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3 term metabolic function of microencapsulated xenogeneic adult porcine islets (API) was assessed in a
5 When rejection occurred on days 4 and 8 in xenogeneic and allogeneic recipients, 60% (57-68) and 55
11 possibility of imaging inflammation in both xenogeneic and syngeneic tumor models, which resulted in
12 We estimated the decrease in expression of a xenogeneic antigen, Galalpha1-3Gal, which might be neede
14 ursor experiments have been carried out in a xenogeneic background in order to utilize species-specif
15 licited immune response of healthy dogs to a xenogeneic BAL was blocked and BAL performance significa
17 wo strategies to induce tolerance across the xenogeneic barrier, namely thymus transplantation and mi
20 ial, but also to understanding the nature of xenogeneic barriers and mechanisms of heterochronicity,
22 e transplant tolerance across allogeneic and xenogeneic barriers, and to support long-term thymopoies
27 nts of antigenicity in a clinically relevant xenogeneic biomaterial (i.e. BP) and further validates a
28 onstrate that anti-CD40L in combination with xenogeneic BMT can tolerize preexisting peripheral and i
34 une response against the therapeutic and the xenogeneic carbohydrate galactose-alpha1-3-galactose, an
37 on of KO mice with pig kidney membranes (ie, xenogeneic cell membranes expressing an abundance of alp
38 become key components for the development of xenogeneic cells and organs for human transplantation.
39 s play an important role in the rejection of xenogeneic cells and therefore represent a major obstacl
41 contributes significantly to phagocytosis of xenogeneic cells by macrophages and suggest that genetic
43 recent years, hepatic support systems using xenogeneic cells have been developed to support patients
44 nsplantation of a bioartificial adrenal with xenogeneic cells may be a treatment option for patients
47 Even after immunization with Gal-bearing xenogeneic cells, mixed chimeras were devoid of anti-Gal
49 ly high precursor frequency was detected for xenogeneic cellular responses in the rat anti-mouse comb
52 y xenogeneic chimeras (rat --> mouse), mixed xenogeneic chimeras exhibit superior immunocompetence fo
54 We have previously demonstrated that mixed xenogeneic chimerism and donor-specific T-cell tolerance
55 e ability of anti-CD40L mAb to promote mixed xenogeneic chimerism and donor-specific tolerance in B6
58 lability of human adrenal glands, sources of xenogeneic chromaffin cells will need to be identified i
64 e purpose of this study is to determine if a xenogeneic collagen matrix (CM) might be as effective as
66 of inducing tolerance in a highly disparate xenogeneic combination and may have clinical potential t
67 lity has not been demonstrated in discordant xenogeneic combinations because of the difficulty in ach
69 ity induced by TCR adenoviruses required the xenogeneic constant regions and was mediated by CD8+ T c
70 ion in a pig-to-human model also reduces the xenogeneic consumption of human platelets by the porcine
71 the effect that these modifications have on xenogeneic consumption of human platelets in the absence
72 human CD19(+) B-lineage cells purified from xenogeneic cord blood stem cell/MS-5 murine stromal cell
73 We wished to determine the extent to which xenogeneic cornea fragments placed in the eyes of normal
78 , we wished to determine the extent to which xenogeneic corneal fragments placed intraocularly in nor
80 man CD19(+) cells developing in human/murine xenogeneic cultures show differential expression of the
83 ght to improve on this strategy by combining xenogeneic DNA vaccination with an agonist anti-glucocor
84 In contrast to allogeneic donor ECDI-SPs, xenogeneic donor ECDI-SPs induced production of xenodono
87 porcine endogenous retroviruses (PERV) from xenogeneic donors into humans has been widely debated.
