ライフサイエンスコーパス: zonadhesin

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1 fic manner was recently identified and named zonadhesin.

2 not inhibit adhesion of spermatozoa lacking zonadhesin.

3 We have now cloned a cDNA for mouse zonadhesin (16.4 kb), and it demonstrates a large specie

4 DEX-1 and DYF-7 contain, respectively, zonadhesin and zona pellucida domains, and DYF-7 self-as

5 t autoantibodies to an orchitogenic antigen (zonadhesin), and develop CD4 T-cell- and antibody-depend

6 tigen mu receptor, and mucin-like domains in zonadhesin are rapidly evolving and, thus, may be involv

7 Zonadhesin-binding sites were distributed over the entir

8 produced by targeted disruption of Zan that zonadhesin confers species specificity to sperm-ZP adhes

9 Additionally, mouse zonadhesin contains a mucin-like domain and a domain hom

10 e p105/45 form constituted a minority of all zonadhesin forms in sperm membrane fractions, it was the

11 The active form of pig zonadhesin from capacitated, epididymal spermatozoa comp

12 ange chromatography resolved active, p105/45 zonadhesin from the p60-90 inactive forms.

13 ucin, D-, and EGF domains suggest that mouse zonadhesin functions in multiple cell adhesion processes

14 Remarkably, however, loss of zonadhesin increased adhesion of mouse spermatozoa to pi

15 Zonadhesin is a male reproductive protein localized on t

16 Zonadhesin is a mosaic protein in sperm membrane fractio

17 In mammals, the sperm acrosomal protein zonadhesin is a rapidly evolving molecule with species-s

18 Zonadhesin is a recently discovered sperm membrane prote

19 t detection and characterization of multiple zonadhesin isoforms in freshly ejaculated cells.

20 h family and the Tecta(C1619S/+) mouse for a zonadhesin-like (ZA) domain mutation responsible for pro

21 Zonadhesin localized to the apical head of pig spermatoz

22 The gene for zonadhesin maps to chromosome 5 in the mouse (Zan) and t

23 We conclude that zonadhesin mediates species-specific ZP adhesion, and Za

24 Expression of mouse zonadhesin mRNA is evident only within the testis, and t

25 d a partial von Willebrand D domain of mouse zonadhesin on the surface of living, motile cells.

26 Willebrand D0-D1, D1, and D3 domains of pig zonadhesin recognized p105, p45, and additional M(r) 60,

27 Without disulfide bond reduction some zonadhesin was M(r) > or = 300,000, including M(r) 300,0

28 n the sperm head generates multiple forms of zonadhesin with differing avidities for the zona pelluci

29 election and positive selection occurring in zonadhesin (ZAN) within human populations.

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