ライフサイエンスコーパス: yersiniabactin

1 strains, such as KIM5, lack the siderophore yersiniabactin.

2 ch encodes a transporter for the siderophore yersiniabactin.

3 olved in the biosynthesis of the siderophore yersiniabactin.

4 d to genes for enterobactin, aerobactin, and yersiniabactin.

5 of the newly detected VF genes, e.g., fyuA (yersiniabactin; 76%) and focG (F1C fimbriae; 25%), were

6 oducing polyketide synthase (PKS) modules of yersiniabactin and epothilone were characterized using m

7 lmochelin) and non-catecholate siderophores (yersiniabactin and ferrichrome) fail to inhibit MPO acti

8 erophores for high-affinity iron scavenging, yersiniabactin and pyoverdin, and we uncover a third sid

9 hiazoline-containing siderophores pyochelin, yersiniabactin, and Micacocidin A all have D-thiazoline

10 shown to synthesize a siderophore molecule, yersiniabactin, as a virulence factor during iron starva

11 ae vibriobactin and HMWP2 of Yersinia pestis yersiniabactin assembly lines were evolved by random mut

12 ase homologue, and YbtE in the initiation of yersiniabactin biosynthesis.

13 gen-associated iron acquisition systems like yersiniabactin, common among pathogenic species in the f

14 Given that yersiniabactin contributes to the virulence of several p

15 and salmochelin deficient), hvKP1Deltairp2 (yersiniabactin deficient), and hvKP1DeltaentBDeltairp2 (

16 ntBDeltairp2 (enterobactin, salmochelin, and yersiniabactin deficient).

17 cally complemented in vitro during iron(III)-yersiniabactin-dependent growth.

18 re receptors for salmochelin, aerobactin, or yersiniabactin displayed reduced fitness in wild-type mi

19 tant (strain 536DeltafyuA) unable to acquire yersiniabactin during infection, we established the yers

20 e activity being enterobactin > aerobactin > yersiniabactin > salmochelin, suggesting that the contri

21 tte (ABC) proteins associated with iron(III)-yersiniabactin import in Yersinia pestis In this study,

22 oducing the virulence-conferring siderophore yersiniabactin in Yersinia pestis.

23 ity to produce enterobactin, salmochelin, or yersiniabactin individually or in combination did not de

24 nd sfaS (S fimbriae), hly (hemolysin), fyuA (yersiniabactin), iroN (siderophore), and ompT (outer mem

25 monstrated that production of colibactin and yersiniabactin is abolished in the absence of Hsp90Ec We

26 n in vivo and the reverse being true for the yersiniabactin locus.

27 mbly of the iron-chelating virulence factor, yersiniabactin of the plague bacterium Yersinia pestis.

28 fyuA (yersiniabactin: overall prevalence, 93%), traT (serum re

29 o form a gem-dimethylated product, while the yersiniabactin PKS could methylate before or after ketos

30 in positive (Ent(+)) (81%), enterobactin and yersiniabactin positive (Ent(+) Ybt(+)) (17%), and enter

31 ld be cross-fed by culture supernatants from yersiniabactin-producing strains of Y. pestis grown unde

32 mology and organization to those involved in yersiniabactin production and uptake.

33 that synthesize vibriobactin, enterobactin, yersiniabactin, pyochelin, and anguibactin, we examined

34 the nikkomycin, clorobiocin, coumermycin A1, yersiniabactin, pyochelin, and enterobactin biosynthetic

35 abactin during infection, we established the yersiniabactin receptor as a UPEC virulence factor durin

36 located immediately upstream of the pesticin/yersiniabactin receptor gene (psn).

37 aerobactin receptor mutant and the DeltafyuA yersiniabactin receptor mutant, were frequently outcompe

38 bmaE (M fimbriae), gafD (G fimbriae), fyuA (yersiniabactin receptor), ireA and iroN (novel sideropho

39 produce yersiniabactin, suggesting that this yersiniabactin-related locus is functionally distinct.

