ライフサイエンスコーパス: zona

1 opriate site on the sperm surface to mediate zona binding.

2 iffusion of cross-linked clusters containing zona-binding molecules and GM1 gangliosides in the plasm

3 ethyl-beta-cyclodextrin, clusters containing zona-binding molecules diffuse randomly over the acrosom

4 Initially, GM1 and zona-binding molecules localize to the apical ridge on t

5 novel lipid raft-like structures containing zona-binding molecules over the sperm acrosome.

6 Both GM1 gangliosides and zona-binding molecules partition into a low density Trit

7 ced coalescence of GM1 gangliosides (but not zona-binding molecules) suggestive of a specific mechano

8 dopaminergic neurons of the substantia nigra zona compacta.

9 Each zona protein contains a "zona domain" with eight conserved cysteine residues that

10 resting membrane potential of bovine adrenal zona fasciculata (AZF) cells and function pivotally in t

11 Bovine adrenal zona fasciculata (AZF) cells express bTREK-1 K+ channels

12 Bovine adrenal zona fasciculata (AZF) cells express Ca(v)3.2 T-type Ca(

13 9.9 times higher in zona glomerulosa than in zona fasciculata (p=6.6 x 10(-24)).

14 lomerulosa (ZG) and glucocorticoids by inner zona fasciculata (ZF).

15 he outer zona glomerulosa (zG) and the inner zona fasciculata (zF).

16 ling cortisol-secreting cells of the adrenal zona fasciculata but are absent in a subset of APAs rese

17 channels in inside-out patches from adrenal zona fasciculata cells was inhibited by application of C

18 eta-catenin signaling pathway in a subset of zona fasciculata cells.

19 ced the number of steroidogenic cells in the zona fasciculata of the adrenal cortex.

20 omparing transcriptomes of zona glomerulosa, zona fasciculata, and tumour in human adrenal tissue, an

21 compared transcriptomes of zona glomerulosa, zona fasciculata, and tumour obtained by laser capture m

22 adrenocortical zones [zona glomerulosa (ZG), zona fasciculata, and zona reticularis].

23 rexpressed in zona glomerulosa compared with zona fasciculata.

24 o fertilization with both cumulus intact and zona-free eggs, and the definition of complementary SLLP

25 Co-incubation of zona-free mouse oocytes with capacitated mouse spermatoz

26 However, sAC(-/-) sperm fertilize zona-free oocytes, indicating that gamete fusion does no

27 ceptors (AT(1)Rs), present in adrenocortical zona glomerulosa (AZG) cell membranes.

28 produced and secreted by the adrenocortical zona glomerulosa (AZG) cells after angiotensin II (AngII

29 ntial for production of aldosterone by outer zona glomerulosa (ZG) and glucocorticoids by inner zona

30 c layers that develop postnatally, the outer zona glomerulosa (zG) and the inner zona fasciculata (zF

31 nenolone, and progesterone in bovine adrenal zona glomerulosa (ZG) cells.

32 erproduction of aldosterone from the adrenal zona glomerulosa (ZG) is also the most frequent cause of

33 tome with conventional adrenocortical zones [zona glomerulosa (ZG), zona fasciculata, and zona reticu

34 Zona glomerulosa (ZG)-like APAs frequently have mutation

35 Zona glomerulosa cells (ZG) of the adrenal gland constan

36 at were at least five times overexpressed in zona glomerulosa compared with zona fasciculata.

37 ssociated with a pattern of decreased normal zona glomerulosa CYP11B2 expression and increased aldost

38 disruption of this signaling complex in the zona glomerulosa may provide a new therapeutic approach

39 is one of the most highly expressed genes in zona glomerulosa of the human adrenal gland.

40 s in situ and in cells of the native adrenal zona glomerulosa stimulated by Ang II in vivo.

