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1 tive inhibitor for miRNAs, termed 'small RNA zipper'.
2 rs self-assemble using electrostatic 'charge zippers'.
3 of its residues, which we term 'statistical zippering'.
4 interface to allow the formation of a serine zipper.
5 C terminus is mediated by a putative leucine zipper.
6 he CA-SP1 junction region fused to a leucine zipper.
7 Ne/Epi) boundary just ahead of the advancing zipper.
8 t domains: EF-hand, coiled coil, and leucine zipper.
9 nce attached to N-terminal of bZIP53 leucine zipper.
10 tions, such as those between pairing leucine zippers.
11 ckdown of miRNA levels by 30-50 nM small RNA zippers.
12 abilized the CTD, facilitating further SNARE zippering.
13 l contraction mechanism for robust efficient zippering.
14 s concentrated at the C-terminal part of CTD zippering.
15 utcome of alpha-SNAP interference with SNARE zippering.
16 termediate, and fast C-terminal domain (CTD) zippering.
17 as a fusion clamp that restricts full SNARE zippering.
18 osine interacting with PH domain and leucine zipper 1 (APPL1) signaling endosomes and MYO6+ expressio
19 atory pathway in which spermatogenic leucine zipper 1 (SPZ1) promotes EMT through its transactivating
22 porally perturbed a master TF (Basic Leucine Zipper 1, bZIP1) and the nitrogen (N) signal it transduc
23 inding activity of protagonist basic leucine zipper 53 (bZIP53) transcription factor and its heterodi
24 quiring protein-1) and bZIP60 (basic leucine zipper 60), two RSRE containing unfolded protein-respons
25 rdimer interactions between adjacent leucine zippers allow TbBILBO1 to form extended filaments in vit
26 olymerization, thus corroborating that lipid zippering alone is sufficient for this crucial first ste
27 AAM and Diaphanous caused mislocalization of Zipper and induced ectopic heart lumina, as characterize
28 rodimers and bind to DNA via a basic leucine zipper and regulate the cell cycle, apoptosis, different
29 s to a helical state when fused to a leucine zipper and that these helical molecules further associat
30 AP-25 C terminus promote tight SNARE complex zippering and are required for high release frequency an
31 each other through their shafts, leading to zippering and unzippering behavior that regulates their
32 s that promote tetramerization when fused to zippers and those that permit the proper assembly of ful
36 MR, using hybrids with self-complementary CG zipper arms or non-self-complementary TC dimer arms.
38 ne and 2,6-diaminopurine, and +1 interstrand zipper arrangements of intercalator-functionalized nucle
40 full-length myosin-X construct with leucine zipper at the C-terminal end of the tail (M10(Full)LZ) a
42 er vaccination, both migratory basic leucine zipper ATF-like transcription factor 3 (BatF3)-dependent
43 In addition, we demonstrate that the miR-221 zipper attenuates doxorubicin resistance with higher eff
50 s), SFH3 (SEC14-like 3), bZIP (basic-leucine zipper), bHLH (basic helix-loop-helix) and SBP (SQUAMOSA
51 rtner Mlx are basic helix-loop-helix leucine zipper (bHLHZip) transcription factors that sense and ex
52 trated that inhibition of the LecA/Gb3 lipid zipper by either lecA knockout, Gb3 depletion, or applic
53 gnificantly reduced the energy of C-terminal zippering by 10 kBT, but did not affect N-terminal asse
54 IRs identified a heterodimeric basic leucine zipper (bZIP) complex between an uncharacterized protein
55 protein consists of the basic region-leucine zipper (BZip) domain of the CCAAT/enhancer-binding prote
56 leukemia virus type 1 (HTLV-1) basic leucine zipper (bZIP) factor (HBZ) could be used for immunothera
57 nts identified to date, HY5, a basic leucine zipper (bZIP) transcription factor, has been investigate
58 ive dimerization of the basic-region leucine-zipper (bZIP) transcription factors presents a vivid exa
61 periment, and show that 2 populations of DNA zippers can be distinguished using per-molecule statisti
62 tion factors in hematopoiesis is the leucine zipper CCAAT-enhancer binding protein alpha (C/EBPalpha)
64 tyrosine Interaction, PH domain, and leucine zipper containing 1 (APPL1) that were identified by mean
66 e MAP3K ZAK (Sterile alpha motif and leucine zipper-containing kinase) has also been proven to positi
67 brosarcoma oncogene homolog (MAF), a leucine zipper-containing transcription factor of the AP1 superf
69 en the NC domain was replaced with a leucine zipper dimerization motif that promotes Gag multimerizat
70 ion between the LOV and basic region leucine zipper DNA-binding domain that together with LOV dimeriz
73 cid-binding domain with a dimerizing leucine zipper domain leads to the assembly of RNA-free VLPs.
