ライフサイエンスコーパス: xenoreactive

1 e, suggesting that combined inhibition of C, xenoreactive Ab responses, and cellular immunity may be

2 Elicited xenoreactive Abs (EXA) are thought to initiate hamster t

3 +/- 1.7 days) by promoting production of IgG xenoreactive Abs (XAb).

4 s of mammalian origin, even while generating xenoreactive, and potentially autoreactive, antibodies a

5 in a xenograft, human serum, as a source of xenoreactive anti-endothelial Abs and complement, induce

6 pha1,3Gal (Gal) as the main target for human xenoreactive (anti-pig) antibodies and the development o

7 isolectin B4, and elicited primate anti-pig xenoreactive antibodies (decomplemented cynomolgus monke

8 Production of IgM elicited xenoreactive antibodies (EXA) peaked on day 4 after tran

9 The xenoreactive antibodies accompanying acute or late xenog

10 formation could explain the peculiar fate of xenoreactive antibodies after pulmonary xenotransplantat

11 normalities in eicosanoid release induced by xenoreactive antibodies and complement might provide one

12 protective genes, and deposition of elicited xenoreactive antibodies and complement on the graft endo

13 n (PG) I2, endothelial cells stimulated with xenoreactive antibodies and complement released PGE2 and

14 s hyperacute rejection, which is mediated by xenoreactive antibodies and complement, and results in r

15 we investigated endothelial cells exposed to xenoreactive antibodies and complement, as might occur i

16 We investigated whether circulating xenoreactive antibodies are a useful indicator of this x

17 ic lectins as compared with XNAs or elicited xenoreactive antibodies can directly elicit type II porc

18 pig xenoantigens recognized by natural human xenoreactive antibodies has led to the development of st

19 on of complement regulation and depletion of xenoreactive antibodies improves the outcome of pulmonar

20 Depletion of xenoreactive antibodies is more effective than membrane-

21 ds reduced the level of anti-pig IgM and IgG xenoreactive antibodies to nearly background, but column

22 fts is thought to be triggered by binding of xenoreactive antibodies to the graft.

23 rvested and the functional activities of the xenoreactive antibodies were quantitated by in vivo pass

24 to limit xenograft rejection by NK cells and xenoreactive antibodies will need to incorporate carbohy

25 Thought to be initiated by xenoreactive antibodies, acute vascular rejection might,

26 Elicited xenoreactive antibodies, and to non-Gal epitopes alone,

27 ly by components of natural immunity such as xenoreactive antibodies, complement and natural killer c

28 of the previously known anti-alpha-galactose xenoreactive antibodies.

29 rejection and the accompanying production of xenoreactive antibodies.

30 eans of overcoming the rejection mediated by xenoreactive antibodies.

31 on, which is associated with a rise in serum xenoreactive antibody (Ab) and a cellular infiltrate, tr

32 splenectomy influences the magnitude of the xenoreactive antibody (XAb) response and thus hamster he

33 iopsy specimens were obtained for studies of xenoreactive antibody binding and tissue factor expressi

34 Many waitlisted patients have minimal xenoreactive antibody binding to the triple KO pig, but

35 is histologically characterized by extensive xenoreactive antibody deposition and cellular infiltrati

36 umptive coagulopathy occurred when there was xenoreactive antibody deposition and increase of tissue

37 In vivo, AVR was associated with xenoreactive antibody deposition in the graft.

38 to conventional immunosuppression, extensive xenoreactive antibody deposition, and cellular infiltrat

39 tomized rats, only about one tenth of normal xenoreactive antibody levels.

40 sociated with 7.7-fold and 78.0-fold rise in xenoreactive antibody titers after first and second trea

41 ection but are rejected within 3-4 days when xenoreactive antibody titers rise exponentially to level

42 When vascular endothelial binding of xenoreactive antibody was combined with the expression o

43 Titers of xenoreactive antibody were monitored until elective deat

44 These results suggest strategies to remove xenoreactive antibody-secreting cells prior to transplan

45 xenoreactive counterparts (P<0.05), although xenoreactive CD4+ CD25+ T cells proliferated more than a

46 xenografts revealed the presence of residual xenoreactive cells.

47 e was not due to complete clonal deletion of xenoreactive cells.

48 sponder T cells proliferated more than their xenoreactive counterparts (P<0.05), although xenoreactiv

49 antigen on porcine endothelium recognized by xenoreactive human antibodies.