41 ANO4 was 19.9 times higher in zona glomerulosa than in zona fasciculata (p=6.6 x 10(-2

42 these adenomas, composed of cells resembling zona glomerulosa, have mutations in genes ATP1A1 and CAC

43 derstand whether the adenomas originate from zona glomerulosa, we carried out a microarray analysis c

44 roarray analysis comparing transcriptomes of zona glomerulosa, zona fasciculata, and tumour in human

45 Wycombe, UK), we compared transcriptomes of zona glomerulosa, zona fasciculata, and tumour obtained

46 We performed exome sequencing of ten zona glomerulosa-like APAs and identified nine with soma

47 One of the most zona glomerulosa-selective genes was ANO4, a member of t

48 e aldosterone-secreting cells of the adrenal zona glomerulosa.

49 ost cells and maintain the properties of the zona glomerulosa.

50 functional role of genes upregulated in the zona glomerulosa.

51 , and a glycan release model postulates that zona glycans are ligands for sperm.

52 s binding of acrosome-reacted spermatozoa to zona glycoproteins via a stereospecific polysulfate reco

53 go insufficient cortical granule release and zona-hardening, causing altered mechanics after fertiliz

54 neurons within the lateral hypothalamic area/zona incerta (LH) and the arcuate (Arc) nucleus.

55 imulated, with peak p values in superior STN/zona incerta (quantified bradykinesia), dorsal STN (mood

56 The subthalamic nucleus (STN) and the zona incerta (ZI) are two major structures of the subtha

57 e find that optogenetic stimulation of mouse zona incerta (ZI) gamma-aminobutyric acid (GABA) neurons

58 cleus (VPM), neurons of the ventral thalamus zona incerta (ZI) have been shown to exhibit multiwhiske

59 We found that mouse zona incerta (ZI) projection neurons form a GABAergic ax

60 ith DBS of the ventro-oralis posterior (VOP)/zona incerta (ZI) region, and subsequently underwent bli

61 on of activity in the GABAergic nucleus, the zona incerta (ZI), and concomitant increased activity in

62 ntrast, the ETI (arising from basal ganglia, zona incerta (ZI), anterior pretectum, and pontine retic

63 located in the lateral hypothalamus (LH) and zona incerta (ZI), but MCHR1 mRNA is widely expressed th

64 AAV-orexin gene delivery into neurons of the zona incerta (ZI), or the lateral hypothalamus (LH) bloc

65 ir neurons), midline raphe (26%), LHA (22%), zona incerta (ZI, 15%), CeA (5%), paraventricular nucleu

66 colliculus terminated densely in the ventral zona incerta (ZIv), but did not overlap the labeled neur

67 by medial hypothalamic areas as well as the zona incerta and projected to specific forebrain areas s

68 periaqueductal gray, caudal portions of the zona incerta and subparafascicular nucleus, and the late

69 w images for differentiation of STN from the zona incerta and substantia nigra, respectively, and was

70 tion of Lhx6-positive neurons in the ventral zona incerta bidirectionally regulate sleep time in adul

71 roxylase-positive) neurons; however, <10% of zona incerta dopaminergic neurons (which are not hypophy

72 othalamic groups (A12, A14), the prethalamic zona incerta group (A13), the preoptic groups (A15), and

73 ld explain why deep brain stimulation of the zona incerta is beneficial to patients who suffer from P

74 polaris, posteromedial thalamic, and ventral zona incerta nuclei, are only weakly modulated by touch.

75 subsequently targeted the caudal part of the zona incerta nucleus (cZI).

76 By demonstrating that the zona incerta regulates communication between the superio

77 rgic subpopulation of neurons in the ventral zona incerta that promote sleep.

78 n of the pallidofugal fibres and the rostral zona incerta) or at the junction between the dorsal bord

79 GCs, but not DRD4-DSGCs, also project to the zona incerta, a thalamic area not previously known to re

80 ion in the olfactory regions, dentate gyrus, zona incerta, and dorsal motor vagal nucleus.

81 example, inhibition from the basal ganglia, zona incerta, and pretectal regions, and chemical modula

82 lamus, including the posterior thalamus, the zona incerta, and the anterior pretectum.

83 ocessing, including the superior colliculus, zona incerta, and the visual and retrosplenial cortices.