76 ore, we introduce a biophysical model of the zippering dynamics, and we quantitatively relate the ind
77 hondrial Na/Ca exchanger) and LETM1 (leucine zipper-EF-hand-containing transmembrane protein 1) were
78 key biophysical SNARE properties such as the zippering energy landscape and the surface charge distri
82 ts proviral genome, the HTLV-1 basic leucine zipper factor (HBZ), which inhibits Tax-1-mediated viral
84 shortening of Ne/Epi junctions, driving the zipper forward and drawing the neural folds together.
87 Induction of glucocorticoid-induced leucine zipper (GILZ) by glucocorticoids plays a key role in the
89 ssion of glucocorticoid (GC)-induced leucine zipper (GILZ) in bone marrow mesenchymal lineage cells o
91 ine 211 and expression of GC-induced leucine zipper (GILZ) were significantly reduced in ASM cells fr
93 ne, and mutagenesis indicates that a glycine zipper/GXXXG motif within the linker helps mediate oligo
94 at GTPase activation and trans-SNARE complex zippering have opposing effects on fragment formation an
95 e gamma-clade of class I homeodomain-leucine zipper (HD-Zip I) transcription factors (TFs) constitute
97 (HAT1), which encodes a homeodomain-leucine zipper (HD-Zip) class II transcription factor, was ident
98 Here we report that a homeodomain-leucine zipper (HD-ZIP) transcription factor, GhHOX3, controls c
99 revealed that ATHB13, a homeodomain-leucine zipper (HD-Zip) transcription factor, was constitutively
100 ree paralogous class III homeodomain leucine zipper (HD-ZIPIII) genes leads to aberrations in ovule i
101 members of the class III homeodomain leucine zipper (HD-ZIPIII) transcription factor family specify t
102 orm stable homodimers, whereas c-Fos leucine zipper homodimers were found to be much less stable in e
103 Characterization of the homeodomain leucine zipper I transcription factor AtHB13, which is expressed
104 Pull in plants using the HOMEODOMAIN LEUCINE ZIPPER III (HD-ZIPIII) and LITTLE ZIPPER (ZPR) interacti
105 porter system, we defined a putative leucine zipper in the N terminus of human pro-EMAP II protein (a
108 cell-cell contacts, filopodia, and membrane zippers, indicative of involvement in cell-cell adhesion
110 eveal tightly packed beta-sheets with steric zipper interfaces characteristic of the amyloid state.
