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2 udies have been conducted to understand post-zygotic accumulation of mutations in cells of the health
7 separate chromosomes, are each linked with a zygotic antidote able to rescue maternal-effect lethalit
8 nge will have a larger effect on eroding pre-zygotic barriers (eco-geographical isolation and phenolo
9 seen in naturally produced hybrids where pre-zygotic barriers are the largest contributors to reprodu
11 graphical isolation and phenology) than post-zygotic barriers, shifting the relative importance of th
13 tide family is required for formation of the zygotic basal cell lineage and proembryo patterning in A
17 rrors in meiosis, mitotic errors during post-zygotic cell division contribute to pervasive aneuploidy
18 of mouse PGC specification and suggest that zygotic cell signaling may direct PGC specification in G
20 chibana-Konwalski shows that a Chk1-mediated zygotic checkpoint monitors the cohesin-dependent repair
24 ylated, but the loci are demethylated during zygotic cleavage stages to precisely the state observed
25 isabling pancreatogenesis in pig embryos via zygotic co-delivery of Cas9 mRNA and dual sgRNAs targeti
28 henotype of zebrafish that lack maternal and zygotic contributions of the Hh signaling transducer Smo
29 ent insights into the balance of gametic and zygotic contributions to imprint specification should he
36 indicate the events leading to noncanonical zygotic cytokinesis, segregating the parental genomes in
39 s essential for proper interpretation of the zygotic Decapentaplegic (Dpp) morphogen gradient that pa
44 However, proof that PAWP initiates mammalian zygotic development relies on demonstration that it acts
45 gulatory genes appear to function similar to zygotic development, making somatic embryogenesis a valu
50 ou5f1 and SoxB1 are required to initiate the zygotic developmental program and induce clearance of th
52 at Etv2 protein levels persisted in maternal-zygotic dicer1 mutant embryos, suggesting that microRNAs
56 usly, we discovered that ZFP57 is a maternal-zygotic effect gene, and it maintains DNA methylation ge
58 ore-derived embryos and Arabidopsis thaliana zygotic embryos, and demonstrate that AUX1, LAX1 and LAX
61 ish tp53(M214K)(w/m) line and the ewsa(w/m), zygotic ewsa(m/m), and Maternal-Zygotic (MZ) ewsa(m/m) l
65 and are actively suppressed by parental and zygotic factors such as the conserved exonuclease ERI-1.
66 ecular "hand-off" between maternal Foxh1 and zygotic Foxa at these CRMs to maintain enhancer activati
68 layer specification is tightly coupled with zygotic gene activation and, in most metazoans, is depen
69 nal transcript turnover and failure in early zygotic gene activation appeared to associate with the a
70 of aneuploidy, but does not appear to affect zygotic gene activation at the two-cell stage or lineage
71 histone locus body (HLB) assembles prior to zygotic gene activation early during development and con
73 e revised rates permit substantial levels of zygotic gene activity prior to the mid-blastula transiti
74 ility is counteracted by PI(3,4,5)P3 and the zygotic gene bottleneck, which acts by limiting myosin r
75 embryos, haploids exhibited a delay in both zygotic gene expression and cell cycle lengthening, whil
78 nce sex determination in C. elegans requires zygotic gene expression to read the sex chromosome karyo
81 MBT embryos leads to premature activation of zygotic gene transcription and early onset of longer cel
82 N/C volume ratios showed early expression of zygotic genes and premature lengthening of cell cycles.
89 is not required for the activation of early zygotic genes, but is essential to implement nodal activ
96 example of the interweaving of maternal and zygotic genetic functions during the egg-to-embryo trans
97 action and applied the system to investigate zygotic genome activation (ZGA) and RNA localization in
98 bryo, global epigenetic changes occur during zygotic genome activation (ZGA) at the 2-cell stage.