84 put to the superior colliculus (SC) from the zona incerta, as well as the organization of D1- and D2-

85 were with the claustrum, reticular nucleus, zona incerta, lateral posterior and medial pulvinar nucl

86 asalis of Meynert, medial habenular nucleus, zona incerta, neurosecretory arcuate nucleus, cranial mo

87 paraventricular and posterior hypothalamus, zona incerta, periaqueductal gray, intermediate layers o

88 iative thalamic nuclei, superior colliculus, zona incerta, pontine nucleus, multiple other brainstem

89 tical inhibition, we performed recordings in zona incerta, where 10, but not 40, Hz stimulation evoke

90 et of GABAergic neurons in the mouse ventral zona incerta, which express the LIM homeodomain factor L

91 ct to the caudate, the basis pontis, and the zona incerta.

92 thalamic area, dorsal hypothalamic area, and zona incerta.

93 he globus pallidus, subthalamic nucleus, and zona incerta.

94 sensory cortex, paraventricular nucleus, and zona incerta; no regions were higher in maternal mice.

95 ressive motility and are unable to fertilize zona-intact eggs.

96 that sperm ZP3R/sp56 is important for sperm-zona interactions during fertilization and support the c

97 f ZP2 and that binding at the surface of the zona is not sufficient to induce sperm acrosome exocytos

98 A defining characteristic of an essential zona ligand is sterility after genetic ablation.

99 d by Sonic hedgehog (Shh) signaling from the zona limitans intrathalamica (ZLI) at the rostral border

100 position the shh-positive signaling boundary zona limitans intrathalamica (ZLI) in the forebrain.

101 The zona limitans intrathalamica (ZLI) is located at the bor

102 ecode a set of brain enhancers active in the zona limitans intrathalamica (zli), a signaling center e

103 The thalamic organizer is the zona limitans intrathalamica (ZLI), a transverse linear

104 alic signaling centers, the cortical hem and zona limitans intrathalamica (ZLI), are merged, oblitera

105 from rostral to caudal: the prethalamus, the zona limitans intrathalamica (ZLI), the thalamus and the

106 the entire thalamic ventricular zone and the zona limitans intrathalamica (ZLI).

107 mus and an intervening boundary region - the zona limitans intrathalamica (ZLI).

108 y with putative signalling properties -- the zona limitans intrathalamica (ZLI).

109 ignalling centres-the anterior neural ridge, zona limitans intrathalamica and isthmic organizer-are p

110 embryo, including in a domain in or near the zona limitans intrathalamica.

111 ndergo acrosome exocytosis and penetrate the zona matrix before gamete fusion.

112 tive mechanism in which penetration into the zona matrix initiates a mechanosensory signal transducti

113 tion and incorporation into an extracellular zona matrix.

114 to four postsynaptic density-95/discs large/zona occluden-1 (PDZ) domains of sodium-hydrogen exchang

115 -terminal postsynaptic density 95/disc-large/zona occludens (PDZ) binding domain increased its range

116 -terminal postsynaptic density 95/disc-large/zona occludens (PDZ) binding motif.

117 with the postsynaptic density-25/Discs large/zona occludens (PDZ) domain of RIM.

118 mediates interactions with PSD-95/disc large/zona occludens (PDZ) domain-containing proteins.

119 BP50) are postsynaptic density 95/disc-large/zona occludens (PDZ)-domain-containing scaffolding prote

120 Zona occludens (ZO) proteins are molecular scaffolds loc

121 tabolite of arachidonic acid, by stimulating zona occludens (ZO)-2 tyrosine phosphorylation and its d

122 unction components [Occludin, Claudin-1, -2, Zona occludens (ZO-1, -2)].

123 te for the interaction of PSD-95/Discs Large/Zona Occludens 1 (PDZ) domain-containing proteins.

124 the GAT1 postsynaptic density 95/Discs large/zona occludens 1 (PDZ)-interacting domain.

125 ) and blood-brain barrier (BBB) occludin and zona occludens 1 (ZO-1) expression were significantly de

126 ulation of tight-junction-associated protein zona occludens 1 (ZO-1), translocation of ZO-1 to cell-c

127 cause cell elongation, and alter junctional zona occludens 1 and vascular endothelial-cadherin stain

128 nd colocalization of CD31, beta-catenin, and zona occludens 1 in junctions between sinus cells.

