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1 ppearing sperm are not able to penetrate the zona pellucida.
2 l binding, penetration, and signaling by the zona pellucida.
3 ciated, sperm-binding ligand on the ovulated zona pellucida.
4 red for secretion and incorporation into the zona pellucida.
5 required for mouse sperm binding to the egg zona pellucida.
6 nd an inner, thick extracellular matrix, the zona pellucida.
7 and secreted prior to incorporation into the zona pellucida.
8 binding sulfated carbohydrates of the oocyte zona pellucida.
9 exocytosis, enabling sperm to penetrate the zona pellucida.
10 nding sites were distributed over the entire zona pellucida.
11 zonadhesin with differing avidities for the zona pellucida.
12 edominant form capable of binding to the pig zona pellucida.
13 induced acrosome reaction, and penetrate the zona pellucida.
14 cles in ovaries isolated from mice lacking a zona pellucida.
15 e involved in the sperm's passage across the zona pellucida.
16 e distinct native B cell determinants of the zona pellucida.
17 rior to secretion and incorporation into the zona pellucida.
18 fic and human sperm do not bind to the mouse zona pellucida.
19 rus into the oviduct, and binding to the egg zona pellucida.
20 mete recognition and penetration through the zona pellucida.
21 ible existence of a P-selectin ligand in the zona pellucida.
22 -selectin ligand is expressed in the porcine zona pellucida.
23 ion along the oviduct and penetration of the zona pellucida.
24 triggered by adhesion to the mammalian egg's zona pellucida.
25 l contact between the sperm and the oocyte's zona pellucida.
26 rovulated, adult mZP3-/- females also lack a zona pellucida.
27 grown oocytes, the oocytes completely lack a zona pellucida.
28 blocked hatching of the blastocysts from the zona pellucida.
29 are incapable of fusing with eggs that lack zona pellucida.
30 protein in the egg's extracellular coat, the zona pellucida.
31 ole in mediating the binding of sperm to the zona pellucida.
32 sperm binding and/or penetration through the zona pellucida.
33 ted the interaction of this protein with the zona pellucida.
34 ADAM2 with ADAM3 in sperm binding to the egg zona pellucida.
35 pigs and named for its binding to the oocyte zona pellucida.
36 rom these mutant mice cannot bind to the egg zona pellucida.
37 phic sperm with reduced ability to penetrate zona pellucida.
38 ire more thrust to penetrate the cumulus and zona pellucida.
39 acellular matrix of mouse eggs, known as the zona pellucida.
40 hrough the oocyte prior to assembly into the zona pellucida.
41 osis event that occurs upon contact with the zona pellucida.
42 drastically deficient in adhesion to the egg zona pellucida (0.3% of wild type) and to the egg plasma
45 olled by regulatory sequences from the mouse zona pellucida 3 (Zp3) gene, which is normally expressed
46 unction of CPEB after pachytene, we used the zona pellucida 3 (Zp3) promoter to generate transgenic m
47 t an analysis of the pattern of evolution of Zona Pellucida 3 (ZP3), a protein present on the avian e
48 ld-type mice, we have generated human ORMDL3 zona pellucida 3 Cre (hORMDL3(zp3-Cre)) mice that overex
50 h an epitope-specific autoantibody to murine zona pellucida 3 induces severe ovarian disease in neona
51 lgus macaques immunized with monkey or human zona pellucida 3 peptide (pZP3) in adjuvant, developed T
53 forms immune complex with endogenous ovarian zona pellucida 3, and a pathogenic CD4(+) T cell respons
54 ility and, given the conserved nature of the zona pellucida, a similar phenotype is expected in other
56 as a template the structure of CUB domain in zona pellucida adhesion protein PSP-I/PSP-II from porcin
58 t resulted in human sperm penetration of the zona pellucida and accumulation in the perivitelline spa
61 oviducts causes premature degradation of the zona pellucida and embryo lysis, and wild-type embryos t
64 that they demonstrate maximal binding to the zona pellucida and greatly increased sensitivity to iono
65 tein specifically reacted with ZP3 of oocyte zona pellucida and its affinity-purified antibodies comp
68 ole of ZP2 in mediating sperm binding to the zona pellucida and support a model in which human sperm-
72 st undergo capacitation in order to bind the zona pellucida and undergo a Ca(2+) ionophore-induced ac
73 P3, human sperm did not bind to the chimeric zona pellucida, and notwithstanding the absence of mouse
74 he sperm is induced by sperm adhesion to the zona pellucida, and signaling in the egg by gamete fusio
76 es is known to have binding activity for the zona pellucida, and this action may serve to anchor sper
78 ting that the changes that take place in the zona pellucida at fertilization affected the interaction
81 , regulatory inhibitor subunit 1B (PPP1R1B), zona pellucida binding protein 2 (ZPBP2), and gasdermin
83 6p21 (HLA-DQA1), 9p24 (IL33), and 17q12-q21 (zona pellucida binding protein 2 [ZPBP2]-gasdermin A [GS
84 s that rabbit proacrosin contains a specific zona pellucida binding site and that the loop containing
85 ike the latter, does not inhibit human sperm-zona pellucida binding under hemizona assay conditions.