40 The fitness requirement for the yersiniabactin-related siderophore during UTI shows, for

41 dings clearly show that proteobactin and the yersiniabactin-related siderophore function as iron acqu

42 both siderophores, only mutants lacking the yersiniabactin-related siderophore have reduced fitness

43 commonly produce the additional siderophores yersiniabactin, salmochelin, and enterobactin.

44 P. mirabilis is unable to utilize or produce yersiniabactin, suggesting that this yersiniabactin-rela

45 ing sites, designated sid, is similar to the yersiniabactin synthesis and uptake genes encoded on the

46 the ClpQ protease involved in colibactin and yersiniabactin synthesis.

47 (1896-3163) of the 350-kDa HMWP1 subunit of yersiniabactin synthetase have been expressed in and pur

48 tion domain embedded in the HMWP2 subunit of yersiniabactin synthetase, acting in trans.

49 from surfactin synthetase and Ybt PCP1 from yersiniabactin synthetase, was observed at rates of 0.5

50 The NRPS shares similarity with the yersiniabactin system found in the high-pathogenicity is

51 Although the yersiniabactin system was recently identified as a vacci

52 that iron acquisition systems, including the yersiniabactin system, are highly expressed by bacteria

53 [uropathogenic-specific protein], and fyuA [yersiniabactin system]) were most closely associated wit

54 Here we compare yersiniabactin to other extracellular copper-binding mol

55 The ability of yersiniabactin to protect E. coli from copper toxicity a

56 produced by uropathogenic Escherichia coli, yersiniabactin, was found to also bind copper ions durin

57 for the synthesis of either enterobactin or yersiniabactin were constructed, and the growth of these

58 thogenicity island, encoding the siderophore yersiniabactin, which belongs to the same chemical famil

59 nthetase that biosynthesizes the siderophore yersiniabactin (Ybt) activates three molecules of L-cyst

60 tructurally distinct siderophores, including yersiniabactin (Ybt) and glycosylated Ent (GlyEnt, or sa

61 strains capable of producing the siderophore yersiniabactin (Ybt) and the putative ferrous transporte

62 For the PKS module (205 kDa) from the yersiniabactin (Ybt) gene cluster of Yersinia pestis, li

63 n Yersinia pestis, the siderophore-dependent yersiniabactin (Ybt) iron transport system and heme tran

64 g the synthetase (HMWP2) for the siderophore yersiniabactin (Ybt) is required for growth under Zn(2+)

65 he causative agent of bubonic plague, is the yersiniabactin (Ybt) siderophore-dependent iron transpor

66 s, causative agent of bubonic plague, is the yersiniabactin (Ybt) siderophore-dependent iron transpor

67 a pestis has multiple iron transporters, the yersiniabactin (Ybt) siderophore-dependent system plays

68 In addition to the yersiniabactin (Ybt) siderophore-dependent system, two i

69 To explore these strategies, yersiniabactin (Ybt) synthetase containing two subunits,

70 229 kDa HMWP2 subunit of the Yersinia pestis yersiniabactin (Ybt) synthetase has been expressed in so

71 Yersiniabactin (Ybt) synthetase is a three-subunit, 17-d

72 studies with pyochelin (Pch) synthetase and yersiniabactin (Ybt) synthetase reconstituted from pure

73 The HMWP2 subunit of yersiniabactin (Ybt) synthetase, a 230 kDa nonribosomal

74 The yersiniabactin (Ybt) system is a siderophore-dependent t

75 and (HPI), which directs the biosynthesis of yersiniabactin (Ybt), a virulence-associated metallophor

76 hesis of SA, the SA-incorporated siderophore yersiniabactin (Ybt), and the fluorescent siderophore py

77 thesis of the Y. pestis cognate siderophore, yersiniabactin (Ybt), and which is located immediately u

78 agent of plague, makes a siderophore termed yersiniabactin (Ybt), which it uses to obtain iron durin