129 ith PDZ (postsynaptic density 95/Discs large/zona occludens 1) protein PICK1 (protein interacting wit

130 tion, PDZ2 (postsynaptic density/Discs large/zona occludens 1), PDZ3, and PDZ4 of the PCP protein Scr

131 ies as evidenced by staining for F-actin and zona occludens 1.

132 ment of the blood-brain barrier (claudin 5a, zona occludens 1a and b).

133 lls, silencing of the tight junction protein zona occludens 2 (ZO-2 KD) induces cell hypertrophy by t

134 Zona occludens 2 (ZO-2) has a dual localization.

135 NAs and protein for claudin-5, occludin, and zona occludens 2 were also reduced in infected cells.

136 ht junction proteins (claudin 1, 14, 16, and zona occludens 2), nine gap junction proteins (connexin

137 ents of inositol pentakisphosphate 2-kinase, zona occludens 3, and FAT tumor suppressor 2).

138 in granule-like cytoplasmic structures, and zona occludens 3.

139 lti-PDZ (postsynaptic density 95/discs large/zona occludens) domain AMPAR-binding protein, is bidirec

140 smic PDZ (postsynaptic density 95/disc large/zona occludens) protein that assembles macromolecular co

141 postsynaptic density-95 (PSD-95)/Discs large/zona occludens-1 (PDZ) binding domain, which is present

142 postsynaptic density-95 (PSD-95)/Discs large/zona occludens-1 (PDZ) binding motif, is localized to th

143 een, the postsynaptic density-95/Discs large/zona occludens-1 (PDZ) domain protein interacting specif

144 nsity protein of 95 kilodaltons, disc large, zona occludens-1 (PDZ) domain-containing proteins appear

145 ptor-mediated signals and PSD-95-discs large-zona occludens-1 (PDZ) domain-dependent signals are requ

146 t of two postsynaptic density 95/disks large/zona occludens-1 (PDZ) domains and a tail ending in an e

147 irst two postsynaptic density-95/Discs large/zona occludens-1 (PDZ) domains of the scaffolding protei

148 postsynaptic density-95 (PSD-95)/discs large/zona occludens-1 (PDZ) interaction to AMPA receptor (AMP

149 ntains a postsynaptic density-95/Discs large/zona occludens-1 (PDZ) ligand, which is absent in EAAT2a

150 cking a Postsynaptic density 95, Disk large, Zona occludens-1 (PDZ) motif.

151 rich and postsynaptic density-95/Discs large/zona occludens-1 (PDZ)] protein erbin and delta-catenin,

152 l microscopy using the tight junction marker zona occludens-1 (ZO-1) and end-binding protein-1 (EB-1)

153 fragments yielded several proteins including zona occludens-1 (ZO-1), a structural protein previously

154 naptic density-95 (PSD-95)/Discs large (Dlg)/zona occludens-1 (ZO-1)] binding domain and localizes to

155 naptic density-95 (PSD-95)/Discs large (Dlg)/zona occludens-1 (ZO-1)] interactions with members of th

156 Connexin43 (Cx43) and zona occludens-1 are improperly localized in Akap9 mutan

157 postsynaptic density protein-95/discs large/zona occludens-1 domain (PDZ).

158 he NHERF1 postsynaptic density 95/disc-large/zona occludens-1 domain.

159 ntaining PostSynaptic Density-95/Discs large/Zona Occludens-1 domains, is an ortholog of the Drosophi

160 in and podocyte dysfunction, as evidenced by zona occludens-1 translocation to the membrane.

