ライフサイエンスコーパス: yersiniae

1 Yop protein production in the intracellular yersiniae.

2 er, Yops were produced only by extracellular yersiniae.

3 rs of T3SS gene expression in the pathogenic yersiniae.

4 ogy to proteins of unknown function in other yersiniae.

5 that is translocated into mammalian cells by Yersiniae.

6 o activate type III secretion than wild-type yersiniae.

7 Pathogenic Yersiniae adhere to and kill macrophages by targeting so

8 accines to prime protective immunity against yersiniae and other pathogens.

9 ficient for bacteriostasis of Ca(2+)-starved yersiniae and suggest that abrupt restriction of Y. pest

10 op targeting at the extracellular surface of yersiniae and that the protective efficacy of LcrV-speci

11 contact-activated, extracellularly localized yersiniae and were targeted to the HeLa cell cytosol.

12 Yersiniae bearing deletion mutations in yopN, tyeA, sycN

13 oes not decrease survival of YadA-expressing Yersiniae because C3b becomes readily inactivated by fac

14 in lcrV reduced type III targeting of mutant yersiniae but did not promote secretion into the extrace

15 heterogeneity of size and sequence among the yersiniae, but the functional consequences of this varia

16 estis lacking effector Yops, even though the yersiniae could strongly express LcrV, suggesting that Y

17 Delayed expression of YopR-DHFR, when yersiniae have already engaged the type III pathway, blo

18 In yersiniae, important virulence-associated traits are und

19 odulate and evade host immune systems, these yersiniae inject effector proteins into host macrophages

20 The virulence of yersiniae is promoted in part by shared approximately 70

21 Yersiniae lacking yopN (lcrE), yscB, sycN, or tyeA do no

22 Together these results suggest that yersiniae may have evolved distinct secretion reactions

23 Yersiniae modulate and evade host immune defences throug

24 We find that tyeA mutant yersiniae not only secreted YopE, YopH, YopM, and YopN i

25 no significant effect of the iron status of yersiniae or of the pigmentation locus on invasion and l

26 Human pathogenic yersiniae organisms export and translocate the Yop virul

27 pe III targeting pathway in the cytoplasm of yersiniae, presumably by preventing the export of YopN.

28 Thus, competition studies with wild-type yersiniae reveal critical roles of Yops in combating hos

29 Pathogenic yersiniae secrete 14 Yop proteins via the type III pathw

30 To counteract this response, Yersiniae secrete a protease (Yersinia outer protein J (

31 at during infection of tissue culture cells, yersiniae secrete small amounts of LcrV into the extrace

32 We show here that the type III machines of yersiniae secrete three proteins into the extracellular

33 such as Salmonella spp., Shigellae spp. and Yersiniae spp., use specialized virulence factors to ove

34 ttsA mutant yersiniae synthesize reduced amounts of Yops and display

35 en grown at 21 degrees C, however, the three yersiniae synthesized LPS containing predominantly hexa-

36 ut mutations in both genes caused DeltalcrGV yersiniae to display a Los phenotype similar to that of

37 contact with host cells and is necessary for Yersiniae to establish a replicative niche and cause dis

38 otide phosphorylase (PNPase) is required for Yersiniae to grow at low temperatures.

39 hat knockout mutations of lcrG caused mutant yersiniae to prematurely secrete Yops into the extracell

40 After attaching to host cells, yersiniae transform the type III machinery into an injec

41 Pathogenic yersiniae utilize a type III secretion system to inject

42 tasis of Y. pestis (but not enteropathogenic yersiniae) was abrupt in Ca(2+)-deficient medium at neut

43 ovided evidence that the Deltalpp mutants of yersiniae were significantly attenuated and could be use

44 V antibody also promoted phagocytosis of the yersiniae, whereas F(ab')(2) fragments did not.

45 In contrast, yersiniae with a deletion in yopD or lcrH synthesized Yo

46 the injection of Yop proteins by tyeA mutant yersiniae with the digitonin fractionation technique.

47 or more of Y. pestis or the enteropathogenic yersiniae Yersinia enterocolitica and Yersinia pseudotub

48 ce (complement resistance) in the pathogenic Yersiniae (Yersinia pestis, Y. enterocolitica, and Y. ps

49 high homology to the YscB-L proteins of the yersiniae Yop type III export apparatus.