111 y distinct packing arrangements (i.e. steric zipper interfaces) within the amyloid core, as indicated
112 sociation, a pause in a force-dependent half-zippered intermediate, and fast C-terminal domain (CTD)
113 orm a dimer driven by formation of a glycine zipper involving alpha helix formed by amino acid residu
114 Trm112 interact through formation of a beta-zipper involving main-chain atoms, burying an important
117 In contrast, when complete C-terminal SNARE zippering is prevented, fusion strictly requires Sec18 a
118 dent fusion which occurs upon complete SNARE zippering is stimulated by Sec17 and Sec18:ATP without r
121 uch as the widely used GCN4-based isoleucine zipper (IZ) and the T4 bacteriophage fibritin foldon (Fd
122 ress response controlled by the Dual Leucine Zipper Kinase (DLK) and contributes to DLK-mediated neur
123 ation in neurons is mediated by dual leucine zipper kinase (DLK) and JNK-interacting protein 3 (JIP3)
128 ing to ApoE receptors activates dual leucine-zipper kinase (DLK), a MAP-kinase kinase kinase that the
134 ly partially protective, we identify leucine zipper kinase (LZK) as cooperating with DLK to activate
136 a novel selective maternal embryonic leucine zipper kinase (MELK) inhibitor HTH-01-091, CRISPR/Cas9-m
137 rotein kinase maternal and embryonic leucine zipper kinase (MELK) is critical for mitotic progression
138 injury is regulated in part by dual-leucine zipper kinase 1 (DLK-1), a conserved regulator of axon r
139 tivity of type II maternal embryonic leucine zipper kinase inhibitors by applying these two complemen
140 d, retrograde DLK-1 MAPK (DLK-1/dual leucine zipper kinase) pathway, which triggered synaptic branch
141 r protein kinase, also known as dual leucine zipper kinase), a mitogen-activated protein kinase kinas
142 ned targeting, we introduce here the "Killer Zipper" (KZip(+)), a suppressor that makes Split GAL4 ta
143 ructure of the polyQ fibrils might also be a zipper layer with antiparallel four-stranded stretches a
144 cing can interlock with multiple TLR9 like a zipper, leading to multivalent electrostatic interaction
145 an self-assemble to form supramolecular DNA "zipper" like structures through intermolecular hydrogen
147 e-specific figure-of-eight, dumbbell-shaped, zipper-like and multi-loop quaternary structures were fo
148 oIIIAH and forespore-protein SpoIIQ leads to zipper-like engulfment, but quantitative understanding i
149 w that the C-terminal helices, arranged in a zipper-like fashion, play a crucial role in guiding the
151 spacing of the trans-Golgi cisternae through zipper-like interactions, thereby forcing cargo to the t
156 om apposed cell surfaces, possibly forming a zipper-like protein assembly, and thus providing a size-
158 tions in initial lymphatics transform from a zipper-like to a button-like pattern during collecting v
160 id nanotube backbones with interpenetrating "zipper-like" aromatic interlocks that result in stiffnes
161 Furthermore, DUSP23 knockdown produced "zipper-like" cell-cell adhesions, caused defects in tran
163 with target membrane-associated t-SNAREs, a zippering-like process releasing approximately 65 kT per
164 Ne/Epi --> Ne/Ne + Epi/Epi) just behind the zipper lower tissue resistance to zipper progression by
165 scaffold assembly requires conserved leucine zipper (LZ) and Cnn-motif 2 (CM2) domains that co-assemb
166 l coiled-coil domain (CC) and/or the leucine zipper (LZ) domain of the myosin light-chain phosphatase
167 modules of the FN70K region by a tandem beta-zipper mechanism, and in doing so increases accessibilit
168 in a "buttoning" pattern, divergent from the zippering mechanism observed in the overlying epidermis
170 ARE complexes assemble by the same step-wise zippering mechanism: slow N-terminal domain (NTD) associ
171 ina, we used Nrl(-/-) (neural retina leucine zipper) mice, to generate Rpgr(ko)::Nrl(-/-) double-knoc
172 this character state is incongruent with the zipper model of metopic closure described by Falk and co
173 consistent with the common amyloid sterical zipper model, whereas NtQ42P10 fibrils present a better
175 rA8; another proposed a so-called 'staggered zipper' model in which oligo(rA) strands overlap in mult