91 tolerance in allogeneic and closely related xenogeneic (eg, rat-to-mouse) combinations, the ability
93 c, nude rats injected intraperitoneally with xenogeneic endothelial cells (ECs) produce antibodies ag
94 redox systems may provide a means to protect xenogeneic endothelial cells from NK cell-mediated cytot
95 erated from monocytes under the influence of xenogeneic endothelial cells in the absence of exogenous
98 d hematopoietic progenitor cells within this xenogeneic environment generated mature functional T cel
99 f specific T cell receptor-Vbeta occurs in a xenogeneic environment in a predictable fashion parallel
104 l biological scaffolds made of allogeneic or xenogeneic extracellular matrix derived from non-autolog
105 ival 3 weeks after injection of syngeneic or xenogeneic ferumoxides-labeled stem cells (cardiac-deriv
106 r tumorigenesis, we selectively targeted the xenogeneic form of survivin, a survival protein overexpr
107 ty was induced by DNA immunization against a xenogeneic form of TRP-2, but not against the syngeneic
109 an embryonic stem (hES) cells in defined and xenogeneic-free conditions will contribute substantially
114 t, in a preclinical humanized mouse model of xenogeneic graft-versus-host disease (GVHD), sGARP preve
115 onstrate that IL-15 but not IL-2 exacerbates xenogeneic graft-versus-host disease (X-GVHD) in severe
116 a-treated Treg in a humanized mouse model of xenogeneic graft-versus-host disease confirmed IFN-alpha
117 e induction of IFNgamma-secreting Tregs in a xenogeneic graft-versus-host disease model and in adopti
118 T cells and complete rescue from hyperacute xenogeneic graft-versus-host disease modeling early and
119 ls mediated tumor rejection without inducing xenogeneic graft-versus-host disease, thus resulting in
120 generated Tregs that consistently suppressed xenogeneic graft-vs-host disease in immunodeficient mice
121 munosuppression by human Tregs in a model of xenogeneic graft-vs.-host disease induced by the transfe
122 d could influence the findings; for example, xenogeneic grafts may not recognize host inhibitory sign
123 nd residual host immune function against the xenogeneic grafts results in defective development and m
124 to enhance the recruitment of host huTreg to xenogeneic grafts to regulate cell-mediated xenograft re
129 R gene also conferred resistance to DEX in a xenogeneic GVHD model in sublethally irradiated NOD-scid
133 Murine complement is capable of resisting xenogeneic hematopoietic engraftment through an antibody
135 osuppression allows long-term functioning of xenogeneic hepatocyte retransplants and suggests that he
136 tocytes might address this problem; however, xenogeneic hepatocytes are thought to be functionally in
140 e-specific autoimmunity was seen only when a xenogeneic homolog of PAP was used as the immunogen.
144 hibiting allogeneic pig T cell responses and xenogeneic human anti-pig T cell responses in vitro.
146 and the effects of costimulatory blockade on xenogeneic human anti-porcine T cell responses are also
150 ostimulatory pathways block the rejection of xenogeneic human embryonic-stem-cell-derived pancreatic
153 fficient zygote genome editing technologies, xenogeneic human pluripotent stem cells may also open ne
154 We conclude that porcine Kupffer cells bind xenogeneic human RBC by recognition of a carbohydrate ep
156 is a murine T cell clone that recognizes the xenogeneic (human) class I MHC HLA-A2.1 molecule (A2) an
157 f primary GalT-KO skin grafts led to an anti-xenogeneic humoral response with no evidence for sensiti
161 not appear to differ in the nature of their xenogeneic immune response to the administered rabbit se
162 and exhibited similar levels of anti-rabbit xenogeneic immune response, the NZW mice had significant
166 tested this hypothesis in a human-into-mouse xenogeneic islet transplant model and validated the conc
168 nal requirements for tolerance induction for xenogeneic islet transplantation using donor ECDI-SPs.
172 nologic challenges facing transplantation of xenogeneic islets, and the concerns regarding transmissi
173 mechanisms of post-transplant proteinuria in xenogeneic kidney transplantation and a potential strate
176 is to investigate the effect of filling with xenogeneic material the postextractive sockets of two su
177 results suggest that indirect recognition of xenogeneic MHC antigen plays a predominant role in graft
180 survival of T cells positively selected by a xenogeneic MHC, as well as incomplete intrathymic deleti
181 ed decreased signal intensity not only for a xenogeneic mismatch in species but, surprisingly, also f
185 t efficiency have been explored in a primate xenogeneic model of in utero hematopoietic stem cell tra
186 the induction of tolerance in the discordant xenogeneic model of pig-to-rodent thymic transplantation
197 his study reports the establishment of fully xenogeneic mouse-->rat multilineage chimeras and evaluat
201 further genetic modification of the pig, and xenogeneic NK cell recognition and activation may be inh
203 of JAM-C in homing of human B cells, using a xenogeneic nonobese diabetic/severe combined immunodefic
204 of T cells (and T cell subsets) after either xenogeneic or allogeneic activation in vitro or in vivo.