50 We report here the characterization of xenoreactive human natural antibodies against antigens w

51 herefore, HLA-E protected porcine cells from xenoreactive human NK cells through a CD94/NKG2-dependen

52 that porcine chimerism induces tolerance of xenoreactive human T cells.

53 These data indicate that Ts induce anergy of xenoreactive human Th cells upon specific recognition of

54 n resulted in approximately 90% reduction in xenoreactive IgM levels, as measured by ELISA.

55 s HAR with prolongation of survival and that xenoreactive IgM may be the predominant immunoglobulin i

56 rgan survival was negatively associated with xenoreactive IgM nAb levels measured immediately before

57 Previous studies have implicated xenoreactive IgM natural antibody (nAb) as the predomina

58 determined and the levels of alloreactive or xenoreactive immunoglobulin (Ig)M and IgG were determine

59 ) by CD16+ NK cells in the presence of human xenoreactive immunoglobulin G.

60 -cells were analyzed via flow cytometry, and xenoreactive lymphocytes via ELISPOT, 90 days after impl

61 We also present two additional xenoreactive MAIT TCR/MR1 complexes that recapitulate th

62 The TCR from a xenoreactive murine cytotoxic T lymphocyte clone, AHIII

63 The orientation of this xenoreactive murine TCR atop human MHC deviates from the

64 vitro, was also strongly associated with IgM xenoreactive nAb levels (r=0.92; P<0.0001).

65 level of alphaGal-reactive IgM suggests that xenoreactive NAbs may be the product of germ-line genes.

66 The majority of xenoreactive natural Abs in humans recognize the carbohy

67 known about the B-cell subsets that produce xenoreactive natural antibodies (NAb).

68 from pig to human, is rejection mediated by xenoreactive natural antibodies (XNA) that bind the carb

69 In additional groups, xenoreactive natural antibodies (XNA) were depleted by p

70 as purified by protein-G chromatography, and xenoreactive natural antibodies (XNA) were depleted by p

71 Human xenoreactive natural antibodies (XNA), both IgM and IgG

72 Human xenoreactive natural antibodies (XNA), of IgM and IgG su

73 Hyperacute rejection (HAR) mediated by xenoreactive natural antibodies (XNA), which are thought

74 rminant recognized on porcine cells by human xenoreactive natural antibodies (XNA).

75 Xenoreactive natural antibodies (XNAs) and complement me

76 consequence of the failure to fully deplete xenoreactive natural antibodies and block complement, or

77 Xenoreactive natural antibodies and complement were depl

78 (HAR) is prevented by strategies directed at xenoreactive natural antibodies and/or complement activa

79 e previously demonstrated very low levels of xenoreactive natural antibodies in newborns, suggesting

80 gher primates is initiated by the binding of xenoreactive natural antibodies of the recipient to bloo

81 edicted, this resulted in reduced binding of xenoreactive natural antibodies to endothelial cells of

82 nts is initiated by the binding of preformed xenoreactive natural antibodies to the vascular endothel

83 vels, except in NOD-scid-beta2 m-, including xenoreactive natural antibodies.

84 ft recipients with complement inhibitors and xenoreactive natural antibody depletion leads to delayed

85 , naive or sensitized baboon sera containing xenoreactive natural or elicited antibodies were used to

86 rmine the frequency and cytokine profiles of xenoreactive PBLs from a panel of human volunteers.

87 Levels of CD4+-effector cells and xenoreactive splenocytes showed similar results.

88 iters, frequency of CD4+-effector cells, and xenoreactive splenocytes were 2- to 4-fold lower (P<0.00

89 l and specifically sensitized mice activated xenoreactive T and B cells.

90 splantation in humans, but whether analogous xenoreactive T cell immunity develops is not known.

91 MHC-bound peptide to the responding allo- or xenoreactive T cell repertoire is not clear.

92 Cloning studies identified two groups of xenoreactive T-cell clones.

93 The human xenoreactive T-cell receptor (TCR) repertoire is not wel

94 These novel observations suggest that xenoreactive T-independent humoral responses can be dele

95 their ability to inhibit early activation of xenoreactive Th (up-regulation of CD40 ligand).

96 Ts drastically reduced the capacity of xenoreactive Th cells to produce interleukin (IL)-2 in r

97 iomedical benefits, for example, ablation of xenoreactive transplantation antigens, inactivation of g

98 nsion and precursor frequencies of allo- and xenoreactive Tregs were assessed by labeling with FoxP3