86 ed, there was no significant effect on sperm-zona pellucida binding; however, fertilization was reduc
87 uding motility, capacitation, binding to the zona pellucida, binding to the oocyte membrane, and pene
98 channels during gamete interaction inhibits zona pellucida-dependent Ca2+ elevations, as demonstrate
100 lass, DPY, and terminating in a crosslinking zona pellucida domain and membrane anchor sequence.
101 des a light-responsive and membrane-anchored Zona Pellucida domain protein that supports light-depend
102 eins possess an N-terminal signal peptide, a zona pellucida domain, a consensus furin-like cleavage s
103 ct structure and contained peptides from the zona pellucida domain, which is involved in cell differe
104 DYF-7 contain, respectively, zonadhesin and zona pellucida domains, and DYF-7 self-associates into m
107 es of capacitation, the ability to undergo a zona pellucida-evoked acrosome reaction, develops more s
108 e shotgun cell adhesion protein gene and the zona pellucida family transmembrane protein gene, CG1319
112 e normal when null spermatozoa were added to zona pellucida-free eggs, but in the presence of the ext
114 he ability of Tenr mutant sperm to fertilize zona pellucida-free oocytes and to bind to, but not fert
115 sults demonstrate that a genetic defect in a zona pellucida gene causes infertility and, given the co
117 coproteins in this regard because only human zona pellucida glycoprotein 3 (ZP3) and bovine proopiome
118 eta1,3-galactosyltransferase 1 (C1galt1)(FF):zona pellucida glycoprotein 3 Cre (ZP3Cre)] and Control
122 to be a cell-surface receptor for the murine zona pellucida glycoprotein ZP3, standard immunoelectron
124 protein that functions as a receptor for the zona pellucida glycoprotein, ZP3, and as an inducer of t
125 specific oligosaccharide ligands within the zona pellucida glycoprotein, ZP3, via beta1,4-galactosyl
127 ctin glycoprotein ligand-1 (PSGL-1) and from zona pellucida glycoproteins of porcine oocytes indicate
128 of these female fertilization proteins, the zona pellucida glycoproteins ZP2 and ZP3, are part of th
129 mZP3 (approximately 83 000 Mr), one of three zona pellucida glycoproteins, and once bound undergo the
132 This extracellular matrix is known as the zona pellucida in eutherian mammals and consists of thre
134 tively induced Ab to ZP3335-342 bound to the zona pellucida in the functional and degenerative ovaria
140 e oocytes and to bind to, but not fertilize, zona pellucida-intact oocytes suggests that the normal-a
142 s that sp56 may function in acrosomal matrix-zona pellucida interactions during and immediately follo
143 l adhesion event between mouse sperm and the zona pellucida is a high affinity event which is suffici
154 crosomes indicates that sperm binding to the zona pellucida is not sufficient to induce acrosome exoc
155 embryos, these data are consistent with the zona pellucida maintaining interactions between granulos
156 nal-vesicle-intact oocytes but that lacked a zona pellucida matrix and had a disorganized corona radi
158 en mutated to prevent incorporation into the zona pellucida matrix, complementing earlier studies ind
161 erm initiate fertilization by binding to the zona pellucida (mZP), the specialized extracellular matr
163 in which the supramolecular structure of the zona pellucida necessary for sperm binding is modulated
174 hey do not acrosome-react in response to egg zona pellucida proteins and have reduced fertilizing abi
175 luorophore conjugated to solubilized porcine zona pellucida proteins to observe zona receptors on liv