205 issue because the ability to implant either xenogeneic or allogeneic cells would greatly enhance the
207 tiple rounds of stimulation with allogeneic, xenogeneic, or antigen-pulsed autologous antigen-present
208 Immunization of mice with plasmids encoding xenogeneic orthologues of tumor differentiation antigens
211 uch as eptifibatide, interfere directly with xenogeneic PBPC-platelet interactions and may further am
215 prolong allogeneic islet graft survival and xenogeneic pig islet graft survival in diabetic NOD mice
216 prolongs allogeneic islet graft survival and xenogeneic pig islet graft survival in diabetic NOD mice
219 een with either allogeneic (rat-into-rat) or xenogeneic (pig-into-rat) transplants over 28 days, comp
221 d ASGR1 expression as well as ASGR1-mediated xenogeneic platelet phagocytosis in vitro and ex vivo on
222 tiated cell lines are capable of recognizing xenogeneic porcine aortic endothelial cells in a calcium
223 rge-animal model raises the possibility that xenogeneic porcine islet tissue will also survive in hum
225 CD4 T cells are specifically tolerant of the xenogeneic porcine thymus donor and the recipient, but a
228 he hypothesis that porcine sialoadhesin is a xenogeneic receptor that mediates porcine macrophage bin
230 swine-specific tolerance in widely disparate xenogeneic recipients, this study aimed to achieve long-
233 ever, the immunogenicity of cells expressing xenogeneic reporter constructs limits their survival and
237 uTreg) suppress CD4+ T cell-mediated antipig xenogeneic responses in vitro and might therefore be use
241 repared from monocytes ex vivo without using xenogeneic serum and may be used for immunotherapy.
244 standing of the mechanisms and importance of xenogeneic silencing and counter-silencing in the succes
247 ession of foreign DNA in a process known as 'xenogeneic silencing.' Counter-silencing by a variety of
249 opoietic engraftment across highly disparate xenogeneic species barriers poses a major obstacle to ex
251 ant in the rejection of solid organs in some xenogeneic species combinations, its role in the rejecti
253 This could present major limitations to xenogeneic stem cell transplantation as an approach to t
254 use of homologous stem cells, allogeneic or xenogeneic stem cells have been studied extensively in e
255 ated inflammatory reaction to allogeneic and xenogeneic stem cells may elicit a spectrum of effects,
267 tudies suggest that mouse NK cells recognize xenogeneic targets in a strain-specific manner, implicat
268 autologous fibroblasts and rVVenv-expressing xenogeneic targets similarly, suggesting a lack of genet
270 Our results support the interpretation that xenogeneic thymic transplantation is a feasible strategy
271 normal mice usually remain healthy following xenogeneic thymic transplantation, thymus-grafted congen
279 haracterize further the cellular response to xenogeneic tissues, we used the intracellular fluorescen
282 LIV in the mediastinum, suggesting that full xenogeneic tolerance was not achieved in euthymic mice.
283 t before syngeneic, suboptimal syngeneic, or xenogeneic transplant exhibited superior function compar
285 rent research efforts in both allogeneic and xenogeneic transplantation are presented and discussed.
286 ed from the islets of the pancreas can cross xenogeneic transplantation immune barriers, induce tissu
297 luenza virus type 1 (Sendai virus [SV]) as a xenogeneic vector to deliver the G glycoprotein of RSV.
299 linical efficacy of synthetic, allogeneic or xenogeneic vessels has been limited by thrombosis, rejec
300 llogeneic BALB/c or phylogenetically related xenogeneic WF rat stimulator cells while having undetect
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