99 ernal factors direct development and trigger zygotic genome activation (ZGA) at the maternal-to-zygot
104 of cellular genes normally restricted to the zygotic genome activation (ZGA) period also become up-re
110 is likely reflects its preparation for early zygotic genome activation and comparatively accelerated
111 hat transcription factor Nfya contributes to zygotic genome activation and DHS formation at the 2-cel
112 lases KDM5A and KDM5B is required for normal zygotic genome activation and is essential for early emb
113 gulated by inherited maternal gene products: zygotic genome activation commences at the tenth cell cy
115 promoters are differentially used during the zygotic genome activation, presumably because they have
121 se knockout embryos, we demonstrate that the zygotic genome folds into loops and domains that critica
123 Delayed transcriptional activation of the zygotic genome is a nearly universal phenomenon in metaz
124 During this developmental transition, the zygotic genome is largely transcriptionally quiescent an
126 stigated whether TDCPP altered the status of zygotic genome methylation during early zebrafish embryo
128 most part, been negative in vivo and because zygotic genome remethylation is a key biological event d
129 Using these zygotes, we found that when the zygotic genome was replaced with that of a somatic cell,
130 TDCPP-induced delays in remethylation of the zygotic genome, a mechanism that may be associated with
131 cell-specific differential activation of the zygotic genome, and identify genes that were previously
132 some transcripts must derive from the early zygotic genome, implying that the prevailing model does
140 on of a hesx1 morpholino into a 'sensitised' zygotic headless (tcf3) mutant background leads to sever
144 t animals, including mice, appear to utilize zygotic inductive cell signals to specify germ cells dur
152 ryo fate and auxin markers, we show that the zygotic-like pathway requires polar auxin transport for
153 spore embryos are formed via two pathways: a zygotic-like pathway, characterized by initial suspensor
154 entify missing sequences, and then allow the zygotic macronucleus to reproduce the same deletions.
155 loops, but not compartments, are present in zygotic maternal chromatin, suggesting that these are ge
160 ocked down have normal activation of several zygotic mesoderm, endoderm and ectoderm patterning genes
162 S-derived BWMs can be restored by preventing zygotic MOM-2 expression, which removes the inhibitory s
163 require precise spatiotemporal expression of zygotic MOM-2, which is dependent upon two distinct Notc
165 These results illustrate the impact of post-zygotic mosaicism on disease risk, could explain why mal
166 Furthermore, accumulation of translatable zygotic mRNAs is minimal in 1-cell embryos because of in
168 Elimination of Gdf3 in oocytes of maternal-zygotic mutants results in embryonic lethality that can
169 nos 3' UTR led to the generation of maternal-zygotic mutants, as well as increased viability and decr
171 gives insight into the contribution of post-zygotic mutations and population-specific mutational pro
172 parent-offspring trios, suggesting that post-zygotic mutations contribute little to the human germ-li
173 ructural mosaic abnormalities are large post-zygotic mutations present in a subset of cells and have
176 e ewsa(w/m), zygotic ewsa(m/m), and Maternal-Zygotic (MZ) ewsa(m/m) lines all displayed zero to low i
180 The developmental failure of Cdx2 maternal-zygotic null embryos is associated with cell death and f
181 rlier lethal phenotype than observed in Cdx2 zygotic null embryos that develop until the late blastoc
182 ssessment of a large cohort of Cdx2 maternal-zygotic null embryos, all individually filmed, examined
183 dges meet, closely resemble defects in canoe zygotic null mutants and in embryos lacking the actin re
185 ouse embryos deficient for both maternal and zygotic Oct4 suggest that it is dispensable for zygote f
187 of the information dynamics in the maternal-zygotic one-eyed pinhead mutant, which is defective in m
189 ctor responsible for initiating the earliest zygotic patterns along the dorsal-ventral axis, have rev
190 ula stage onwards and that both maternal and zygotic pools of Cdx2 are required for correct pre-impla
191 Ectopic maternal expression of an early zygotic pre-mRNA was sufficient to suppress its splicing
198 embryonic loss-of-gene function in maternal-zygotic ptk7 mutants (MZptk7) leads to vertebral anomali
203 rm band elongation, and is likely to require zygotic reprogramming rather than alternative deployment