161 (postsynaptic density-95)/Discs large/ZO-1 (zona occludens-1) (PDZ) domain-containing protein, erbin

162 VI PDZ (postsynaptic density 95, Disk large, Zona occludens-1) adaptor protein synectin was essential

163 t junction proteins (occludin, claudin-1 and zona occludens-1) are internalized through an NF-kappaB-

164 ugh PDZ (postsynaptic density-95/Discs large/zona occludens-1) binding domain interactions and trigge

165 the PDZ (postsynaptic density-95/Discs large/zona occludens-1) binding domain, which interacts with T

166 is PDZ (postsynaptic density-95/Discs large/zona occludens-1) domain independent and is regulated by

167 SD) PDZ (postsynaptic density-95/Discs large/zona occludens-1) domain proteins that target AMPA recep

168 The PDZ (postsynaptic density-95/discs large/zona occludens-1) domain-based interactions play importa

169 93)/Chapsyn-110 is a PDZ (PSD-95/Discs large/zona occludens-1) domain-containing membrane-associated

170 the PDZ (postsynaptic density-95/Discs large/zona occludens-1) domain-containing protein interacting

171 g through two of its PDZ (PSD-95/Discs large/zona occludens-1) domains as well as intact N-terminal a

172 postsynaptic density-95 (PSD-95)/Discs large/zona occludens-1) domains that bind the synaptic scaffol

173 ization and the first two PDZ (PSD-95, Dlg1, zona occludens-1) domains, the PDZ3 and guanylate kinase

174 d a PDZ (postsynaptic density-95/Discs Large/zona occludens-1) scaffold protein, INAD (inactivation n

175 the PDZ (postsynaptic density-95/Discs large/zona occludens-1)-binding kinase/T-LAK (lymphokine-activ

176 the PDZ (postsynaptic density-95/Discs large/zona occludens-1)-containing protein dX11/Mint/Lin-10, w

177 he induction of the tight-junction molecules zona occludens-1, claudin 3, and claudin 5 and other pat

178 9, substrates of matrix metalloproteinase-9 (zona occludens-1, laminin), tissue inhibitor of matrix m

179 The expression of tight junction proteins zona occludens-1, occludin, claudin-1, and claudin-4, as

180 e found reduced expression of E-cadherin and zona occludens-1, whereas collagen-I and alpha-smooth mu

181 nolayer integrity and tight junction protein zona occludens-1, while the result for cells infected wi

182 g to the postsynaptic density-95/Discs large/zona occludens-1-binding domain of PTEN.

183 tein laminin, and the tight junction protein zona occludens-1.

184 postsynaptic density-95 (PSD-95)/Discs large/zona occludens-1] domains of membrane-associated guanyla

185 the PDZ [postsynaptic density-95/Discs large/zona occludens-1]-domain containing protein, protein int

186 uses its PDZ-binding motif to interact with zona occludens-2 (ZO-2) protein, which promotes YAP's tr

187 LIN-10, a postsynaptic density 95/disc-large/zona occludens-domain containing protein: GLR-1 accumula

188 loss of tight junction proteins occludin and zona occludin- 1 (ZO-1).

189 pithelial resistance (R(T)), dissociation of zona occludins 1 (ZO-1) from the tight junction complex,

190 a restrictive function in abduction; and the zona orbicularis could be evaluated equally well in any

191 erm initiate fertilization by binding to the zona pellucida (mZP), the specialized extracellular matr

192 of the transient immunocontraceptive porcine zona pellucida (PZP), and found that repeated vaccinatio

193 with high K(+) or by addition of solubilized zona pellucida (sZP).

194 At fertilization, mouse sperm bind to the zona pellucida (which consists of glycoproteins ZP1, ZP2

195 Proteins harboring a zona pellucida (ZP) domain are prominent components of v

196 The zona pellucida (ZP) domain is a bipartite protein struct

197 ations; the Tecta(L1820F,G1824D/+) mouse for zona pellucida (ZP) domain mutations causing stable mid-

198 h includes a domain of eight cysteines and a zona pellucida (ZP) domain.

199 proteins share a sequence designated as the zona pellucida (ZP) domain.

200 ics (OMD), cortical granule (CG) status, and zona pellucida (ZP) hardening as well as the integrity o

201 e involved directly in binding to the female zona pellucida (ZP) in a species-specific manner.

202 ge leading to conformational activation of a Zona Pellucida (ZP) polymerisation domain.

203 tilization the spermatozoon binds to the egg zona pellucida (ZP) via sperm receptor(s) and undergoes

204 expression of an antibody that binds to the zona pellucida (ZP), a glycoprotein matrix that surround

205 r matrix coating of the oocyte, known as the zona pellucida (ZP).