176 hotyrosine-binding (PTB) domain, and leucine zipper motif (APPL)-positive endosomes and EEA1-positive
177 hosphotyrosine-binding domain, and a leucine zipper motif (APPL)1, an early endosomal protein, is req
178 iant: G539I, A542I, G553I) or in the glycine zipper motif (GZ variant: G540I, G544I) and expressed YF
180 rather than through the alternative glycine zipper motif A(536)X3G(540)X3G(544) (typical for TMD dim
182 evolutionarily conserved, truncated leucine zipper motif near the N terminus as well as a strictly c
183 pans the crystal lattice, featuring a steric-zipper motif that is common in structures of amyloid-for
184 , phosphotyrosine binding domain and leucine zipper motif) mediates rab5 overactivation in Down syndr
187 tching between the heptad repeat and glycine zipper motifs, corresponding to inactive and active rece
188 n-like proteins CdzC and CdzD harbor glycine-zipper motifs, often found in amyloids, and CdzC forms l
189 dimer association featuring a "phenylalanine zipper" notable for the dual roles of phenylalanines in
190 rried out a detailed biophysical analysis of zippering, occurring either spontaneously or induced by
191 ons assemble into beta-hairpins via top down zippering of backbone hydrogen bonds to form the membran
192 The expanding integrin wave facilitates the zippering of Fcgamma receptors onto the target and integ
193 at alpha-SNAP on its own interferes with the zippering of membrane-anchored SNARE complexes midway th
194 ted microtubule transport and oMAP4-mediated zippering of microtubules drives formation of a paraxial
195 tant hemocytes coupled with impaired midline zippering of mutant epithelium creates a situation in so
197 O goes beyond its participation in the final zippering of the complex, because mutations of residues
200 1 molecules unlocks the complex, allows full zippering of the SNARE complex, and triggers membrane fu
201 NARE serves as a spring to prevent premature zippering of the SNARE complex, thereby reducing the lik
203 st that the SM protein Munc18-1 promotes the zippering of trans-SNARE complexes and accelerates the k
205 l aspects of KYE28, constituting an aromatic zipper, of potential importance for the development of n
207 ins unclear how these mutations affect SNARE zippering, partly due to difficulties to quantify the en
208 Thus, SNARE complexes share a conserved zippering pathway and polarized energy release to effici
210 nalysis revealed tissue expansion around the zippering point after ablation, but predominant tissue c
213 This zone is biomechanically coupled to the zippering point by a supracellular F-actin network, whic
214 n vivo to generate a sufficient pause in the zippering process for the regulators to set in place.
215 icient to explain the speed and direction of zipper progression and highlight key advantages of a seq
216 behind the zipper lower tissue resistance to zipper progression by allowing transiently stretched cel
218 and we quantitatively relate the individual zipper properties to global characteristics of the devel
219 levels of the glucocorticoid-induced leucine zipper protein (GILZ) generate antigen-specific IL-10-Tr
220 show that the glucocorticoid-induced leucine zipper protein (GILZ), already known to regulate effecto
221 ription of three related Homeodomain leucine zipper protein (HD-ZIP)-encoding genes: HOMEOBOX PROTEIN
222 mall heterodimer partner interacting leucine zipper protein (SMILE) has been identified as a nuclear
223 Arabodopsis thaliana homeodomain-leucine zipper protein 1 (HAT1), which encodes a homeodomain-leu
224 expression of glucocorticoid-induced leucine-zipper protein and the alpha-subunit of the epithelial N
226 -negative mutant of the basic region leucine zipper protein c-Jun, a major constituent of the AP-1 tr
227 n neonatal mice deficient in either ZPK/DLK (zipper protein kinase, also known as dual leucine zipper
229 encoding for Neural retina-specific leucine zipper protein, a rod fate determinant during photorecep
231 -anchored SNARE complexes midway through the zippering reaction, arresting SNAREs in a partially asse
232 served that the previously described leucine zipper region at the C terminus of MSP3 may not be the o