205 oci could not be attributed entirely to post-zygotic selective loss of F2 individuals that failed to
206 ed to the sex-determining region because the zygotic sex ratio is determined by the relative number a
211 Focussing on the liver and eye, we show that zygotic Ssrp1a is essential for proliferation and differ
212 f the maternal genome, and by the end of the zygotic stage the genome-wide methylation level in male
213 he methylome of human early embryos from the zygotic stage through to post-implantation by reduced re
214 we focus on hermaphrodites that nourish post-zygotic stages, e.g. flowering plants and internally fer
215 development of organisms starting from their zygotic state involves a tight integration of the myriad
221 distinct mechanisms regulating the onset of zygotic transcription and changes to the cell cycle duri
222 s gambiae Yob, activated at the beginning of zygotic transcription and expressed throughout a male's
223 ryos can partially proceed in the absence of zygotic transcription and is a multi-level hierarchical
224 sely, decreasing the N/C volume ratio delays zygotic transcription and leads to additional rapid cell
225 e-associated positioning at promoters before zygotic transcription and subsequent transcription-indep
226 rrently experiences a receding first wave of zygotic transcription and the surge of a massive second
227 ry for the establishment of proper levels of zygotic transcription at the MBT, and that genes activat
228 smic ratio and depended on the activation of zygotic transcription at the MBT, including expression o
229 on is the midblastula transition (MBT), when zygotic transcription begins and cell cycles elongate.
231 wing this period of transcriptional silence, zygotic transcription begins, the maternal influence on
236 ion of maternal transcripts; a broad wave of zygotic transcription detectable as early as the seventh
237 de CENP-A incorporation in progeny, and that zygotic transcription during early embryogenesis remodel
240 e of alternate cell divisions we manipulated zygotic transcription induced by beta-catenin or downreg
241 embryo titrate out these factors, leading to zygotic transcription initiation, presumably in response
242 al mRNAs are required for different modes of zygotic transcription initiation, which is not simply de
246 The results also suggest that the first zygotic transcription itself is an active component of c
248 e nucleocytoplasmic ratio-dependent onset of zygotic transcription of tribbles and other unknown gene
250 the slowing of the cell cycle, the onset of zygotic transcription, and the developmental activation
251 nsition (MBT) marks the onset of large-scale zygotic transcription, as well as an increase in cell cy
253 arge mRNAs emerge shortly after the onset of zygotic transcription, with several of these genes acqui
254 ns are specified prior to the broad onset of zygotic transcription, yet when transcription initiates
260 This switch complements an earlier switch to zygotic transcriptional control and explains why the pre
261 hich presumptively derive from divergent pre-zygotic transcriptional states established in the gamete
262 how that the transition from the maternal to zygotic transcriptome is characterized by a switch betwe
264 f: (1) maternally loaded shRNAs to knockdown zygotic transcripts and (2) maternally loaded Gal4 prote
268 plays a critical role during the maternal-to-zygotic transition (MZT) to promote developmental proces
269 ion in vertebrate embryos is the maternal-to-zygotic transition (MZT) when maternal mRNAs are degrade
270 ogenesis is characterized by the maternal to zygotic transition (MZT), in which maternally deposited
276 pufferfish and zebrafish during maternal to zygotic transition and annotated 1120 long non-coding RN
277 rk that is shedding light on the maternal to zygotic transition and the interrelated but distinct mec
279 one modifications throughout the maternal-to-zygotic transition in embryos of Drosophila melanogaster
280 ternal mRNA clearance during the maternal-to-zygotic transition in zebrafish, Xenopus, mouse, and Dro
282 sequencing during key stages of maternal to zygotic transition of Tetraodon nigroviridis and report
284 murine zygotes prior to the maternal to the zygotic transition yet absent in oocytes, consistent wit
286 ular mechanisms controlling this maternal to zygotic transition, it is important to distinguish betwe
295 n A/T-rich (W-box) motif, is replaced with a zygotic TSS selection grammar characterized by broader p
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