206 pecies-specific binding activity for the egg zona pellucida (ZP).

207 At fertilization, spermatozoa bind to the zona pellucida (ZP1, ZP2, ZP3) surrounding ovulated mous

208 unction of CPEB after pachytene, we used the zona pellucida 3 (Zp3) promoter to generate transgenic m

209 t an analysis of the pattern of evolution of Zona Pellucida 3 (ZP3), a protein present on the avian e

210 ld-type mice, we have generated human ORMDL3 zona pellucida 3 Cre (hORMDL3(zp3-Cre)) mice that overex

211 t resulted in human sperm penetration of the zona pellucida and accumulation in the perivitelline spa

212 oviducts causes premature degradation of the zona pellucida and embryo lysis, and wild-type embryos t

213 epare for the prospective penetration of the zona pellucida and fusion with the egg.

214 Acrosome reaction, binding to zona pellucida and fusion with the oolemma were lower in

215 MII) oocytes exhibited irregularities of the zona pellucida and meiotic spindle.

216 ly embryo transduction protocols (removal of zona pellucida and subzonal microinjection).

217 ole of ZP2 in mediating sperm binding to the zona pellucida and support a model in which human sperm-

218 ctions between the cumulus cells outside the zona pellucida and the oocyte within.

219 ting that the changes that take place in the zona pellucida at fertilization affected the interaction

220 Zona pellucida binding protein 1 (ZPBP1), a spermatid an

221 , regulatory inhibitor subunit 1B (PPP1R1B), zona pellucida binding protein 2 (ZPBP2), and gasdermin

222 family of zinc finger 3 (AIOLOS; IKZF3) and zona pellucida binding protein 2 (ZPBP2).

223 6p21 (HLA-DQA1), 9p24 (IL33), and 17q12-q21 (zona pellucida binding protein 2 [ZPBP2]-gasdermin A [GS

224 The mouse zona pellucida consists of three glycoproteins that are

225 Rgs2(-/-) eggs also underwent premature zona pellucida conversion in vivo.

226 ases that were sufficient to cause premature zona pellucida conversion.

227 des a light-responsive and membrane-anchored Zona Pellucida domain protein that supports light-depend

228 eins possess an N-terminal signal peptide, a zona pellucida domain, a consensus furin-like cleavage s

229 ct structure and contained peptides from the zona pellucida domain, which is involved in cell differe

230 DYF-7 contain, respectively, zonadhesin and zona pellucida domains, and DYF-7 self-associates into m

231 e shotgun cell adhesion protein gene and the zona pellucida family transmembrane protein gene, CG1319

232 w comparisons to be made with the process of zona pellucida formation in mammals.

233 coproteins in this regard because only human zona pellucida glycoprotein 3 (ZP3) and bovine proopiome

234 eta1,3-galactosyltransferase 1 (C1galt1)(FF):zona pellucida glycoprotein 3 Cre (ZP3Cre)] and Control

235 Each zona pellucida glycoprotein is synthesized in growing oo

236 Zona pellucida glycoproteins are responsible for species

237 ndings and reveal novel functions for murine zona pellucida glycoproteins.

238 These embryos do not hatch from the zona pellucida in vitro, fail to grow in culture, and ex

239 The mammalian zona pellucida is an egg extracellular matrix to which s

240 The mouse zona pellucida is composed of three glycoproteins (ZP1,

241 In mice, the zona pellucida is composed of three glycoproteins, but t

242 crosomes indicates that sperm binding to the zona pellucida is not sufficient to induce acrosome exoc

243 present in MVA and is incorporated into the zona pellucida matrix of transgenic mice.

244 en mutated to prevent incorporation into the zona pellucida matrix, complementing earlier studies ind

245 rane domain and assembled into the insoluble zona pellucida matrix.

246 Via its bipartite zona pellucida module (ZP-N/ZP-C), UMOD forms extracellu

247 that mediate recognition and binding to the zona pellucida of the egg are still not understood.

248 ctivity interferes with sperm binding to the zona pellucida of the ovum.

