ライフサイエンスコーパス: young-onset

1 d by an autosomal dominant inheritance and a young onset.

2 ide linkage scan in Pima Indians indicated a young-onset (aged <45 years) type 2 diabetes susceptibil

3 rich variation in phenotypes among cases of young-onset amyotrophic lateral sclerosis, bulbar onset

4 'Young-onset' amyotrophic lateral sclerosis typically ref

5 be tailored to a specific diagnosis of both young-onset and late-onset dementia.

6 utations and determine their contribution in young-onset and more typical later onset Parkinson's dis

7 of African ancestry are more likely to have young-onset and oestrogen receptor (ER) negative breast

8 Young-onset autoimmune diabetes associated with addition

9 neuron disease with TDP-43 type B pathology; young-onset behavioural variant frontotemporal dementia

10 Most multiple case families of young onset breast cancer and ovarian cancer are thought

11 se was inversely associated with the risk of young-onset breast cancer (odds ratio = 0.58, 95% confid

12 was not associated with an increased risk of young-onset breast cancer (odds ratio = 0.80, 95% confid

13 proven in 1990 by mapping predisposition to young-onset breast cancer in families to chromosome 17q2

14 us progestin HT or unopposed estrogen HT and young-onset breast cancer using data from the Two Sister

15 eria or prediction models; isolated sporadic young-onset cases can be prescreened by tumor testing, w

16 % of controls versus 15% of cases and 20% of young-onset cases, both highly significant differences.

17 ants were 13102 patients diagnosed as having young-onset colon adenocarcinoma aged 18 to 49 years and

18 Treatment options for patients with young-onset colon cancer remain to be defined and their

19 However, the prognosis of young-onset colon cancer remains poorly defined given si

20 Most young-onset colon cancer was initially seen at advanced

21 We identified 28,145 patients with young-onset CRC (19,497 NHW; 4,384 NHB; 4,264 Hispanic)

22 We compared the survival of young-onset CRC among non-Hispanic black (NHB), non-Hisp

23 se may be more important in the aetiology of young-onset dementia than previously believed, and is of

24 Moreover, many of the young-onset dementias are treatable.

25 mutation (p.G1117E) in the PASK gene from a young-onset diabetes family, which modulates glucose-sti

26 majority (438/597 (73%)) with other types of young-onset diabetes had an HbA1c above the upper limit

27 in the PASK gene that may be associated with young-onset diabetes in humans.

28 ine diabetes exposure or parental history of young-onset diabetes increased a child's absolute risk o

29 ibility, a genome-wide association study for young-onset diabetes was conducted in an American-Indian

30 chanisms and is therefore valid for studying young-onset disease in which genotype does not influence

31 of onset was variable but included cases of young-onset disease.

32 DYT1 dystonia is a severe form of young-onset dystonia caused by a mutation in the gene th

33 Young-onset families may therefore represent a group in

34 In conclusion, young-onset families provide both disproportionate evide

35 with an apparent autosomal recessive, novel, young-onset, generalised form of dystonia parkinsonism.

36 vealed a far higher proportion of cases with young onset (>50%), with a steady decline to the contemp

37 n 10 years (89.4% vs. 76.8%), especially for young-onset HCCs <50 years (79.4% vs. 40.6%), under slig

38 wing it is also present in two patients with young-onset Huntington's disease (26 and 40 years old at

39 runcating FANCG mutations were identified in young onset (<55 years) pancreatic cancer cases with no

40 of familial aggregation of lung cancer among young onset (<or=55 years of age) lung cancer cases.

41 of primary progressive aphasia (naPPA) is a young-onset neurodegenerative disorder characterised by

42 A young onset of type 2 diabetes is likely to result, in p

43 I has a clear impact on the investigation of young-onset or complex dementia while reducing the overa

44 atic mutations of FANCC and FANCG present in young-onset pancreatic cancer.

45 Data were compared with a young-onset Parkinson's disease (YOPD) cohort, matched f

46 reported in two consanguineous families with young-onset Parkinson's disease (YOPD).

47 ive early-onset or juvenile parkinsonism and young-onset Parkinson's disease and also had similaritie

48 ith a fairly pure parkinsonian syndrome (eg, young-onset Parkinson's disease; YOPD) are due to typica

49 near normal longevity of these patients with young onset parkinsonism.

50 T serially to study members of a family with young-onset parkinsonism who are compound heterozygous f

51 se of autosomal recessive juvenile-onset and young-onset parkinsonism.

52 d be considered in the diagnostic work up of young-onset parkinsonism.

53 Young-onset patients in the UK, but not the Japanese coh

54 .76, 95% confidence interval: 1.43, 2.15) or young-onset prostatitis (adjusted OR = 1.55, 95% confide

55 istories of sexually transmitted infections, young-onset prostatitis, and frequency of ejaculation, w

56 The current study reports a GWAS for young-onset T2DM in American Indians.

57 first description of a pathologically proved young-onset tauopathy with apparent recessive inheritanc

58 mutation from unaffected family members and young-onset type 1 (T1D) and type 2 diabetes (T2D) and t

59 Genetic susceptibility to young-onset type 1 diabetes is well defined and does not

60 s of the young (MODY), and 463 patients with young-onset type 2 diabetes (nonobese, diagnosed <45 yea

61 /A variant in the 3'-UTR was associated with young-onset type 2 diabetes (odds ratio 2.09 per copy of

62 this variant, were nominally associated with young-onset type 2 diabetes (P = 0.01; odds ratio 3.39)

63 an age, 52.2 years), and 83 individuals with young-onset type 2 diabetes (YT2D), diagnosed at age 45

64 Young-onset type 2 diabetes also affects more individual

65 Furthermore, evidence is accumulating that young-onset type 2 diabetes has a more aggressive diseas

66 with variants that confer susceptibility to young-onset type 2 diabetes in American Indians.

67 8M substitution identified in a patient with young-onset type 2 diabetes may be a rare nonfunctional

68 irm our hypothesis that families segregating young-onset type 2 diabetes represent a more powerful re

69 Optimal prevention of young-onset type 2 diabetes requires identification of t