176 ass spectrometric analysis of the native rat zona pellucida proteome (defined as the fraction of the
177 of the transient immunocontraceptive porcine zona pellucida (PZP), and found that repeated vaccinatio
178 However, the sperm proteins that recognise zona pellucida receptors remain contentious despite long
180 e folliculogenesis and those that encode the zona pellucida required for fertilization and early embr
181 present in a number of proteins such as the zona pellucida sperm binding proteins, and uromodulin, I
182 t occur until the morula stage, and that the zona pellucida suffices to maintain blastomere proximity
194 ocytes and secreted to form an extracellular zona pellucida that mediates sperm binding and fertiliza
196 Mammalian oocytes synthesize and secrete a zona pellucida that surrounds the growing oocytes, ovula
197 ZP3 is a protein in the mammalian egg coat (zona pellucida) that binds sperm and stimulates acrosoma
198 urrounded by a thick extracellular coat, the zona pellucida, that plays important roles during early
199 y a relatively thick extracellular coat, the zona pellucida, that plays vital roles during oogenesis,
200 ce of BSA, as measured by the ability of the zona pellucida to induce the acrosome reaction and by su
201 required for the structural integrity of the zona pellucida to minimize precocious hatching and reduc
202 n to the mammalian egg extracellular matrix (zona pellucida) to allow penetration of the egg coat.
203 at about 75-80% of the murine sperm bound to zona pellucida under well defined in vitro conditions is
205 Although porcine sperm first contact the zona pellucida via their plasma membrane, the regions of
206 e sperm were able to fertilize eggs once the zona pellucida was removed but displayed persistent abno
207 At fertilization, mouse sperm bind to the zona pellucida (which consists of glycoproteins ZP1, ZP2
208 P-ZP3 associate with the inner aspect of the zona pellucida, which is distinct from the plasma membra
209 o establish a tenacious association with the zona pellucida, yet they are capable of fertilization.
210 odular extracellular segment that includes a zona pellucida (ZP) domain and several plasminogen N-ter
213 ations; the Tecta(L1820F,G1824D/+) mouse for zona pellucida (ZP) domain mutations causing stable mid-
214 f protein, bone morphogenetic protein-1) and zona pellucida (ZP) domain-containing protein we find pr
218 f these proteins is related to mammalian egg zona pellucida (ZP) glycoproteins ZP1-3 and possesses an
219 ics (OMD), cortical granule (CG) status, and zona pellucida (ZP) hardening as well as the integrity o
220 ics (OMD), cortical granule (CG) exocytosis, zona pellucida (ZP) hardening, and spindle/chromatin int
223 ) is essential to fertilization, and the egg zona pellucida (ZP) is generally believed to be an in vi
226 tilization the spermatozoon binds to the egg zona pellucida (ZP) via sperm receptor(s) and undergoes
227 tion, mammalian sperm must first bind to the zona pellucida (ZP), a glycoprotein matrix surrounding t
228 expression of an antibody that binds to the zona pellucida (ZP), a glycoprotein matrix that surround
230 spermatozoa bound tightly or penetrated the zona pellucida (ZP), and fewer underwent acrosome reacti
231 alpha-EC) binds to the microvillar region of zona pellucida (ZP)-free eggs, the region of the membran
234 At fertilization, spermatozoa bind to the zona pellucida (ZP1, ZP2, ZP3) surrounding ovulated mous
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