ライフサイエンスコーパス: zonula occludens

1 s is the postsynaptic density 95/discs large/zonula occludens 1 (PDZ) domain, involved in scaffolding

2 and an integrated component of the occludin/zonula occludens 1 (ZO-1) adhesion complex at the BTB, s

3 se cells express the tight junction proteins zonula occludens 1 (ZO-1) and occludin and form a barrie

4 s of the tight junctional complex, including zonula occludens 1 (ZO-1) and occludin.

5 We previously found that depleting zonula occludens 1 (ZO-1) family proteins in MDCK cells

6 udin-18 to interact with a scaffold protein, zonula occludens 1 (ZO-1), demonstrating that one claudi

7 e 2), and the outer limiting membrane (OLM) (zonula occludens 1 and occludin).

8 nolocalization of the tight junction protein zonula occludens 1 and of the junction-associated actin

9 Reduced zonula occludens 1 expression was observed after HbG tra

10 he GCD had a small decrease in expression of zonula occludens 1 in SB mucosa and significant decrease

11 n claudin-1 protein level, relocation of the zonula occludens 1 protein (ZO-1) to the TJ, and redistr

12 so shown by the disengagement of the protein zonula occludens 1 protein from the tight junctional com

13 Zonula occludens 1 protein redistribution after bacteria

14 In contrast, zonula occludens 1 was well preserved along intercellula

15 including MUPP1 (multi-PDZ protein-1), ZO1 (zonula occludens 1), and Af6.

16 nd eosin), apoptosis (M30), tight junctions (zonula occludens 1), and neutrophil influx (myeloperoxid

17 ssion of the tight junction scaffold protein zonula occludens 1, and disrupted junctional localizatio

18 Upon calcium repletion, occludin, zonula occludens 1, and E-cadherin failed to redistribut

19 smoplakin, plakoglobin, claudin-4, occludin, zonula occludens 1, and tricellulin were decreased at ce

20 creased, transient disruption of claudin-18, zonula occludens 1, and zonula occludens 2 localization

21 a and significant decreases in expression of zonula occludens 1, claudin-1, and occludin in rectosigm

22 sion of endothelial tight junction proteins (zonula occludens 1, claudin-5, and occludin), astrocyte

23 nce of Ca2+ as revealed by the relocation of zonula occludens 1, the establishment of transepithelial

24 al effects on the cytoplasmic plaque protein zonula occludens 1.

25 pool of ROCK with the tight junction protein zonula occludens 1.

26 expression of the TJ molecules occludin and zonula occludens 1.

27 ly restored the expression of E-cadherin and zonula occludens 1.

28 second post-synaptic density-95/discs large/zonula occludens-1 (PDZ) domain of the human protein tyr

29 the post synaptic density, discs large, and zonula occludens-1 (PDZ) domain protein SAP97 is a compo

30 ffolding postsynaptic density-95/disks large/zonula occludens-1 (PDZ) domain-containing protein melan

31 single post-synaptic density-95/discs large/zonula occludens-1 (PDZ) domain.

32 ontaining postsynaptic density 95/disc large/zonula occludens-1 (PDZ) domains have been shown to play

33 three postsynaptic density 95, discs large, zonula occludens-1 (PDZ) domains to engage the transport

34 postsynaptic density protein 95/disks large/zonula occludens-1 (PDZ)-domain proteins and A-kinase an

35 ctomyosin ring (PAMR), and redistribution of zonula occludens-1 (ZO-1) and cadherins.

36 lantation, we investigated the expression of zonula occludens-1 (ZO-1) and E-cadherin, two molecules

37 nal barrier using the tight junction markers zonula occludens-1 (ZO-1) and occludin.

38 3 with retention of Cx43 scaffolding protein Zonula Occludens-1 (ZO-1) at cell surfaces, suggesting t

39 ning the steady-state levels of occludin and zonula occludens-1 (ZO-1) at the BTB site via the p38 MA

40 cing the steady-state levels of occludin and zonula occludens-1 (ZO-1) at the BTB via the p38 mitogen

41 protection against IL-1beta-induced loss of zonula occludens-1 (ZO-1) at the tight junctions and alt

42 Zonula occludens-1 (ZO-1) binds the carboxy terminus of

43 nction (TJ)-associated proteins occludin and zonula occludens-1 (ZO-1) following stimulation of brain

44 s serine and threonine residues, we screened zonula occludens-1 (ZO-1) immunoprecipitates for the exi

45 ding G proteins) have been co-localized with zonula occludens-1 (ZO-1) in the tight junction of epith

46 lar, c-Src can disrupt the connexin43 (Cx43)-zonula occludens-1 (ZO-1) interaction, leading to down-r

47 a hallmark of polarized epithelial cells and zonula occludens-1 (ZO-1) is a known key regulator of ti

48 Zonula occludens-1 (ZO-1) is a submembrane scaffolding p

49 calcium levels, the tight junctional protein Zonula Occludens-1 (ZO-1) is distributed intracellularly

50 s also a marked decrease in beta-catenin and zonula occludens-1 (ZO-1) localization to the intercalat

51 c-Src binds to the Cx43 scaffolding protein zonula occludens-1 (ZO-1) with a higher affinity than do

52 sed expression of TTF-1, aquaporin-5 (AQP5), zonula occludens-1 (ZO-1), and cytokeratins.