249 Recombinant ZP3R/sp56 bound to the zona pellucida of unfertilized eggs but not to 2-cell em

250 hey do not acrosome-react in response to egg zona pellucida proteins and have reduced fertilizing abi

251 However, the sperm proteins that recognise zona pellucida receptors remain contentious despite long

252 Sperm at the surface of the zona pellucida remained acrosome-intact for more than 2

253 tion in mammals is mediated primarily by the zona pellucida surrounding ovulated eggs.

254 rcome barriers and penetrate the cumulus and zona pellucida surrounding the egg.

255 The extracellular zona pellucida surrounds mammalian eggs and mediates tax

256 The extracellular zona pellucida surrounds ovulated eggs and mediates game

257 Specific binding of spermatozoa to the zona pellucida that surrounds mammalian eggs is a key st

258 at about 75-80% of the murine sperm bound to zona pellucida under well defined in vitro conditions is

259 n to the mammalian egg extracellular matrix (zona pellucida) to allow penetration of the egg coat.

260 To prevent polyspermy, the zona pellucida, a structure that surrounds mammalian egg

261 nteracts with the female reproductive tract, zona pellucida, and the oolemma.

262 ontact with the egg extracellular matrix, or zona pellucida, by the matrix glycoprotein ZP3.

263 In the absence of the zona pellucida, embryos lacking CTNNB1 undergo fission a

264 y a relatively thick extracellular coat, the zona pellucida, that plays vital roles during oogenesis,

265 o establish a tenacious association with the zona pellucida, yet they are capable of fertilization.

266 Many candidates have been proposed as zona pellucida-binding proteins.

267 es of capacitation, the ability to undergo a zona pellucida-evoked acrosome reaction, develops more s

268 cous media and in their ability to fertilize zona pellucida-intact eggs.

269 l contact between the sperm and the oocyte's zona pellucida.

270 blocked hatching of the blastocysts from the zona pellucida.

271 are incapable of fusing with eggs that lack zona pellucida.

272 protein in the egg's extracellular coat, the zona pellucida.

273 ole in mediating the binding of sperm to the zona pellucida.

274 sperm binding and/or penetration through the zona pellucida.

275 ted the interaction of this protein with the zona pellucida.

276 ADAM2 with ADAM3 in sperm binding to the egg zona pellucida.

277 pigs and named for its binding to the oocyte zona pellucida.

278 rom these mutant mice cannot bind to the egg zona pellucida.

279 phic sperm with reduced ability to penetrate zona pellucida.

280 ire more thrust to penetrate the cumulus and zona pellucida.

281 acellular matrix of mouse eggs, known as the zona pellucida.

282 hrough the oocyte prior to assembly into the zona pellucida.

283 mete recognition and penetration through the zona pellucida.

284 ion along the oviduct and penetration of the zona pellucida.

285 ncrease in cAMP levels, hyperactivation, the zona pellucidae-induced acrosome reaction, and most impo

286 Each zona protein contains a "zona domain" with eight conserv

287 Each zona protein undergoes extensive co- and post-translatio

288 These data suggest that the presence of four zona proteins are not sufficient to support human sperm

289 to play a role in the polymerization of the zona proteins into matrix filaments.

290 es the possibility that the presence of four zona proteins will support human sperm binding.

291 either alone or coexpressed with other human zona proteins.

292 arts with intact early blastocysts that upon zona removal can attach to the substrate and develop int

293 zona glomerulosa (ZG), zona fasciculata, and zona reticularis].

294 bthalamic nucleus (STN) and substantia nigra zona reticulata (SNR).

295 s derived from huZP2 rescue mice supports a ;zona scaffold' model of sperm-egg recognition in which i

296 t retain acrosome reacted spermatozoa on the zona surface prior to penetration.

297 e test set, sensitivity ranged from 67% (rio zona) to 100% (soft) while specificity ranged from 71% (

298 The structural changes in the zona upon fertilization are driven by the exocytosis of

299 O-1 siRNA delivery inside the blastomeres of zona-weakened embryos using electroporation not only kno

300 erm injection, and who received AH which the zona were completely removed.