodies to guinea pig xenoantigens.

6 genes that encode human Ab responses to pig xenoantigens.

7 e long-term immune response of recipients to xenoantigens.

8 rat monoclonal antibodies that recognize pig xenoantigens.

9 to react against the immunizing MHC class II xenoantigens.

10 eness to alloantigens and/or third-party pig xenoantigens.

11 and better control of the B-cell response to xenoantigens.

12 es believed to be secreted in the absence of xenoantigens.

13 Long-term hyporesponsiveness to xenoantigen across both a concordant and discordant spec

14 ral and elicited antibodies specific for pig xenoantigens, alpha-(1,3)-galactose (GAL) and N-glycolyl

15 le prepared from uninfected hamster tissues (xenoantigen and injection trauma control).

16 ymus donor and responded to nondonor porcine xenoantigens and alloantigens.

17 hat react with similar epitopes expressed on xenoantigens and bacteria may share structurally similar

18 aft recipients can be stimulated in vitro by xenoantigens and IL-2 to differentiate into highly react

19 for their capacity to respond to guinea pig xenoantigens and to lyse guinea pig target cells.

20 Human CD4+ T cells can recognize xenoantigens by either a direct or indirect pathway.

21 ets are primarily CD4+ and recognize porcine xenoantigens by the indirect Ag pathway presentation.

22 lpha1,3-galactose (alpha1,3Gal) is the major xenoantigen causing hyperacute rejection in pig-to-human

23 a1,3Galbeta1,4GlcNAc-R), which are the major xenoantigens causing hyperacute rejection in pig-to-huma

24 nce to A/B-incompatible alloantigens and pig xenoantigens could be achieved in infant baboons.

25 he human cellular immune response to porcine xenoantigens, cytolytic T lymphocyte (CTL) cell lines we

26 Presensitization of mice to guinea pig xenoantigens failed to increase the proportion of grafts

27 al alpha(1-3)Gal epitope (xenograft antigen, xenoantigen) found on the cell surfaces of the donor org

28 pression of one of seven recently identified xenoantigens from the surface of pig aortic endothelial

29 re addition to the cultures, indicating that xenoantigens had to be processed in order to be recogniz

30 These results demonstrate that xenoantigen immunization can break tolerance to a self-A

31 To explore the potential role of xenoantigen immunization in cancer patients, we performe

32 alpha(1-3)-galactose (alpha-gal), the major xenoantigen in the pig to primate xenotransplant model.

33 0 pathways to inhibit the immune response to xenoantigen in the rat-to-mouse and pig-to-mouse models.

34 arked inhibition of the cellular response to xenoantigen in vivo and produced long-term acceptance of

35 tolerance to alloantigens, and in the future xenoantigens, in vivo is essential to progress in transp

36 ive PAECs recognized strain-specific porcine xenoantigens indirectly.

37 ptides that have been identified as allo- or xenoantigens is consistent with this hypothesis.

38 T cell recognition of xenoantigens is likely to play a key role in rejection o

39 cancer received two monthly vaccinations of xenoantigen-loaded dendritic cells with minimal treatmen

40 also suggest using IgGs lacking these major xenoantigens may improve safety and efficacy of ATG trea

41 s, before and after BAL exposure, recognized xenoantigens on PAECs with similar molecular weights, su

42 rum and Hu-PBL-SCID serum recognized similar xenoantigens on PI, indicating that Hu-PBL-SCID containe

43 presented here will add to our knowledge of xenoantigens on porcine red cells and be important for d

44 ns without the alphaGal epitope (nonalphaGal xenoantigens) on porcine erythrocytes using flow cytomet

45 lucose homeostasis in DKO pigs for two major xenoantigens paves the way to their use in (pre)clinical

46 in heterologous animal products can acquire xenoantigens, potentially limiting their utility.

47 ated that the clones are recognizing porcine xenoantigens presented by self-APCs.

48 ession of Galalpha1,3-Gal epitope, the major xenoantigen recognized by human natural antibodies.

49 nce of self-APC, indicating that the primary xenoantigens recognized are peptides derived from SLA.

50 rmore, we demonstrate that the major porcine xenoantigens recognized are SLA class I molecules.

51 Delineation of the major pig xenoantigens recognized by natural human xenoreactive an

52 alpha(1,3)-gal and N-glycolylneuraminic acid xenoantigens reduces human antibody binding to porcine p

53 s behind human T-cell recognition of porcine xenoantigens remain to be elucidated.

54 cNAc-R) has been identified as being a major xenoantigen responsible for hyperacute rejection, the re

55 tively adhered to PAEC and were activated by xenoantigen, resulting in highly efficient antigen prese

56 phenotype and efficiently present allo- and xenoantigens to allogeneic T cells after co-culturing wi

57 tive immunogenicity of autoantigens, whereas xenoantigens, typically not presented during induction o

58 f pig aortic endothelial cell (PAEC) surface xenoantigens was analyzed by immunoprecipitation.

59 Importantly, immunity to xenoantigens was only induced after xenotransplantation

60 ne responses of recipient mice to guinea pig xenoantigens were assessed.

61 directed at the gal carbohydrate or porcine xenoantigens were detected by enzyme-linked immunosorben

62 with GalT, but normal Ab responses to other xenoantigens were detected.

63 eras, but normal antibody responses to other xenoantigens were detected.

64 The identification of porcine xenoantigens whose recognition by human natural antibodi

65 IgM and IgG XNA from hu-PBL-SCID recognized xenoantigens with similar molecular mass as those recogn