53 used to assay for the presence of occludin, zonula occludens-1 (ZO-1), cadherin-5, and beta-catenin.

54 MP22 and known junctional proteins including zonula occludens-1 (ZO-1), occludin, and claudin-5.

55 ial cell-cell contacts in close proximity to zonula occludens-1 (ZO-1), oxLDL treatment induced a dis

56 o activate tight-junction-associated protein Zonula Occludens-1 (ZO-1), which in turn plays a critica

57 ion of another element of the E-cad complex, zonula occludens-1 (ZO-1).

58 ght junction membrane proteins, occludin and zonula occludens-1 (ZO-1).

59 n E-cadherin and tight junction (TJ) protein Zonula Occludens-1 (ZO-1).

60 tight junction proteins such as occludin and zonula occludens-1 (ZO-1).

61 d with the tight junction-associated protein zonula occludens-1 (ZO-1).

62 ion of tight junction proteins, occludin and zonula occludens-1 (ZO-1).

63 The junctional proteins zonula occludens-1 and beta-catenin stained positively i

64 the dexamethasone-stimulated localization of zonula occludens-1 and beta-catenin to sites of cell-cel

65 n levels of tight junction proteins, such as zonula occludens-1 and Occludin.

66 actin and tight-junction-associated proteins zonula occludens-1 and occludin.

67 striking upregulation of dermal N-cadherin, Zonula Occludens-1 and the gap junction protein Connexin

68 sed paracellular flux, and redistribution of zonula occludens-1 and VE-cadherin but failed to induce

69 to the postsynaptic density-95, discs large, zonula occludens-1 binding motif in the C terminus of KV

70 d in large gap junction plaques, had reduced zonula occludens-1 binding, and displayed increased stab

71 In addition, zonula occludens-1 co-localized with Muller cells within

72 ell adhesion via its effects on the occludin-zonula occludens-1 complex.

73 ression of epithelial markers E-cadherin and Zonula occludens-1 decreased while expression of mesench

74 calization with both endogenous occludin and zonula occludens-1 demonstrating that exogenous occludin

75 uated cytokine-induced hyperpermeability and zonula occludens-1 downregulation in NS-398-treated C2BB

76 of Id1 suppressed epithelial E-cadherin and zonula occludens-1 expression.

77 ed FD4 permeability and reduced occludin and zonula occludens-1 expression.

78 with HDM-induced AR, with lower occludin and zonula occludens-1 expression.

79 correlated with an increase in claudin-5 and zonula occludens-1 immunofluorescence at cell-cell contr

80 t was associated with a potent protection of zonula occludens-1 linear border pattern in endothelial

81 Zonula occludens-1 molecules are also highly dynamic in

82 osophila disc large tumor suppressor (Dlg1), zonula occludens-1 protein (zo-1) (PDZ) domain proteins.

83 phosphorylation regulates the known role of zonula occludens-1 protein (ZO-1) in gap junction (GJ) f

84 n addition, immunofluorescent assessments of zonula occludens-1 tight junction protein cellular distr

85 e PDZ (postsynaptic density 95, discs large, zonula occludens-1) domains and other regions.

86 ing PDZ (postsynaptic density 95/discs large/zonula occludens-1) domains are believed to provide rela

87 PDZ (post-synaptic density-95/discs large/zonula occludens-1) domains are small, protein-protein b

88 PDZ (Post-Synaptic Density-95, Discs Large, Zonula Occludens-1) domains followed by a short carboxyl

89 creased tight junction protein (occludin and zonula occludens-1) expression.

90 gulated by several PDZ (PSD-95, discs large, zonula occludens-1) proteins, which mediate protein-prot

91 (connexin 43), Cx45 (connexin 45), and ZO-1 (zonula occludens-1) were identified as novel mRNA target

92 e synthetase, expressed by Muller cells, and zonula occludens-1, a tight-junction protein.

93 Knockdown of Cx43 and N-cadherin, but not Zonula Occludens-1, accelerated cell migration in a scra

94 ecreased levels of alanine aminotransferase, zonula occludens-1, and interleukin-1beta compared with

95 lit diaphragm-associated protein P-cadherin, zonula occludens-1, and nephrin, a change consistent wit

96 ychaetoid (pyd), the Drosophila homologue of Zonula Occludens-1, are characterized by two phenotypes

97 ted proteins, including occludin, claudin-5, zonula occludens-1, junctional adhesion molecule-A, and

98 In vivo, in addition to loss of nephrin and zonula occludens-1, mesenchymal markers such as desmin,

99 nic epithelial cells such as cytokeratin 18, zonula occludens-1, mucins-1 and -2, antigen A33, and di

100 ed expression of the tight junction proteins zonula occludens-1, occludin, and claudin-1 in the ileum

101 e expression of junctional proteins, such as zonula occludens-1, occludin, and claudin-4.