233 a switch to enable fast and controlled SNARE zippering required for synaptic vesicle fusion and neuro
234 ion conversion, four of which were in steric zipper segments where side chains from amino acids tight
235 inding) is shown to be dominated by a simple zipper sequence, only occasionally accelerated by loop f
239 arrier transiently traps SNAREpins in a half-zippered state similar to the partial assembly that enga
244 eceptor, vimentin, fibrin, and phenylalanine zippers that vary in size and topology of their alpha-he
245 of the mammalian embryo involves a wave of "zippering" that passes down the elongating spinal axis,
247 the receptor extracellular domains with Jun zippers to control the position of its transmembrane (TM
249 and vesicle-attached (v-SNARE) proteins that zipper together to form a coiled-coil SNARE bundle that
250 virus (IBV), induces regions of ER that are zippered together and tethered open-necked double membra
251 artner BTB and CNC homology 1, basic leucine zipper transcription factor 1 (BACH1), the chromatin rem
253 hat the BTB and CNC homology 1 basic leucine zipper transcription factor 2 (BACH2) induces negative s
256 DING FACTOR2 (VvABF2), a grape basic leucine zipper transcription factor belonging to a phylogenetic
257 A complex between FT and the basic leucine-zipper transcription factor FD is proposed to form in th
258 rtholog of the class III homeodomain-leucine zipper transcription factor gene REVOLUTA (PtREV) were s
260 ual specificity T-box/basic-helix-loop-helix-zipper transcription factor Mga is expressed in the plur
264 hanced expression of the homeodomain-leucine zipper transcription factor REVOLUTA/INTERFASCICULAR FIB
265 photomorphogenesis promoting a basic leucine zipper transcription factor that is degraded by COP1 ubi
266 s (Arabidopsis thaliana) homeodomain-leucine zipper transcription factor that participates in hypocot
267 ugh the interaction with FD, a basic leucine zipper transcription factor which plays a critical role
268 c reticulum (ER) transmembrane basic leucine zipper transcription factor whose mRNA and protein local
271 of the Bcl6 target genes Batf (basic leucine zipper transcription factor, ATF-like) and Bcl6, in part
272 his correlated inversely BATF (basic leucine zipper transcription factor, ATF-like) and IRF4 (interfe
273 zinc deficiency B. distachyon basic leucine zipper transcription factor, BdbZIP10, and its role in o
277 g a newly developed BBS mouse model [Leucine zipper transcription factor-like 1 (Lztfl1)/Bbs17 mutant
278 lies in the supernode network, BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR1-TGA and HYPERSENSITIVITY TO
279 l/lipid-binding class IV homeodomain leucine zipper transcription factors as potential regulators.
280 ich revealed that the group S1 basic leucine zipper transcription factors bZIP1 and bZIP53 reprogram
281 tween GL2 and HDG11, two homeodomain leucine zipper transcription factors previously thought to media
284 SM subunit Vps33, is followed by subsequent zippering transitions that increase the probability of f
288 eukaryotic life, requiring SNARE proteins to zipper up in an alpha-helical bundle to pull two membran
289 ease of an inserted tryptophan, facilitating zippering up of 20-bp guide RNA:target DNA heteroduplex
290 uently forming successive evaginations that "zipper" up proximally, but at their leading edges are fr
291 sicles revealed that LecA/Gb3-mediated lipid zippering was sufficient to achieve complete membrane en
292 e ability of Munc18-1 to promote trans-SNARE zippering, whereas other known Munc18-1/SNARE-binding mo
294 nal association followed by rapid C-terminal zippering, which serves as a power stroke to drive membr
296 y is the formation of a three-protein charge zipper with interdigitated complementary charged residue
297 ctivated the t-SNARE complex to initiate NTD zippering with the v-SNARE, a mechanism likely shared by
298 ex on the target plasma membrane, which then zippers with the vesicle (v)-SNARE on the vesicle to dri
299 ucture provides direct evidence for a steric zipper within a fibril formed by full-length Abeta pepti
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