102 representative tight junction proteins (ie, zonula occludens-1, Occludin, Claudin-1) that critically

103 and tracer permeability, junctional protein zonula occludens-1, occludin, claudins and E-cadherin ex

104 binding post-synaptic density-95/discs large/zonula occludens-1-domain-containing (PDZ) proteins and

105 ce staining of the TJ molecules occludin and zonula occludens-1.

106 foil factor 3, Toll-interacting protein, and zonula occludens-1.

107 protein kinase and increasing expression of zonula occludens-1.

108 protein kinase and increasing expression of zonula occludens-1.

109 audin-1, junctional adhesion molecule-A, and zonula occludens-1.

110 Zonula occludens-1/NF-kappaB/CXCL8: a new regulatory axi

111 d suppression of TJ transcripts, claudin-11, zonula-occludens-1 (ZO-1) and tricellulin in human SC en

112 The scaffold protein zonula-occludens-1 (ZO-1), a member of the MAGUK family

113 ption of claudin-18, zonula occludens 1, and zonula occludens 2 localization to lung tight junctions

114 specifically interact with the protein ZO-2 (zonula occludens-2).

115 omplete dissolution of some tight junctions (zonula occludens) and zonula adherens without loss of de

116 unohistochemistry showed that E-cadherin and Zonula occludens are down-regulated in MCF-7/CXCR4-Delta

117 Staining for the zonula occludens complex (ZO-1) and adherens complex (al

118 e protein, Crumbs, and two PSD95/discs large/zonula occludens domain proteins, protein associated wit

119 The His-ZO-1-PDZ1 (first PDZ domain of zonula occludens) domain that binds Neph1-CD was also an

120 g PDZ (postsynaptic density-95, discs large, zonula occludens) domains play a general role in recruit

121 The scaffold proteins of the zonula occludens family are required for the correct loc

122 The tight junction, or zonula occludens, is a specialized cell-cell junction th

123 nction is accomplished in vertebrates by the zonula occludens, or tight junction.

124 ial cells, because the presence of an intact zonula occludens prevented passage.

125 lial antigen 2), blood-retinal barrier [anti-zonula occludens protein 1 (ZO-1) and anti-occludin], an

126 llagen-IV, laminin, claudin-5, occludin, and zonula occludens protein 1 was also better preserved in

127 s no obvious change of claudin-1, claudin-4, zonula occludens protein 1, and zonula occludens protein

128 , claudin-4, zonula occludens protein 1, and zonula occludens protein 2 expressions was observed.

129 rotein) PDZ (postsynaptic density/disc large/zonula occludens) protein binding assays, that these sol

130 audins binds to the N-terminal PDZ domain of zonula occludens proteins (PDZ1).

131 Zonula occludens proteins are multidomain proteins usual

132 n of occludin but no change in expression of zonula occludens proteins ZO-1 and -2.

133 MDCKII cells, this complex localizes to the zonula occludens (tight junctions) and appears to regula

134 Zonula occludens toxin (Zot) is an enterotoxin elaborate

135 ed that these structures can be modulated by Zonula occludens toxin (Zot).

136 The intestinal secretion induced by zonula occludens toxin follows the opening of tight junc

137 Zonula occludens toxin induced a time- and dose-dependen

138 Zonula occludens toxin is a novel toxin elaborated by Vi

139 The tissues were also fixed, exposed to zonula occludens toxin, and processed for fluorescence m

140 elial cells is regulated by tight junctions (zonula occludens), we wished to determine whether they a

141 e structural and functional integrity of the zonula occludens (ZA) induced by ATP depletion of renal

142 We have determined that the zonula occludens (ZO) family of TJ plaque proteins seque

143 ability of this barrier are dependent on the zonula occludens (ZO) membrane-associated guanylate kina

144 The zonula occludens (ZO) protein-1 is a membrane-associated

145 Thus the manner in which the zonula occludens (ZO) proteins multimerize has implicati

146 Specific TJ proteins, such as zonula occludens (ZO) proteins, localize not only at the

147 ility of these junctions is dependent on the zonula occludens (ZO) proteins, members of the membrane-

148 The zonula occludens (ZO) subfamily of membrane-associated g

149 The zonula occludens (ZO)-1 and -2 proteins have context-dep

150 Zonula occludens (ZO)-1 is a member of the MAGUK (membra

151 The tight junction (TJ) protein zonula occludens (ZO)-1 links the intracellular domain o

152 Here, we show that zonula occludens (ZO)-1 localizes preferentially to the

153 l tight junction proteins, namely, occludin, zonula occludens (ZO)-1, and ZO-2 in the caveolar fracti

154 xpression of occludin, claudin-1, claudin-5, zonula occludens (ZO)-1, and ZO-2, and a TJ accessory pr

155 nucleotide exchange factor (GEF) 2, but not zonula occludens (ZO)-1, in epithelial cells, and these

156 nges in the distribution of the TJ proteins, zonula occludens (ZO)-1, ZO-2, and cingulin, examination

157 l adhesion molecule-A (JAM)-A, occludin, and zonula occludens (ZO)-1.

158 In cell culture zonula occludens (ZO)-family proteins are important for

159 ignificant disruption of actin filaments and zonula occludens (ZO-1), and a decrease in transepitheli